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Q8TF32

- ZN431_HUMAN

UniProt

Q8TF32 - ZN431_HUMAN

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Protein

Zinc finger protein 431

Gene

ZNF431

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. core promoter sequence-specific DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 431
Gene namesi
Name:ZNF431
Synonyms:KIAA1969
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20809. ZNF431.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Zinc finger protein 431PRO_0000047579Add
BLAST

Proteomic databases

MaxQBiQ8TF32.
PaxDbiQ8TF32.
PRIDEiQ8TF32.

PTM databases

PhosphoSiteiQ8TF32.

Expressioni

Gene expression databases

BgeeiQ8TF32.
CleanExiHS_ZNF431.
ExpressionAtlasiQ8TF32. baseline and differential.
GenevestigatoriQ8TF32.

Interactioni

Subunit structurei

Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi128094. 7 interactions.
IntActiQ8TF32. 5 interactions.
MINTiMINT-8247365.

Structurei

3D structure databases

ProteinModelPortaliQ8TF32.
SMRiQ8TF32. Positions 174-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10672KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

The KRAB domain is necessary for its repressive activity.By similarity

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF32.
KOiK09228.
OMAiNCEECDN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF32.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE
60 70 80 90 100
CLNPAQQNLY MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE
110 120 130 140 150
MVDEPPAMCS YFTKDLWPEQ DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS
160 170 180 190 200
VDEYKVHKEG YNELNQCLTT TQSKIFPCDK YVKVFHKFLN ANRHKTRHTG
210 220 230 240 250
KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA FKWFSTLTRH
260 270 280 290 300
KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS
310 320 330 340 350
SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD
360 370 380 390 400
KAFNRFSYLT KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY
410 420 430 440 450
KCEVCGKAFN ESSNLTTHKM IHTGEKPYKC EECGKAFNRS PQLTAHKIIH
460 470 480 490 500
TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG EKPYKCEECG KAFNRSSNLT
510 520 530 540 550
KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY NCEECDNTFN
560 570
QSSNLIKQNN SYWRETLQMS RMWESL
Length:576
Mass (Da):67,217
Last modified:April 23, 2003 - v2
Checksum:i532774BF69EC9E2A
GO

Sequence cautioni

The sequence BAB85555.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981H → R in AAH40506. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31D → G.
Corresponds to variant rs17445374 [ dbSNP | Ensembl ].
VAR_052825

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075849 mRNA. Translation: BAB85555.1. Different initiation.
AK293072 mRNA. Translation: BAF85761.1.
CH471106 Genomic DNA. Translation: EAW84889.1.
BC040506 mRNA. Translation: AAH40506.1.
CCDSiCCDS32979.1.
RefSeqiNP_597730.2. NM_133473.2.
UniGeneiHs.656394.
Hs.687547.

Genome annotation databases

EnsembliENST00000311048; ENSP00000308578; ENSG00000196705.
GeneIDi170959.
KEGGihsa:170959.
UCSCiuc002npp.2. human.

Polymorphism databases

DMDMi30173456.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075849 mRNA. Translation: BAB85555.1 . Different initiation.
AK293072 mRNA. Translation: BAF85761.1 .
CH471106 Genomic DNA. Translation: EAW84889.1 .
BC040506 mRNA. Translation: AAH40506.1 .
CCDSi CCDS32979.1.
RefSeqi NP_597730.2. NM_133473.2.
UniGenei Hs.656394.
Hs.687547.

3D structure databases

ProteinModelPortali Q8TF32.
SMRi Q8TF32. Positions 174-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128094. 7 interactions.
IntActi Q8TF32. 5 interactions.
MINTi MINT-8247365.

PTM databases

PhosphoSitei Q8TF32.

Polymorphism databases

DMDMi 30173456.

Proteomic databases

MaxQBi Q8TF32.
PaxDbi Q8TF32.
PRIDEi Q8TF32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311048 ; ENSP00000308578 ; ENSG00000196705 .
GeneIDi 170959.
KEGGi hsa:170959.
UCSCi uc002npp.2. human.

Organism-specific databases

CTDi 170959.
GeneCardsi GC19P021324.
HGNCi HGNC:20809. ZNF431.
neXtProti NX_Q8TF32.
PharmGKBi PA134932493.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8TF32.
KOi K09228.
OMAi NCEECDN.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8TF32.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 170959.
NextBioi 89153.
PROi Q8TF32.

Gene expression databases

Bgeei Q8TF32.
CleanExi HS_ZNF431.
ExpressionAtlasi Q8TF32. baseline and differential.
Genevestigatori Q8TF32.

Family and domain databases

Gene3Di 3.30.160.60. 14 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN431_HUMAN
AccessioniPrimary (citable) accession number: Q8TF32
Secondary accession number(s): A8KAK7, Q8IWC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3