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Q8TEZ7

- MPRB_HUMAN

UniProt

Q8TEZ7 - MPRB_HUMAN

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Protein
Membrane progestin receptor beta
Gene
PAQR8, C6orf33, LMPB1, MPRB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation By similarity.

GO - Molecular functioni

  1. steroid binding Source: RefGenome
  2. steroid hormone receptor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. oogenesis Source: UniProtKB-KW
  3. response to steroid hormone Source: RefGenome
  4. steroid hormone mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Oogenesis

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor beta
Short name:
mPR beta
Alternative name(s):
Lysosomal membrane protein in brain 1
Progestin and adipoQ receptor family member 8
Progestin and adipoQ receptor family member VIII
Gene namesi
Name:PAQR8
Synonyms:C6orf33, LMPB1, MPRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:15708. PAQR8.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Colocalizes with a lysosomal protein CTSD/cathepsin D.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini97 – 11115Extracellular Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini133 – 17442Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini196 – 21318Extracellular Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini235 – 2439Cytoplasmic Reviewed prediction
Transmembranei244 – 26421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini265 – 28319Extracellular Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini305 – 31915Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei320 – 34021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini341 – 35414Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Membrane progestin receptor beta
PRO_0000218840Add
BLAST

Proteomic databases

PaxDbiQ8TEZ7.
PRIDEiQ8TEZ7.

Expressioni

Tissue specificityi

Expressed in brain and spinal cord. Also expressed in kidney and testis.3 Publications

Gene expression databases

ArrayExpressiQ8TEZ7.
BgeeiQ8TEZ7.
CleanExiHS_PAQR8.
GenevestigatoriQ8TEZ7.

Interactioni

Protein-protein interaction databases

BioGridi124469. 1 interaction.
STRINGi9606.ENSP00000406197.

Structurei

3D structure databases

ProteinModelPortaliQ8TEZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
HOGENOMiHOG000230872.
HOVERGENiHBG052504.
InParanoidiQ8TEZ7.
OMAiREPYIHA.
OrthoDBiEOG7SN8D2.
PhylomeDBiQ8TEZ7.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY    50
IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE 100
ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG 150
VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR 200
YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL 250
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI 300
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT 350
KKDS 354
Length:354
Mass (Da):40,464
Last modified:June 1, 2002 - v1
Checksum:iB0ECCD9C54C0CA24
GO

Sequence cautioni

The sequence AAR08374.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC05478.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347029 mRNA. Translation: AAL79777.2.
AY424286 mRNA. Translation: AAR08374.1. Different initiation.
AK315088 mRNA. Translation: BAG37553.1.
AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation.
BC030664 mRNA. Translation: AAH30664.2.
AF313619 mRNA. Translation: AAO47232.1.
CCDSiCCDS4941.1.
RefSeqiNP_588608.1. NM_133367.4.
UniGeneiHs.239388.

Genome annotation databases

EnsembliENST00000360726; ENSP00000353953; ENSG00000170915.
ENST00000442253; ENSP00000406197; ENSG00000170915.
GeneIDi85315.
KEGGihsa:85315.
UCSCiuc003pao.4. human.

Polymorphism databases

DMDMi51316493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347029 mRNA. Translation: AAL79777.2 .
AY424286 mRNA. Translation: AAR08374.1 . Different initiation.
AK315088 mRNA. Translation: BAG37553.1 .
AL136125 Genomic DNA. Translation: CAC05478.1 . Different initiation.
BC030664 mRNA. Translation: AAH30664.2 .
AF313619 mRNA. Translation: AAO47232.1 .
CCDSi CCDS4941.1.
RefSeqi NP_588608.1. NM_133367.4.
UniGenei Hs.239388.

3D structure databases

ProteinModelPortali Q8TEZ7.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124469. 1 interaction.
STRINGi 9606.ENSP00000406197.

Polymorphism databases

DMDMi 51316493.

Proteomic databases

PaxDbi Q8TEZ7.
PRIDEi Q8TEZ7.

Protocols and materials databases

DNASUi 85315.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360726 ; ENSP00000353953 ; ENSG00000170915 .
ENST00000442253 ; ENSP00000406197 ; ENSG00000170915 .
GeneIDi 85315.
KEGGi hsa:85315.
UCSCi uc003pao.4. human.

Organism-specific databases

CTDi 85315.
GeneCardsi GC06P052226.
HGNCi HGNC:15708. PAQR8.
MIMi 607780. gene.
neXtProti NX_Q8TEZ7.
PharmGKBi PA25934.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1272.
HOGENOMi HOG000230872.
HOVERGENi HBG052504.
InParanoidi Q8TEZ7.
OMAi REPYIHA.
OrthoDBi EOG7SN8D2.
PhylomeDBi Q8TEZ7.
TreeFami TF319738.

Miscellaneous databases

GeneWikii PAQR8.
GenomeRNAii 85315.
NextBioi 75811.
PROi Q8TEZ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TEZ7.
Bgeei Q8TEZ7.
CleanExi HS_PAQR8.
Genevestigatori Q8TEZ7.

Family and domain databases

InterProi IPR004254. HlyIII-related.
[Graphical view ]
PANTHERi PTHR20855. PTHR20855. 1 hit.
Pfami PF03006. HlyIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein."
    Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., Inazawa J., Delgado-Escueta A.V., Yamakawa K.
    Biochem. Biophys. Res. Commun. 288:626-636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
    Zhu Y., Bond J., Thomas P.
    Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-354, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "The further redefining of steroid-mediated signaling."
    Hammes S.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMPRB_HUMAN
AccessioniPrimary (citable) accession number: Q8TEZ7
Secondary accession number(s): B2RCF6
, Q86WL0, Q8N6D3, Q9HD02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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