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Protein

Partitioning defective 3 homolog B

Gene

PARD3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 3 homolog B
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein
PAR3-beta
Partitioning defective 3-like protein
Short name:
PAR3-L protein
Gene namesi
Name:PARD3B
Synonyms:ALS2CR19, PAR3B, PAR3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14446. PARD3B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi117583.
OpenTargetsiENSG00000116117.
PharmGKBiPA162398721.

Polymorphism and mutation databases

BioMutaiPARD3B.
DMDMi30913163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850721 – 1205Partitioning defective 3 homolog BAdd BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei635PhosphoserineBy similarity1
Modified residuei710PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei730PhosphoserineBy similarity1
Modified residuei746PhosphoserineCombined sources1
Modified residuei749PhosphoserineBy similarity1
Modified residuei801PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TEW8.
PeptideAtlasiQ8TEW8.
PRIDEiQ8TEW8.

PTM databases

iPTMnetiQ8TEW8.
PhosphoSitePlusiQ8TEW8.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.

Gene expression databases

BgeeiENSG00000116117.
CleanExiHS_PARD3B.
ExpressionAtlasiQ8TEW8. baseline and differential.
GenevisibleiQ8TEW8. HS.

Organism-specific databases

HPAiHPA035283.

Interactioni

Subunit structurei

Interacts with PARD6B. Interacts with INSC/inscuteable.2 Publications

Protein-protein interaction databases

BioGridi125592. 2 interactors.
DIPiDIP-42276N.
IntActiQ8TEW8. 2 interactors.
MINTiMINT-1688375.

Structurei

3D structure databases

ProteinModelPortaliQ8TEW8.
SMRiQ8TEW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 289PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini383 – 468PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini498 – 585PDZ 3PROSITE-ProRule annotationAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi830 – 896Lys-richAdd BLAST67
Compositional biasi1144 – 1149Poly-Pro6

Domaini

The N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed.

Sequence similaritiesi

Belongs to the PAR3 family.Curated
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119017.
HOVERGENiHBG053508.
InParanoidiQ8TEW8.
OMAiAMLRFGK.
OrthoDBiEOG091G04AU.
PhylomeDBiQ8TEW8.
TreeFamiTF323729.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEW8-1) [UniParc]FASTAAdd to basket
Also known as: Par3La, a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVTVCFGRT GIVVPCKEGQ LRVGELTQQA LQRYLKTREK GPGYWVKIHH
60 70 80 90 100
LEYTDGGILD PDDVLADVVE DKDKLIAVFE EQEPLHKIES PSGNPADRQS
110 120 130 140 150
PDAFETEVAA QLAAFKPIGG EIEVTPSALK LGTPLLVRRS SDPVPGPPAD
160 170 180 190 200
TQPSASHPGG QSLKLVVPDS TQNLEDREVL NGVQTELLTS PRTKDTLSDM
210 220 230 240 250
TRTVEISGEG GPLGIHVVPF FSSLSGRILG LFIRGIEDNS RSKREGLFHE
260 270 280 290 300
NECIVKINNV DLVDKTFAQA QDVFRQAMKS PSVLLHVLPP QNREQYEKSV
310 320 330 340 350
IGSLNIFGNN DGVLKTKVPP PVHGKSGLKT ANLTGTDSPE TDASASLQQN
360 370 380 390 400
KSPRVPRLGG KPSSPSLSPL MGFGSNKNAK KIKIDLKKGP EGLGFTVVTR
410 420 430 440 450
DSSIHGPGPI FVKNILPKGA AIKDGRLQSG DRILEVNGRD VTGRTQEELV
460 470 480 490 500
AMLRSTKQGE TASLVIARQE GHFLPRELKG EPDCCALSLE TSEQLTFEIP
510 520 530 540 550
LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK DGRLRMNDQL
560 570 580 590 600
IAVNGESLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPMEDPA
610 620 630 640 650
ECGAFSKPCF ENCQNAVTTS RRNDNSILHP LGTCSPQDKQ KGLLLPNDGW
660 670 680 690 700
AESEVPPSPT PHSALGLGLE DYSHSSGVDS AVYFPDQHIN FRSVTPARQP
710 720 730 740 750
ESINLKASKS MDLVPDESKV HSLAGQKSES PSKDFGPTLG LKKSSSLESL
760 770 780 790 800
QTAVAEVRKN DLPFHRPRPH MVRGRGCNES FRAAIDKSYD GPEEIEADGL
810 820 830 840 850
SDKSSHSGQG ALNCESAPQG NSELEDMENK ARKVKKTKEK EKKKEKGKLK
860 870 880 890 900
VKEKKRKEEN EDPERKIKKK GFGAMLRFGK KKEDKGGKAE QKGTLKHGGL
910 920 930 940 950
REEELEKMKE ERERIGAKHQ ELREKQARGL LDYATGAIGS VYDMDDDEMD
960 970 980 990 1000
PNYARVNHFR EPCTSANVFR SPSPPRAGPF GYPRDGHPLS PERDHLEGLY
1010 1020 1030 1040 1050
AKVNKPYHPL VPADSGRPTG GSTDRIQKLR KEYYQARREG FPLYEDDEGR
1060 1070 1080 1090 1100
ARPSEYDLLW VPGRGPDGNA HNLRFEGMER QYASLPRGGP ADPVDYLPAA
1110 1120 1130 1140 1150
PRGLYKEREL PYYPGAHPMH PPKGSYPRPT ELRVADLRYP QHYPPPPAPQ
1160 1170 1180 1190 1200
HKGPFRQDVP PSPPQHQRMP AYQETGRPGP RGGSPDQYPY RTQDSRQKNP

