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Protein

Ankyrin repeat domain-containing protein 24

Gene

ANKRD24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 24
Gene namesi
Name:ANKRD24
Synonyms:KIAA1981
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29424. ANKRD24.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089847.
PharmGKBiPA134937612.

Polymorphism and mutation databases

BioMutaiANKRD24.
DMDMi182627626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288361 – 1146Ankyrin repeat domain-containing protein 24Add BLAST1146

Proteomic databases

EPDiQ8TF21.
PaxDbiQ8TF21.
PeptideAtlasiQ8TF21.
PRIDEiQ8TF21.

PTM databases

iPTMnetiQ8TF21.
PhosphoSitePlusiQ8TF21.

Expressioni

Gene expression databases

BgeeiENSG00000089847.
CleanExiHS_ANKRD24.
ExpressionAtlasiQ8TF21. baseline and differential.
GenevisibleiQ8TF21. HS.

Organism-specific databases

HPAiHPA041534.
HPA048498.

Interactioni

Protein-protein interaction databases

BioGridi128096. 5 interactors.
IntActiQ8TF21. 6 interactors.
MINTiMINT-1373428.
STRINGi9606.ENSP00000321731.

Structurei

3D structure databases

ProteinModelPortaliQ8TF21.
SMRiQ8TF21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 110ANK 1Add BLAST30
Repeati114 – 143ANK 2Add BLAST30
Repeati147 – 176ANK 3Add BLAST30
Repeati180 – 209ANK 4Add BLAST30
Repeati213 – 242ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 517Sequence analysisAdd BLAST198
Coiled coili714 – 1110Sequence analysisAdd BLAST397

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 311Poly-Pro4

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEXQ. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063369.
HOGENOMiHOG000033956.
HOVERGENiHBG104795.
InParanoidiQ8TF21.
OMAiHHRLQEE.
OrthoDBiEOG091G025R.
PhylomeDBiQ8TF21.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLRARFKK TELRLSPTDL GSCPPCGPCP IPKPAARGRR QSQDWGKSDE
60 70 80 90 100
RLLQAVENND APRVAALIAR KGLVPTKLDP EGKSAFHLAA MRGAASCLEV
110 120 130 140 150
MIAHGSNVMS ADGAGYNALH LAAKYGHPQC LKQLLQASCV VDVVDSSGWT
160 170 180 190 200
ALHHAAAGGC LSCSEVLCSF KAHLNPQDRS GATPLIIAAQ MCHTDLCRLL
210 220 230 240 250
LQQGAAANDQ DLQGRTALML ACEGASPETV EVLLQGGAQP GITDALGQDA
260 270 280 290 300
AHYGALAGDK LILHLLQEAA QRPSPPSALT EDDSGEASSQ NSMSSHGKQG
310 320 330 340 350
APKKRKAPPP PASIPMPDDR DAYEEIVRLR QERGRLLQKI RGLEQHKERR
360 370 380 390 400
QQESPEASSL HILERQVQEL QQLLVERQEE KESLGREVES LQSRLSLLEN
410 420 430 440 450
ERENTSYDVT TLQDEEGELP DLPGAEVLLS RQLSPSAQEH LASLQEQVAV
460 470 480 490 500
LTRQNQELME KVQILENFEK DETQMEVEAL AEVIPLALYD SLRAEFDQLR
510 520 530 540 550
RQHAEALQAL RQQETREVPR EEGAACGESE VAGATATKNG PTHMELNGSV
560 570 580 590 600
APETKVNGAE TIDEEAAGDE TMEARTMEAE ATGAEATGAE ATGAKVTETK
610 620 630 640 650
PTGAEVREME TTEEEANMET KPTGAQATDT ETTGVEAMGV EATKTKAEEA
660 670 680 690 700
EMQAYGVGAG QAEPPVTGTT NMEATGSRAT GMESTGVSAT GVENPGVEAT
710 720 730 740 750
VPGISAGPIL HPGAAEASEK LQVELETRIR GLEEALRQRE REAAAELEAA
760 770 780 790 800
LGKCEAAEAE AGRLRERVRE AEGSGASGGG GGDTTQLRAA LEQAREDLRD
810 820 830 840 850
RDSRLRELEA ASACLDEARA SRLLAEEEAR GLRAELAQRE EARLEQSREL
860 870 880 890 900
EVLREQLATA RATGEQQRTA AAELGRARDA AEARVAELPA ACEEARQGLA
910 920 930 940 950
ELREASEALR QSVVPASEHR RLQEEALELR GRAASLEQEV VATGKEAARL
960 970 980 990 1000
RAELERERVC SVALSEHERI VGTLQANVAQ LEGQLEELGR RHEKTSAEVF
1010 1020 1030 1040 1050
QVQREALFMK SERHAAEAQL ATAEQQLRGL RTEAERARQA QSRAQEALDK
1060 1070 1080 1090 1100
AKEKDKKITE LSKEVFNLKE ALKEQPAALA TPEVEALRDQ VKDLQQQLQE
1110 1120 1130 1140
AARDHSSVVA LYRSHLLYAI QGQMDEDVQR ILSQILQMQR LQAQGR
Length:1,146
Mass (Da):124,187
Last modified:April 8, 2008 - v2
Checksum:i89E82EAD9056DCCB
GO
Isoform 2 (identifier: Q8TF21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MKTLRARFKK...PKPAARGRRQ → MQPAACAGEG...LCLCAAASFA

Note: No experimental confirmation available.
Show »
Length:1,236
Mass (Da):132,379
Checksum:i47CB3FA05D3CB79F
GO

Sequence cautioni

The sequence AAC33490 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD15479 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042536111A → T.1 PublicationCorresponds to variant rs2052191dbSNPEnsembl.1
Natural variantiVAR_042537349R → Q.1 PublicationCorresponds to variant rs12978469dbSNPEnsembl.1
Natural variantiVAR_042538585E → K.1 PublicationCorresponds to variant rs10413818dbSNPEnsembl.1
Natural variantiVAR_042539684S → A.1 PublicationCorresponds to variant rs353693dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328111 – 41MKTLR…RGRRQ → MQPAACAGEGAGPPAPRPPH PPGDKVRRGRGGAPSLSPQP PAPYLGLPIPSRGGGGWRGG QGGGGGTREGGTGRAGGAGS SGSAQPRPPAAPRGPSRPSG RRLLLEPRAPPAPRAPDAMK QLCLCAAASFA in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006930 Genomic DNA. Translation: AAD15479.1. Sequence problems.
AC005578 Genomic DNA. Translation: AAC33490.1. Sequence problems.
AB075861 mRNA. Translation: BAB85567.1.
CCDSiCCDS45925.1. [Q8TF21-1]
RefSeqiNP_597732.1. NM_133475.1. [Q8TF21-1]
UniGeneiHs.197872.

Genome annotation databases

EnsembliENST00000262970; ENSP00000262970; ENSG00000089847. [Q8TF21-2]
ENST00000318934; ENSP00000321731; ENSG00000089847. [Q8TF21-1]
ENST00000600132; ENSP00000471252; ENSG00000089847. [Q8TF21-1]
GeneIDi170961.
KEGGihsa:170961.
UCSCiuc002lzt.3. human. [Q8TF21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006930 Genomic DNA. Translation: AAD15479.1. Sequence problems.
AC005578 Genomic DNA. Translation: AAC33490.1. Sequence problems.
AB075861 mRNA. Translation: BAB85567.1.
CCDSiCCDS45925.1. [Q8TF21-1]
RefSeqiNP_597732.1. NM_133475.1. [Q8TF21-1]
UniGeneiHs.197872.

3D structure databases

ProteinModelPortaliQ8TF21.
SMRiQ8TF21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128096. 5 interactors.
IntActiQ8TF21. 6 interactors.
MINTiMINT-1373428.
STRINGi9606.ENSP00000321731.

PTM databases

iPTMnetiQ8TF21.
PhosphoSitePlusiQ8TF21.

Polymorphism and mutation databases

BioMutaiANKRD24.
DMDMi182627626.

Proteomic databases

EPDiQ8TF21.
PaxDbiQ8TF21.
PeptideAtlasiQ8TF21.
PRIDEiQ8TF21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262970; ENSP00000262970; ENSG00000089847. [Q8TF21-2]
ENST00000318934; ENSP00000321731; ENSG00000089847. [Q8TF21-1]
ENST00000600132; ENSP00000471252; ENSG00000089847. [Q8TF21-1]
GeneIDi170961.
KEGGihsa:170961.
UCSCiuc002lzt.3. human. [Q8TF21-1]

Organism-specific databases

CTDi170961.
GeneCardsiANKRD24.
H-InvDBHIX0014655.
HGNCiHGNC:29424. ANKRD24.
HPAiHPA041534.
HPA048498.
neXtProtiNX_Q8TF21.
OpenTargetsiENSG00000089847.
PharmGKBiPA134937612.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXQ. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063369.
HOGENOMiHOG000033956.
HOVERGENiHBG104795.
InParanoidiQ8TF21.
OMAiHHRLQEE.
OrthoDBiEOG091G025R.
PhylomeDBiQ8TF21.
TreeFamiTF331274.

Miscellaneous databases

GenomeRNAii170961.
PROiQ8TF21.

Gene expression databases

BgeeiENSG00000089847.
CleanExiHS_ANKRD24.
ExpressionAtlasiQ8TF21. baseline and differential.
GenevisibleiQ8TF21. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR24_HUMAN
AccessioniPrimary (citable) accession number: Q8TF21
Secondary accession number(s): O75268, O95781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.