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Protein

Membrane progestin receptor beta

Gene

PAQR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).By similarity

GO - Molecular functioni

  1. steroid binding Source: GO_Central
  2. steroid hormone receptor activity Source: GO_Central

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. oogenesis Source: UniProtKB-KW
  3. response to steroid hormone Source: GO_Central
  4. steroid hormone mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Oogenesis

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor beta
Short name:
mPR beta
Alternative name(s):
Lysosomal membrane protein in brain 1
Progestin and adipoQ receptor family member 8
Progestin and adipoQ receptor family member VIII
Gene namesi
Name:PAQR8
Synonyms:C6orf33, LMPB1, MPRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:15708. PAQR8.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Colocalizes with a lysosomal protein CTSD/cathepsin D.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini133 – 17442CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini196 – 21318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini235 – 2439CytoplasmicSequence Analysis
Transmembranei244 – 26421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini265 – 28319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini341 – 35414ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Membrane progestin receptor betaPRO_0000218840Add
BLAST

Proteomic databases

PaxDbiQ8TEZ7.
PRIDEiQ8TEZ7.

Expressioni

Tissue specificityi

Expressed in brain and spinal cord. Also expressed in kidney and testis.3 Publications

Gene expression databases

BgeeiQ8TEZ7.
CleanExiHS_PAQR8.
ExpressionAtlasiQ8TEZ7. baseline and differential.
GenevestigatoriQ8TEZ7.

Interactioni

Protein-protein interaction databases

BioGridi124469. 1 interaction.
STRINGi9606.ENSP00000406197.

Structurei

3D structure databases

ProteinModelPortaliQ8TEZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000230872.
HOVERGENiHBG052504.
InParanoidiQ8TEZ7.
OMAiREPYIHA.
OrthoDBiEOG7SN8D2.
PhylomeDBiQ8TEZ7.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY
60 70 80 90 100
IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE
110 120 130 140 150
ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG
160 170 180 190 200
VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR
210 220 230 240 250
YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL
260 270 280 290 300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
310 320 330 340 350
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT

KKDS
Length:354
Mass (Da):40,464
Last modified:June 1, 2002 - v1
Checksum:iB0ECCD9C54C0CA24
GO

Sequence cautioni

The sequence AAR08374.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC05478.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347029 mRNA. Translation: AAL79777.2.
AY424286 mRNA. Translation: AAR08374.1. Different initiation.
AK315088 mRNA. Translation: BAG37553.1.
AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation.
BC030664 mRNA. Translation: AAH30664.2.
AF313619 mRNA. Translation: AAO47232.1.
CCDSiCCDS4941.1.
RefSeqiNP_588608.1. NM_133367.4.
UniGeneiHs.239388.

Genome annotation databases

EnsembliENST00000360726; ENSP00000353953; ENSG00000170915.
ENST00000442253; ENSP00000406197; ENSG00000170915.
GeneIDi85315.
KEGGihsa:85315.
UCSCiuc003pao.4. human.

Polymorphism databases

DMDMi51316493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347029 mRNA. Translation: AAL79777.2.
AY424286 mRNA. Translation: AAR08374.1. Different initiation.
AK315088 mRNA. Translation: BAG37553.1.
AL136125 Genomic DNA. Translation: CAC05478.1. Different initiation.
BC030664 mRNA. Translation: AAH30664.2.
AF313619 mRNA. Translation: AAO47232.1.
CCDSiCCDS4941.1.
RefSeqiNP_588608.1. NM_133367.4.
UniGeneiHs.239388.

3D structure databases

ProteinModelPortaliQ8TEZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124469. 1 interaction.
STRINGi9606.ENSP00000406197.

Polymorphism databases

DMDMi51316493.

Proteomic databases

PaxDbiQ8TEZ7.
PRIDEiQ8TEZ7.

Protocols and materials databases

DNASUi85315.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360726; ENSP00000353953; ENSG00000170915.
ENST00000442253; ENSP00000406197; ENSG00000170915.
GeneIDi85315.
KEGGihsa:85315.
UCSCiuc003pao.4. human.

Organism-specific databases

CTDi85315.
GeneCardsiGC06P052226.
HGNCiHGNC:15708. PAQR8.
MIMi607780. gene.
neXtProtiNX_Q8TEZ7.
PharmGKBiPA25934.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000230872.
HOVERGENiHBG052504.
InParanoidiQ8TEZ7.
OMAiREPYIHA.
OrthoDBiEOG7SN8D2.
PhylomeDBiQ8TEZ7.
TreeFamiTF319738.

Miscellaneous databases

GeneWikiiPAQR8.
GenomeRNAii85315.
NextBioi75811.
PROiQ8TEZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TEZ7.
CleanExiHS_PAQR8.
ExpressionAtlasiQ8TEZ7. baseline and differential.
GenevestigatoriQ8TEZ7.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein."
    Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., Inazawa J., Delgado-Escueta A.V., Yamakawa K.
    Biochem. Biophys. Res. Commun. 288:626-636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
    Zhu Y., Bond J., Thomas P.
    Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-354, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "The further redefining of steroid-mediated signaling."
    Hammes S.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMPRB_HUMAN
AccessioniPrimary (citable) accession number: Q8TEZ7
Secondary accession number(s): B2RCF6
, Q86WL0, Q8N6D3, Q9HD02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.