UniProtKB - Q8TF40 (FNIP1_HUMAN)
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Protein
Folliculin-interacting protein 1
Gene
FNIP1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).3 Publications
Miscellaneous
Elevated expression levels in histologic variants of renal tumors.
GO - Molecular functioni
- ATPase inhibitor activity Source: UniProtKB
- chaperone binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- cellular response to starvation Source: UniProtKB
- immature B cell differentiation Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of B cell apoptotic process Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of protein complex assembly Source: ParkinsonsUK-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- regulation of pro-B cell differentiation Source: UniProtKB
- regulation of protein phosphorylation Source: UniProtKB
- TOR signaling Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Folliculin-interacting protein 1 |
Gene namesi | Name:FNIP1 Synonyms:KIAA1961 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000217128.11. |
HGNCi | HGNC:29418. FNIP1. |
MIMi | 610594. gene. |
neXtProti | NX_Q8TF40. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 96459. |
OpenTargetsi | ENSG00000217128. |
PharmGKBi | PA142671758. |
Polymorphism and mutation databases
BioMutai | FNIP1. |
DMDMi | 313104236. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308484 | 1 – 1166 | Folliculin-interacting protein 1Add BLAST | 1166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 594 | PhosphoserineCombined sources | 1 | |
Modified residuei | 760 | PhosphoserineCombined sources | 1 | |
Modified residuei | 763 | PhosphoserineCombined sources | 1 | |
Modified residuei | 941 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated by AMPK.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TF40. |
MaxQBi | Q8TF40. |
PaxDbi | Q8TF40. |
PeptideAtlasi | Q8TF40. |
PRIDEi | Q8TF40. |
PTM databases
iPTMneti | Q8TF40. |
PhosphoSitePlusi | Q8TF40. |
Expressioni
Tissue specificityi
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.3 Publications
Gene expression databases
Bgeei | ENSG00000217128. |
CleanExi | HS_FNIP1. |
ExpressionAtlasi | Q8TF40. baseline and differential. |
Genevisiblei | Q8TF40. HS. |
Organism-specific databases
HPAi | HPA068099. HPA071213. |
Interactioni
Subunit structurei
Homodimer and homomultimer. Heterodimer and heteromultimer with FNIP2 (PubMed:27353360, PubMed:18403135). Interacts with FLCN (via C-terminus) (PubMed:17028174, PubMed:27353360). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound (PubMed:17028174). Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4. Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (PubMed:27353360).3 Publications
Binary interactionsi
GO - Molecular functioni
- chaperone binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 125175. 25 interactors. |
DIPi | DIP-57169N. |
IntActi | Q8TF40. 10 interactors. |
MINTi | Q8TF40. |
STRINGi | 9606.ENSP00000421985. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 478 | uDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 442 | |
Domaini | 486 – 1092 | cDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 607 | |
Domaini | 1102 – 1157 | dDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 929 – 1166 | Interaction with HSP90AA11 PublicationAdd BLAST | 238 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 99 | Poly-Ser | 4 |
Sequence similaritiesi
Belongs to the FNIP family.Curated
Phylogenomic databases
eggNOGi | KOG3693. Eukaryota. ENOG410ZIEC. LUCA. |
GeneTreei | ENSGT00390000009391. |
HOGENOMi | HOG000112624. |
HOVERGENi | HBG059425. |
InParanoidi | Q8TF40. |
KOi | K20400. |
OMAi | PNCNCKY. |
OrthoDBi | EOG091G016D. |
PhylomeDBi | Q8TF40. |
TreeFami | TF324090. |
Family and domain databases
InterProi | View protein in InterPro IPR037545. DENN_FNIP1/2. IPR028086. FNIP_C_dom. IPR026156. FNIP_fam. IPR028085. FNIP_mid_dom. IPR028084. FNIP_N_dom. |
PANTHERi | PTHR21634. PTHR21634. 1 hit. |
Pfami | View protein in Pfam PF14638. FNIP_C. 1 hit. PF14637. FNIP_M. 1 hit. PF14636. FNIP_N. 1 hit. |
PRINTSi | PR02073. FOLLICULNIP1. |
PROSITEi | View protein in PROSITE PS51836. DENN_FNIP12. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TF40-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD MVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLVTMHR NKSSLLFKES
610 620 630 640 650
EEIRTPNCNC KYCSHPLLGQ NVENISQQER EDIQNSSKEL LGISDECQMI
660 670 680 690 700
SPSDCQEENA VDVKQYRDKL RTCFDAKLET VVCTGSVPVD KCALSESGLE
710 720 730 740 750
STEETWQSEK LLDSDSHTGK AMRSTGMVVE KKPPDKIVPA SFSCEAAQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQITRHH TKPLKEERGA IDQHQETKQT
810 820 830 840 850
TKDQSGESDT QNMVSEEPCE LPCWNHSDPE SMSLFDEYFN DDSIETRTID
860 870 880 890 900
DVPFKTSTDS KDHCCMLEFS KILCTKNNKQ NNEFCKCIET VPQDSCKTCF
910 920 930 940 950
PQQDQRDTLS ILVPHGDKES SDKKIAVGTE WDIPRNESSD SALGDSESED
960 970 980 990 1000
TGHDMTRQVS SYYGGEQEDW AEEDEIPFPG SKLIEVSAVQ PNIANFGRSL
1010 1020 1030 1040 1050
LGGYCSSYVP DFVLQGIGSD ERFRQCLMSD LSHAVQHPVL DEPIAEAVCI
1060 1070 1080 1090 1100
IADMDKWTVQ VASSQRRVTD NKLGKEVLVS SLVSNLLHST LQLYKHNLSP
1110 1120 1130 1140 1150
NFCVMHLEDR LQELYFKSKM LSEYLRGQMR VHVKELGVVL GIESSDLPLL
1160
AAVASTHSPY VAQILL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036824 | 76 | G → C2 PublicationsCorresponds to variant dbSNP:rs7730228Ensembl. | 1 | |
Natural variantiVAR_036825 | 354 | S → L. Corresponds to variant dbSNP:rs13177318Ensembl. | 1 | |
Natural variantiVAR_036826 | 648 | Q → R3 PublicationsCorresponds to variant dbSNP:rs26008Ensembl. | 1 | |
Natural variantiVAR_036827 | 738 | V → L. Corresponds to variant dbSNP:rs12109782Ensembl. | 1 | |
Natural variantiVAR_036828 | 844 | I → V. Corresponds to variant dbSNP:rs7717874Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028984 | 208 – 235 | Missing in isoform 3. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_028982 | 508 | D → M in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_028983 | 509 – 1166 | Missing in isoform 2. 1 PublicationAdd BLAST | 658 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ145719 mRNA. Translation: AAZ65854.1. AC004227 Genomic DNA. No translation available. AC004622 Genomic DNA. No translation available. AC005593 Genomic DNA. No translation available. AC008695 Genomic DNA. No translation available. AC008497 Genomic DNA. No translation available. AC026754 Genomic DNA. No translation available. BC001956 mRNA. Translation: AAH01956.1. AB075841 mRNA. Translation: BAB85547.1. AL832008 mRNA. Translation: CAD91145.1. |
CCDSi | CCDS34226.1. [Q8TF40-3] CCDS34227.1. [Q8TF40-1] |
RefSeqi | NP_001008738.2. NM_001008738.2. NP_001333042.1. NM_001346113.1. NP_588613.2. NM_133372.2. |
UniGenei | Hs.591273. |
Genome annotation databases
Ensembli | ENST00000307968; ENSP00000309266; ENSG00000217128. [Q8TF40-3] ENST00000510461; ENSP00000421985; ENSG00000217128. [Q8TF40-1] ENST00000511848; ENSP00000425619; ENSG00000217128. [Q8TF40-2] |
GeneIDi | 96459. |
KEGGi | hsa:96459. |
UCSCi | uc003kvs.2. human. [Q8TF40-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | FNIP1_HUMAN | |
Accessioni | Q8TF40Primary (citable) accession number: Q8TF40 Secondary accession number(s): D6RJH5, Q86T47, Q9BUT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | March 28, 2018 | |
This is version 108 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |