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Q8TF44

- C2C4C_HUMAN

UniProt

Q8TF44 - C2C4C_HUMAN

Protein

C2 calcium-dependent domain-containing protein 4C

Gene

C2CD4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C2 calcium-dependent domain-containing protein 4C
    Alternative name(s):
    Nuclear-localized factor 3
    Protein FAM148C
    Gene namesi
    Name:C2CD4C
    Synonyms:FAM148C, KIAA1957, NLF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29417. C2CD4C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165393218.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421C2 calcium-dependent domain-containing protein 4CPRO_0000293734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TF44.
    PaxDbiQ8TF44.
    PRIDEiQ8TF44.

    PTM databases

    PhosphoSiteiQ8TF44.

    Expressioni

    Gene expression databases

    BgeeiQ8TF44.
    CleanExiHS_FAM148C.
    GenevestigatoriQ8TF44.

    Organism-specific databases

    HPAiHPA055915.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328677.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF44.
    SMRiQ8TF44. Positions 320-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini307 – 411105C2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the C2CD4 family.Curated
    Contains 1 C2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG44694.
    HOGENOMiHOG000060308.
    HOVERGENiHBG056001.
    InParanoidiQ8TF44.
    OMAiFHSEHGA.
    OrthoDBiEOG76T9RX.
    PhylomeDBiQ8TF44.
    TreeFamiTF330989.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TF44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF    50
    FIPPKLPSGP AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES 100
    KSLLKAATRH VIQIESAEDW LSEEATDADP QAQGAMSLPS VPKAQTSYGF 150
    AMLAESPHTR RKESLFHSEH GALAQVGSPG AGRRRAAAKA NGGDGGPREA 200
    GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK GFAQDSQAKV 250
    SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT 300
    VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL 350
    VPGKLQKQRS TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS 400
    LKRDTLLGEK ELPLTSLLPF L 421
    Length:421
    Mass (Da):44,576
    Last modified:July 10, 2007 - v2
    Checksum:i0CB73547E08571BD
    GO

    Sequence cautioni

    The sequence BAB85543.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075837 mRNA. Translation: BAB85543.1. Different initiation.
    AL834341 mRNA. Translation: CAD39008.1.
    CCDSiCCDS45890.1.
    RefSeqiNP_001129735.1. NM_001136263.1.
    UniGeneiHs.223770.

    Genome annotation databases

    EnsembliENST00000332235; ENSP00000328677; ENSG00000183186.
    GeneIDi126567.
    KEGGihsa:126567.
    UCSCiuc002loo.3. human.

    Polymorphism databases

    DMDMi152032539.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075837 mRNA. Translation: BAB85543.1 . Different initiation.
    AL834341 mRNA. Translation: CAD39008.1 .
    CCDSi CCDS45890.1.
    RefSeqi NP_001129735.1. NM_001136263.1.
    UniGenei Hs.223770.

    3D structure databases

    ProteinModelPortali Q8TF44.
    SMRi Q8TF44. Positions 320-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328677.

    PTM databases

    PhosphoSitei Q8TF44.

    Polymorphism databases

    DMDMi 152032539.

    Proteomic databases

    MaxQBi Q8TF44.
    PaxDbi Q8TF44.
    PRIDEi Q8TF44.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332235 ; ENSP00000328677 ; ENSG00000183186 .
    GeneIDi 126567.
    KEGGi hsa:126567.
    UCSCi uc002loo.3. human.

    Organism-specific databases

    CTDi 126567.
    GeneCardsi GC19M000363.
    HGNCi HGNC:29417. C2CD4C.
    HPAi HPA055915.
    MIMi 610336. gene.
    neXtProti NX_Q8TF44.
    PharmGKBi PA165393218.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44694.
    HOGENOMi HOG000060308.
    HOVERGENi HBG056001.
    InParanoidi Q8TF44.
    OMAi FHSEHGA.
    OrthoDBi EOG76T9RX.
    PhylomeDBi Q8TF44.
    TreeFami TF330989.

    Miscellaneous databases

    GenomeRNAii 126567.
    NextBioi 81854.
    PROi Q8TF44.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TF44.
    CleanExi HS_FAM148C.
    Genevestigatori Q8TF44.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-421.
      Tissue: Amygdala.
    3. "A novel gene family induced by acute inflammation in endothelial cells."
      Warton K., Foster N.C., Gold W.A., Stanley K.K.
      Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiC2C4C_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF44
    Secondary accession number(s): Q8N3H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3