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Protein

Arginine/serine-rich protein PNISR

Gene

PNISR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich protein PNISR
Alternative name(s):
PNN-interacting serine/arginine-rich protein
SR-related protein
SR-rich protein
Serine/arginine-rich-splicing regulatory protein 130
Short name:
SRrp130
Splicing factor, arginine/serine-rich 130
Splicing factor, arginine/serine-rich 18
Gene namesi
Name:PNISR
Synonyms:C6orf111, SFRS18, SRRP130
ORF Names:HSPC261, HSPC306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21222. PNISR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402984.

Polymorphism and mutation databases

BioMutaiPNISR.
DMDMi152031686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Arginine/serine-rich protein PNISRPRO_0000081947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei211 – 2111PhosphoserineCombined sources
Cross-linki218 – 218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290 – 2901PhosphoserineCombined sources
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei313 – 3131PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources
Modified residuei465 – 4651PhosphoserineCombined sources
Modified residuei467 – 4671PhosphoserineCombined sources
Modified residuei485 – 4851PhosphothreonineCombined sources
Modified residuei726 – 7261PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TF01.
MaxQBiQ8TF01.
PaxDbiQ8TF01.
PeptideAtlasiQ8TF01.
PRIDEiQ8TF01.

PTM databases

iPTMnetiQ8TF01.
PhosphoSiteiQ8TF01.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000132424.
CleanExiHS_SFRS18.
GenevisibleiQ8TF01. HS.

Organism-specific databases

HPAiHPA038796.

Interactioni

Subunit structurei

Interacts with PNN.1 Publication

Protein-protein interaction databases

BioGridi117448. 21 interactions.
IntActiQ8TF01. 12 interactions.
STRINGi9606.ENSP00000358242.

Structurei

3D structure databases

ProteinModelPortaliQ8TF01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili237 – 27640Sequence analysisAdd
BLAST
Coiled coili429 – 46133Sequence analysisAdd
BLAST
Coiled coili673 – 70331Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 5653Gln-richAdd
BLAST
Compositional biasi100 – 222123Pro-richAdd
BLAST
Compositional biasi508 – 57770Ser-richAdd
BLAST
Compositional biasi722 – 80483Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEQY. Eukaryota.
ENOG4111NIS. LUCA.
GeneTreeiENSGT00730000111138.
HOVERGENiHBG062408.
InParanoidiQ8TF01.
KOiK13170.
OMAiHSEPEMT.
OrthoDBiEOG091G0B6V.
PhylomeDBiQ8TF01.
TreeFamiTF332904.

Family and domain databases

InterProiIPR031937. PNISR.
[Graphical view]
PfamiPF15996. PNISR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ
60 70 80 90 100
QSMVEQPPGM MPNGQDMSTM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP
110 120 130 140 150
PHPPPDQPWM PPTPGPMDIV PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG
160 170 180 190 200
GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH PPYWQPGPPG PPAPPQNRRE
210 220 230 240 250
RPSSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL EKMEREKQKK
260 270 280 290 300
LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEEEDTENV
310 320 330 340 350
EAASSGKVTR SPSPVPQEEH SDPEMTEEEK EYQMMLLTKM LLTEILLDVT
360 370 380 390 400
DEEIYYVAKD AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER
410 420 430 440 450
SDRGSESSDT DDEELRHRIR QKQEAFWRKE KEQQLLHDKQ MEEEKQQTER
460 470 480 490 500
VTKEMNEFIH KEQNSLSLLE AREADGDVVN EKKRTPNETT SVLEPKKEHK
510 520 530 540 550
EKEKQGRSRS GSSSSGSSSS NSRTSSTSST VSSSSYSSSS GSSRTSSRSS
560 570 580 590 600
SPKRKKRHSR SRSPTIKARR SRSRSYSRRI KIESNRARVK IRDRRRSNRN
610 620 630 640 650
SIERERRRNR SPSRERRRSR SRSRDRRTNR ASRSRSRDRR KIDDQRGNLS
660 670 680 690 700
GNSHKHKGEA KEQERKKERS RSIDKDRKKK DKEREREQDK RKEKQKREEK
710 720 730 740 750
DFKFSSQDDR LKRKRESERT FSRSGSISVK IIRHDSRQDS KKSTTKDSKK
760 770 780 790 800
HSGSDSSGRS SSESPGSSKE KKAKKPKHSR SRSVEKSQRS GKKASRKHKS

KSRSR
Length:805
Mass (Da):92,577
Last modified:July 10, 2007 - v2
Checksum:i7738BC276B6E80B2
GO
Isoform 2 (identifier: Q8TF01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-413: APAKQLAQSS...GSESSDTDDE → GIFWCFWFCF...ILLHVLTLKD
     414-805: Missing.

