Reviewed, UniProtKB/Swiss-Prot Q8TF27 (AGA11_HUMAN)

Names and origin

Protein names

Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
Alternative name(s):
    Centaurin-gamma-like protein KIAA1975

Gene names

Name:	AGAP11
Synonyms:	KIAA1975

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11		PRO_0000328758
Regions
	Domain	121 – 307	187	PH
	Domain	328 – 448	121	Arf-GAP
	Repeat	487 – 516	30	ANK 1
	Repeat	520 – 549	30	ANK 2
	Zinc finger	343 – 366	24	C4-type
Natural variations
	Natural variant	82	1	I → V: dbSNP rs2641563.		VAR_042518

Sequences

	Sequence		Length	Mass (Da)
	Q8TF27-1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: A3A6A204B3ACC967	FASTA	550	60,549
	10 20 30 40 50 60 MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL NNYSSSIPLT 70 80 90 100 110 120 PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD PDKGRKALES HADTIGSGRA 130 140 150 160 170 180 IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP 190 200 210 220 230 240 GKWPSLATSA CAPISSSKSN GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP 250 260 270 280 290 300 PSPHANKKKH LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ 310 320 330 340 350 360 AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN PKWASLNLGV 370 380 390 400 410 420 LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG NDLANSIWEG SSQGQTKPSI 430 440 450 460 470 480 ESTREEKERW IRSKYEHKLF LAPLPCTELS LGQHLLRATA DEDLRTAILL LAHGSREEVN 490 500 510 520 530 540 ETCGEGDGCT ALHLACRKGN VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL 550 LQYGCPDECV

References

[1]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed: 11853319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-82.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-82. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL136982 Genomic DNA. No translation available. AB075855 mRNA. Translation: BAB85561.1. Different initiation. CH471142 Genomic DNA. Translation: EAW80308.1. BC140762 mRNA. Translation: AAI40763.1.
IPI	IPI00398893.
RefSeq	NP_597704.1.
UniGene	Hs.511787
3D structure databases
HSSP	HSSP built from PDB template 2B0O based on UniProtKB Q8TDY4.
ModBase	Search...
Proteomic databases
PRIDE	Q8TF27.
Genome annotation databases
Ensembl	ENST00000425187; ENSP00000416541; ENSG00000204164; Homo sapiens. [Genome view] ENST00000445434; ENSP00000409052; ENSG00000204164; Homo sapiens. [Genome view]
GeneID	119385.
KEGG	hsa:119385.
UCSC	uc001kee.2. human.
Organism-specific databases
CTD	119385.
GeneCards	GC10P088720.
HGNC	HGNC:29421. AGAP11.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TF27.
Gene expression databases
Bgee	Q8TF27.
CleanEx	HS_AGAP11.
Genevestigator	Q8TF27.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	80402.

Entry information

Entry name

AGA11_HUMAN

Accession

Primary (citable) accession number: Q8TF27
Secondary accession number(s): B9EIP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	November 24, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.