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Q8TF32

- ZN431_HUMAN

UniProt

Q8TF32 - ZN431_HUMAN

Protein

Zinc finger protein 431

Gene

ZNF431

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (23 Apr 2003)
      Previous versions | rss
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    Functioni

    Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. core promoter sequence-specific DNA binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 431
    Gene namesi
    Name:ZNF431
    Synonyms:KIAA1969
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20809. ZNF431.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932493.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Zinc finger protein 431PRO_0000047579Add
    BLAST

    Proteomic databases

    MaxQBiQ8TF32.
    PaxDbiQ8TF32.
    PRIDEiQ8TF32.

    PTM databases

    PhosphoSiteiQ8TF32.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TF32.
    BgeeiQ8TF32.
    CleanExiHS_ZNF431.
    GenevestigatoriQ8TF32.

    Interactioni

    Subunit structurei

    Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi128094. 7 interactions.
    IntActiQ8TF32. 5 interactions.
    MINTiMINT-8247365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF32.
    SMRiQ8TF32. Positions 174-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 10672KRABPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The KRAB domain is necessary for its repressive activity.By similarity

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8TF32.
    KOiK09228.
    OMAiNCEECDN.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TF32.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 14 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TF32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE    50
    CLNPAQQNLY MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE 100
    MVDEPPAMCS YFTKDLWPEQ DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS 150
    VDEYKVHKEG YNELNQCLTT TQSKIFPCDK YVKVFHKFLN ANRHKTRHTG 200
    KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA FKWFSTLTRH 250
    KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS 300
    SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD 350
    KAFNRFSYLT KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY 400
    KCEVCGKAFN ESSNLTTHKM IHTGEKPYKC EECGKAFNRS PQLTAHKIIH 450
    TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG EKPYKCEECG KAFNRSSNLT 500
    KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY NCEECDNTFN 550
    QSSNLIKQNN SYWRETLQMS RMWESL 576
    Length:576
    Mass (Da):67,217
    Last modified:April 23, 2003 - v2
    Checksum:i532774BF69EC9E2A
    GO

    Sequence cautioni

    The sequence BAB85555.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981H → R in AAH40506. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31D → G.
    Corresponds to variant rs17445374 [ dbSNP | Ensembl ].
    VAR_052825

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075849 mRNA. Translation: BAB85555.1. Different initiation.
    AK293072 mRNA. Translation: BAF85761.1.
    CH471106 Genomic DNA. Translation: EAW84889.1.
    BC040506 mRNA. Translation: AAH40506.1.
    CCDSiCCDS32979.1.
    RefSeqiNP_597730.2. NM_133473.2.
    UniGeneiHs.656394.
    Hs.687547.

    Genome annotation databases

    EnsembliENST00000311048; ENSP00000308578; ENSG00000196705.
    GeneIDi170959.
    KEGGihsa:170959.
    UCSCiuc002npp.2. human.

    Polymorphism databases

    DMDMi30173456.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075849 mRNA. Translation: BAB85555.1 . Different initiation.
    AK293072 mRNA. Translation: BAF85761.1 .
    CH471106 Genomic DNA. Translation: EAW84889.1 .
    BC040506 mRNA. Translation: AAH40506.1 .
    CCDSi CCDS32979.1.
    RefSeqi NP_597730.2. NM_133473.2.
    UniGenei Hs.656394.
    Hs.687547.

    3D structure databases

    ProteinModelPortali Q8TF32.
    SMRi Q8TF32. Positions 174-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128094. 7 interactions.
    IntActi Q8TF32. 5 interactions.
    MINTi MINT-8247365.

    PTM databases

    PhosphoSitei Q8TF32.

    Polymorphism databases

    DMDMi 30173456.

    Proteomic databases

    MaxQBi Q8TF32.
    PaxDbi Q8TF32.
    PRIDEi Q8TF32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311048 ; ENSP00000308578 ; ENSG00000196705 .
    GeneIDi 170959.
    KEGGi hsa:170959.
    UCSCi uc002npp.2. human.

    Organism-specific databases

    CTDi 170959.
    GeneCardsi GC19P021324.
    HGNCi HGNC:20809. ZNF431.
    neXtProti NX_Q8TF32.
    PharmGKBi PA134932493.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8TF32.
    KOi K09228.
    OMAi NCEECDN.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TF32.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 170959.
    NextBioi 89153.
    PROi Q8TF32.

    Gene expression databases

    ArrayExpressi Q8TF32.
    Bgeei Q8TF32.
    CleanExi HS_ZNF431.
    Genevestigatori Q8TF32.

    Family and domain databases

    Gene3Di 3.30.160.60. 14 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN431_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF32
    Secondary accession number(s): A8KAK7, Q8IWC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3