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Q8TEW6

- DOK4_HUMAN

UniProt

Q8TEW6 - DOK4_HUMAN

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Protein

Docking protein 4

Gene

DOK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.By similarity

GO - Molecular functioni

  1. receptor signaling protein activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. nervous system development Source: Ensembl
  3. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8TEW6.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 4
Alternative name(s):
Downstream of tyrosine kinase 4
Insulin receptor substrate 5
Short name:
IRS-5
Short name:
IRS5
Gene namesi
Name:DOK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19868. DOK4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Docking protein 4PRO_0000187274Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TEW6.
PRIDEiQ8TEW6.

PTM databases

PhosphoSiteiQ8TEW6.

Expressioni

Tissue specificityi

Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.2 Publications

Gene expression databases

BgeeiQ8TEW6.
CleanExiHS_DOK4.
ExpressionAtlasiQ8TEW6. baseline and differential.
GenevestigatoriQ8TEW6.

Organism-specific databases

HPAiHPA052844.
HPA055849.

Interactioni

Subunit structurei

Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046262EBI-6918542,EBI-641062
OPRM1P353724EBI-6918542,EBI-2624570

Protein-protein interaction databases

BioGridi120837. 23 interactions.
IntActiQ8TEW6. 3 interactions.
MINTiMINT-1491631.
STRINGi9606.ENSP00000344277.

Structurei

3D structure databases

ProteinModelPortaliQ8TEW6.
SMRiQ8TEW6. Positions 134-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 112106PHAdd
BLAST
Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi265 – 27511DKFBH motifAdd
BLAST

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiNOG256436.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ8TEW6.
PhylomeDBiQ8TEW6.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS
60 70 80 90 100
VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA
110 120 130 140 150
EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD
160 170 180 190 200
VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR
210 220 230 240 250
MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK
260 270 280 290 300
GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET
310 320
DLLNRFILLK PKPSQGDSSE AKTPSQ
Length:326
Mass (Da):37,028
Last modified:May 10, 2005 - v2
Checksum:i1595B0CEC5584816
GO

Sequence cautioni

The sequence AAC24310.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641N → S no nucleotide entry (PubMed:12730241)Curated
Sequence conflicti64 – 641N → S in BAA91642. (PubMed:14702039)Curated
Sequence conflicti75 – 751T → A in AAL74195. (PubMed:12595900)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466369 mRNA. Translation: AAL74195.1.
AK001350 mRNA. Translation: BAA91642.1.
AC004382 Genomic DNA. Translation: AAC24310.1. Sequence problems.
BC001540 mRNA. Translation: AAH01540.1.
BC003541 mRNA. Translation: AAH03541.1.
CCDSiCCDS10783.1.
RefSeqiNP_060580.2. NM_018110.3.
XP_005256100.1. XM_005256043.1.
UniGeneiHs.279832.

Genome annotation databases

EnsembliENST00000340099; ENSP00000344277; ENSG00000125170.
ENST00000569548; ENSP00000455128; ENSG00000125170.
GeneIDi55715.
KEGGihsa:55715.
UCSCiuc002elv.4. human.

Polymorphism databases

DMDMi84029600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466369 mRNA. Translation: AAL74195.1 .
AK001350 mRNA. Translation: BAA91642.1 .
AC004382 Genomic DNA. Translation: AAC24310.1 . Sequence problems.
BC001540 mRNA. Translation: AAH01540.1 .
BC003541 mRNA. Translation: AAH03541.1 .
CCDSi CCDS10783.1.
RefSeqi NP_060580.2. NM_018110.3.
XP_005256100.1. XM_005256043.1.
UniGenei Hs.279832.

3D structure databases

ProteinModelPortali Q8TEW6.
SMRi Q8TEW6. Positions 134-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120837. 23 interactions.
IntActi Q8TEW6. 3 interactions.
MINTi MINT-1491631.
STRINGi 9606.ENSP00000344277.

PTM databases

PhosphoSitei Q8TEW6.

Polymorphism databases

DMDMi 84029600.

Proteomic databases

PaxDbi Q8TEW6.
PRIDEi Q8TEW6.

Protocols and materials databases

DNASUi 55715.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340099 ; ENSP00000344277 ; ENSG00000125170 .
ENST00000569548 ; ENSP00000455128 ; ENSG00000125170 .
GeneIDi 55715.
KEGGi hsa:55715.
UCSCi uc002elv.4. human.

Organism-specific databases

CTDi 55715.
GeneCardsi GC16M057505.
HGNCi HGNC:19868. DOK4.
HPAi HPA052844.
HPA055849.
MIMi 608333. gene.
neXtProti NX_Q8TEW6.
PharmGKBi PA134892921.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256436.
GeneTreei ENSGT00730000110348.
HOGENOMi HOG000247025.
HOVERGENi HBG002356.
InParanoidi Q8TEW6.
PhylomeDBi Q8TEW6.
TreeFami TF324994.

Enzyme and pathway databases

SignaLinki Q8TEW6.

Miscellaneous databases

GeneWikii DOK4.
GenomeRNAii 55715.
NextBioi 60599.
PROi Q8TEW6.
SOURCEi Search...

Gene expression databases

Bgeei Q8TEW6.
CleanExi HS_DOK4.
ExpressionAtlasi Q8TEW6. baseline and differential.
Genevestigatori Q8TEW6.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DOK4 and DOK5: new Dok-related genes expressed in human T cells."
    Favre C., Gerard A., Clauzier E., Pontarotti P., Olive D., Nunes J.A.
    Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: T-cell.
  2. "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5."
    Cai D., Dhe-Paganon S., Melendez P.A., Lee J., Shoelson S.E.
    J. Biol. Chem. 278:25323-25330(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PHOSPHORYLATION AT TYROSINE RESIDUES.
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Pancreas.

Entry informationi

Entry nameiDOK4_HUMAN
AccessioniPrimary (citable) accession number: Q8TEW6
Secondary accession number(s): O75209, Q9BTP2, Q9NVV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3