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Q8TEW6

- DOK4_HUMAN

UniProt

Q8TEW6 - DOK4_HUMAN

Protein

Docking protein 4

Gene

DOK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway By similarity. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor signaling protein activity Source: Ensembl

    GO - Biological processi

    1. MAPK cascade Source: Ensembl
    2. nervous system development Source: Ensembl
    3. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Enzyme and pathway databases

    SignaLinkiQ8TEW6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Docking protein 4
    Alternative name(s):
    Downstream of tyrosine kinase 4
    Insulin receptor substrate 5
    Short name:
    IRS-5
    Short name:
    IRS5
    Gene namesi
    Name:DOK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19868. DOK4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134892921.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Docking protein 4PRO_0000187274Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8TEW6.
    PRIDEiQ8TEW6.

    PTM databases

    PhosphoSiteiQ8TEW6.

    Expressioni

    Tissue specificityi

    Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.2 Publications

    Gene expression databases

    ArrayExpressiQ8TEW6.
    BgeeiQ8TEW6.
    CleanExiHS_DOK4.
    GenevestigatoriQ8TEW6.

    Organism-specific databases

    HPAiHPA052844.
    HPA055849.

    Interactioni

    Subunit structurei

    Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046262EBI-6918542,EBI-641062
    OPRM1P353724EBI-6918542,EBI-2624570

    Protein-protein interaction databases

    BioGridi120837. 5 interactions.
    IntActiQ8TEW6. 3 interactions.
    MINTiMINT-1491631.
    STRINGi9606.ENSP00000344277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEW6.
    SMRiQ8TEW6. Positions 134-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 112106PHAdd
    BLAST
    Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi265 – 27511DKFBH motifAdd
    BLAST

    Domaini

    PTB domain mediates receptor interaction.By similarity

    Sequence similaritiesi

    Belongs to the DOK family. Type B subfamily.Curated
    Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
    Contains 1 PH domain.Curated

    Phylogenomic databases

    eggNOGiNOG256436.
    HOGENOMiHOG000247025.
    HOVERGENiHBG002356.
    InParanoidiQ8TEW6.
    PhylomeDBiQ8TEW6.
    TreeFamiTF324994.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF02174. IRS. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view]
    PROSITEiPS51064. IRS_PTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TEW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS    50
    VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA 100
    EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD 150
    VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR 200
    MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK 250
    GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET 300
    DLLNRFILLK PKPSQGDSSE AKTPSQ 326
    Length:326
    Mass (Da):37,028
    Last modified:May 10, 2005 - v2
    Checksum:i1595B0CEC5584816
    GO

    Sequence cautioni

    The sequence AAC24310.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641N → S no nucleotide entry (PubMed:12730241)Curated
    Sequence conflicti64 – 641N → S in BAA91642. (PubMed:14702039)Curated
    Sequence conflicti75 – 751T → A in AAL74195. (PubMed:12595900)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466369 mRNA. Translation: AAL74195.1.
    AK001350 mRNA. Translation: BAA91642.1.
    AC004382 Genomic DNA. Translation: AAC24310.1. Sequence problems.
    BC001540 mRNA. Translation: AAH01540.1.
    BC003541 mRNA. Translation: AAH03541.1.
    CCDSiCCDS10783.1.
    RefSeqiNP_060580.2. NM_018110.3.
    XP_005256100.1. XM_005256043.1.
    UniGeneiHs.279832.

    Genome annotation databases

    EnsembliENST00000340099; ENSP00000344277; ENSG00000125170.
    ENST00000569548; ENSP00000455128; ENSG00000125170.
    GeneIDi55715.
    KEGGihsa:55715.
    UCSCiuc002elv.4. human.

    Polymorphism databases

    DMDMi84029600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466369 mRNA. Translation: AAL74195.1 .
    AK001350 mRNA. Translation: BAA91642.1 .
    AC004382 Genomic DNA. Translation: AAC24310.1 . Sequence problems.
    BC001540 mRNA. Translation: AAH01540.1 .
    BC003541 mRNA. Translation: AAH03541.1 .
    CCDSi CCDS10783.1.
    RefSeqi NP_060580.2. NM_018110.3.
    XP_005256100.1. XM_005256043.1.
    UniGenei Hs.279832.

    3D structure databases

    ProteinModelPortali Q8TEW6.
    SMRi Q8TEW6. Positions 134-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120837. 5 interactions.
    IntActi Q8TEW6. 3 interactions.
    MINTi MINT-1491631.
    STRINGi 9606.ENSP00000344277.

    PTM databases

    PhosphoSitei Q8TEW6.

    Polymorphism databases

    DMDMi 84029600.

    Proteomic databases

    PaxDbi Q8TEW6.
    PRIDEi Q8TEW6.

    Protocols and materials databases

    DNASUi 55715.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340099 ; ENSP00000344277 ; ENSG00000125170 .
    ENST00000569548 ; ENSP00000455128 ; ENSG00000125170 .
    GeneIDi 55715.
    KEGGi hsa:55715.
    UCSCi uc002elv.4. human.

    Organism-specific databases

    CTDi 55715.
    GeneCardsi GC16M057505.
    HGNCi HGNC:19868. DOK4.
    HPAi HPA052844.
    HPA055849.
    MIMi 608333. gene.
    neXtProti NX_Q8TEW6.
    PharmGKBi PA134892921.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256436.
    HOGENOMi HOG000247025.
    HOVERGENi HBG002356.
    InParanoidi Q8TEW6.
    PhylomeDBi Q8TEW6.
    TreeFami TF324994.

    Enzyme and pathway databases

    SignaLinki Q8TEW6.

    Miscellaneous databases

    GeneWikii DOK4.
    GenomeRNAii 55715.
    NextBioi 60599.
    PROi Q8TEW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEW6.
    Bgeei Q8TEW6.
    CleanExi HS_DOK4.
    Genevestigatori Q8TEW6.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF02174. IRS. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view ]
    PROSITEi PS51064. IRS_PTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DOK4 and DOK5: new Dok-related genes expressed in human T cells."
      Favre C., Gerard A., Clauzier E., Pontarotti P., Olive D., Nunes J.A.
      Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: T-cell.
    2. "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5."
      Cai D., Dhe-Paganon S., Melendez P.A., Lee J., Shoelson S.E.
      J. Biol. Chem. 278:25323-25330(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PHOSPHORYLATION AT TYROSINE RESIDUES.
      Tissue: Skeletal muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Pancreas.

    Entry informationi

    Entry nameiDOK4_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEW6
    Secondary accession number(s): O75209, Q9BTP2, Q9NVV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3