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Protein

Cytochrome c oxidase subunit 7B2, mitochondrial

Gene

COX7B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb2
Gene namesi
Name:COX7B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24381. COX7B2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 338Mitochondrial matrixBy similarity
Transmembranei34 – 6027HelicalBy similarityAdd
BLAST
Topological domaini61 – 8121Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885922.

Polymorphism and mutation databases

BioMutaiCOX7B2.
DMDMi229462876.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 8156Cytochrome c oxidase subunit 7B2, mitochondrialPRO_0000006161Add
BLAST

Proteomic databases

PaxDbiQ8TF08.
PRIDEiQ8TF08.

Expressioni

Gene expression databases

BgeeiQ8TF08.
CleanExiHS_COX7B2.
ExpressionAtlasiQ8TF08. baseline and differential.
GenevisibleiQ8TF08. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305964.

Structurei

3D structure databases

ProteinModelPortaliQ8TF08.
SMRiQ8TF08. Positions 31-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiQ8TF08.
KOiK02271.
OMAiKHSPDFH.
OrthoDBiEOG7T7GWR.
PhylomeDBiQ8TF08.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TF08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPLARNAL SSLKIQSILQ SMARHSHVKH SPDFHDKYGN AVLASGTAFC
60 70 80
VATWVFTATQ IGIEWNLSPV GRVTPKEWKH Q
Length:81
Mass (Da):9,077
Last modified:May 5, 2009 - v2
Checksum:i3E9769D2EBF42E25
GO

Sequence cautioni

The sequence AAH35923.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI07856.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL75946.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271H → Q.1 Publication
Corresponds to variant rs201505906 [ dbSNP | Ensembl ].
VAR_026231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125109 mRNA. Translation: AAL75946.1. Different initiation.
BC035923 mRNA. Translation: AAH35923.1. Different initiation.
BC107855 mRNA. Translation: AAI07856.1. Different initiation.
CCDSiCCDS3472.2.
RefSeqiNP_570972.2. NM_130902.2.
XP_005248113.1. XM_005248056.3.
XP_011511932.1. XM_011513630.1.
XP_011511933.1. XM_011513631.1.
XP_011511934.1. XM_011513632.1.
XP_011511935.1. XM_011513633.1.
XP_011511936.1. XM_011513634.1.
XP_011511937.1. XM_011513635.1.
XP_011511938.1. XM_011513636.1.
XP_011511939.1. XM_011513637.1.
XP_011511940.1. XM_011513638.1.
UniGeneiHs.479656.

Genome annotation databases

EnsembliENST00000355591; ENSP00000347799; ENSG00000170516.
ENST00000396533; ENSP00000379784; ENSG00000170516.
GeneIDi170712.
KEGGihsa:170712.
UCSCiuc003gxf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125109 mRNA. Translation: AAL75946.1. Different initiation.
BC035923 mRNA. Translation: AAH35923.1. Different initiation.
BC107855 mRNA. Translation: AAI07856.1. Different initiation.
CCDSiCCDS3472.2.
RefSeqiNP_570972.2. NM_130902.2.
XP_005248113.1. XM_005248056.3.
XP_011511932.1. XM_011513630.1.
XP_011511933.1. XM_011513631.1.
XP_011511934.1. XM_011513632.1.
XP_011511935.1. XM_011513633.1.
XP_011511936.1. XM_011513634.1.
XP_011511937.1. XM_011513635.1.
XP_011511938.1. XM_011513636.1.
XP_011511939.1. XM_011513637.1.
XP_011511940.1. XM_011513638.1.
UniGeneiHs.479656.

3D structure databases

ProteinModelPortaliQ8TF08.
SMRiQ8TF08. Positions 31-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305964.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Polymorphism and mutation databases

BioMutaiCOX7B2.
DMDMi229462876.

Proteomic databases

PaxDbiQ8TF08.
PRIDEiQ8TF08.

Protocols and materials databases

DNASUi170712.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355591; ENSP00000347799; ENSG00000170516.
ENST00000396533; ENSP00000379784; ENSG00000170516.
GeneIDi170712.
KEGGihsa:170712.
UCSCiuc003gxf.4. human.

Organism-specific databases

CTDi170712.
GeneCardsiCOX7B2.
HGNCiHGNC:24381. COX7B2.
MIMi609811. gene.
neXtProtiNX_Q8TF08.
PharmGKBiPA134885922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiQ8TF08.
KOiK02271.
OMAiKHSPDFH.
OrthoDBiEOG7T7GWR.
PhylomeDBiQ8TF08.
TreeFamiTF105068.

Miscellaneous databases

GenomeRNAii170712.
PROiQ8TF08.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF08.
CleanExiHS_COX7B2.
ExpressionAtlasiQ8TF08. baseline and differential.
GenevisibleiQ8TF08. HS.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new human cDNA similar to Homo sapiens coxVIIb mRNA."
    Jin L., Yu L., Zhao S.Y.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  3. "A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma."
    Liang H., Chen H., Shen Y., Feng Q., Jin W., Huang W., Zeng Y.
    Sci. China, Ser. C, Life Sci. 47:449-453(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-27.

Entry informationi

Entry nameiCX7B2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF08
Secondary accession number(s): Q32Q40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.