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Protein

Partitioning defective 3 homolog

Gene

PARD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Differentiation

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-HSA-420029. Tight junction interactions.
SignaLinkiQ8TEW0.
SIGNORiQ8TEW0.

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 3 homolog
Short name:
PAR-3
Short name:
PARD-3
Alternative name(s):
Atypical PKC isotype-specific-interacting protein
Short name:
ASIP
CTCL tumor antigen se2-5
PAR3-alpha
Gene namesi
Name:PARD3
Synonyms:PAR3, PAR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16051. PARD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi962S → A: Abolishes phosphorylation by AURKA. 1 Publication1
Mutagenesisi1127Y → F: Delayed epithelial tight junction assembly. 1

Organism-specific databases

DisGeNETi56288.
OpenTargetsiENSG00000148498.
PharmGKBiPA32936.

Polymorphism and mutation databases

BioMutaiPARD3.
DMDMi30913162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850691 – 1356Partitioning defective 3 homologAdd BLAST1356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei91PhosphothreonineCombined sources1
Modified residuei156PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei489PhosphotyrosineCombined sources1
Modified residuei692PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei834N6-acetyllysineBy similarity1
Modified residuei837PhosphoserineCombined sources1
Modified residuei851N6-acetyllysineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei885N6-acetyllysineBy similarity1
Modified residuei962Phosphoserine; by AURKACombined sources1 Publication1
Modified residuei971PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1350N6-acetyllysineBy similarity1
Isoform 5 (identifier: Q8TEW0-5)
Modified residuei792PhosphoserineCombined sources1

Post-translational modificationi

Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.1 Publication
Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TEW0.
MaxQBiQ8TEW0.
PaxDbiQ8TEW0.
PeptideAtlasiQ8TEW0.
PRIDEiQ8TEW0.

PTM databases

iPTMnetiQ8TEW0.
PhosphoSitePlusiQ8TEW0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000148498.
ExpressionAtlasiQ8TEW0. baseline and differential.
GenevisibleiQ8TEW0. HS.

Organism-specific databases

HPAiHPA030443.

Interactioni

Subunit structurei

Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2. Interacts with ECT2, FBF1 and SIRT2.By similarity11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDH5P331515EBI-81968,EBI-2903122
CTNNB1P352222EBI-81968,EBI-491549
F11RQ9Y6242EBI-81968,EBI-742600
PARD6AQ9NPB69EBI-81968,EBI-81876
PARD6BQ9BYG55EBI-81968,EBI-295391
Pard6bQ9JK833EBI-81968,EBI-81861From a different organism.
PARD6GQ9BYG43EBI-81968,EBI-295417
PNMA1Q8ND904EBI-81968,EBI-302345
PRKCIP417433EBI-81968,EBI-286199
Tiam2Q6ZPF36EBI-9118204,EBI-7565978From a different organism.
TP53P046373EBI-81968,EBI-366083
YWHAHQ049176EBI-81968,EBI-306940
YWHAZP631044EBI-81968,EBI-347088

Protein-protein interaction databases

BioGridi121134. 66 interactors.
DIPiDIP-31315N.
IntActiQ8TEW0. 48 interactors.
MINTiMINT-7711810.
STRINGi9606.ENSP00000363921.

Structurei

Secondary structure

11356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi458 – 465Combined sources8
Beta strandi473 – 476Combined sources4
Beta strandi481 – 485Combined sources5
Beta strandi488 – 493Combined sources6
Helixi498 – 501Combined sources4
Beta strandi507 – 514Combined sources8
Helixi524 – 533Combined sources10
Beta strandi539 – 546Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KOMNMR-A451-549[»]
ProteinModelPortaliQ8TEW0.
SMRiQ8TEW0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TEW0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 359PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini461 – 546PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini590 – 677PDZ 3PROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni712 – 936Interaction with PRKCI and PRKCZBy similarityAdd BLAST225

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1049 – 1077Sequence analysisAdd BLAST29
Coiled coili1151 – 1174Sequence analysisAdd BLAST24
Coiled coili1201 – 1224Sequence analysisAdd BLAST24
Coiled coili1280 – 1301Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi984 – 1042Lys-richAdd BLAST59

