Q8TEY5 (CR3L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name=cAMP-responsive element-binding protein 3-like protein 4

Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name=AIbZIP
Attaching to CRE-like 1
Short name=ATCE1
Cyclic AMP-responsive element-binding protein 4
Short name=CREB-4
Short name=cAMP-responsive element-binding protein 4
Transcript induced in spermiogenesis protein 40
Short name=Tisp40
hJAL

Cleaved into the following chain:

1. Processed cyclic AMP-responsive element-binding protein 3-like protein 4

Gene names

Name:	CREB3L4
Synonyms:	AIBZIP, CREB4, JAL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements By similarity. Ref.10
Subunit structure	Binds DNA as a dimer By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein Potential. Note: May also be located in Golgi apparatus. Ref.9 Ref.10 Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus By similarity. Ref.9 Ref.10
Tissue specificity	According to Ref.1, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to Ref.2, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. Ref.1 Ref.2 Ref.11
Induction	By androgens.
Post-translational modification	N-glycosylated in the C-terminal region. Ref.9 Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region By similarity.
Sequence similarities	Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Unfolded protein response
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	DNA-binding
Molecular function	Activator
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara response to unfolded protein Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEY5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEY5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Cyclic AMP-responsive element-binding protein 3-like protein 4		PRO_0000288079
	Chain	1 – ?		Processed cyclic AMP-responsive element-binding protein 3-like protein 4		PRO_0000296219
Regions
	Topological domain	1 – 295	295	Cytoplasmic Potential
	Transmembrane	296 – 316	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	317 – 395	79	Lumenal Potential
	Domain	217 – 280	64	bZIP
	Region	219 – 248	30	Basic motif By similarity
	Region	259 – 280	22	Leucine-zipper By similarity
Sites
	Site	338 – 339	2	Cleavage; by PS1 By similarity
Amino acid modifications
	Glycosylation	366	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	39 – 58	20	Missing in isoform 2.		VSP_045426
	Natural variant	95	1	P → S. Corresponds to variant rs11264743 [ dbSNP | Ensembl ].		VAR_048444
Experimental info
	Mutagenesis	335	1	R → G: Abolishes cleavage by SP1. Ref.10
	Sequence conflict	35	1	P → L in AAO33070. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: F3DDF288421AE5F2	FASTA	395	43,432
	10 20 30 40 50 60 MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW KSGGDRGCGL 70 80 90 100 110 120 QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS PPAPRATSSP MLYEVVYEAG 130 140 150 160 170 180 ALERMQGETG PNVGLISIQL DQWSPAFMVP DSCMVSELPF DAHAHILPRA GTVAPVPCTT 190 200 210 220 230 240 LLPCQTLFLT DEEKRLLGQE GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE 250 260 270 280 290 300 YIDGLESRVA ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI 310 320 330 340 350 360 LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ VVESRLREPP 370 380 390 GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM
	Isoform 2 [UniParc]. Checksum: 69E272BB4E51E127	FASTA	375	41,275
	10 20 30 40 50 60 MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPGL QESEPEDFLK LFIDPNEVYC 70 80 90 100 110 120 SEASPGSDSG ISEDPCHPDS PPAPRATSSP MLYEVVYEAG ALERMQGETG PNVGLISIQL 130 140 150 160 170 180 DQWSPAFMVP DSCMVSELPF DAHAHILPRA GTVAPVPCTT LLPCQTLFLT DEEKRLLGQE 190 200 210 220 230 240 GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE YIDGLESRVA ACSAQNQELQ 250 260 270 280 290 300 KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI LLFSLALIIL PSFSPFQSRP 310 320 330 340 350 360 EAGSEDYQPH GVTSRNILTH KDVTENLETQ VVESRLREPP GAKDANGSTR TLLEKMGGKP 370 RPSGRIRSVL HADEM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells." Qi H., Fillion C., Labrie Y., Grenier J., Fournier A., Berger L., El-Alfy M., Labrie C. Cancer Res. 62:721-733(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)." Cao G., Ni X., Jiang M., Ma Y., Cheng H., Guo L., Ji C., Gu S., Xie Y., Mao Y. J. Hum. Genet. 47:373-376(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Homo sapiens and Mus musculus JAL gene." Fujita K., Hatakeyama S., Ishikawa F. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[4]	"Human ATCE1 - a novel protein that contains a CRE binding domain." Guo J.H., Dai F.Y., Yu L. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[9]	"Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway." Nagamori I., Yabuta N., Fujii T., Tanaka H., Yomogida K., Nishimune Y., Nojima H. Genes Cells 10:575-594(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION.
[10]	"CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P." Stirling J., O'hare P. Mol. Biol. Cell 17:413-426(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-335.
[11]	"Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases." Levesque M.H., El-Alfy M., Berger L., Labrie F., Labrie C. Urology 69:196-201(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF394167 mRNA. Translation: AAL76113.1. AF468007 mRNA. Translation: AAO33070.1. AB052778 mRNA. Translation: BAC45035.1. AB052781 Genomic DNA. Translation: BAC45224.1. AY049977 mRNA. Translation: AAL13157.1. AK304665 mRNA. Translation: BAG65440.1. AL358472 Genomic DNA. Translation: CAI14026.1. AL358472 Genomic DNA. Translation: CAI14027.1. CH471121 Genomic DNA. Translation: EAW53251.1. CH471121 Genomic DNA. Translation: EAW53253.1. CH471121 Genomic DNA. Translation: EAW53254.1. CH471121 Genomic DNA. Translation: EAW53256.1. CH471121 Genomic DNA. Translation: EAW53257.1. CH471121 Genomic DNA. Translation: EAW53258.1. BC038962 mRNA. Translation: AAH38962.1.
IPI	IPI00152889.
RefSeq	NP_001242907.1. NM_001255978.1. NP_001242908.1. NM_001255979.1. NP_001242909.1. NM_001255980.1. NP_001242910.1. NM_001255981.1. NP_570968.1. NM_130898.3.
UniGene	Hs.372924. Hs.744219.
3D structure databases
ProteinModelPortal	Q8TEY5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TEY5. 3 interactions.
STRING	9606.ENSP00000271889.
PTM databases
PhosphoSite	Q8TEY5.
Polymorphism databases
DMDM	74751463.
Proteomic databases
PaxDb	Q8TEY5.
PRIDE	Q8TEY5.
Protocols and materials databases
DNASU	148327.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000271889; ENSP00000271889; ENSG00000143578. ENST00000368600; ENSP00000357589; ENSG00000143578. ENST00000368603; ENSP00000357592; ENSG00000143578. ENST00000368607; ENSP00000357596; ENSG00000143578.
GeneID	148327.
KEGG	hsa:148327.
UCSC	uc001fdm.1. human. uc001fdo.3. human.
Organism-specific databases
CTD	148327.
GeneCards	GC01P153940.
HGNC	HGNC:18854. CREB3L4.
HPA	HPA038122.
MIM	607138. gene.
neXtProt	NX_Q8TEY5.
PharmGKB	PA134922919.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288874.
HOGENOM	HOG000059566.
HOVERGEN	HBG058316.
InParanoid	Q8TEY5.
KO	K09048.
OMA	PNEVYCS.
PhylomeDB	Q8TEY5.
Gene expression databases
ArrayExpress	Q8TEY5.
Bgee	Q8TEY5.
CleanEx	HS_CREB3L4.
Genevestigator	Q8TEY5.
Family and domain databases
InterPro	IPR004827. bZIP. IPR008917. Euk_TF_DNA-bd. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
SUPFAM	SSF47454. Euk_transcr_DNA. 1 hit.
PROSITE	PS50217. BZIP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	148327.
NextBio	85909.
PMAP-CutDB	Q8TEY5.
SOURCE	Search...

Entry information

Entry name

CR3L4_HUMAN

Accession

Primary (citable) accession number: Q8TEY5
Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	June 1, 2002
Last modified:	May 29, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.