Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TEY5

- CR3L4_HUMAN

UniProt

Q8TEY5 - CR3L4_HUMAN

Protein

Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene

CREB3L4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei338 – 3392Cleavage; by PS1By similarity

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. response to unfolded protein Source: UniProtKB-KW
    3. spermatogenesis Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Unfolded protein response

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 4
    Short name:
    cAMP-responsive element-binding protein 3-like protein 4
    Alternative name(s):
    Androgen-induced basic leucine zipper protein
    Short name:
    AIbZIP
    Attaching to CRE-like 1
    Short name:
    ATCE1
    Cyclic AMP-responsive element-binding protein 4
    Short name:
    CREB-4
    Short name:
    cAMP-responsive element-binding protein 4
    Transcript induced in spermiogenesis protein 40
    Short name:
    Tisp40
    hJAL
    Cleaved into the following chain:
    Gene namesi
    Name:CREB3L4
    Synonyms:AIBZIP, CREB4, JAL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18854. CREB3L4.

    Subcellular locationi

    Chain Processed cyclic AMP-responsive element-binding protein 3-like protein 4 : Nucleus
    Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi335 – 3351R → G: Abolishes cleavage by SP1. 1 Publication

    Organism-specific databases

    PharmGKBiPA134922919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000288079Add
    BLAST
    Chaini1 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000296219

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated in the C-terminal region.1 Publication
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region By similarity.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8TEY5.
    PaxDbiQ8TEY5.
    PRIDEiQ8TEY5.

    PTM databases

    PhosphoSiteiQ8TEY5.

    Miscellaneous databases

    PMAP-CutDBQ8TEY5.

    Expressioni

    Tissue specificityi

    According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.3 Publications

    Inductioni

    By androgens.

    Gene expression databases

    ArrayExpressiQ8TEY5.
    BgeeiQ8TEY5.
    CleanExiHS_CREB3L4.
    GenevestigatoriQ8TEY5.

    Organism-specific databases

    HPAiHPA038122.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer.By similarity

    Protein-protein interaction databases

    BioGridi127142. 6 interactions.
    IntActiQ8TEY5. 4 interactions.
    STRINGi9606.ENSP00000271889.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEY5.
    SMRiQ8TEY5. Positions 191-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 295295CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 39579LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei296 – 31621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini217 – 28064bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 24830Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni259 – 28022Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288874.
    HOGENOMiHOG000059566.
    HOVERGENiHBG058316.
    InParanoidiQ8TEY5.
    KOiK09048.
    OMAiHGVISRN.
    PhylomeDBiQ8TEY5.
    TreeFamiTF316079.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TEY5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW    50
    KSGGDRGCGL QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS 100
    PPAPRATSSP MLYEVVYEAG ALERMQGETG PNVGLISIQL DQWSPAFMVP 150
    DSCMVSELPF DAHAHILPRA GTVAPVPCTT LLPCQTLFLT DEEKRLLGQE 200
    GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE YIDGLESRVA 250
    ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI 300
    LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ 350
    VVESRLREPP GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM 395
    Length:395
    Mass (Da):43,432
    Last modified:June 1, 2002 - v1
    Checksum:iF3DDF288421AE5F2
    GO
    Isoform 2 (identifier: Q8TEY5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-58: Missing.

    Show »
    Length:375
    Mass (Da):41,275
    Checksum:i69E272BB4E51E127
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351P → L in AAO33070. (PubMed:12111373)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951P → S.
    Corresponds to variant rs11264743 [ dbSNP | Ensembl ].
    VAR_048444

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 5820Missing in isoform 2. 1 PublicationVSP_045426Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394167 mRNA. Translation: AAL76113.1.
    AF468007 mRNA. Translation: AAO33070.1.
    AB052778 mRNA. Translation: BAC45035.1.
    AB052781 Genomic DNA. Translation: BAC45224.1.
    AY049977 mRNA. Translation: AAL13157.1.
    AK304665 mRNA. Translation: BAG65440.1.
    AL358472 Genomic DNA. Translation: CAI14026.1.
    AL358472 Genomic DNA. Translation: CAI14027.1.
    CH471121 Genomic DNA. Translation: EAW53251.1.
    CH471121 Genomic DNA. Translation: EAW53253.1.
    CH471121 Genomic DNA. Translation: EAW53254.1.
    CH471121 Genomic DNA. Translation: EAW53256.1.
    CH471121 Genomic DNA. Translation: EAW53257.1.
    CH471121 Genomic DNA. Translation: EAW53258.1.
    BC038962 mRNA. Translation: AAH38962.1.
    CCDSiCCDS1056.1. [Q8TEY5-1]
    CCDS58029.1. [Q8TEY5-2]
    RefSeqiNP_001242907.1. NM_001255978.1. [Q8TEY5-1]
    NP_001242908.1. NM_001255979.1. [Q8TEY5-1]
    NP_001242909.1. NM_001255980.1. [Q8TEY5-2]
    NP_001242910.1. NM_001255981.1. [Q8TEY5-2]
    NP_570968.1. NM_130898.3. [Q8TEY5-1]
    XP_006711235.1. XM_006711172.1. [Q8TEY5-2]
    UniGeneiHs.372924.
    Hs.745148.

