##gff-version 3 Q8TEW0 UniProtKB Chain 1 1356 . . . ID=PRO_0000185069;Note=Partitioning defective 3 homolog Q8TEW0 UniProtKB Domain 271 359 . . . Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 Q8TEW0 UniProtKB Domain 461 546 . . . Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 Q8TEW0 UniProtKB Domain 590 677 . . . Note=PDZ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 Q8TEW0 UniProtKB Region 81 100 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Region 154 262 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Region 408 448 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Region 712 936 . . . Note=Interaction with PRKCI and PRKCZ;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z340 Q8TEW0 UniProtKB Region 865 886 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Region 932 1025 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Region 935 1356 . . . Note=Interaction with FRMD4A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Region 1129 1356 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Coiled coil 1049 1077 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TEW0 UniProtKB Coiled coil 1151 1174 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TEW0 UniProtKB Coiled coil 1201 1224 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TEW0 UniProtKB Coiled coil 1280 1301 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TEW0 UniProtKB Compositional bias 154 187 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 188 202 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 203 224 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 959 978 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 979 1025 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 1149 1178 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 1183 1203 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 1215 1267 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 1285 1300 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Compositional bias 1301 1315 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TEW0 UniProtKB Modified residue 25 25 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q8TEW0 UniProtKB Modified residue 91 91 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q8TEW0 UniProtKB Modified residue 156 156 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Modified residue 174 174 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 383 383 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Q8TEW0 UniProtKB Modified residue 489 489 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q8TEW0 UniProtKB Modified residue 692 692 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q8TEW0 UniProtKB Modified residue 695 695 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18220336,PMID:18669648,PMID:23186163 Q8TEW0 UniProtKB Modified residue 715 715 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 728 728 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163 Q8TEW0 UniProtKB Modified residue 809 809 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q8TEW0 UniProtKB Modified residue 827 827 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 834 834 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Modified residue 837 837 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 851 851 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Modified residue 852 852 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Q8TEW0 UniProtKB Modified residue 873 873 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 Q8TEW0 UniProtKB Modified residue 885 885 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Modified residue 962 962 . . . Note=Phosphoserine%3B by AURKA;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19812038,ECO:0007744|PubMed:23186163;Dbxref=PMID:19812038,PMID:23186163 Q8TEW0 UniProtKB Modified residue 971 971 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 973 973 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 1046 1046 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TEW0 UniProtKB Modified residue 1350 1350 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NH2 Q8TEW0 UniProtKB Alternative sequence 195 238 . . . ID=VSP_007462;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10934474,ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187;Dbxref=PMID:10934474,PMID:11642408,PMID:12234671,PMID:12459187 Q8TEW0 UniProtKB Alternative sequence 557 569 . . . ID=VSP_007463;Note=In isoform 3%2C isoform 5%2C isoform 6%2C isoform 7%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10934474,ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10934474,PMID:11642408,PMID:12234671,PMID:12459187,PMID:14702039,PMID:15489334 Q8TEW0 UniProtKB Alternative sequence 740 742 . . . ID=VSP_007464;Note=In isoform 2%2C isoform 3%2C isoform 5%2C isoform 6%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10934474,ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10934474,PMID:11642408,PMID:12234671,PMID:12459187,PMID:14702039,PMID:15489334 Q8TEW0 UniProtKB Alternative sequence 827 856 . . . ID=VSP_007465;Note=In isoform 3%2C isoform 6%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10934474,ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:14702039;Dbxref=PMID:10934474,PMID:11642408,PMID:12234671,PMID:14702039 Q8TEW0 UniProtKB Alternative sequence 857 858 . . . ID=VSP_007467;Note=In isoform 10. IA->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8TEW0 UniProtKB Alternative sequence 857 857 . . . ID=VSP_007466;Note=In isoform 5. I->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187;Dbxref=PMID:12234671,PMID:12459187 Q8TEW0 UniProtKB Alternative sequence 858 872 . . . ID=VSP_007468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187;Dbxref=PMID:12234671,PMID:12459187 Q8TEW0 UniProtKB Alternative sequence 1025 1061 . . . ID=VSP_007469;Note=In isoform 4%2C isoform 5 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:12234671,ECO:0000303|PubMed:12459187;Dbxref=PMID:11642408,PMID:12234671,PMID:12459187 Q8TEW0 UniProtKB Alternative sequence 1025 1034 . . . ID=VSP_007470;Note=In isoform 8%2C isoform 9 and isoform 10. RFGKHRKDDK->SLAKLKPEKR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:14702039;Dbxref=PMID:11642408,PMID:14702039 Q8TEW0 UniProtKB Alternative sequence 1035 1356 . . . ID=VSP_007471;Note=In isoform 8%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11642408,ECO:0000303|PubMed:14702039;Dbxref=PMID:11642408,PMID:14702039 Q8TEW0 UniProtKB Natural variant 107 107 . . . ID=VAR_015663;Note=E->D;Dbxref=dbSNP:rs1436731 Q8TEW0 UniProtKB Natural variant 349 349 . . . ID=VAR_079846;Note=In NTD%3B uncertain significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27925688;Dbxref=dbSNP:rs199923448,PMID:27925688 Q8TEW0 UniProtKB Natural variant 575 575 . . . ID=VAR_050453;Note=D->N;Dbxref=dbSNP:rs3758459 Q8TEW0 UniProtKB Natural variant 783 783 . . . ID=VAR_079847;Note=In NTD%3B reduces interaction with PRKCA%2C disrupts tight junction formation in epithelial cells. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27925688;Dbxref=dbSNP:rs1114167354,PMID:27925688 Q8TEW0 UniProtKB Natural variant 913 913 . . . ID=VAR_079848;Note=In NTD%3B reduces interaction with PRKCA%3B increases phosphorylation%3B disrupts tight junction formation in epithelial cells. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27925688;Dbxref=dbSNP:rs781461462,PMID:27925688 Q8TEW0 UniProtKB Mutagenesis 962 962 . . . Note=Abolishes phosphorylation by AURKA. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19812038;Dbxref=PMID:19812038 Q8TEW0 UniProtKB Mutagenesis 1127 1127 . . . Note=Delayed epithelial tight junction assembly. Y->F Q8TEW0 UniProtKB Sequence conflict 190 190 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TEW0 UniProtKB Sequence conflict 233 233 . . . Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TEW0 UniProtKB Sequence conflict 594 594 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TEW0 UniProtKB Sequence conflict 764 764 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TEW0 UniProtKB Sequence conflict 996 1000 . . . Note=GKEKK->VELHE;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TEW0 UniProtKB Beta strand 458 465 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Beta strand 473 476 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Beta strand 481 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Beta strand 488 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Helix 498 501 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Beta strand 507 514 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Helix 524 533 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Beta strand 539 546 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KOM Q8TEW0 UniProtKB Modified residue 792 792 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569