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Protein

Zinc finger protein 431

Gene

ZNF431

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 431
Gene namesi
Name:ZNF431
Synonyms:KIAA1969
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196705.8
HGNCiHGNC:20809 ZNF431
neXtProtiNX_Q8TF32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196705
PharmGKBiPA134932493

Polymorphism and mutation databases

BioMutaiZNF431
DMDMi30173456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475791 – 576Zinc finger protein 431Add BLAST576

Proteomic databases

EPDiQ8TF32
MaxQBiQ8TF32
PaxDbiQ8TF32
PeptideAtlasiQ8TF32
PRIDEiQ8TF32

PTM databases

iPTMnetiQ8TF32
PhosphoSitePlusiQ8TF32

Expressioni

Gene expression databases

BgeeiENSG00000196705
CleanExiHS_ZNF431
ExpressionAtlasiQ8TF32 baseline and differential
GenevisibleiQ8TF32 HS

Organism-specific databases

HPAiHPA059135

Interactioni

Subunit structurei

Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi1280949 interactors.
IntActiQ8TF32 5 interactors.
MINTiQ8TF32
STRINGi9606.ENSP00000308578

Structurei

3D structure databases

ProteinModelPortaliQ8TF32
SMRiQ8TF32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 106KRABPROSITE-ProRule annotationAdd BLAST72

Domaini

The KRAB domain is necessary for its repressive activity.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TF32
KOiK09228
OMAiNCEECDN
OrthoDBiEOG091G02KC
PhylomeDBiQ8TF32
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q8TF32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE
60 70 80 90 100
CLNPAQQNLY MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE
110 120 130 140 150
MVDEPPAMCS YFTKDLWPEQ DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS
160 170 180 190 200
VDEYKVHKEG YNELNQCLTT TQSKIFPCDK YVKVFHKFLN ANRHKTRHTG
210 220 230 240 250
KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA FKWFSTLTRH
260 270 280 290 300
KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS
310 320 330 340 350
SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD
360 370 380 390 400
KAFNRFSYLT KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY
410 420 430 440 450
KCEVCGKAFN ESSNLTTHKM IHTGEKPYKC EECGKAFNRS PQLTAHKIIH
460 470 480 490 500
TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG EKPYKCEECG KAFNRSSNLT
510 520 530 540 550
KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY NCEECDNTFN
560 570
QSSNLIKQNN SYWRETLQMS RMWESL
Length:576
Mass (Da):67,217
Last modified:April 23, 2003 - v2
Checksum:i532774BF69EC9E2A
GO

Sequence cautioni

The sequence BAB85555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198H → R in AAH40506 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0528253D → G. Corresponds to variant dbSNP:rs17445374Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075849 mRNA Translation: BAB85555.1 Different initiation.
AK293072 mRNA Translation: BAF85761.1
CH471106 Genomic DNA Translation: EAW84889.1
BC040506 mRNA Translation: AAH40506.1
CCDSiCCDS32979.1
RefSeqiNP_001306053.1, NM_001319124.1
NP_001306055.1, NM_001319126.1
NP_001306056.1, NM_001319127.1
NP_597730.2, NM_133473.3
UniGeneiHs.156256
Hs.656394
Hs.687547
Hs.689835

Genome annotation databases

EnsembliENST00000311048; ENSP00000308578; ENSG00000196705
GeneIDi170959
KEGGihsa:170959
UCSCiuc002npp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN431_HUMAN
AccessioniPrimary (citable) accession number: Q8TF32
Secondary accession number(s): A8KAK7, Q8IWC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome