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Protein

C2 calcium-dependent domain-containing protein 4C

Gene

C2CD4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4C
Alternative name(s):
Nuclear-localized factor 3
Protein FAM148C
Gene namesi
Name:C2CD4C
Synonyms:FAM148C, KIAA1957, NLF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183186.7.
HGNCiHGNC:29417. C2CD4C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183186.
PharmGKBiPA165393218.

Polymorphism and mutation databases

BioMutaiC2CD4C.
DMDMi152032539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937341 – 421C2 calcium-dependent domain-containing protein 4CAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF44.
MaxQBiQ8TF44.
PaxDbiQ8TF44.
PeptideAtlasiQ8TF44.
PRIDEiQ8TF44.

PTM databases

iPTMnetiQ8TF44.
PhosphoSitePlusiQ8TF44.
SwissPalmiQ8TF44.

Expressioni

Gene expression databases

BgeeiENSG00000183186.
CleanExiHS_FAM148C.
GenevisibleiQ8TF44. HS.

Organism-specific databases

HPAiHPA055915.

Interactioni

Protein-protein interaction databases

BioGridi126002. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8TF44.
SMRiQ8TF44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 411C2PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the C2CD4 family.Curated

Phylogenomic databases

eggNOGiENOG410IFYM. Eukaryota.
ENOG41101WY. LUCA.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG056001.
InParanoidiQ8TF44.
OMAiQGAMSLP.
OrthoDBiEOG091G0AJU.
PhylomeDBiQ8TF44.
TreeFamiTF330989.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR030533. C2CD4.
PANTHERiPTHR10024:SF116. PTHR10024:SF116. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TF44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF
60 70 80 90 100
FIPPKLPSGP AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES
110 120 130 140 150
KSLLKAATRH VIQIESAEDW LSEEATDADP QAQGAMSLPS VPKAQTSYGF
160 170 180 190 200
AMLAESPHTR RKESLFHSEH GALAQVGSPG AGRRRAAAKA NGGDGGPREA
210 220 230 240 250
GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK GFAQDSQAKV
260 270 280 290 300
SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT
310 320 330 340 350
VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL
360 370 380 390 400
VPGKLQKQRS TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS
410 420
LKRDTLLGEK ELPLTSLLPF L
Length:421
Mass (Da):44,576
Last modified:July 10, 2007 - v2
Checksum:i0CB73547E08571BD
GO

Sequence cautioni

Q8TF44: The sequence BAB85543 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075837 mRNA. Translation: BAB85543.1. Different initiation.
AL834341 mRNA. Translation: CAD39008.1.
CCDSiCCDS45890.1.
RefSeqiNP_001129735.1. NM_001136263.1.
UniGeneiHs.223770.

Genome annotation databases

EnsembliENST00000332235; ENSP00000328677; ENSG00000183186.
GeneIDi126567.
KEGGihsa:126567.
UCSCiuc002loo.4. human.

Similar proteinsi

Entry informationi

Entry nameiC2C4C_HUMAN
AccessioniPrimary (citable) accession number: Q8TF44
Secondary accession number(s): Q8N3H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families