##gff-version 3 Q8TF40 UniProtKB Chain 1 1166 . . . ID=PRO_0000308484;Note=Folliculin-interacting protein 1 Q8TF40 UniProtKB Domain 37 478 . . . Note=UDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180 Q8TF40 UniProtKB Domain 486 1092 . . . Note=CDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180 Q8TF40 UniProtKB Domain 1102 1157 . . . Note=DDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180 Q8TF40 UniProtKB Region 611 612 . . . Note=KY-finger;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Region 781 817 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TF40 UniProtKB Region 912 956 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TF40 UniProtKB Region 929 1166 . . . Note=Interaction with HSP90AA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27353360;Dbxref=PMID:27353360 Q8TF40 UniProtKB Motif 608 615 . . . Note=Cys degron;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Compositional bias 781 803 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TF40 UniProtKB Compositional bias 912 930 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TF40 UniProtKB Binding site 608 608 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Binding site 610 610 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Binding site 613 613 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Binding site 613 613 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Binding site 615 615 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD7 Q8TF40 UniProtKB Modified residue 220 220 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:37079666,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569,PMID:37079666 Q8TF40 UniProtKB Modified residue 230 230 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Modified residue 232 232 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Modified residue 261 261 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Modified residue 294 294 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TF40 UniProtKB Modified residue 296 296 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TF40 UniProtKB Modified residue 593 593 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:37079666,ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648,PMID:37079666 Q8TF40 UniProtKB Modified residue 594 594 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q8TF40 UniProtKB Modified residue 760 760 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 Q8TF40 UniProtKB Modified residue 763 763 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 Q8TF40 UniProtKB Modified residue 938 938 . . . Note=Phosphoserine%3B alternate%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Modified residue 939 939 . . . Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Modified residue 941 941 . . . Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Modified residue 946 946 . . . Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Modified residue 948 948 . . . Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Glycosylation 938 938 . . . Note=O-linked (GlcNAc) serine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Cross-link 1119 1119 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Alternative sequence 208 235 . . . ID=VSP_028984;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319 Q8TF40 UniProtKB Alternative sequence 508 508 . . . ID=VSP_028982;Note=In isoform 2. D->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8TF40 UniProtKB Alternative sequence 509 1166 . . . ID=VSP_028983;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8TF40 UniProtKB Natural variant 76 76 . . . ID=VAR_036824;Note=G->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17028174;Dbxref=dbSNP:rs7730228,PMID:15489334,PMID:17028174 Q8TF40 UniProtKB Natural variant 290 1166 . . . ID=VAR_086807;Note=In IMD93%3B undetectable protein in homozygous patient cells. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32905580;Dbxref=PMID:32905580 Q8TF40 UniProtKB Natural variant 354 354 . . . ID=VAR_036825;Note=S->L;Dbxref=dbSNP:rs13177318 Q8TF40 UniProtKB Natural variant 648 648 . . . ID=VAR_036826;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11853319,ECO:0000269|PubMed:17028174,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs26008,PMID:11853319,PMID:17028174,PMID:17974005 Q8TF40 UniProtKB Natural variant 738 738 . . . ID=VAR_036827;Note=V->L;Dbxref=dbSNP:rs12109782 Q8TF40 UniProtKB Natural variant 844 844 . . . ID=VAR_036828;Note=I->V;Dbxref=dbSNP:rs7717874 Q8TF40 UniProtKB Natural variant 1118 1118 . . . ID=VAR_086808;Note=In IMD93%3B uncertain significance. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32181500;Dbxref=PMID:32181500 Q8TF40 UniProtKB Mutagenesis 220 220 . . . Note=In SA5 mutant%3B Abolishes phosphorylation by AMPK%2C leading to activation of the non-canonical mTORC1 signaling%3B when associated with 230-A--A-232%2C A-261 and A-593. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Mutagenesis 230 232 . . . Note=In SA5 mutant%3B Abolishes phosphorylation by AMPK%2C leading to activation of the non-canonical mTORC1 signaling%3B when associated with A-220%2C A-261 and A-593. SAS->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Mutagenesis 261 261 . . . Note=In SA5 mutant%3B Abolishes phosphorylation by AMPK%2C leading to activation of the non-canonical mTORC1 signaling%3B when associated with A-220%2C 230-A--A-232 and A-593. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Mutagenesis 593 593 . . . Note=In SA5 mutant%3B Abolishes phosphorylation by AMPK%2C leading to activation of the non-canonical mTORC1 signaling%3B when associated with A-220%2C 230-A--A-232 and A-261. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37079666;Dbxref=PMID:37079666 Q8TF40 UniProtKB Mutagenesis 938 948 . . . Note=Mimics phosphorylation status%3B leading to inhibit ATPase activity of HSP90AA1/Hsp90. SSDSALGDSES->EDEALGDEEE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Mutagenesis 938 938 . . . Note=Impaired phosphorylation by CK2 and interaction with HSP90AA1/Hsp90. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Mutagenesis 982 982 . . . Note=No effect on ubiquitination and protein stability. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Mutagenesis 1117 1117 . . . Note=No effect on ubiquitination and protein stability. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Mutagenesis 1119 1119 . . . Note=Impaired ubiquitination%2C leading to increased stability. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359 Q8TF40 UniProtKB Mutagenesis 1134 1134 . . . Note=No effect on ubiquitination and protein stability. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30699359;Dbxref=PMID:30699359