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Q8TF44

- C2C4C_HUMAN

UniProt

Q8TF44 - C2C4C_HUMAN

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Protein

C2 calcium-dependent domain-containing protein 4C

Gene
C2CD4C, FAM148C, KIAA1957, NLF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4C
Alternative name(s):
Nuclear-localized factor 3
Protein FAM148C
Gene namesi
Name:C2CD4C
Synonyms:FAM148C, KIAA1957, NLF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29417. C2CD4C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421C2 calcium-dependent domain-containing protein 4CPRO_0000293734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TF44.
PaxDbiQ8TF44.
PRIDEiQ8TF44.

PTM databases

PhosphoSiteiQ8TF44.

Expressioni

Gene expression databases

BgeeiQ8TF44.
CleanExiHS_FAM148C.
GenevestigatoriQ8TF44.

Organism-specific databases

HPAiHPA055915.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328677.

Structurei

3D structure databases

ProteinModelPortaliQ8TF44.
SMRiQ8TF44. Positions 320-419.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini307 – 411105C2Add
BLAST

Sequence similaritiesi

Belongs to the C2CD4 family.
Contains 1 C2 domain.

Phylogenomic databases

eggNOGiNOG44694.
HOGENOMiHOG000060308.
HOVERGENiHBG056001.
InParanoidiQ8TF44.
OMAiFHSEHGA.
OrthoDBiEOG76T9RX.
PhylomeDBiQ8TF44.
TreeFamiTF330989.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF44-1 [UniParc]FASTAAdd to Basket

« Hide

MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF    50
FIPPKLPSGP AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES 100
KSLLKAATRH VIQIESAEDW LSEEATDADP QAQGAMSLPS VPKAQTSYGF 150
AMLAESPHTR RKESLFHSEH GALAQVGSPG AGRRRAAAKA NGGDGGPREA 200
GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK GFAQDSQAKV 250
SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT 300
VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL 350
VPGKLQKQRS TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS 400
LKRDTLLGEK ELPLTSLLPF L 421
Length:421
Mass (Da):44,576
Last modified:July 10, 2007 - v2
Checksum:i0CB73547E08571BD
GO

Sequence cautioni

The sequence BAB85543.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075837 mRNA. Translation: BAB85543.1. Different initiation.
AL834341 mRNA. Translation: CAD39008.1.
CCDSiCCDS45890.1.
RefSeqiNP_001129735.1. NM_001136263.1.
UniGeneiHs.223770.

Genome annotation databases

EnsembliENST00000332235; ENSP00000328677; ENSG00000183186.
GeneIDi126567.
KEGGihsa:126567.
UCSCiuc002loo.3. human.

Polymorphism databases

DMDMi152032539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075837 mRNA. Translation: BAB85543.1 . Different initiation.
AL834341 mRNA. Translation: CAD39008.1 .
CCDSi CCDS45890.1.
RefSeqi NP_001129735.1. NM_001136263.1.
UniGenei Hs.223770.

3D structure databases

ProteinModelPortali Q8TF44.
SMRi Q8TF44. Positions 320-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328677.

PTM databases

PhosphoSitei Q8TF44.

Polymorphism databases

DMDMi 152032539.

Proteomic databases

MaxQBi Q8TF44.
PaxDbi Q8TF44.
PRIDEi Q8TF44.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332235 ; ENSP00000328677 ; ENSG00000183186 .
GeneIDi 126567.
KEGGi hsa:126567.
UCSCi uc002loo.3. human.

Organism-specific databases

CTDi 126567.
GeneCardsi GC19M000363.
HGNCi HGNC:29417. C2CD4C.
HPAi HPA055915.
MIMi 610336. gene.
neXtProti NX_Q8TF44.
PharmGKBi PA165393218.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44694.
HOGENOMi HOG000060308.
HOVERGENi HBG056001.
InParanoidi Q8TF44.
OMAi FHSEHGA.
OrthoDBi EOG76T9RX.
PhylomeDBi Q8TF44.
TreeFami TF330989.

Miscellaneous databases

GenomeRNAii 126567.
NextBioi 81854.
PROi Q8TF44.
SOURCEi Search...

Gene expression databases

Bgeei Q8TF44.
CleanExi HS_FAM148C.
Genevestigatori Q8TF44.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
PROSITEi PS50004. C2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-421.
    Tissue: Amygdala.
  3. "A novel gene family induced by acute inflammation in endothelial cells."
    Warton K., Foster N.C., Gold W.A., Stanley K.K.
    Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC2C4C_HUMAN
AccessioniPrimary (citable) accession number: Q8TF44
Secondary accession number(s): Q8N3H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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