MTAAV
Length:1,205
Mass (Da):132,494
Last modified:May 16, 2003 - v2
Checksum:i26E6704CCDCE8CD8
GO
Isoform 2 (identifier: Q8TEW8-2) [UniParc]FASTAAdd to basket
Also known as: Par3Lb, b

The sequence of this isoform differs from the canonical sequence as follows:
     479-540: Missing.

Show »
Length:1,143
Mass (Da):126,102
Checksum:i368B69CF81D45E7E
GO
Isoform 3 (identifier: Q8TEW8-3) [UniParc]FASTAAdd to basket
Also known as: Par3Lc, c

The sequence of this isoform differs from the canonical sequence as follows:
     730-798: Missing.

Show »
Length:1,136
Mass (Da):124,885
Checksum:iDE734844F61CBB6B
GO
Isoform 4 (identifier: Q8TEW8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-79: GPGYWVKIHH...EDKDKLIAVF → VSAARRSGAR...IYRWRNPGSR
     80-1205: Missing.

Show »
Length:79
Mass (Da):9,007
Checksum:iD5DDC8745B5C0B0D
GO
Isoform 5 (identifier: Q8TEW8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     914-1014: Missing.

Show »
Length:1,104
Mass (Da):121,168
Checksum:iBD05011D955583E3
GO
Isoform 6 (identifier: Q8TEW8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     729-797: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,136
Mass (Da):124,871
Checksum:i1B963A3F07485434
GO

Sequence cautioni

The sequence BAB71106 differs from that shown. Reason: Frameshift at position 528.Curated
The sequence BAB71623 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti893 – 901GTLKHGGLR → WLINFVLIW in BAB71623 (PubMed:14702039).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015664165L → P.2 PublicationsCorresponds to variant rs1510765dbSNPEnsembl.1
Natural variantiVAR_015665192R → K.1 PublicationCorresponds to variant rs2289025dbSNPEnsembl.1
Natural variantiVAR_015666295Q → K.Corresponds to variant rs1061522dbSNPEnsembl.1
Natural variantiVAR_056642317K → R.Corresponds to variant rs34751010dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00747641 – 79GPGYW…LIAVF → VSAARRSGARLQPRHLPGSW LLGEDSSLRIYRWRNPGSR in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_00747780 – 1205Missing in isoform 4. 1 PublicationAdd BLAST1126
Alternative sequenceiVSP_007478479 – 540Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_054048729 – 797Missing in isoform 6. CuratedAdd BLAST69
Alternative sequenceiVSP_007479730 – 798Missing in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_007543914 – 1014Missing in isoform 5. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053321 mRNA. Translation: BAB69028.1.
AB073472 mRNA. Translation: BAC54035.1.
AB092439 mRNA. Translation: BAC54285.1.
AF428250 mRNA. Translation: AAL30664.1.
AF428251 mRNA. Translation: AAL30665.1.
AF466152 mRNA. Translation: AAL79827.1.
AC007385 Genomic DNA. No translation available.
AC007465 Genomic DNA. No translation available.
AC007736 Genomic DNA. No translation available.
AC007746 Genomic DNA. No translation available.
AC008168 Genomic DNA. No translation available.
AC008171 Genomic DNA. No translation available.
AC009316 Genomic DNA. No translation available.
AC011750 Genomic DNA. No translation available.
AC016903 Genomic DNA. No translation available.
AC108468 Genomic DNA. No translation available.
AK056157 mRNA. Translation: BAB71106.1. Frameshift.
AK057965 mRNA. Translation: BAB71623.1. Different initiation.
CCDSiCCDS42804.1. [Q8TEW8-5]
CCDS42805.1. [Q8TEW8-6]
CCDS42806.1. [Q8TEW8-2]
CCDS77511.1. [Q8TEW8-1]
RefSeqiNP_001289698.1. NM_001302769.1. [Q8TEW8-1]
NP_476518.4. NM_057177.6. [Q8TEW8-6]
NP_689739.4. NM_152526.5. [Q8TEW8-2]
NP_995585.2. NM_205863.3. [Q8TEW8-5]
UniGeneiHs.657382.

