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Q8TEY5

- CR3L4_HUMAN

UniProt

Q8TEY5 - CR3L4_HUMAN

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Protein
Cyclic AMP-responsive element-binding protein 3-like protein 4
Gene
CREB3L4, AIBZIP, CREB4, JAL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei338 – 3392Cleavage; by PS1 By similarity

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. response to unfolded protein Source: UniProtKB-KW
  3. spermatogenesis Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Unfolded protein response

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name:
cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name:
AIbZIP
Attaching to CRE-like 1
Short name:
ATCE1
Cyclic AMP-responsive element-binding protein 4
Short name:
CREB-4
Short name:
cAMP-responsive element-binding protein 4
Transcript induced in spermiogenesis protein 40
Short name:
Tisp40
hJAL
Cleaved into the following chain:
Gene namesi
Name:CREB3L4
Synonyms:AIBZIP, CREB4, JAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18854. CREB3L4.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein Reviewed prediction
Note: May also be located in Golgi apparatus.2 Publications
Chain Processed cyclic AMP-responsive element-binding protein 3-like protein 4 : Nucleus
Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus By similarity.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 295295Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei296 – 31621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini317 – 39579Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi335 – 3351R → G: Abolishes cleavage by SP1. 1 Publication

Organism-specific databases

PharmGKBiPA134922919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Cyclic AMP-responsive element-binding protein 3-like protein 4
PRO_0000288079Add
BLAST
Chaini1 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000296219

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated in the C-terminal region.1 Publication
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TEY5.
PaxDbiQ8TEY5.
PRIDEiQ8TEY5.

PTM databases

PhosphoSiteiQ8TEY5.

Miscellaneous databases

PMAP-CutDBQ8TEY5.

Expressioni

Tissue specificityi

According to 1 Publication, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to 1 Publication, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.3 Publications

Inductioni

By androgens.

Gene expression databases

ArrayExpressiQ8TEY5.
BgeeiQ8TEY5.
CleanExiHS_CREB3L4.
GenevestigatoriQ8TEY5.

Organism-specific databases

HPAiHPA038122.

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity.

Protein-protein interaction databases

BioGridi127142. 6 interactions.
IntActiQ8TEY5. 3 interactions.
STRINGi9606.ENSP00000271889.

Structurei

3D structure databases

ProteinModelPortaliQ8TEY5.
SMRiQ8TEY5. Positions 191-273.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 28064bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 24830Basic motif By similarity
Add
BLAST
Regioni259 – 28022Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288874.
HOGENOMiHOG000059566.
HOVERGENiHBG058316.
InParanoidiQ8TEY5.
KOiK09048.
OMAiHGVISRN.
PhylomeDBiQ8TEY5.
TreeFamiTF316079.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TEY5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW    50
KSGGDRGCGL QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS 100
PPAPRATSSP MLYEVVYEAG ALERMQGETG PNVGLISIQL DQWSPAFMVP 150
DSCMVSELPF DAHAHILPRA GTVAPVPCTT LLPCQTLFLT DEEKRLLGQE 200
GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE YIDGLESRVA 250
ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI 300
LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ 350
VVESRLREPP GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM 395
Length:395
Mass (Da):43,432
Last modified:June 1, 2002 - v1
Checksum:iF3DDF288421AE5F2
GO
Isoform 2 (identifier: Q8TEY5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: Missing.

Show »
Length:375
Mass (Da):41,275
Checksum:i69E272BB4E51E127
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951P → S.
Corresponds to variant rs11264743 [ dbSNP | Ensembl ].
VAR_048444

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 5820Missing in isoform 2.
VSP_045426Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351P → L in AAO33070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394167 mRNA. Translation: AAL76113.1.
AF468007 mRNA. Translation: AAO33070.1.
AB052778 mRNA. Translation: BAC45035.1.
AB052781 Genomic DNA. Translation: BAC45224.1.
AY049977 mRNA. Translation: AAL13157.1.
AK304665 mRNA. Translation: BAG65440.1.
AL358472 Genomic DNA. Translation: CAI14026.1.
AL358472 Genomic DNA. Translation: CAI14027.1.
CH471121 Genomic DNA. Translation: EAW53251.1.
CH471121 Genomic DNA. Translation: EAW53253.1.
CH471121 Genomic DNA. Translation: EAW53254.1.
CH471121 Genomic DNA. Translation: EAW53256.1.
CH471121 Genomic DNA. Translation: EAW53257.1.
CH471121 Genomic DNA. Translation: EAW53258.1.
BC038962 mRNA. Translation: AAH38962.1.
CCDSiCCDS1056.1. [Q8TEY5-1]
CCDS58029.1. [Q8TEY5-2]
RefSeqiNP_001242907.1. NM_001255978.1. [Q8TEY5-1]
NP_001242908.1. NM_001255979.1. [Q8TEY5-1]
NP_001242909.1. NM_001255980.1. [Q8TEY5-2]
NP_001242910.1. NM_001255981.1. [Q8TEY5-2]
NP_570968.1. NM_130898.3. [Q8TEY5-1]
XP_006711235.1. XM_006711172.1. [Q8TEY5-2]
UniGeneiHs.372924.
Hs.745148.

