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Protein

C2 calcium-dependent domain-containing protein 4C

Gene

C2CD4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4C
Alternative name(s):
Nuclear-localized factor 3
Protein FAM148C
Gene namesi
Name:C2CD4C
Synonyms:FAM148C, KIAA1957, NLF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29417. C2CD4C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421C2 calcium-dependent domain-containing protein 4CPRO_0000293734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TF44.
PaxDbiQ8TF44.
PRIDEiQ8TF44.

PTM databases

PhosphoSiteiQ8TF44.

Expressioni

Gene expression databases

BgeeiQ8TF44.
CleanExiHS_FAM148C.
GenevestigatoriQ8TF44.

Organism-specific databases

HPAiHPA055915.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328677.

Structurei

3D structure databases

ProteinModelPortaliQ8TF44.
SMRiQ8TF44. Positions 306-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini307 – 411105C2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the C2CD4 family.Curated
Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG44694.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG056001.
InParanoidiQ8TF44.
OMAiATRHVIQ.
OrthoDBiEOG76T9RX.
PhylomeDBiQ8TF44.
TreeFamiTF330989.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR030533. C2CD4.
[Graphical view]
PANTHERiPTHR10024:SF116. PTHR10024:SF116. 1 hit.
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF
60 70 80 90 100
FIPPKLPSGP AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES
110 120 130 140 150
KSLLKAATRH VIQIESAEDW LSEEATDADP QAQGAMSLPS VPKAQTSYGF
160 170 180 190 200
AMLAESPHTR RKESLFHSEH GALAQVGSPG AGRRRAAAKA NGGDGGPREA
210 220 230 240 250
GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK GFAQDSQAKV
260 270 280 290 300
SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT
310 320 330 340 350
VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL
360 370 380 390 400
VPGKLQKQRS TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS
410 420
LKRDTLLGEK ELPLTSLLPF L
Length:421
Mass (Da):44,576
Last modified:July 9, 2007 - v2
Checksum:i0CB73547E08571BD
GO

Sequence cautioni

The sequence BAB85543.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075837 mRNA. Translation: BAB85543.1. Different initiation.
AL834341 mRNA. Translation: CAD39008.1.
CCDSiCCDS45890.1.
RefSeqiNP_001129735.1. NM_001136263.1.
UniGeneiHs.223770.

Genome annotation databases

EnsembliENST00000332235; ENSP00000328677; ENSG00000183186.
GeneIDi126567.
KEGGihsa:126567.
UCSCiuc002loo.3. human.

Polymorphism databases

DMDMi152032539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075837 mRNA. Translation: BAB85543.1. Different initiation.
AL834341 mRNA. Translation: CAD39008.1.
CCDSiCCDS45890.1.
RefSeqiNP_001129735.1. NM_001136263.1.
UniGeneiHs.223770.

3D structure databases

ProteinModelPortaliQ8TF44.
SMRiQ8TF44. Positions 306-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328677.

PTM databases

PhosphoSiteiQ8TF44.

Polymorphism databases

DMDMi152032539.

Proteomic databases

MaxQBiQ8TF44.
PaxDbiQ8TF44.
PRIDEiQ8TF44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332235; ENSP00000328677; ENSG00000183186.
GeneIDi126567.
KEGGihsa:126567.
UCSCiuc002loo.3. human.

Organism-specific databases

CTDi126567.
GeneCardsiGC19M000406.
HGNCiHGNC:29417. C2CD4C.
HPAiHPA055915.
MIMi610336. gene.
neXtProtiNX_Q8TF44.
PharmGKBiPA165393218.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44694.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG056001.
InParanoidiQ8TF44.
OMAiATRHVIQ.
OrthoDBiEOG76T9RX.
PhylomeDBiQ8TF44.
TreeFamiTF330989.

Miscellaneous databases

GenomeRNAii126567.
NextBioi81854.
PROiQ8TF44.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF44.
CleanExiHS_FAM148C.
GenevestigatoriQ8TF44.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR030533. C2CD4.
[Graphical view]
PANTHERiPTHR10024:SF116. PTHR10024:SF116. 1 hit.
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-421.
    Tissue: Amygdala.
  3. "A novel gene family induced by acute inflammation in endothelial cells."
    Warton K., Foster N.C., Gold W.A., Stanley K.K.
    Gene 342:85-95(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC2C4C_HUMAN
AccessioniPrimary (citable) accession number: Q8TF44
Secondary accession number(s): Q8N3H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2007
Last sequence update: July 9, 2007
Last modified: March 31, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.