Genome annotation databases

EnsembliENST00000349953; ENSP00000340280; ENSG00000116117. [Q8TEW8-5]
ENST00000351153; ENSP00000317261; ENSG00000116117. [Q8TEW8-6]
ENST00000358768; ENSP00000351618; ENSG00000116117. [Q8TEW8-2]
ENST00000406610; ENSP00000385848; ENSG00000116117. [Q8TEW8-1]
ENST00000415947; ENSP00000407718; ENSG00000116117. [Q8TEW8-4]
GeneIDi117583.
KEGGihsa:117583.
UCSCiuc002vao.3. human. [Q8TEW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053321 mRNA. Translation: BAB69028.1.
AB073472 mRNA. Translation: BAC54035.1.
AB092439 mRNA. Translation: BAC54285.1.
AF428250 mRNA. Translation: AAL30664.1.
AF428251 mRNA. Translation: AAL30665.1.
AF466152 mRNA. Translation: AAL79827.1.
AC007385 Genomic DNA. No translation available.
AC007465 Genomic DNA. No translation available.
AC007736 Genomic DNA. No translation available.
AC007746 Genomic DNA. No translation available.
AC008168 Genomic DNA. No translation available.
AC008171 Genomic DNA. No translation available.
AC009316 Genomic DNA. No translation available.
AC011750 Genomic DNA. No translation available.
AC016903 Genomic DNA. No translation available.
AC108468 Genomic DNA. No translation available.
AK056157 mRNA. Translation: BAB71106.1. Frameshift.
AK057965 mRNA. Translation: BAB71623.1. Different initiation.
CCDSiCCDS42804.1. [Q8TEW8-5]
CCDS42805.1. [Q8TEW8-6]
CCDS42806.1. [Q8TEW8-2]
CCDS77511.1. [Q8TEW8-1]
RefSeqiNP_001289698.1. NM_001302769.1. [Q8TEW8-1]
NP_476518.4. NM_057177.6. [Q8TEW8-6]
NP_689739.4. NM_152526.5. [Q8TEW8-2]
NP_995585.2. NM_205863.3. [Q8TEW8-5]
UniGeneiHs.657382.

3D structure databases

ProteinModelPortaliQ8TEW8.
SMRiQ8TEW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125592. 2 interactors.
DIPiDIP-42276N.
IntActiQ8TEW8. 2 interactors.
MINTiMINT-1688375.

PTM databases

iPTMnetiQ8TEW8.
PhosphoSitePlusiQ8TEW8.

Polymorphism and mutation databases

BioMutaiPARD3B.
DMDMi30913163.

Proteomic databases

MaxQBiQ8TEW8.
PeptideAtlasiQ8TEW8.
PRIDEiQ8TEW8.

Protocols and materials databases

DNASUi117583.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349953; ENSP00000340280; ENSG00000116117. [Q8TEW8-5]
ENST00000351153; ENSP00000317261; ENSG00000116117. [Q8TEW8-6]
ENST00000358768; ENSP00000351618; ENSG00000116117. [Q8TEW8-2]
ENST00000406610; ENSP00000385848; ENSG00000116117. [Q8TEW8-1]
ENST00000415947; ENSP00000407718; ENSG00000116117. [Q8TEW8-4]
GeneIDi117583.
KEGGihsa:117583.
UCSCiuc002vao.3. human. [Q8TEW8-1]

Organism-specific databases

CTDi117583.
DisGeNETi117583.
GeneCardsiPARD3B.
H-InvDBHIX0002763.
HGNCiHGNC:14446. PARD3B.
HPAiHPA035283.
neXtProtiNX_Q8TEW8.
OpenTargetsiENSG00000116117.
PharmGKBiPA162398721.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119017.
HOVERGENiHBG053508.
InParanoidiQ8TEW8.
OMAiAMLRFGK.
OrthoDBiEOG091G04AU.
PhylomeDBiQ8TEW8.
TreeFamiTF323729.

Miscellaneous databases

ChiTaRSiPARD3B. human.
GeneWikiiPARD3B.
GenomeRNAii117583.
PROiQ8TEW8.

Gene expression databases

BgeeiENSG00000116117.
CleanExiHS_PARD3B.
ExpressionAtlasiQ8TEW8. baseline and differential.
GenevisibleiQ8TEW8. HS.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR3L_HUMAN
AccessioniPrimary (citable) accession number: Q8TEW8
Secondary accession number(s): E9PE87
, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.