Domaini

Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.By similarity
The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.By similarity

Sequence similaritiesi

Belongs to the PAR3 family.Curated
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITAJ. Eukaryota.
ENOG410ZDVK. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.
InParanoidiQ8TEW0.
KOiK04237.
OMAiFQRDNAR.
OrthoDBiEOG091G04AU.
PhylomeDBiQ8TEW0.
TreeFamiTF323729.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEW0-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR
60 70 80 90 100
LEHGDGGILD LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS
110 120 130 140 150
PEIFGSELGT NNVSAFQPYQ ATSEIEVTPS VLRANMPLHV RRSSDPALIG
160 170 180 190 200
LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL KQNTAGSPKT CDRKKDENYR
210 220 230 240 250
SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE DGTEEDNSRV
260 270 280 290 300
EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG
310 320 330 340 350
LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT
360 370 380 390 400
PIIWFHVVPA ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH
410 420 430 440 450
TVQRAPRLNH PPEQIDSHSR LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG
460 470 480 490 500
YNTKKIGKRL NIQLKKGTEG LGFSITSRDV TIGGSAPIYV KNILPRGAAI
510 520 530 540 550
QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV SLLVFRQEDA
560 570 580 590 600
FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG
610 620 630 640 650
LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL
660 670 680 690 700
LGKTNQDAME TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE
710 720 730 740 750
LPIETALDDR ERRISHSLYS GIEGLDESPS RNAALSRIMG ESGKYQLSPT
760 770 780 790 800
VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS SHDDVGFVTA DAGTWAKAAI
810 820 830 840 850
SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS QLDFVKTRKS
860 870 880 890 900
KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV
910 920 930 940 950
TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE
960 970 980 990 1000
DTEESSRSGR ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK
1010 1020 1030 1040 1050
KDRDKEKDKM KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE
1060 1070 1080 1090 1100
EERIRMKQEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG
1110 1120 1130 1140 1150
VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN
1160 1170 1180 1190 1200
HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE
1210 1220 1230 1240 1250
VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF
1260 1270 1280 1290 1300
QSAKENPRYS SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK
1310 1320 1330 1340 1350
QPPSEGPSNY DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK

GRPFYS
Length:1,356
Mass (Da):151,423
Last modified:May 16, 2003 - v2
Checksum:iA4FD3F4F9AD8B92A
GO
Isoform 2 (identifier: Q8TEW0-2) [UniParc]FASTAAdd to basket
Also known as: B, La

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.

Show »
Length:1,353
Mass (Da):151,150
Checksum:iBC531577B9C31AE3
GO
Isoform 3 (identifier: Q8TEW0-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Show »
Length:1,266
Mass (Da):141,072
Checksum:i92DF51B68081A4A2
GO
Isoform 4 (identifier: Q8TEW0-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1061: Missing.

Show »
Length:1,319
Mass (Da):146,877
Checksum:iF5FBF3CE4E67163B
GO
Isoform 5 (identifier: Q8TEW0-5) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     857-857: I → S
     858-872: Missing.
     1025-1061: Missing.

Show »
Length:1,244
Mass (Da):138,332
Checksum:iC3C156C8811D49C2
GO
Isoform 6 (identifier: Q8TEW0-6) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Show »
Length:1,310
Mass (Da):146,276
Checksum:i57361092A273AC60
GO
Isoform 7 (identifier: Q8TEW0-7) [UniParc]FASTAAdd to basket
Also known as: Lb

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1061: Missing.

Show »
Length:1,273
Mass (Da):141,730
Checksum:i53C1A94D8CB7341E
GO
Isoform 8 (identifier: Q8TEW0-8) [UniParc]FASTAAdd to basket
Also known as: Sa

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Show »
Length:1,031
Mass (Da):113,419
Checksum:i40DD593636EAE999
GO
Isoform 9 (identifier: Q8TEW0-9) [UniParc]FASTAAdd to basket
Also known as: Sb

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Show »
Length:988
Mass (Da):108,545
Checksum:i89F2139B096F7F7F
GO
Isoform 10 (identifier: Q8TEW0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     827-856: Missing.
     857-858: IA → T
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Note: No experimental confirmation available.
Show »
Length:1,000
Mass (Da):109,917
Checksum:i135A54F80C144606
GO
Isoform 11 (identifier: Q8TEW0-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.

