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Protein

Folliculin-interacting protein 1

Gene

FNIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).3 Publications

GO - Molecular functioni

  • ATPase inhibitor activity Source: UniProtKB
  • chaperone binding Source: UniProtKB
  • guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158987-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin-interacting protein 1
Gene namesi
Name:FNIP1
Synonyms:KIAA1961
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29418. FNIP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi96459.
OpenTargetsiENSG00000217128.
PharmGKBiPA142671758.

Polymorphism and mutation databases

BioMutaiFNIP1.
DMDMi313104236.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003084841 – 1166Folliculin-interacting protein 1Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphoserineCombined sources1
Modified residuei294PhosphothreonineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei941PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by AMPK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TF40.
PaxDbiQ8TF40.
PeptideAtlasiQ8TF40.
PRIDEiQ8TF40.

PTM databases

iPTMnetiQ8TF40.
PhosphoSitePlusiQ8TF40.

Expressioni

Tissue specificityi

Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.3 Publications

Gene expression databases

BgeeiENSG00000217128.
CleanExiHS_FNIP1.
ExpressionAtlasiQ8TF40. baseline and differential.
GenevisibleiQ8TF40. HS.

Organism-specific databases

HPAiHPA068099.
HPA071213.

Interactioni

Subunit structurei

Homodimer and homomultimer. Heterodimer and heteromultimer with FNIP2 (PubMed:27353360, PubMed:18403135). Interacts with FLCN (via C-terminus) (PubMed:17028174, PubMed:27353360). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound (PubMed:17028174). Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4. Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (PubMed:27353360).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951665EBI-2946919,EBI-712001
GABARAPL1Q9H0R82EBI-2946919,EBI-746969
ORFQ9Q2G43EBI-2946919,EBI-6248094From a different organism.

GO - Molecular functioni

  • chaperone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125175. 15 interactors.
DIPiDIP-57169N.
IntActiQ8TF40. 8 interactors.
MINTiMINT-7298196.
STRINGi9606.ENSP00000421985.

Structurei

3D structure databases

ProteinModelPortaliQ8TF40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni929 – 1166Interaction with HSP90AA11 PublicationAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 99Poly-Ser4

Sequence similaritiesi

Belongs to the FNIP family.Curated

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ8TF40.
KOiK20400.
OMAiPNCNCKY.
OrthoDBiEOG091G016D.
PhylomeDBiQ8TF40.
TreeFamiTF324090.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD MVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLVTMHR NKSSLLFKES
610 620 630 640 650
EEIRTPNCNC KYCSHPLLGQ NVENISQQER EDIQNSSKEL LGISDECQMI
660 670 680 690 700
SPSDCQEENA VDVKQYRDKL RTCFDAKLET VVCTGSVPVD KCALSESGLE
710 720 730 740 750
STEETWQSEK LLDSDSHTGK AMRSTGMVVE KKPPDKIVPA SFSCEAAQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQITRHH TKPLKEERGA IDQHQETKQT
810 820 830 840 850
TKDQSGESDT QNMVSEEPCE LPCWNHSDPE SMSLFDEYFN DDSIETRTID
860 870 880 890 900
DVPFKTSTDS KDHCCMLEFS KILCTKNNKQ NNEFCKCIET VPQDSCKTCF
910 920 930 940 950
PQQDQRDTLS ILVPHGDKES SDKKIAVGTE WDIPRNESSD SALGDSESED
960 970 980 990 1000
TGHDMTRQVS SYYGGEQEDW AEEDEIPFPG SKLIEVSAVQ PNIANFGRSL
1010 1020 1030 1040 1050
LGGYCSSYVP DFVLQGIGSD ERFRQCLMSD LSHAVQHPVL DEPIAEAVCI
1060 1070 1080 1090 1100
IADMDKWTVQ VASSQRRVTD NKLGKEVLVS SLVSNLLHST LQLYKHNLSP
1110 1120 1130 1140 1150
NFCVMHLEDR LQELYFKSKM LSEYLRGQMR VHVKELGVVL GIESSDLPLL
1160
AAVASTHSPY VAQILL
Length:1,166
Mass (Da):130,555
Last modified:November 30, 2010 - v3
Checksum:i3B99DBA98E7169C5
GO
Isoform 2 (identifier: Q8TF40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-508: D → M
     509-1166: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):56,802
Checksum:i59A0719AD6A85CF9
GO
Isoform 3 (identifier: Q8TF40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-235: Missing.

Note: No experimental confirmation available.
Show »
Length:1,138
Mass (Da):127,444
Checksum:i3CA14555745B9C37
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03682476G → C.2 PublicationsCorresponds to variant rs7730228dbSNPEnsembl.1
Natural variantiVAR_036825354S → L.Corresponds to variant rs13177318dbSNPEnsembl.1
Natural variantiVAR_036826648Q → R.3 PublicationsCorresponds to variant rs26008dbSNPEnsembl.1
Natural variantiVAR_036827738V → L.Corresponds to variant rs12109782dbSNPEnsembl.1
Natural variantiVAR_036828844I → V.Corresponds to variant rs7717874dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028984208 – 235Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_028982508D → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_028983509 – 1166Missing in isoform 2. 1 PublicationAdd BLAST658

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ145719 mRNA. Translation: AAZ65854.1.
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC005593 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC001956 mRNA. Translation: AAH01956.1.
AB075841 mRNA. Translation: BAB85547.1.
AL832008 mRNA. Translation: CAD91145.1.
CCDSiCCDS34226.1. [Q8TF40-3]
CCDS34227.1. [Q8TF40-1]
RefSeqiNP_001008738.2. NM_001008738.2.
NP_588613.2. NM_133372.2.
UniGeneiHs.591273.

Genome annotation databases

EnsembliENST00000307968; ENSP00000309266; ENSG00000217128. [Q8TF40-3]
ENST00000510461; ENSP00000421985; ENSG00000217128. [Q8TF40-1]
ENST00000511848; ENSP00000425619; ENSG00000217128. [Q8TF40-2]
GeneIDi96459.
KEGGihsa:96459.
UCSCiuc003kvs.2. human. [Q8TF40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ145719 mRNA. Translation: AAZ65854.1.
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC005593 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC001956 mRNA. Translation: AAH01956.1.
AB075841 mRNA. Translation: BAB85547.1.
AL832008 mRNA. Translation: CAD91145.1.
CCDSiCCDS34226.1. [Q8TF40-3]
CCDS34227.1. [Q8TF40-1]
RefSeqiNP_001008738.2. NM_001008738.2.
NP_588613.2. NM_133372.2.
UniGeneiHs.591273.

3D structure databases

ProteinModelPortaliQ8TF40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125175. 15 interactors.
DIPiDIP-57169N.
IntActiQ8TF40. 8 interactors.
MINTiMINT-7298196.
STRINGi9606.ENSP00000421985.

PTM databases

iPTMnetiQ8TF40.
PhosphoSitePlusiQ8TF40.

Polymorphism and mutation databases

BioMutaiFNIP1.
DMDMi313104236.

Proteomic databases

MaxQBiQ8TF40.
PaxDbiQ8TF40.
PeptideAtlasiQ8TF40.
PRIDEiQ8TF40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307968; ENSP00000309266; ENSG00000217128. [Q8TF40-3]
ENST00000510461; ENSP00000421985; ENSG00000217128. [Q8TF40-1]
ENST00000511848; ENSP00000425619; ENSG00000217128. [Q8TF40-2]
GeneIDi96459.
KEGGihsa:96459.
UCSCiuc003kvs.2. human. [Q8TF40-1]

Organism-specific databases

CTDi96459.
DisGeNETi96459.
GeneCardsiFNIP1.
HGNCiHGNC:29418. FNIP1.
HPAiHPA068099.
HPA071213.
MIMi610594. gene.
neXtProtiNX_Q8TF40.
OpenTargetsiENSG00000217128.
PharmGKBiPA142671758.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ8TF40.
KOiK20400.
OMAiPNCNCKY.
OrthoDBiEOG091G016D.
PhylomeDBiQ8TF40.
TreeFamiTF324090.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158987-MONOMER.

Miscellaneous databases

GenomeRNAii96459.
PROiQ8TF40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000217128.
CleanExiHS_FNIP1.
ExpressionAtlasiQ8TF40. baseline and differential.
GenevisibleiQ8TF40. HS.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.
ProtoNetiSearch...

Entry informationi

Entry nameiFNIP1_HUMAN
AccessioniPrimary (citable) accession number: Q8TF40
Secondary accession number(s): D6RJH5, Q86T47, Q9BUT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Elevated expression levels in histologic variants of renal tumors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.