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Q8TEZ7

- MPRB_HUMAN

UniProt

Q8TEZ7 - MPRB_HUMAN

Protein

Membrane progestin receptor beta

Gene

PAQR8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation By similarity.By similarity

    GO - Molecular functioni

    1. steroid binding Source: RefGenome
    2. steroid hormone receptor activity Source: RefGenome

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. oogenesis Source: UniProtKB-KW
    3. response to steroid hormone Source: RefGenome
    4. steroid hormone mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Oogenesis

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane progestin receptor beta
    Short name:
    mPR beta
    Alternative name(s):
    Lysosomal membrane protein in brain 1
    Progestin and adipoQ receptor family member 8
    Progestin and adipoQ receptor family member VIII
    Gene namesi
    Name:PAQR8
    Synonyms:C6orf33, LMPB1, MPRB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:15708. PAQR8.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Colocalizes with a lysosomal protein CTSD/cathepsin D.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25934.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Membrane progestin receptor betaPRO_0000218840Add
    BLAST

    Proteomic databases

    PaxDbiQ8TEZ7.
    PRIDEiQ8TEZ7.

    Expressioni

    Tissue specificityi

    Expressed in brain and spinal cord. Also expressed in kidney and testis.3 Publications

    Gene expression databases

    ArrayExpressiQ8TEZ7.
    BgeeiQ8TEZ7.
    CleanExiHS_PAQR8.
    GenevestigatoriQ8TEZ7.

    Interactioni

    Protein-protein interaction databases

    BioGridi124469. 1 interaction.
    STRINGi9606.ENSP00000406197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 17442CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini196 – 21318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 2439CytoplasmicSequence Analysis
    Topological domaini265 – 28319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini341 – 35414ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000230872.
    HOVERGENiHBG052504.
    InParanoidiQ8TEZ7.
    OMAiREPYIHA.
    OrthoDBiEOG7SN8D2.
    PhylomeDBiQ8TEZ7.
    TreeFamiTF319738.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TEZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY    50
    IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE 100
    ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG 150
    VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR 200
    YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL 250
    QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI 300
    LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT 350
    KKDS 354
    Length:354
    Mass (Da):40,464
    Last modified:June 1, 2002 - v1
    Checksum:iB0ECCD9C54C0CA24
    GO

    Sequence cautioni

    The sequence AAR08374.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC05478.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF347029 mRNA. Translation: AAL79777.2.
    AY424286 mRNA. Translation: AAR08374.1. Different initiation.
    AK315088 mRNA. Translation: BAG37553.1.
    AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation.
    BC030664 mRNA. Translation: AAH30664.2.
    AF313619 mRNA. Translation: AAO47232.1.
    CCDSiCCDS4941.1.
    RefSeqiNP_588608.1. NM_133367.4.
    UniGeneiHs.239388.

    Genome annotation databases

    EnsembliENST00000360726; ENSP00000353953; ENSG00000170915.
    ENST00000442253; ENSP00000406197; ENSG00000170915.
    GeneIDi85315.
    KEGGihsa:85315.
    UCSCiuc003pao.4. human.

    Polymorphism databases

    DMDMi51316493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF347029 mRNA. Translation: AAL79777.2 .
    AY424286 mRNA. Translation: AAR08374.1 . Different initiation.
    AK315088 mRNA. Translation: BAG37553.1 .
    AL136125 Genomic DNA. Translation: CAC05478.1 . Different initiation.
    BC030664 mRNA. Translation: AAH30664.2 .
    AF313619 mRNA. Translation: AAO47232.1 .
    CCDSi CCDS4941.1.
    RefSeqi NP_588608.1. NM_133367.4.
    UniGenei Hs.239388.

    3D structure databases

    ProteinModelPortali Q8TEZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124469. 1 interaction.
    STRINGi 9606.ENSP00000406197.

    Polymorphism databases

    DMDMi 51316493.

    Proteomic databases

    PaxDbi Q8TEZ7.
    PRIDEi Q8TEZ7.

    Protocols and materials databases

    DNASUi 85315.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360726 ; ENSP00000353953 ; ENSG00000170915 .
    ENST00000442253 ; ENSP00000406197 ; ENSG00000170915 .
    GeneIDi 85315.
    KEGGi hsa:85315.
    UCSCi uc003pao.4. human.

    Organism-specific databases

    CTDi 85315.
    GeneCardsi GC06P052226.
    HGNCi HGNC:15708. PAQR8.
    MIMi 607780. gene.
    neXtProti NX_Q8TEZ7.
    PharmGKBi PA25934.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000230872.
    HOVERGENi HBG052504.
    InParanoidi Q8TEZ7.
    OMAi REPYIHA.
    OrthoDBi EOG7SN8D2.
    PhylomeDBi Q8TEZ7.
    TreeFami TF319738.

    Miscellaneous databases

    GeneWikii PAQR8.
    GenomeRNAii 85315.
    NextBioi 75811.
    PROi Q8TEZ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEZ7.
    Bgeei Q8TEZ7.
    CleanExi HS_PAQR8.
    Genevestigatori Q8TEZ7.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein."
      Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., Inazawa J., Delgado-Escueta A.V., Yamakawa K.
      Biochem. Biophys. Res. Commun. 288:626-636(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Brain.
    2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
      Zhu Y., Bond J., Thomas P.
      Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-354, TISSUE SPECIFICITY.
      Tissue: Brain.
    7. "The further redefining of steroid-mediated signaling."
      Hammes S.R.
      Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiMPRB_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEZ7
    Secondary accession number(s): B2RCF6
    , Q86WL0, Q8N6D3, Q9HD02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3