Q8TEZ7 (MPRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane progestin receptor beta
Short name=mPR beta

Alternative name(s):
Lysosomal membrane protein in brain 1
Progestin and adipoQ receptor family member 8
Progestin and adipoQ receptor family member VIII

Gene names

Name:	PAQR8
Synonyms:	C6orf33, LMPB1, MPRB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Colocalizes with a lysosomal protein CTSD/cathepsin D. Ref.1
Tissue specificity	Expressed in brain and spinal cord. Also expressed in kidney and testis. Ref.1 Ref.2 Ref.6
Sequence similarities	Belongs to the ADIPOR family.
Sequence caution	The sequence AAR08374.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC05478.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Oogenesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Lipid-binding Steroid-binding
Molecular function	Developmental protein Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW oogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	steroid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Membrane progestin receptor beta		PRO_0000218840
Regions
	Topological domain	1 – 75	75	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Name=1; Potential
	Topological domain	97 – 111	15	Extracellular Potential
	Transmembrane	112 – 132	21	Helical; Name=2; Potential
	Topological domain	133 – 174	42	Cytoplasmic Potential
	Transmembrane	175 – 195	21	Helical; Name=3; Potential
	Topological domain	196 – 213	18	Extracellular Potential
	Transmembrane	214 – 234	21	Helical; Name=4; Potential
	Topological domain	235 – 243	9	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Name=5; Potential
	Topological domain	265 – 283	19	Extracellular Potential
	Transmembrane	284 – 304	21	Helical; Name=6; Potential
	Topological domain	305 – 319	15	Cytoplasmic Potential
	Transmembrane	320 – 340	21	Helical; Name=7; Potential
	Topological domain	341 – 354	14	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TEZ7 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B0ECCD9C54C0CA24	FASTA	354	40,464
	10 20 30 40 50 60 MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY IRTGYRPTGH 70 80 90 100 110 120 EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE ALPWASTHSL PLLLFILSSI 130 140 150 160 170 180 TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL 190 200 210 220 230 240 PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC 250 260 270 280 290 300 QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI 310 320 330 340 350 LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT KKDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein." Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., Inazawa J., Delgado-Escueta A.V., Yamakawa K. Biochem. Biophys. Res. Commun. 288:626-636(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Brain.
[2]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor." Zhu Y., Bond J., Thomas P. Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-354, TISSUE SPECIFICITY. Tissue: Brain.
[7]	"The further redefining of steroid-mediated signaling." Hammes S.R. Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF347029 mRNA. Translation: AAL79777.2. AY424286 mRNA. Translation: AAR08374.1. Different initiation. AK315088 mRNA. Translation: BAG37553.1. AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation. BC030664 mRNA. Translation: AAH30664.2. AF313619 mRNA. Translation: AAO47232.1.
IPI	IPI00479237.
RefSeq	NP_588608.1. NM_133367.4.
UniGene	Hs.239388.
3D structure databases
ProteinModelPortal	Q8TEZ7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000406197.
Polymorphism databases
DMDM	51316493.
Proteomic databases
PaxDb	Q8TEZ7.
PRIDE	Q8TEZ7.
Protocols and materials databases
DNASU	85315.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360726; ENSP00000353953; ENSG00000170915. ENST00000442253; ENSP00000406197; ENSG00000170915.
GeneID	85315.
KEGG	hsa:85315.
UCSC	uc003pao.4. human.
Organism-specific databases
CTD	85315.
GeneCards	GC06P052226.
HGNC	HGNC:15708. PAQR8.
MIM	607780. gene.
neXtProt	NX_Q8TEZ7.
PharmGKB	PA25934.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000230872.
HOVERGEN	HBG052504.
InParanoid	Q8TEZ7.
OMA	REPYIHA.
OrthoDB	EOG40P472.
Gene expression databases
ArrayExpress	Q8TEZ7.
Bgee	Q8TEZ7.
CleanEx	HS_PAQR8.
Genevestigator	Q8TEZ7.
GermOnline	ENSG00000170915. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85315.
NextBio	75811.
SOURCE	Search...

Entry information

Entry name

MPRB_HUMAN

Accession

Primary (citable) accession number: Q8TEZ7
Secondary accession number(s): B2RCF6 , Q86WL0, Q8N6D3, Q9HD02

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.