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Protein

Ubiquitin-associated and SH3 domain-containing protein B

Gene

UBASH3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei390By similarity1
Active sitei391Tele-phosphohistidine intermediateBy similarity1
Active sitei576By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiQ8TF42
SIGNORiQ8TF42

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated and SH3 domain-containing protein B (EC:3.1.3.48)
Alternative name(s):
Cbl-interacting protein p70
Suppressor of T-cell receptor signaling 1
Short name:
STS-1
T-cell ubiquitin ligand 2
Short name:
TULA-2
Tyrosine-protein phosphatase STS1/TULA2
Gene namesi
Name:UBASH3B
Synonyms:KIAA1959, STS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000154127.9
HGNCiHGNC:29884 UBASH3B
MIMi609201 gene
neXtProtiNX_Q8TF42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84959
OpenTargetsiENSG00000154127
PharmGKBiPA162407840

Polymorphism and mutation databases

BioMutaiUBASH3B
DMDMi110287974

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455081 – 649Ubiquitin-associated and SH3 domain-containing protein BAdd BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF42
MaxQBiQ8TF42
PaxDbiQ8TF42
PeptideAtlasiQ8TF42
PRIDEiQ8TF42
ProteomicsDBi74552

PTM databases

DEPODiQ8TF42
iPTMnetiQ8TF42
PhosphoSitePlusiQ8TF42

Expressioni

Gene expression databases

BgeeiENSG00000154127
CleanExiHS_UBASH3B
GenevisibleiQ8TF42 HS

Organism-specific databases

HPAiHPA038605
HPA038607

Interactioni

Subunit structurei

Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphoprotein binding Source: Ensembl
  • ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

BioGridi124390, 113 interactors
IntActiQ8TF42, 50 interactors
MINTiQ8TF42
STRINGi9606.ENSP00000284273

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Helixi40 – 47Combined sources8
Helixi51 – 60Combined sources10
Turni61 – 63Combined sources3
Helixi66 – 74Combined sources9
Beta strandi252 – 254Combined sources3
Beta strandi257 – 261Combined sources5
Beta strandi268 – 272Combined sources5
Beta strandi280 – 283Combined sources4
Helixi285 – 287Combined sources3
Turni291 – 294Combined sources4
Beta strandi295 – 303Combined sources9
Beta strandi306 – 310Combined sources5
Helixi311 – 313Combined sources3
Beta strandi314 – 316Combined sources3
Beta strandi385 – 390Combined sources6
Helixi395 – 399Combined sources5
Helixi403 – 407Combined sources5
Helixi432 – 437Combined sources6
Helixi443 – 458Combined sources16
Beta strandi465 – 468Combined sources4
Helixi472 – 485Combined sources14
Turni488 – 490Combined sources3
Beta strandi493 – 495Combined sources3
Helixi497 – 499Combined sources3
Helixi503 – 505Combined sources3
Beta strandi508 – 510Combined sources3
Helixi517 – 522Combined sources6
Helixi537 – 539Combined sources3
Helixi546 – 564Combined sources19
Beta strandi565 – 567Combined sources3
Beta strandi569 – 575Combined sources7
Helixi579 – 582Combined sources4
Turni583 – 585Combined sources3
Helixi586 – 588Combined sources3
Helixi595 – 602Combined sources8
Beta strandi610 – 615Combined sources6
Turni617 – 619Combined sources3
Beta strandi622 – 625Combined sources4
Helixi642 – 645Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPWNMR-A26-76[»]
2E5KNMR-A248-328[»]
5VR6X-ray1.87A/B384-649[»]
5W5GX-ray2.48A/B/C383-644[»]
ProteinModelPortaliQ8TF42
SMRiQ8TF42
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TF42

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 76UBAPROSITE-ProRule annotationAdd BLAST50
Domaini254 – 319SH3PROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 649Protein tyrosine phosphataseBy similarityAdd BLAST270

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3734 Eukaryota
ENOG410YGUZ LUCA
GeneTreeiENSGT00390000018249
HOGENOMiHOG000012936
HOVERGENiHBG018025
InParanoidiQ8TF42
KOiK18993
OMAiGCASNWE
OrthoDBiEOG091G0DJ2
PhylomeDBiQ8TF42
TreeFamiTF313334

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
cd11936 SH3_UBASH3B, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR035632 UBASH3B_SH3
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
PF14604 SH3_9, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF50044 SSF50044, 1 hit
SSF53254 SSF53254, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TF42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYGHPSPL GMAAREELYS KVTPRRNRQQ RPGTIKHGSA LDVLLSMGFP
60 70 80 90 100
RARAQKALAS TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL
110 120 130 140 150
AQKLSDFWQQ SKQICGKNKA HNIFPHITLC QFFMCEDSKV DALGEALQTT
160 170 180 190 200
VSRWKCKFSA PLPLELYTSS NFIGLFVKED SAEVLKKFAA DFAAEAASKT
210 220 230 240 250
EVHVEPHKKQ LHVTLAYHFQ ASHLPTLEKL AQNIDVKLGC DWVATIFSRD
260 270 280 290 300
IRFANHETLQ VIYPYTPQND DELELVPGDF IFMSPMEQTS TSEGWIYGTS
310 320 330 340 350
LTTGCSGLLP ENYITKADEC STWIFHGSYS ILNTSSSNSL TFGDGVLERR
360 370 380 390 400
PYEDQGLGET TPLTIICQPM QPLRVNSQPG PQKRCLFVCR HGERMDVVFG
410 420 430 440 450
KYWLSQCFDA KGRYIRTNLN MPHSLPQRSG GFRDYEKDAP ITVFGCMQAR
460 470 480 490 500
LVGEALLESN TIIDHVYCSP SLRCVQTAHN ILKGLQQENH LKIRVEPGLF
510 520 530 540 550
EWTKWVAGST LPAWIPPSEL AAANLSVDTT YRPHIPISKL VVSESYDTYI
560 570 580 590 600
SRSFQVTKEI ISECKSKGNN ILIVAHASSL EACTCQLQGL SPQNSKDFVQ
610 620 630 640
MVRKIPYLGF CSCEELGETG IWQLTDPPIL PLTHGPTGGF NWRETLLQE
Length:649
Mass (Da):72,696
Last modified:July 11, 2006 - v2
Checksum:i70ED9F50EA20BF43
GO

Sequence cautioni

The sequence AAL16953 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85545 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti465H → R in BAD96563 (Ref. 3) Curated1
Sequence conflicti465H → R in BAD96566 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05267668A → T1 PublicationCorresponds to variant dbSNP:rs12790613Ensembl.1
Natural variantiVAR_061923569N → S. Corresponds to variant dbSNP:rs35343548Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075839 mRNA Translation: BAB85545.1 Different initiation.
AK075203 mRNA Translation: BAC11468.1
AK222843 mRNA Translation: BAD96563.1
AK222846 mRNA Translation: BAD96566.1
BC007541 mRNA Translation: AAH07541.2
AF425252 mRNA Translation: AAL16953.1 Different initiation.
CCDSiCCDS31694.1
RefSeqiNP_116262.2, NM_032873.4
UniGeneiHs.444075

Genome annotation databases

EnsembliENST00000284273; ENSP00000284273; ENSG00000154127
GeneIDi84959
KEGGihsa:84959
UCSCiuc001pyi.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBS3B_HUMAN
AccessioniPrimary (citable) accession number: Q8TF42
Secondary accession number(s): Q53GT5
, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 20, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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