    Genome annotation databases

    EnsembliENST00000271889; ENSP00000271889; ENSG00000143578. [Q8TEY5-1]
    ENST00000368600; ENSP00000357589; ENSG00000143578. [Q8TEY5-2]
    ENST00000368603; ENSP00000357592; ENSG00000143578. [Q8TEY5-1]
    ENST00000368607; ENSP00000357596; ENSG00000143578. [Q8TEY5-1]
    GeneIDi148327.
    KEGGihsa:148327.
    UCSCiuc001fdm.2. human. [Q8TEY5-1]
    uc001fdo.4. human.

    Polymorphism databases

    DMDMi74751463.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394167 mRNA. Translation: AAL76113.1 .
    AF468007 mRNA. Translation: AAO33070.1 .
    AB052778 mRNA. Translation: BAC45035.1 .
    AB052781 Genomic DNA. Translation: BAC45224.1 .
    AY049977 mRNA. Translation: AAL13157.1 .
    AK304665 mRNA. Translation: BAG65440.1 .
    AL358472 Genomic DNA. Translation: CAI14026.1 .
    AL358472 Genomic DNA. Translation: CAI14027.1 .
    CH471121 Genomic DNA. Translation: EAW53251.1 .
    CH471121 Genomic DNA. Translation: EAW53253.1 .
    CH471121 Genomic DNA. Translation: EAW53254.1 .
    CH471121 Genomic DNA. Translation: EAW53256.1 .
    CH471121 Genomic DNA. Translation: EAW53257.1 .
    CH471121 Genomic DNA. Translation: EAW53258.1 .
    BC038962 mRNA. Translation: AAH38962.1 .
    CCDSi CCDS1056.1. [Q8TEY5-1 ]
    CCDS58029.1. [Q8TEY5-2 ]
    RefSeqi NP_001242907.1. NM_001255978.1. [Q8TEY5-1 ]
    NP_001242908.1. NM_001255979.1. [Q8TEY5-1 ]
    NP_001242909.1. NM_001255980.1. [Q8TEY5-2 ]
    NP_001242910.1. NM_001255981.1. [Q8TEY5-2 ]
    NP_570968.1. NM_130898.3. [Q8TEY5-1 ]
    XP_006711235.1. XM_006711172.1. [Q8TEY5-2 ]
    UniGenei Hs.372924.
    Hs.745148.

    3D structure databases

    ProteinModelPortali Q8TEY5.
    SMRi Q8TEY5. Positions 191-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127142. 6 interactions.
    IntActi Q8TEY5. 4 interactions.
    STRINGi 9606.ENSP00000271889.

    PTM databases

    PhosphoSitei Q8TEY5.

    Polymorphism databases

    DMDMi 74751463.

    Proteomic databases

    MaxQBi Q8TEY5.
    PaxDbi Q8TEY5.
    PRIDEi Q8TEY5.

    Protocols and materials databases

    DNASUi 148327.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271889 ; ENSP00000271889 ; ENSG00000143578 . [Q8TEY5-1 ]
    ENST00000368600 ; ENSP00000357589 ; ENSG00000143578 . [Q8TEY5-2 ]
    ENST00000368603 ; ENSP00000357592 ; ENSG00000143578 . [Q8TEY5-1 ]
    ENST00000368607 ; ENSP00000357596 ; ENSG00000143578 . [Q8TEY5-1 ]
    GeneIDi 148327.
    KEGGi hsa:148327.
    UCSCi uc001fdm.2. human. [Q8TEY5-1 ]
    uc001fdo.4. human.

    Organism-specific databases

    CTDi 148327.
    GeneCardsi GC01P153940.
    HGNCi HGNC:18854. CREB3L4.
    HPAi HPA038122.
    MIMi 607138. gene.
    neXtProti NX_Q8TEY5.
    PharmGKBi PA134922919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288874.
    HOGENOMi HOG000059566.
    HOVERGENi HBG058316.
    InParanoidi Q8TEY5.
    KOi K09048.
    OMAi HGVISRN.
    PhylomeDBi Q8TEY5.
    TreeFami TF316079.

    Miscellaneous databases

    GenomeRNAii 148327.
    NextBioi 85909.
    PMAP-CutDB Q8TEY5.
    PROi Q8TEY5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEY5.
    Bgeei Q8TEY5.
    CleanExi HS_CREB3L4.
    Genevestigatori Q8TEY5.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells."
      Qi H., Fillion C., Labrie Y., Grenier J., Fournier A., Berger L., El-Alfy M., Labrie C.
      Cancer Res. 62:721-733(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)."
      Cao G., Ni X., Jiang M., Ma Y., Cheng H., Guo L., Ji C., Gu S., Xie Y., Mao Y.
      J. Hum. Genet. 47:373-376(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Homo sapiens and Mus musculus JAL gene."
      Fujita K., Hatakeyama S., Ishikawa F.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    4. "Human ATCE1 - a novel protein that contains a CRE binding domain."
      Guo J.H., Dai F.Y., Yu L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    9. "Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway."
      Nagamori I., Yabuta N., Fujii T., Tanaka H., Yomogida K., Nishimune Y., Nojima H.
      Genes Cells 10:575-594(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION.
    10. "CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P."
      Stirling J., O'hare P.
      Mol. Biol. Cell 17:413-426(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-335.
    11. "Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases."
      Levesque M.H., El-Alfy M., Berger L., Labrie F., Labrie C.
      Urology 69:196-201(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCR3L4_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEY5
    Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3