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Protein

Zinc finger protein 721

Gene

ZNF721

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri97 – 119C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 24; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri797 – 819C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri825 – 847C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri881 – 903C2H2-type 30PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31089-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 721
Gene namesi
Name:ZNF721
Synonyms:KIAA1982
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29425. ZNF721.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182903.

Polymorphism and mutation databases

DMDMi158706490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068791 – 911Zinc finger protein 721Add BLAST911

Proteomic databases

PaxDbiQ8TF20.
PeptideAtlasiQ8TF20.
PRIDEiQ8TF20.

PTM databases

iPTMnetiQ8TF20.
PhosphoSitePlusiQ8TF20.

Expressioni

Gene expression databases

BgeeiENSG00000182903.
CleanExiHS_ZNF721.
ExpressionAtlasiQ8TF20. baseline and differential.
GenevisibleiQ8TF20. HS.

Interactioni

Protein-protein interaction databases

BioGridi128095. 1 interactor.
STRINGi9606.ENSP00000428878.

Structurei

3D structure databases

ProteinModelPortaliQ8TF20.
SMRiQ8TF20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 30 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri97 – 119C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 24; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri797 – 819C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri825 – 847C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri881 – 903C2H2-type 30PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF20.
KOiK09228.
OMAiYTDLNQH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TF20.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 30 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF16622. zf-C2H2_11. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 25 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 28 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSHFTQDFL PVQGIEDSFH KLILRRYEKC GHDNLQLRKG CKSMNVCKVQ
60 70 80 90 100
KGVYNGINKC LSNTQSKIFQ CNARVKVFSK FANSNKDKTR HTGEKHFKCN
110 120 130 140 150
ECGKSFQKFS DLTQHKGIHA GEKPYTCEER GKDFGWYTDL NQHKKIHTGE
160 170 180 190 200
KPYKCEECGK AFNRSTNLTA HKRIHNREKA YTGEDRDRAF GWSTNLNEYK
210 220 230 240 250
KIHTGDKPYK CKECGKAFMH SSHLNKHEKI HTGEKPYKCK ECGKVISSSS
260 270 280 290 300
SFAKHKRIHT GEKPFKCLEC GKAFNISTTL TKHRRIHTGE KPYTCEVCGK
310 320 330 340 350
AFRQSANLYV HRRIHTGEKP YTCGECGKTF RQSANLYVHR RIHTGEKPYK
360 370 380 390 400
CEDCGKAFGR YTALNQHKKI HTGEKPYKCE ECGKAFNSST NLTAHKRIHT
410 420 430 440 450
REKPYTCEDR GRAFGLSTNL NEYKKIHTGD KPYKCKECGK AFIHSLHLNK
460 470 480 490 500
HEKIHTGKKP YKCKQCGKVI TSSSSFAKHK RIHTGEKPFE CLECGKAFTS
510 520 530 540 550
STTLTKHRRI HTGEKPYTCE VCGKAFRQSA ILYVHRRIHT GEKPYTCEEC
560 570 580 590 600
GKTFRQSANL YVHRRIHTGE KPYKCEECGK AFGRYTDLNQ HKKIHTGEKL
610 620 630 640 650
YKCEECGKDF VWYTDLNQQK KIYTGEKPYK CEECGKAFAP STDLNQHTKI
660 670 680 690 700
LTGEQSYKCE ECGKAFGWSI ALNQHKKIHT GEKPYKCEEC GKAFSRSRNL
710 720 730 740 750
TTHRRVHTRE KPYKCEDRGR SFGWSTNLNE YKKIHTGDKL YKCKECGKVF
760 770 780 790 800
KQSSHLNRHE KIHTGKKPYK CKECGKVITS SSSFAKHKRI HTGEKPFKCL
810 820 830 840 850
ECGKAFTSST TLTKHRRIHT GEKPYTCEEC GKAFRQSAIL YVHRRIHTGE
860 870 880 890 900
KPYTCGECGK TFRQSANLYA HKKIHTGEKP YTCGDCGKTF RQSANLYAHK
910
KIHTGDKTIQ V
Length:911
Mass (Da):105,084
Last modified:October 2, 2007 - v2
Checksum:iAA0D3FBAC9C789AA
GO
Isoform 2 (identifier: Q8TF20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLENYRNLVSLAM

Show »
Length:923
Mass (Da):106,489
Checksum:iA639F47FC62B50CF
GO

Sequence cautioni

The sequence CAH10687 differs from that shown. Reason: Frameshift at positions 246, 250, 392, 394, 401, 409, 416, 418, 426, 444, 454, 492, 500, 540, 553, 690, 779 and 782.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210K → T in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti247 – 249SSS → LIL in CAH10687 (PubMed:17974005).Curated3
Sequence conflicti307N → I in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti324G → E in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti363A → D in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti387 – 388NS → VC in CAH10687 (PubMed:17974005).Curated2
Sequence conflicti391N → D in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti395H → M in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti410R → C in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti416L → M in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti444H → HS in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti465Q → E in CAH10687 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0408791M → MLENYRNLVSLAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834155 mRNA. Translation: CAH10687.1. Frameshift.
AC092574 Genomic DNA. No translation available.
DA309597 mRNA. No translation available.
AB075862 mRNA. Translation: BAB85568.1.
CCDSiCCDS46991.1. [Q8TF20-2]
RefSeqiNP_597731.2. NM_133474.3. [Q8TF20-2]
UniGeneiHs.428360.
Hs.724168.
Hs.745030.

Genome annotation databases

EnsembliENST00000338977; ENSP00000340524; ENSG00000182903. [Q8TF20-1]
ENST00000511833; ENSP00000428878; ENSG00000182903. [Q8TF20-2]
GeneIDi170960.
KEGGihsa:170960.
UCSCiuc003gag.5. human. [Q8TF20-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834155 mRNA. Translation: CAH10687.1. Frameshift.
AC092574 Genomic DNA. No translation available.
DA309597 mRNA. No translation available.
AB075862 mRNA. Translation: BAB85568.1.
CCDSiCCDS46991.1. [Q8TF20-2]
RefSeqiNP_597731.2. NM_133474.3. [Q8TF20-2]
UniGeneiHs.428360.
Hs.724168.
Hs.745030.

3D structure databases

ProteinModelPortaliQ8TF20.
SMRiQ8TF20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128095. 1 interactor.
STRINGi9606.ENSP00000428878.

PTM databases

iPTMnetiQ8TF20.
PhosphoSitePlusiQ8TF20.

Polymorphism and mutation databases

DMDMi158706490.

Proteomic databases

PaxDbiQ8TF20.
PeptideAtlasiQ8TF20.
PRIDEiQ8TF20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338977; ENSP00000340524; ENSG00000182903. [Q8TF20-1]
ENST00000511833; ENSP00000428878; ENSG00000182903. [Q8TF20-2]
GeneIDi170960.
KEGGihsa:170960.
UCSCiuc003gag.5. human. [Q8TF20-1]

Organism-specific databases

CTDi170960.
GeneCardsiZNF721.
HGNCiHGNC:29425. ZNF721.
neXtProtiNX_Q8TF20.
OpenTargetsiENSG00000182903.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF20.
KOiK09228.
OMAiYTDLNQH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TF20.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-31089-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii170960.
PROiQ8TF20.

Gene expression databases

BgeeiENSG00000182903.
CleanExiHS_ZNF721.
ExpressionAtlasiQ8TF20. baseline and differential.
GenevisibleiQ8TF20. HS.

Family and domain databases

Gene3Di3.30.160.60. 30 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF16622. zf-C2H2_11. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 25 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 28 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN721_HUMAN
AccessioniPrimary (citable) accession number: Q8TF20
Secondary accession number(s): Q69YG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.