Show »
Length:413
Mass (Da):47,436
Checksum:i35B426FBABBB3F2E
GO

Sequence cautioni

The sequence AAH07791 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH19074 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH52638 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64413 differs from that shown. Reason: Frameshift at position 267. Curated
The sequence AAH64640 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341W → R in BAB55350 (PubMed:14702039).Curated
Sequence conflicti249 – 2491K → R in BAB55440 (PubMed:14702039).Curated
Sequence conflicti327 – 3271E → G in BAB55273 (PubMed:14702039).Curated
Sequence conflicti507 – 5071R → G in CAB45767 (PubMed:17974005).Curated
Sequence conflicti518 – 5181S → P in AAL76163 (PubMed:14578391).Curated
Sequence conflicti663 – 6631Q → R in CAB45767 (PubMed:17974005).Curated
Sequence conflicti784 – 7841V → A in AAL76163 (PubMed:14578391).Curated
Sequence conflicti784 – 7841V → A in AAL76164 (PubMed:14578391).Curated
Sequence conflicti805 – 8051R → KSSILFKVFCLIFKKN in AAF28939 (Ref. 6) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 41346APAKQ…DTDDE → GIFWCFWFCFSWGILVLMTI LAFFCCPCWISTRYLNILLH VLTLKD in isoform 2. 1 PublicationVSP_014458Add
BLAST
Alternative sequencei414 – 805392Missing in isoform 2. 1 PublicationVSP_014459Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314184 mRNA. Translation: AAL76163.1.
AF314185 mRNA. Translation: AAL76164.1.
AK027658 mRNA. Translation: BAB55273.1.
AK027759 mRNA. Translation: BAB55350.1.
AK027898 mRNA. Translation: BAB55440.1.
AK074628 mRNA. Translation: BAC11098.1. Different termination.
AK291155 mRNA. Translation: BAF83844.1.
AL513550 Genomic DNA. Translation: CAI17194.1.
CH471051 Genomic DNA. Translation: EAW48476.1.
CH471051 Genomic DNA. Translation: EAW48477.1.
CH471051 Genomic DNA. Translation: EAW48479.1.
CH471051 Genomic DNA. Translation: EAW48481.1.
BC007791 mRNA. Translation: AAH07791.1. Sequence problems.
BC019074 mRNA. Translation: AAH19074.1. Sequence problems.
BC052638 mRNA. Translation: AAH52638.1. Sequence problems.
BC064413 mRNA. Translation: AAH64413.1. Frameshift.
BC064640 mRNA. Translation: AAH64640.1. Sequence problems.
AF161379 mRNA. Translation: AAF28939.1.
AF161424 mRNA. Translation: AAF28984.1.
AL080186 mRNA. Translation: CAB45767.1.
CCDSiCCDS5043.1. [Q8TF01-1]
PIRiT12483.
RefSeqiNP_001309334.1. NM_001322405.1. [Q8TF01-1]
NP_001309335.1. NM_001322406.1. [Q8TF01-1]
NP_001309337.1. NM_001322408.1. [Q8TF01-1]
NP_001309341.1. NM_001322412.1.
NP_001309342.1. NM_001322413.1.
NP_001309344.1. NM_001322415.1.
NP_056306.1. NM_015491.2. [Q8TF01-1]
NP_116259.2. NM_032870.3. [Q8TF01-1]
UniGeneiHs.520287.
Hs.644863.
Hs.710131.

Genome annotation databases

EnsembliENST00000369239; ENSP00000358242; ENSG00000132424. [Q8TF01-1]
ENST00000438806; ENSP00000387997; ENSG00000132424. [Q8TF01-1]
ENST00000478777; ENSP00000435246; ENSG00000132424. [Q8TF01-2]
GeneIDi25957.
KEGGihsa:25957.
UCSCiuc003ppo.5. human. [Q8TF01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314184 mRNA. Translation: AAL76163.1.
AF314185 mRNA. Translation: AAL76164.1.
AK027658 mRNA. Translation: BAB55273.1.
AK027759 mRNA. Translation: BAB55350.1.
AK027898 mRNA. Translation: BAB55440.1.
AK074628 mRNA. Translation: BAC11098.1. Different termination.
AK291155 mRNA. Translation: BAF83844.1.
AL513550 Genomic DNA. Translation: CAI17194.1.
CH471051 Genomic DNA. Translation: EAW48476.1.
CH471051 Genomic DNA. Translation: EAW48477.1.
CH471051 Genomic DNA. Translation: EAW48479.1.
CH471051 Genomic DNA. Translation: EAW48481.1.
BC007791 mRNA. Translation: AAH07791.1. Sequence problems.
BC019074 mRNA. Translation: AAH19074.1. Sequence problems.
BC052638 mRNA. Translation: AAH52638.1. Sequence problems.
BC064413 mRNA. Translation: AAH64413.1. Frameshift.
BC064640 mRNA. Translation: AAH64640.1. Sequence problems.
AF161379 mRNA. Translation: AAF28939.1.
AF161424 mRNA. Translation: AAF28984.1.
AL080186 mRNA. Translation: CAB45767.1.
CCDSiCCDS5043.1. [Q8TF01-1]
PIRiT12483.
RefSeqiNP_001309334.1. NM_001322405.1. [Q8TF01-1]
NP_001309335.1. NM_001322406.1. [Q8TF01-1]
NP_001309337.1. NM_001322408.1. [Q8TF01-1]
NP_001309341.1. NM_001322412.1.
NP_001309342.1. NM_001322413.1.
NP_001309344.1. NM_001322415.1.
NP_056306.1. NM_015491.2. [Q8TF01-1]
NP_116259.2. NM_032870.3. [Q8TF01-1]
UniGeneiHs.520287.
Hs.644863.
Hs.710131.

3D structure databases

ProteinModelPortaliQ8TF01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117448. 21 interactions.
IntActiQ8TF01. 12 interactions.
STRINGi9606.ENSP00000358242.

PTM databases

iPTMnetiQ8TF01.
PhosphoSiteiQ8TF01.

Polymorphism and mutation databases

BioMutaiPNISR.
DMDMi152031686.

Proteomic databases

EPDiQ8TF01.
MaxQBiQ8TF01.
PaxDbiQ8TF01.
PeptideAtlasiQ8TF01.
PRIDEiQ8TF01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369239; ENSP00000358242; ENSG00000132424. [Q8TF01-1]
ENST00000438806; ENSP00000387997; ENSG00000132424. [Q8TF01-1]
ENST00000478777; ENSP00000435246; ENSG00000132424. [Q8TF01-2]
GeneIDi25957.
KEGGihsa:25957.
UCSCiuc003ppo.5. human. [Q8TF01-1]

Organism-specific databases

CTDi25957.
GeneCardsiPNISR.
H-InvDBHIX0006088.
HGNCiHGNC:21222. PNISR.
HPAiHPA038796.
MIMi616653. gene.
neXtProtiNX_Q8TF01.
PharmGKBiPA162402984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQY. Eukaryota.
ENOG4111NIS. LUCA.
GeneTreeiENSGT00730000111138.
HOVERGENiHBG062408.
InParanoidiQ8TF01.
KOiK13170.
OMAiHSEPEMT.
OrthoDBiEOG091G0B6V.
PhylomeDBiQ8TF01.
TreeFamiTF332904.

Miscellaneous databases

ChiTaRSiPNISR. human.
GeneWikiiPNISR_(gene).
GenomeRNAii25957.
PROiQ8TF01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132424.
CleanExiHS_SFRS18.
GenevisibleiQ8TF01. HS.

Family and domain databases

InterProiIPR031937. PNISR.
[Graphical view]
PfamiPF15996. PNISR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNISR_HUMAN
AccessioniPrimary (citable) accession number: Q8TF01
Secondary accession number(s): A8K540
, E1P5D2, Q5T064, Q5T065, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8N2L1, Q8TF00, Q96K10, Q96SI3, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.