Folliculin-interacting protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase inhibitor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 27353360
• chaperone binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 27353360
• guanyl-nucleotide exchange factor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22977732

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cellular response to starvation Source: UniProtKB
• immature B cell differentiation Source: UniProtKB
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
• negative regulation of TOR signaling Source: UniProtKB
• negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21209915
• positive regulation of B cell apoptotic process Source: UniProtKB
• positive regulation of peptidyl-serine phosphorylation Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19914239
• positive regulation of protein complex assembly Source: ParkinsonsUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 25126726
• positive regulation of protein phosphorylation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17028174
• regulation of pro-B cell differentiation Source: UniProtKB
• regulation of protein phosphorylation Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18663353
• TOR signaling Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17028174

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cytoplasm Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 17028174
  • 18663353

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chaperone binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 27353360

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC 
        60         70         80         90        100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL 
       110        120        130        140        150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ 
       160        170        180        190        200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI 
       210        220        230        240        250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE 
       260        270        280        290        300
DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG 
       310        320        330        340        350
VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE 
       360        370        380        390        400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF 
       410        420        430        440        450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ 
       460        470        480        490        500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN 
       510        520        530        540        550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD MVQRLLYFLT YFIRCSELQE 
       560        570        580        590        600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLVTMHR NKSSLLFKES 
       610        620        630        640        650
EEIRTPNCNC KYCSHPLLGQ NVENISQQER EDIQNSSKEL LGISDECQMI 
       660        670        680        690        700
SPSDCQEENA VDVKQYRDKL RTCFDAKLET VVCTGSVPVD KCALSESGLE 
       710        720        730        740        750
STEETWQSEK LLDSDSHTGK AMRSTGMVVE KKPPDKIVPA SFSCEAAQTK 
       760        770        780        790        800
VTFLIGDSMS PDSDTELRSQ AVVDQITRHH TKPLKEERGA IDQHQETKQT 
       810        820        830        840        850
TKDQSGESDT QNMVSEEPCE LPCWNHSDPE SMSLFDEYFN DDSIETRTID 
       860        870        880        890        900
DVPFKTSTDS KDHCCMLEFS KILCTKNNKQ NNEFCKCIET VPQDSCKTCF 
       910        920        930        940        950
PQQDQRDTLS ILVPHGDKES SDKKIAVGTE WDIPRNESSD SALGDSESED 
       960        970        980        990       1000
TGHDMTRQVS SYYGGEQEDW AEEDEIPFPG SKLIEVSAVQ PNIANFGRSL 
      1010       1020       1030       1040       1050
LGGYCSSYVP DFVLQGIGSD ERFRQCLMSD LSHAVQHPVL DEPIAEAVCI 
      1060       1070       1080       1090       1100
IADMDKWTVQ VASSQRRVTD NKLGKEVLVS SLVSNLLHST LQLYKHNLSP 
      1110       1120       1130       1140       1150
NFCVMHLEDR LQELYFKSKM LSEYLRGQMR VHVKELGVVL GIESSDLPLL 
      1160 
AAVASTHSPY VAQILL                                  

        10         20         30         40         50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC 
        60         70         80         90        100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL 
       110        120        130        140        150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ 
       160        170        180        190        200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI 
       210        220        230        240        250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE 
       260        270        280        290        300
DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG 
       310        320        330        340        350
VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE 
       360        370        380        390        400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF 
       410        420        430        440        450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ 
       460        470        480        490        500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN 

PLWAQLGM                                             

        10         20         30         40         50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC 
        60         70         80         90        100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL 
       110        120        130        140        150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ 
       160        170        180        190        200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI 
       210        220        230        240        250
NGLLGNIVHS NPMDMPGREL NEDRDSGIAR SASLSSLLIT PFPSPNSSLT 
       260        270        280        290        300
RSCASSYQRR WRRSQTTSLE NGVFPRWSIE ESFNLSDESC GPNPGIVRKK 
       310        320        330        340        350
KIAIGVIFSL SKDEDENNKF NEFFFSHFPL FESHMNKLKS AIEQAMKMSR 
       360        370        380        390        400
RSADASQRSL AYNRIVDALN EFRTTICNLY TMPRIGEPVW LTMMSGTPEK 
       410        420        430        440        450
NHLCYRFMKE FTFLMENASK NQFLPALITA VLTNHLAWVP TVMPNGQPPI 
       460        470        480        490        500
KIFLEKHSSQ SVDMLAKTHP YNPLWAQLGD LYGAIGSPVR LARTVVVGKR 
       510        520        530        540        550
QDMVQRLLYF LTYFIRCSEL QETHLLENGE DEAIVMPGTV ITTTLEKGEI 
       560        570        580        590        600
EESEYVLVTM HRNKSSLLFK ESEEIRTPNC NCKYCSHPLL GQNVENISQQ 
       610        620        630        640        650
EREDIQNSSK ELLGISDECQ MISPSDCQEE NAVDVKQYRD KLRTCFDAKL 
       660        670        680        690        700
ETVVCTGSVP VDKCALSESG LESTEETWQS EKLLDSDSHT GKAMRSTGMV 
       710        720        730        740        750
VEKKPPDKIV PASFSCEAAQ TKVTFLIGDS MSPDSDTELR SQAVVDQITR 
       760        770        780        790        800
HHTKPLKEER GAIDQHQETK QTTKDQSGES DTQNMVSEEP CELPCWNHSD 
       810        820        830        840        850
PESMSLFDEY FNDDSIETRT IDDVPFKTST DSKDHCCMLE FSKILCTKNN 
       860        870        880        890        900
KQNNEFCKCI ETVPQDSCKT CFPQQDQRDT LSILVPHGDK ESSDKKIAVG 
       910        920        930        940        950
TEWDIPRNES SDSALGDSES EDTGHDMTRQ VSSYYGGEQE DWAEEDEIPF 
       960        970        980        990       1000
PGSKLIEVSA VQPNIANFGR SLLGGYCSSY VPDFVLQGIG SDERFRQCLM 
      1010       1020       1030       1040       1050
SDLSHAVQHP VLDEPIAEAV CIIADMDKWT VQVASSQRRV TDNKLGKEVL 
      1060       1070       1080       1090       1100
VSSLVSNLLH STLQLYKHNL SPNFCVMHLE DRLQELYFKS KMLSEYLRGQ 
      1110       1120       1130 
MRVHVKELGV VLGIESSDLP LLAAVASTHS PYVAQILL            

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families