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Q8TF44 (C2C4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C2 calcium-dependent domain-containing protein 4C
Alternative name(s):
Nuclear-localized factor 3
Protein FAM148C
Gene names
Name:C2CD4C
Synonyms:FAM148C, KIAA1957, NLF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the C2CD4 family.

Contains 1 C2 domain.

Sequence caution

The sequence BAB85543.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421C2 calcium-dependent domain-containing protein 4C
PRO_0000293734

Regions

Domain307 – 411105C2

Amino acid modifications

Modified residue2731Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8TF44 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 0CB73547E08571BD

FASTA42144,576
        10         20         30         40         50         60 
MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF FIPPKLPSGP 

        70         80         90        100        110        120 
AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES KSLLKAATRH VIQIESAEDW 

       130        140        150        160        170        180 
LSEEATDADP QAQGAMSLPS VPKAQTSYGF AMLAESPHTR RKESLFHSEH GALAQVGSPG 

       190        200        210        220        230        240 
AGRRRAAAKA NGGDGGPREA GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK 

       250        260        270        280        290        300 
GFAQDSQAKV SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT 

       310        320        330        340        350        360 
VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL VPGKLQKQRS 

       370        380        390        400        410        420 
TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS LKRDTLLGEK ELPLTSLLPF 


L 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-421.
Tissue: Amygdala.
[3]"A novel gene family induced by acute inflammation in endothelial cells."
Warton K., Foster N.C., Gold W.A., Stanley K.K.
Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB075837 mRNA. Translation: BAB85543.1. Different initiation.
AL834341 mRNA. Translation: CAD39008.1.
RefSeqNP_001129735.1. NM_001136263.1.
UniGeneHs.223770.

3D structure databases

ProteinModelPortalQ8TF44.
SMRQ8TF44. Positions 306-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000328677.

PTM databases

PhosphoSiteQ8TF44.

Polymorphism databases

DMDM152032539.

Proteomic databases

PaxDbQ8TF44.
PRIDEQ8TF44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332235; ENSP00000328677; ENSG00000183186.
GeneID126567.
KEGGhsa:126567.
UCSCuc002loo.3. human.

Organism-specific databases

CTD126567.
GeneCardsGC19M000363.
HGNCHGNC:29417. C2CD4C.
HPAHPA055915.
MIM610336. gene.
neXtProtNX_Q8TF44.
PharmGKBPA165393218.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44694.
HOGENOMHOG000060308.
HOVERGENHBG056001.
InParanoidQ8TF44.
OMAFHSEHGA.
OrthoDBEOG76T9RX.
PhylomeDBQ8TF44.
TreeFamTF330989.

Gene expression databases

BgeeQ8TF44.
CleanExHS_FAM148C.
GenevestigatorQ8TF44.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
[Graphical view]
PfamPF00168. C2. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi126567.
NextBio81854.
PROQ8TF44.
SOURCESearch...

Entry information

Entry nameC2C4C_HUMAN
AccessionPrimary (citable) accession number: Q8TF44
Secondary accession number(s): Q8N3H7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM