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Q8TF32

- ZN431_HUMAN

UniProt

Q8TF32 - ZN431_HUMAN

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Protein
Zinc finger protein 431
Gene
ZNF431, KIAA1969
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1; degenerate
Add
BLAST
Zinc fingeri204 – 22623C2H2-type 2
Add
BLAST
Zinc fingeri232 – 25423C2H2-type 3
Add
BLAST
Zinc fingeri260 – 28223C2H2-type 4
Add
BLAST
Zinc fingeri288 – 31023C2H2-type 5
Add
BLAST
Zinc fingeri316 – 33823C2H2-type 6
Add
BLAST
Zinc fingeri344 – 36623C2H2-type 7
Add
BLAST
Zinc fingeri372 – 39423C2H2-type 8
Add
BLAST
Zinc fingeri400 – 42223C2H2-type 9
Add
BLAST
Zinc fingeri428 – 45023C2H2-type 10
Add
BLAST
Zinc fingeri456 – 47823C2H2-type 11
Add
BLAST
Zinc fingeri484 – 50623C2H2-type 12
Add
BLAST
Zinc fingeri512 – 53423C2H2-type 13
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. core promoter sequence-specific DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 431
Gene namesi
Name:ZNF431
Synonyms:KIAA1969
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20809. ZNF431.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Zinc finger protein 431
PRO_0000047579Add
BLAST

Proteomic databases

MaxQBiQ8TF32.
PaxDbiQ8TF32.
PRIDEiQ8TF32.

PTM databases

PhosphoSiteiQ8TF32.

Expressioni

Gene expression databases

ArrayExpressiQ8TF32.
BgeeiQ8TF32.
CleanExiHS_ZNF431.
GenevestigatoriQ8TF32.

Interactioni

Subunit structurei

Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 By similarity.

Protein-protein interaction databases

BioGridi128094. 7 interactions.
IntActiQ8TF32. 5 interactions.
MINTiMINT-8247365.

Structurei

3D structure databases

ProteinModelPortaliQ8TF32.
SMRiQ8TF32. Positions 174-556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10672KRAB
Add
BLAST

Domaini

The KRAB domain is necessary for its repressive activity By similarity.

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF32.
KOiK09228.
OMAiNCEECDN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF32.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF32-1 [UniParc]FASTAAdd to Basket

« Hide

MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE    50
CLNPAQQNLY MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE 100
MVDEPPAMCS YFTKDLWPEQ DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS 150
VDEYKVHKEG YNELNQCLTT TQSKIFPCDK YVKVFHKFLN ANRHKTRHTG 200
KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA FKWFSTLTRH 250
KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS 300
SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD 350
KAFNRFSYLT KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY 400
KCEVCGKAFN ESSNLTTHKM IHTGEKPYKC EECGKAFNRS PQLTAHKIIH 450
TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG EKPYKCEECG KAFNRSSNLT 500
KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY NCEECDNTFN 550
QSSNLIKQNN SYWRETLQMS RMWESL 576
Length:576
Mass (Da):67,217
Last modified:April 23, 2003 - v2
Checksum:i532774BF69EC9E2A
GO

Sequence cautioni

The sequence BAB85555.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31D → G.
Corresponds to variant rs17445374 [ dbSNP | Ensembl ].
VAR_052825

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981H → R in AAH40506. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075849 mRNA. Translation: BAB85555.1. Different initiation.
AK293072 mRNA. Translation: BAF85761.1.
CH471106 Genomic DNA. Translation: EAW84889.1.
BC040506 mRNA. Translation: AAH40506.1.
CCDSiCCDS32979.1.
RefSeqiNP_597730.2. NM_133473.2.
UniGeneiHs.656394.
Hs.687547.

Genome annotation databases

EnsembliENST00000311048; ENSP00000308578; ENSG00000196705.
GeneIDi170959.
KEGGihsa:170959.
UCSCiuc002npp.2. human.

Polymorphism databases

DMDMi30173456.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075849 mRNA. Translation: BAB85555.1 . Different initiation.
AK293072 mRNA. Translation: BAF85761.1 .
CH471106 Genomic DNA. Translation: EAW84889.1 .
BC040506 mRNA. Translation: AAH40506.1 .
CCDSi CCDS32979.1.
RefSeqi NP_597730.2. NM_133473.2.
UniGenei Hs.656394.
Hs.687547.

3D structure databases

ProteinModelPortali Q8TF32.
SMRi Q8TF32. Positions 174-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128094. 7 interactions.
IntActi Q8TF32. 5 interactions.
MINTi MINT-8247365.

PTM databases

PhosphoSitei Q8TF32.

Polymorphism databases

DMDMi 30173456.

Proteomic databases

MaxQBi Q8TF32.
PaxDbi Q8TF32.
PRIDEi Q8TF32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311048 ; ENSP00000308578 ; ENSG00000196705 .
GeneIDi 170959.
KEGGi hsa:170959.
UCSCi uc002npp.2. human.

Organism-specific databases

CTDi 170959.
GeneCardsi GC19P021324.
HGNCi HGNC:20809. ZNF431.
neXtProti NX_Q8TF32.
PharmGKBi PA134932493.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8TF32.
KOi K09228.
OMAi NCEECDN.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8TF32.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 170959.
NextBioi 89153.
PROi Q8TF32.

Gene expression databases

ArrayExpressi Q8TF32.
Bgeei Q8TF32.
CleanExi HS_ZNF431.
Genevestigatori Q8TF32.

Family and domain databases

Gene3Di 3.30.160.60. 14 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN431_HUMAN
AccessioniPrimary (citable) accession number: Q8TF32
Secondary accession number(s): A8KAK7, Q8IWC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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