Reviewed,
UniProtKB/Swiss-Prot Q8TF42 (UBS3B_HUMAN)
Last modified
June 16, 2009.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-associated and SH3 domain-containing protein B Alternative name(s): Suppressor of T-cell receptor signaling 1 Short name=STS-1 Cbl-interacting protein p70 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 649 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Ref.7 |
| Subunit structure | Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Ref.7 |
| Subcellular location | |
| Sequence similarities | Contains 1 SH3 domain. Contains 1 UBA domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Domain | SH3 domain |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 649 | 649 | Ubiquitin-associated and SH3 domain-containing protein B | PRO_0000245508 | ||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||
| Domain | 27 – 76 | 50 | UBA | |||||||||||||||||||||||
| Domain | 254 – 319 | 66 | SH3 | |||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||
| Modified residue | 20 | 1 | Phosphoserine Ref.8 | |||||||||||||||||||||||
| Modified residue | 23 | 1 | Phosphothreonine Ref.8 | |||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||
| Natural variant | 68 | 1 | A → T: dbSNP rs12790613. Ref.3 | VAR_052676 | ||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||
| Sequence conflict | 465 | 1 | H → R in BAD96563. Ref.3 | |||||||||||||||||||||||
| Sequence conflict | 465 | 1 | H → R in BAD96566. Ref.3 | |||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||
| Beta strand | 252 – 254 | 3 | ||||||||||||||||||||||||
| Beta strand | 257 – 261 | 5 | ||||||||||||||||||||||||
| Beta strand | 268 – 272 | 5 | ||||||||||||||||||||||||
| Beta strand | 280 – 283 | 4 | ||||||||||||||||||||||||
| Helix | 285 – 287 | 3 | ||||||||||||||||||||||||
| Turn | 291 – 294 | 4 | ||||||||||||||||||||||||
| Beta strand | 295 – 303 | 9 | ||||||||||||||||||||||||
| Beta strand | 306 – 310 | 5 | ||||||||||||||||||||||||
| Helix | 311 – 313 | 3 | ||||||||||||||||||||||||
| Beta strand | 314 – 316 | 3 | ||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed: 11853319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [2] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [3] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-68. Tissue: Liver. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [5] | Bienvenut W.V., Claeys D. Submitted (NOV-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 89-112; 188-199; 230-237 AND 417-428, MASS SPECTROMETRY. Tissue: Platelet. |
| [6] | "A novel SH3 containing protein is phosphorylated by the nm23-H1 protein kinase activity in vitro and shows reduced mRNA expression in human tumors." Engel M., Seifert M., Maschlanka M., Welter C. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 116-649. |
| [7] | "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases." Kowanetz K., Crosetto N., Haglund K., Schmidt M.H., Heldin C.-H., Dikic I. J. Biol. Chem. 279:32786-32795(2004) [PubMed: 15159412] [Abstract] Cited for: FUNCTION, INTERACTION WITH CBL AND UBIQUITIN, IDENTIFICATION IN A COMPLEX WITH EGFR. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND THR-23, MASS SPECTROMETRY. |
| [9] | "Solution structure of RSGI RUH-031, a UBA domain from human cDNA." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 26-76. |
| [10] | "Solution structure of SH3 domain in suppressor of T-cell receptor signaling 1." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 248-328. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AB075839 mRNA. Translation: BAB85545.1. Different initiation. AK075203 mRNA. Translation: BAC11468.1. AK222843 mRNA. Translation: BAD96563.1. AK222846 mRNA. Translation: BAD96566.1. BC007541 mRNA. Translation: AAH07541.2. AF425252 mRNA. Translation: AAL16953.1. Different initiation. | |||||||||||||||||||
| IPI | IPI00154910. | ||||||||||||||||||
| RefSeq | NP_116262.2. | ||||||||||||||||||
| UniGene | Hs.444075 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q8TF42. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q8TF42. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSG00000154127. Homo sapiens. [Contig view] | ||||||||||||||||||
| GeneID | 84959. | ||||||||||||||||||
| KEGG | hsa:84959. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| GeneCards | GC11P122032. | ||||||||||||||||||
| HGNC | HGNC:29884. UBASH3B. | ||||||||||||||||||
| MIM | 609201. gene. | ||||||||||||||||||
| HUGE | Search... | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | Q8TF42. | ||||||||||||||||||
| HOVERGEN | Q8TF42. | ||||||||||||||||||
| OMA | Q8TF42. IEPGLFE. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q8TF42. | ||||||||||||||||||
| Bgee | Q8TF42. | ||||||||||||||||||
| CleanEx | HS_UBASH3B. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR013078. PG_mutase. IPR001452. SH3_domain. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. [Graphical view] | ||||||||||||||||||
| Pfam | PF00300. PGAM. 1 hit. PF00018. SH3_1. 1 hit. PF00627. UBA. 1 hit. [Graphical view] | ||||||||||||||||||
| ProDom | PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||
| SMART | SM00326. SH3. 1 hit. SM00165. UBA. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS50002. SH3. 1 hit. PS50030. UBA. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 75468. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | UBS3B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TF42 Secondary accession number(s): Q53GT5 Q96NZ2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


