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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11

Gene

AGAP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
Short name:
AGAP-11
Alternative name(s):
Centaurin-gamma-like protein KIAA1975
Gene namesi
Name:AGAP11
Synonyms:KIAA1975
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29421. AGAP11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715011.

Polymorphism and mutation databases

BioMutaiAGAP11.
DMDMi182641995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11PRO_0000328758Add
BLAST

Proteomic databases

PeptideAtlasiQ8TF27.
PRIDEiQ8TF27.

PTM databases

iPTMnetiQ8TF27.
PhosphoSiteiQ8TF27.

Expressioni

Gene expression databases

CleanExiHS_AGAP11.

Interactioni

Protein-protein interaction databases

BioGridi125637. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8TF27.
SMRiQ8TF27. Positions 119-205, 263-311, 334-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 307187PHPROSITE-ProRule annotationAdd
BLAST
Domaini328 – 448121Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati487 – 51630ANK 1Add
BLAST
Repeati520 – 54930ANK 2Add
BLAST

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ8TF27.
PhylomeDBiQ8TF27.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL
60 70 80 90 100
NNYSSSIPLT PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD
110 120 130 140 150
PDKGRKALES HADTIGSGRA IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG
160 170 180 190 200
VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP GKWPSLATSA CAPISSSKSN
210 220 230 240 250
GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP PSPHANKKKH
260 270 280 290 300
LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ
310 320 330 340 350
AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN
360 370 380 390 400
PKWASLNLGV LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG
410 420 430 440 450
NDLANSIWEG SSQGQTKPSI ESTREEKERW IRSKYEHKLF LAPLPCTELS
460 470 480 490 500
LGQHLLRATA DEDLRTAILL LAHGSREEVN ETCGEGDGCT ALHLACRKGN
510 520 530 540 550
VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL LQYGCPDECV
Length:550
Mass (Da):60,549
Last modified:April 8, 2008 - v2
Checksum:iA3A6A204B3ACC967
GO

Sequence cautioni

The sequence BAB85561 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821I → V.2 Publications
Corresponds to variant rs2641563 [ dbSNP | Ensembl ].
VAR_042518

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136982 Genomic DNA. No translation available.
AB075855 mRNA. Translation: BAB85561.1. Different initiation.
CH471142 Genomic DNA. Translation: EAW80308.1.
CH471142 Genomic DNA. Translation: EAW80307.1.
CH471142 Genomic DNA. Translation: EAW80310.1.
CH471142 Genomic DNA. Translation: EAW80311.1.
BC140762 mRNA. Translation: AAI40763.1.
RefSeqiNP_597704.1. NM_133447.1.
UniGeneiHs.511787.

Genome annotation databases

GeneIDi119385.
KEGGihsa:119385.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136982 Genomic DNA. No translation available.
AB075855 mRNA. Translation: BAB85561.1. Different initiation.
CH471142 Genomic DNA. Translation: EAW80308.1.
CH471142 Genomic DNA. Translation: EAW80307.1.
CH471142 Genomic DNA. Translation: EAW80310.1.
CH471142 Genomic DNA. Translation: EAW80311.1.
BC140762 mRNA. Translation: AAI40763.1.
RefSeqiNP_597704.1. NM_133447.1.
UniGeneiHs.511787.

3D structure databases

ProteinModelPortaliQ8TF27.
SMRiQ8TF27. Positions 119-205, 263-311, 334-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125637. 2 interactions.

PTM databases

iPTMnetiQ8TF27.
PhosphoSiteiQ8TF27.

Polymorphism and mutation databases

BioMutaiAGAP11.
DMDMi182641995.

Proteomic databases

PeptideAtlasiQ8TF27.
PRIDEiQ8TF27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi119385.
KEGGihsa:119385.

Organism-specific databases

CTDi119385.
GeneCardsiAGAP11.
HGNCiHGNC:29421. AGAP11.
neXtProtiNX_Q8TF27.
PharmGKBiPA164715011.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ8TF27.
PhylomeDBiQ8TF27.

Miscellaneous databases

GenomeRNAii119385.
PROiQ8TF27.

Gene expression databases

CleanExiHS_AGAP11.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGA11_HUMAN
AccessioniPrimary (citable) accession number: Q8TF27
Secondary accession number(s): B9EIP7, D3DWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.