Genome annotation databases

EnsembliENST00000271889; ENSP00000271889; ENSG00000143578. [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578. [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578. [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578. [Q8TEY5-1]
GeneIDi148327.
KEGGihsa:148327.
UCSCiuc001fdm.2. human. [Q8TEY5-1]
uc001fdo.4. human.

Polymorphism databases

DMDMi74751463.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394167 mRNA. Translation: AAL76113.1 .
AF468007 mRNA. Translation: AAO33070.1 .
AB052778 mRNA. Translation: BAC45035.1 .
AB052781 Genomic DNA. Translation: BAC45224.1 .
AY049977 mRNA. Translation: AAL13157.1 .
AK304665 mRNA. Translation: BAG65440.1 .
AL358472 Genomic DNA. Translation: CAI14026.1 .
AL358472 Genomic DNA. Translation: CAI14027.1 .
CH471121 Genomic DNA. Translation: EAW53251.1 .
CH471121 Genomic DNA. Translation: EAW53253.1 .
CH471121 Genomic DNA. Translation: EAW53254.1 .
CH471121 Genomic DNA. Translation: EAW53256.1 .
CH471121 Genomic DNA. Translation: EAW53257.1 .
CH471121 Genomic DNA. Translation: EAW53258.1 .
BC038962 mRNA. Translation: AAH38962.1 .
CCDSi CCDS1056.1. [Q8TEY5-1 ]
CCDS58029.1. [Q8TEY5-2 ]
RefSeqi NP_001242907.1. NM_001255978.1. [Q8TEY5-1 ]
NP_001242908.1. NM_001255979.1. [Q8TEY5-1 ]
NP_001242909.1. NM_001255980.1. [Q8TEY5-2 ]
NP_001242910.1. NM_001255981.1. [Q8TEY5-2 ]
NP_570968.1. NM_130898.3. [Q8TEY5-1 ]
XP_006711235.1. XM_006711172.1. [Q8TEY5-2 ]
UniGenei Hs.372924.
Hs.745148.

3D structure databases

ProteinModelPortali Q8TEY5.
SMRi Q8TEY5. Positions 191-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127142. 6 interactions.
IntActi Q8TEY5. 3 interactions.
STRINGi 9606.ENSP00000271889.

PTM databases

PhosphoSitei Q8TEY5.

Polymorphism databases

DMDMi 74751463.

Proteomic databases

MaxQBi Q8TEY5.
PaxDbi Q8TEY5.
PRIDEi Q8TEY5.

Protocols and materials databases

DNASUi 148327.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271889 ; ENSP00000271889 ; ENSG00000143578 . [Q8TEY5-1 ]
ENST00000368600 ; ENSP00000357589 ; ENSG00000143578 . [Q8TEY5-2 ]
ENST00000368603 ; ENSP00000357592 ; ENSG00000143578 . [Q8TEY5-1 ]
ENST00000368607 ; ENSP00000357596 ; ENSG00000143578 . [Q8TEY5-1 ]
GeneIDi 148327.
KEGGi hsa:148327.
UCSCi uc001fdm.2. human. [Q8TEY5-1 ]
uc001fdo.4. human.

Organism-specific databases

CTDi 148327.
GeneCardsi GC01P153940.
HGNCi HGNC:18854. CREB3L4.
HPAi HPA038122.
MIMi 607138. gene.
neXtProti NX_Q8TEY5.
PharmGKBi PA134922919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288874.
HOGENOMi HOG000059566.
HOVERGENi HBG058316.
InParanoidi Q8TEY5.
KOi K09048.
OMAi HGVISRN.
PhylomeDBi Q8TEY5.
TreeFami TF316079.

Miscellaneous databases

GenomeRNAii 148327.
NextBioi 85909.
PMAP-CutDB Q8TEY5.
PROi Q8TEY5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TEY5.
Bgeei Q8TEY5.
CleanExi HS_CREB3L4.
Genevestigatori Q8TEY5.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells."
    Qi H., Fillion C., Labrie Y., Grenier J., Fournier A., Berger L., El-Alfy M., Labrie C.
    Cancer Res. 62:721-733(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)."
    Cao G., Ni X., Jiang M., Ma Y., Cheng H., Guo L., Ji C., Gu S., Xie Y., Mao Y.
    J. Hum. Genet. 47:373-376(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Homo sapiens and Mus musculus JAL gene."
    Fujita K., Hatakeyama S., Ishikawa F.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  4. "Human ATCE1 - a novel protein that contains a CRE binding domain."
    Guo J.H., Dai F.Y., Yu L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  9. "Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway."
    Nagamori I., Yabuta N., Fujii T., Tanaka H., Yomogida K., Nishimune Y., Nojima H.
    Genes Cells 10:575-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION.
  10. "CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P."
    Stirling J., O'hare P.
    Mol. Biol. Cell 17:413-426(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-335.
  11. "Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases."
    Levesque M.H., El-Alfy M., Berger L., Labrie F., Labrie C.
    Urology 69:196-201(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCR3L4_HUMAN
AccessioniPrimary (citable) accession number: Q8TEY5
Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi