Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TF40

- FNIP1_HUMAN

UniProt

Q8TF40 - FNIP1_HUMAN

Protein

Folliculin-interacting protein 1

Gene

FNIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.2 Publications

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to starvation Source: UniProtKB
    2. immature B cell differentiation Source: UniProtKB
    3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    4. negative regulation of TOR signaling Source: UniProtKB
    5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. positive regulation of B cell apoptotic process Source: UniProtKB
    7. positive regulation of GTPase activity Source: GOC
    8. positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
    9. positive regulation of protein phosphorylation Source: UniProtKB
    10. regulation of pro-B cell differentiation Source: UniProtKB
    11. regulation of protein phosphorylation Source: UniProtKB
    12. TOR signaling Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folliculin-interacting protein 1
    Gene namesi
    Name:FNIP1
    Synonyms:KIAA1961
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29418. FNIP1.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Colocalizes with FLCN in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11661166Folliculin-interacting protein 1PRO_0000308484Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei593 – 5931Phosphoserine2 Publications
    Modified residuei594 – 5941Phosphoserine2 Publications
    Modified residuei760 – 7601Phosphoserine4 Publications
    Modified residuei763 – 7631Phosphoserine4 Publications

    Post-translational modificationi

    Phosphorylated by AMPK.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TF40.
    PaxDbiQ8TF40.
    PRIDEiQ8TF40.

    PTM databases

    PhosphoSiteiQ8TF40.

    Expressioni

    Tissue specificityi

    Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.2 Publications

    Gene expression databases

    ArrayExpressiQ8TF40.
    BgeeiQ8TF40.
    CleanExiHS_FNIP1.
    GenevestigatoriQ8TF40.

    Interactioni

    Subunit structurei

    Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPO951665EBI-2946919,EBI-712001
    GABARAPL1Q9H0R82EBI-2946919,EBI-746969
    ORFQ9Q2G43EBI-2946919,EBI-6248094From a different organism.

    Protein-protein interaction databases

    BioGridi125175. 8 interactions.
    IntActiQ8TF40. 8 interactions.
    MINTiMINT-7298196.
    STRINGi9606.ENSP00000310453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi96 – 994Poly-Ser

    Sequence similaritiesi

    Belongs to the FNIP family.Curated

    Phylogenomic databases

    eggNOGiNOG330489.
    HOGENOMiHOG000112624.
    HOVERGENiHBG059425.
    InParanoidiQ8TF40.
    PhylomeDBiQ8TF40.
    TreeFamiTF324090.

    Family and domain databases

    InterProiIPR028086. FNIP_C_dom.
    IPR026156. FNIP_fam.
    IPR028085. FNIP_mid_dom.
    IPR028084. FNIP_N_dom.
    [Graphical view]
    PANTHERiPTHR21634. PTHR21634. 1 hit.
    PfamiPF14638. FNIP_C. 1 hit.
    PF14637. FNIP_M. 1 hit.
    PF14636. FNIP_N. 1 hit.
    [Graphical view]
    PRINTSiPR02073. FOLLICULNIP1.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TF40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC     50
    ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL 100
    DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ 150
    IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI 200
    NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE 250
    DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG 300
    VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE 350
    FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF 400
    RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ 450
    FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN 500
    PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD MVQRLLYFLT YFIRCSELQE 550
    THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLVTMHR NKSSLLFKES 600
    EEIRTPNCNC KYCSHPLLGQ NVENISQQER EDIQNSSKEL LGISDECQMI 650
    SPSDCQEENA VDVKQYRDKL RTCFDAKLET VVCTGSVPVD KCALSESGLE 700
    STEETWQSEK LLDSDSHTGK AMRSTGMVVE KKPPDKIVPA SFSCEAAQTK 750
    VTFLIGDSMS PDSDTELRSQ AVVDQITRHH TKPLKEERGA IDQHQETKQT 800
    TKDQSGESDT QNMVSEEPCE LPCWNHSDPE SMSLFDEYFN DDSIETRTID 850
    DVPFKTSTDS KDHCCMLEFS KILCTKNNKQ NNEFCKCIET VPQDSCKTCF 900
    PQQDQRDTLS ILVPHGDKES SDKKIAVGTE WDIPRNESSD SALGDSESED 950
    TGHDMTRQVS SYYGGEQEDW AEEDEIPFPG SKLIEVSAVQ PNIANFGRSL 1000
    LGGYCSSYVP DFVLQGIGSD ERFRQCLMSD LSHAVQHPVL DEPIAEAVCI 1050
    IADMDKWTVQ VASSQRRVTD NKLGKEVLVS SLVSNLLHST LQLYKHNLSP 1100
    NFCVMHLEDR LQELYFKSKM LSEYLRGQMR VHVKELGVVL GIESSDLPLL 1150
    AAVASTHSPY VAQILL 1166
    Length:1,166
    Mass (Da):130,555
    Last modified:November 30, 2010 - v3
    Checksum:i3B99DBA98E7169C5
    GO
    Isoform 2 (identifier: Q8TF40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         508-508: D → M
         509-1166: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:508
    Mass (Da):56,802
    Checksum:i59A0719AD6A85CF9
    GO
    Isoform 3 (identifier: Q8TF40-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         208-235: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,138
    Mass (Da):127,444
    Checksum:i3CA14555745B9C37
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761G → C.2 Publications
    Corresponds to variant rs7730228 [ dbSNP | Ensembl ].
    VAR_036824
    Natural varianti354 – 3541S → L.
    Corresponds to variant rs13177318 [ dbSNP | Ensembl ].
    VAR_036825
    Natural varianti648 – 6481Q → R.3 Publications
    Corresponds to variant rs26008 [ dbSNP | Ensembl ].
    VAR_036826
    Natural varianti738 – 7381V → L.
    Corresponds to variant rs12109782 [ dbSNP | Ensembl ].
    VAR_036827
    Natural varianti844 – 8441I → V.
    Corresponds to variant rs7717874 [ dbSNP | Ensembl ].
    VAR_036828

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei208 – 23528Missing in isoform 3. 1 PublicationVSP_028984Add
    BLAST
    Alternative sequencei508 – 5081D → M in isoform 2. 1 PublicationVSP_028982
    Alternative sequencei509 – 1166658Missing in isoform 2. 1 PublicationVSP_028983Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ145719 mRNA. Translation: AAZ65854.1.
    AC004227 Genomic DNA. No translation available.
    AC004622 Genomic DNA. No translation available.
    AC005593 Genomic DNA. No translation available.
    AC008695 Genomic DNA. No translation available.
    AC008497 Genomic DNA. No translation available.
    AC026754 Genomic DNA. No translation available.
    BC001956 mRNA. Translation: AAH01956.1.
    AB075841 mRNA. Translation: BAB85547.1.
    AL832008 mRNA. Translation: CAD91145.1.
    CCDSiCCDS34226.1. [Q8TF40-3]
    CCDS34227.1. [Q8TF40-1]
    RefSeqiNP_001008738.2. NM_001008738.2.
    NP_588613.2. NM_133372.2.
    UniGeneiHs.591273.

    Genome annotation databases

    EnsembliENST00000307968; ENSP00000309266; ENSG00000217128. [Q8TF40-3]
    ENST00000510461; ENSP00000421985; ENSG00000217128. [Q8TF40-1]
    ENST00000511848; ENSP00000425619; ENSG00000217128. [Q8TF40-2]
    GeneIDi96459.
    KEGGihsa:96459.
    UCSCiuc003kvs.1. human. [Q8TF40-1]
    uc003kvt.1. human. [Q8TF40-3]
    uc003kvu.3. human. [Q8TF40-2]

    Polymorphism databases

    DMDMi313104236.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ145719 mRNA. Translation: AAZ65854.1 .
    AC004227 Genomic DNA. No translation available.
    AC004622 Genomic DNA. No translation available.
    AC005593 Genomic DNA. No translation available.
    AC008695 Genomic DNA. No translation available.
    AC008497 Genomic DNA. No translation available.
    AC026754 Genomic DNA. No translation available.
    BC001956 mRNA. Translation: AAH01956.1 .
    AB075841 mRNA. Translation: BAB85547.1 .
    AL832008 mRNA. Translation: CAD91145.1 .
    CCDSi CCDS34226.1. [Q8TF40-3 ]
    CCDS34227.1. [Q8TF40-1 ]
    RefSeqi NP_001008738.2. NM_001008738.2.
    NP_588613.2. NM_133372.2.
    UniGenei Hs.591273.

    3D structure databases

    ProteinModelPortali Q8TF40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125175. 8 interactions.
    IntActi Q8TF40. 8 interactions.
    MINTi MINT-7298196.
    STRINGi 9606.ENSP00000310453.

    PTM databases

    PhosphoSitei Q8TF40.

    Polymorphism databases

    DMDMi 313104236.

    Proteomic databases

    MaxQBi Q8TF40.
    PaxDbi Q8TF40.
    PRIDEi Q8TF40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307968 ; ENSP00000309266 ; ENSG00000217128 . [Q8TF40-3 ]
    ENST00000510461 ; ENSP00000421985 ; ENSG00000217128 . [Q8TF40-1 ]
    ENST00000511848 ; ENSP00000425619 ; ENSG00000217128 . [Q8TF40-2 ]
    GeneIDi 96459.
    KEGGi hsa:96459.
    UCSCi uc003kvs.1. human. [Q8TF40-1 ]
    uc003kvt.1. human. [Q8TF40-3 ]
    uc003kvu.3. human. [Q8TF40-2 ]

    Organism-specific databases

    CTDi 96459.
    GeneCardsi GC05M130761.
    HGNCi HGNC:29418. FNIP1.
    MIMi 610594. gene.
    neXtProti NX_Q8TF40.
    PharmGKBi PA142671758.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330489.
    HOGENOMi HOG000112624.
    HOVERGENi HBG059425.
    InParanoidi Q8TF40.
    PhylomeDBi Q8TF40.
    TreeFami TF324090.

    Miscellaneous databases

    NextBioi 78545.
    PROi Q8TF40.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TF40.
    Bgeei Q8TF40.
    CleanExi HS_FNIP1.
    Genevestigatori Q8TF40.

    Family and domain databases

    InterProi IPR028086. FNIP_C_dom.
    IPR026156. FNIP_fam.
    IPR028085. FNIP_mid_dom.
    IPR028084. FNIP_N_dom.
    [Graphical view ]
    PANTHERi PTHR21634. PTHR21634. 1 hit.
    Pfami PF14638. FNIP_C. 1 hit.
    PF14637. FNIP_M. 1 hit.
    PF14636. FNIP_N. 1 hit.
    [Graphical view ]
    PRINTSi PR02073. FOLLICULNIP1.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FLCN; HSPCA; PRKAA1; PRKAB1 AND PRKAG1, PHOSPHORYLATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS CYS-76 AND ARG-648.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-76.
      Tissue: Lung.
    4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-1166 (ISOFORM 3), VARIANT ARG-648.
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1166, VARIANT ARG-648.
      Tissue: Skeletal muscle.
    6. "Identification and characterization of a novel folliculin-interacting protein FNIP2."
      Hasumi H., Baba M., Hong S.-B., Hasumi Y., Huang Y., Yao M., Valera V.A., Linehan W.M., Schmidt L.S.
      Gene 415:60-67(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY.
    7. "Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein."
      Takagi Y., Kobayashi T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.
      Oncogene 27:5339-5347(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-593; SER-594; SER-760 AND SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760 AND SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760 AND SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFNIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF40
    Secondary accession number(s): D6RJH5, Q86T47, Q9BUT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Elevated expression levels in histologic variants of renal tumors.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3