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Q8TEZ7 (MPRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane progestin receptor beta

Short name=mPR beta
Alternative name(s):
Lysosomal membrane protein in brain 1
Progestin and adipoQ receptor family member 8
Progestin and adipoQ receptor family member VIII
Gene names
Name:PAQR8
Synonyms:C6orf33, LMPB1, MPRB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Colocalizes with a lysosomal protein CTSD/cathepsin D. Ref.1

Tissue specificity

Expressed in brain and spinal cord. Also expressed in kidney and testis. Ref.1 Ref.2 Ref.6

Sequence similarities

Belongs to the ADIPOR family.

Sequence caution

The sequence AAR08374.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC05478.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Membrane progestin receptor beta
PRO_0000218840

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=1; Potential
Topological domain97 – 11115Extracellular Potential
Transmembrane112 – 13221Helical; Name=2; Potential
Topological domain133 – 17442Cytoplasmic Potential
Transmembrane175 – 19521Helical; Name=3; Potential
Topological domain196 – 21318Extracellular Potential
Transmembrane214 – 23421Helical; Name=4; Potential
Topological domain235 – 2439Cytoplasmic Potential
Transmembrane244 – 26421Helical; Name=5; Potential
Topological domain265 – 28319Extracellular Potential
Transmembrane284 – 30421Helical; Name=6; Potential
Topological domain305 – 31915Cytoplasmic Potential
Transmembrane320 – 34021Helical; Name=7; Potential
Topological domain341 – 35414Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
Q8TEZ7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B0ECCD9C54C0CA24

FASTA35440,464
        10         20         30         40         50         60 
MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY IRTGYRPTGH 

        70         80         90        100        110        120 
EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE ALPWASTHSL PLLLFILSSI 

       130        140        150        160        170        180 
TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL 

       190        200        210        220        230        240 
PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC 

       250        260        270        280        290        300 
QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI 

       310        320        330        340        350 
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT KKDS 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein."
Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., Inazawa J., Delgado-Escueta A.V., Yamakawa K.
Biochem. Biophys. Res. Commun. 288:626-636(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Brain.
[2]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
Zhu Y., Bond J., Thomas P.
Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-354, TISSUE SPECIFICITY.
Tissue: Brain.
[7]"The further redefining of steroid-mediated signaling."
Hammes S.R.
Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF347029 mRNA. Translation: AAL79777.2.
AY424286 mRNA. Translation: AAR08374.1. Different initiation.
AK315088 mRNA. Translation: BAG37553.1.
AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation.
BC030664 mRNA. Translation: AAH30664.2.
AF313619 mRNA. Translation: AAO47232.1.
RefSeqNP_588608.1. NM_133367.4.
UniGeneHs.239388.

3D structure databases

ProteinModelPortalQ8TEZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124469. 1 interaction.
STRING9606.ENSP00000406197.

Polymorphism databases

DMDM51316493.

Proteomic databases

PaxDbQ8TEZ7.
PRIDEQ8TEZ7.

Protocols and materials databases

DNASU85315.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360726; ENSP00000353953; ENSG00000170915.
ENST00000442253; ENSP00000406197; ENSG00000170915.
GeneID85315.
KEGGhsa:85315.
UCSCuc003pao.4. human.

Organism-specific databases

CTD85315.
GeneCardsGC06P052226.
HGNCHGNC:15708. PAQR8.
MIM607780. gene.
neXtProtNX_Q8TEZ7.
PharmGKBPA25934.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000230872.
HOVERGENHBG052504.
InParanoidQ8TEZ7.
OMAREPYIHA.
OrthoDBEOG7SN8D2.
PhylomeDBQ8TEZ7.
TreeFamTF319738.

Gene expression databases

ArrayExpressQ8TEZ7.
BgeeQ8TEZ7.
CleanExHS_PAQR8.
GenevestigatorQ8TEZ7.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPAQR8.
GenomeRNAi85315.
NextBio75811.
PROQ8TEZ7.
SOURCESearch...

Entry information

Entry nameMPRB_HUMAN
AccessionPrimary (citable) accession number: Q8TEZ7
Secondary accession number(s): B2RCF6 expand/collapse secondary AC list , Q86WL0, Q8N6D3, Q9HD02
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM