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Q8TEY5 (CR3L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4

Short name=cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name=AIbZIP
Attaching to CRE-like 1
Short name=ATCE1
Cyclic AMP-responsive element-binding protein 4
Short name=CREB-4
Short name=cAMP-responsive element-binding protein 4
Transcript induced in spermiogenesis protein 40
Short name=Tisp40
hJAL
Gene names
Name:CREB3L4
Synonyms:AIBZIP, CREB4, JAL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements By similarity. Ref.10

Subunit structure

Binds DNA as a dimer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein Potential. Note: May also be located in Golgi apparatus. Ref.9 Ref.10

Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus By similarity. Ref.9 Ref.10

Tissue specificity

According to Ref.1, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to Ref.2, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. Ref.1 Ref.2 Ref.11

Induction

By androgens.

Post-translational modification

N-glycosylated in the C-terminal region. Ref.9

Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region By similarity.

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TEY5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TEY5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Cyclic AMP-responsive element-binding protein 3-like protein 4
PRO_0000288079
Chain1 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000296219

Regions

Topological domain1 – 295295Cytoplasmic Potential
Transmembrane296 – 31621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain317 – 39579Lumenal Potential
Domain217 – 28064bZIP
Region219 – 24830Basic motif By similarity
Region259 – 28022Leucine-zipper By similarity

Sites

Site338 – 3392Cleavage; by PS1 By similarity

Amino acid modifications

Glycosylation3661N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence39 – 5820Missing in isoform 2.
VSP_045426
Natural variant951P → S.
Corresponds to variant rs11264743 [ dbSNP | Ensembl ].
VAR_048444

Experimental info

Mutagenesis3351R → G: Abolishes cleavage by SP1. Ref.10
Sequence conflict351P → L in AAO33070. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: F3DDF288421AE5F2

FASTA39543,432
        10         20         30         40         50         60 
MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW KSGGDRGCGL 

        70         80         90        100        110        120 
QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS PPAPRATSSP MLYEVVYEAG 

       130        140        150        160        170        180 
ALERMQGETG PNVGLISIQL DQWSPAFMVP DSCMVSELPF DAHAHILPRA GTVAPVPCTT 

       190        200        210        220        230        240 
LLPCQTLFLT DEEKRLLGQE GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE 

       250        260        270        280        290        300 
YIDGLESRVA ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI 

       310        320        330        340        350        360 
LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ VVESRLREPP 

       370        380        390 
GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM 

« Hide

Isoform 2 [UniParc].

Checksum: 69E272BB4E51E127
Show »

FASTA37541,275

References

« Hide 'large scale' references
[1]"AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells."
Qi H., Fillion C., Labrie Y., Grenier J., Fournier A., Berger L., El-Alfy M., Labrie C.
Cancer Res. 62:721-733(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)."
Cao G., Ni X., Jiang M., Ma Y., Cheng H., Guo L., Ji C., Gu S., Xie Y., Mao Y.
J. Hum. Genet. 47:373-376(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"Homo sapiens and Mus musculus JAL gene."
Fujita K., Hatakeyama S., Ishikawa F.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[4]"Human ATCE1 - a novel protein that contains a CRE binding domain."
Guo J.H., Dai F.Y., Yu L.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[9]"Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway."
Nagamori I., Yabuta N., Fujii T., Tanaka H., Yomogida K., Nishimune Y., Nojima H.
Genes Cells 10:575-594(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION.
[10]"CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P."
Stirling J., O'hare P.
Mol. Biol. Cell 17:413-426(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-335.
[11]"Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases."
Levesque M.H., El-Alfy M., Berger L., Labrie F., Labrie C.
Urology 69:196-201(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF394167 mRNA. Translation: AAL76113.1.
AF468007 mRNA. Translation: AAO33070.1.
AB052778 mRNA. Translation: BAC45035.1.
AB052781 Genomic DNA. Translation: BAC45224.1.
AY049977 mRNA. Translation: AAL13157.1.
AK304665 mRNA. Translation: BAG65440.1.
AL358472 Genomic DNA. Translation: CAI14026.1.
AL358472 Genomic DNA. Translation: CAI14027.1.
CH471121 Genomic DNA. Translation: EAW53251.1.
CH471121 Genomic DNA. Translation: EAW53253.1.
CH471121 Genomic DNA. Translation: EAW53254.1.
CH471121 Genomic DNA. Translation: EAW53256.1.
CH471121 Genomic DNA. Translation: EAW53257.1.
CH471121 Genomic DNA. Translation: EAW53258.1.
BC038962 mRNA. Translation: AAH38962.1.
RefSeqNP_001242907.1. NM_001255978.1.
NP_001242908.1. NM_001255979.1.
NP_001242909.1. NM_001255980.1.
NP_001242910.1. NM_001255981.1.
NP_570968.1. NM_130898.3.
UniGeneHs.372924.
Hs.745148.

3D structure databases

ProteinModelPortalQ8TEY5.
SMRQ8TEY5. Positions 182-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127142. 6 interactions.
IntActQ8TEY5. 3 interactions.
STRING9606.ENSP00000271889.

PTM databases

PhosphoSiteQ8TEY5.

Polymorphism databases

DMDM74751463.

Proteomic databases

PaxDbQ8TEY5.
PRIDEQ8TEY5.

Protocols and materials databases

DNASU148327.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000271889; ENSP00000271889; ENSG00000143578. [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578. [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578. [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578. [Q8TEY5-1]
GeneID148327.
KEGGhsa:148327.
UCSCuc001fdm.2. human. [Q8TEY5-1]
uc001fdo.4. human.

Organism-specific databases

CTD148327.
GeneCardsGC01P153940.
HGNCHGNC:18854. CREB3L4.
HPAHPA038122.
MIM607138. gene.
neXtProtNX_Q8TEY5.
PharmGKBPA134922919.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288874.
HOGENOMHOG000059566.
HOVERGENHBG058316.
InParanoidQ8TEY5.
KOK09048.
OMACGLQESE.
PhylomeDBQ8TEY5.
TreeFamTF316079.

Gene expression databases

ArrayExpressQ8TEY5.
BgeeQ8TEY5.
CleanExHS_CREB3L4.
GenevestigatorQ8TEY5.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi148327.
NextBio85909.
PMAP-CutDBQ8TEY5.
PROQ8TEY5.
SOURCESearch...

Entry information

Entry nameCR3L4_HUMAN
AccessionPrimary (citable) accession number: Q8TEY5
Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM