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Protein

Dynein light chain roadblock-type 2

Gene

DYNLRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

GO - Molecular functioni

  • microtubule motor activity Source: UniProtKB

GO - Biological processi

  • microtubule-based movement Source: UniProtKB
  • organelle organization Source: Reactome
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 2
Alternative name(s):
Dynein light chain 2B, cytoplasmic
Roadblock domain-containing protein 2
Gene namesi
Name:DYNLRB2
Synonyms:DNCL2B, DNLC2B, ROBLD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:15467. DYNLRB2.

Subcellular locationi

GO - Cellular componenti

  • ciliary tip Source: Reactome
  • cytoplasm Source: UniProtKB-KW
  • cytoplasmic dynein complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • primary cilium Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27437.

Polymorphism and mutation databases

BioMutaiDYNLRB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 9695Dynein light chain roadblock-type 2PRO_0000220958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TF09.
PaxDbiQ8TF09.
PRIDEiQ8TF09.
TopDownProteomicsiQ8TF09.

PTM databases

PhosphoSiteiQ8TF09.

Expressioni

Tissue specificityi

High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.

Gene expression databases

BgeeiQ8TF09.
CleanExiHS_DYNLRB2.
ExpressionAtlasiQ8TF09. baseline and differential.
GenevisibleiQ8TF09. HS.

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.Curated1 Publication

Protein-protein interaction databases

BioGridi123714. 2 interactions.
STRINGi9606.ENSP00000302936.

Structurei

3D structure databases

ProteinModelPortaliQ8TF09.
SMRiQ8TF09. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115. Eukaryota.
ENOG4111NDV. LUCA.
GeneTreeiENSGT00390000011067.
HOGENOMiHOG000232033.
HOVERGENiHBG058598.
InParanoidiQ8TF09.
PhylomeDBiQ8TF09.
TreeFamiTF315165.

Family and domain databases

InterProiIPR016561. DYNLRB1/2.
IPR004942. Roadblock/LAMTOR2_dom.
[Graphical view]
PfamiPF03259. Robl_LC7. 1 hit.
[Graphical view]
PIRSFiPIRSF009998. DLC7. 1 hit.
SMARTiSM00960. Robl_LC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TF09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEETLKR IQSHKGVIGT MVVNAEGIPI RTTLDNSTTV QYAGLLHHLT
60 70 80 90
MKAKSTVRDI DPQNDLTFLR IRSKKHEIMV APDKEYLLIV IQNPCE
Length:96
Mass (Da):10,855
Last modified:June 1, 2002 - v1
Checksum:i526F073855F14330
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141H → R.
Corresponds to variant rs13332289 [ dbSNP | Ensembl ].
VAR_049126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125108 mRNA. Translation: AAL75945.1.
CCDSiCCDS10929.1.
RefSeqiNP_570967.1. NM_130897.2.
XP_006721358.1. XM_006721295.2.
UniGeneiHs.98849.

Genome annotation databases

EnsembliENST00000305904; ENSP00000302936; ENSG00000168589.
GeneIDi83657.
UCSCiuc002ffo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125108 mRNA. Translation: AAL75945.1.
CCDSiCCDS10929.1.
RefSeqiNP_570967.1. NM_130897.2.
XP_006721358.1. XM_006721295.2.
UniGeneiHs.98849.

3D structure databases

ProteinModelPortaliQ8TF09.
SMRiQ8TF09. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123714. 2 interactions.
STRINGi9606.ENSP00000302936.

PTM databases

PhosphoSiteiQ8TF09.

Polymorphism and mutation databases

BioMutaiDYNLRB2.

Proteomic databases

EPDiQ8TF09.
PaxDbiQ8TF09.
PRIDEiQ8TF09.
TopDownProteomicsiQ8TF09.

Protocols and materials databases

DNASUi83657.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305904; ENSP00000302936; ENSG00000168589.
GeneIDi83657.
UCSCiuc002ffo.3. human.

Organism-specific databases

CTDi83657.
GeneCardsiDYNLRB2.
HGNCiHGNC:15467. DYNLRB2.
MIMi607168. gene.
neXtProtiNX_Q8TF09.
PharmGKBiPA27437.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4115. Eukaryota.
ENOG4111NDV. LUCA.
GeneTreeiENSGT00390000011067.
HOGENOMiHOG000232033.
HOVERGENiHBG058598.
InParanoidiQ8TF09.
PhylomeDBiQ8TF09.
TreeFamiTF315165.

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiDYNLRB2. human.
GenomeRNAii83657.
NextBioi72619.
PROiQ8TF09.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF09.
CleanExiHS_DYNLRB2.
ExpressionAtlasiQ8TF09. baseline and differential.
GenevisibleiQ8TF09. HS.

Family and domain databases

InterProiIPR016561. DYNLRB1/2.
IPR004942. Roadblock/LAMTOR2_dom.
[Graphical view]
PfamiPF03259. Robl_LC7. 1 hit.
[Graphical view]
PIRSFiPIRSF009998. DLC7. 1 hit.
SMARTiSM00960. Robl_LC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients."
    Jiang J., Yu L., Huang X., Chen X., Li D., Zhang Y., Tang L., Zhao S.
    Gene 281:103-113(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Testis.
  2. Bienvenut W.V., Lempens A., Norman J.C.
    Submitted (OCT-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10 AND 55-70, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  3. "The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain."
    Susalka S.J., Nikulina K., Salata M.W., Vaughan P.S., King S.M., Vaughan K.T., Pfister K.K.
    J. Biol. Chem. 277:32939-32946(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYNC1I1 AND DYNC1I2.

Entry informationi

Entry nameiDLRB2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2002
Last modified: April 13, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.