Note: No experimental confirmation available.
Show »
Length:1,340
Mass (Da):149,695
Checksum:i3DAB16557C6BBA86
GO

Sequence cautioni

The sequence AAG33676 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190T → A in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti233L → Q in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti594N → S in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti764D → N in AAH71566 (PubMed:15489334).Curated1
Sequence conflicti996 – 1000GKEKK → VELHE in BAA91366 (PubMed:14702039).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015663107E → D.Corresponds to variant rs1436731dbSNPEnsembl.1
Natural variantiVAR_050453575D → N.Corresponds to variant rs3758459dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007462195 – 238Missing in isoform 3 and isoform 5. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_007463557 – 569Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 11. 6 PublicationsAdd BLAST13
Alternative sequenceiVSP_007464740 – 742Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 6 Publications3
Alternative sequenceiVSP_007465827 – 856Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_007467857 – 858IA → T in isoform 10. 1 Publication2
Alternative sequenceiVSP_007466857I → S in isoform 5. 2 Publications1
Alternative sequenceiVSP_007468858 – 872Missing in isoform 5. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0074691025 – 1061Missing in isoform 4, isoform 5 and isoform 7. 3 PublicationsAdd BLAST37
Alternative sequenceiVSP_0074701025 – 1034RFGKHRKDDK → SLAKLKPEKR in isoform 8, isoform 9 and isoform 10. 2 Publications10
Alternative sequenceiVSP_0074711035 – 1356Missing in isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST322

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252293 mRNA. Translation: AAF71530.1.
AF196185 mRNA. Translation: AAK27891.1.
AF196186 mRNA. Translation: AAK27892.1.
AF332592 mRNA. Translation: AAK69192.1.
AF332593 mRNA. Translation: AAK69193.1.
AB073671 mRNA. Translation: BAC54037.1.
AF467002 mRNA. Translation: AAL76042.1.
AF467003 mRNA. Translation: AAL76043.1.
AF467004 mRNA. Translation: AAL76044.1.
AF467005 mRNA. Translation: AAL76045.1.
AF467006 mRNA. Translation: AAL76046.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71161.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71162.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71163.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71165.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71166.1.
AL360233
, AL138768, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71167.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73524.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73525.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73526.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73528.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73529.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15036.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15037.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15038.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15039.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15040.1.
AL450337
, AL138768, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15041.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16985.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16986.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16987.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16988.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16989.1.
AL138768
, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16991.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17304.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17305.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17306.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17308.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17309.1.
AL390766
, AL138768, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17310.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17327.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17328.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17329.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17331.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17332.1.
AL392123
, AL138768, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17333.1.
CH471072 Genomic DNA. Translation: EAW85932.1.
CH471072 Genomic DNA. Translation: EAW85934.1.
BC011711 mRNA. Translation: AAH11711.2.
BC071566 mRNA. Translation: AAH71566.1.
AK000761 mRNA. Translation: BAA91366.1. Different initiation.
AK027735 mRNA. Translation: BAB55330.1. Different initiation.
AF177228 mRNA. Translation: AAG33676.1. Sequence problems.
CCDSiCCDS53509.1. [Q8TEW0-5]
CCDS53510.1. [Q8TEW0-3]
CCDS53511.1. [Q8TEW0-11]
CCDS53512.1. [Q8TEW0-6]
CCDS53513.1. [Q8TEW0-9]
CCDS53514.1. [Q8TEW0-4]
CCDS53515.1. [Q8TEW0-2]
CCDS53516.1. [Q8TEW0-8]
CCDS7178.1. [Q8TEW0-1]
RefSeqiNP_001171714.1. NM_001184785.1. [Q8TEW0-2]
NP_001171715.1. NM_001184786.1. [Q8TEW0-11]
NP_001171716.1. NM_001184787.1. [Q8TEW0-4]
NP_001171717.1. NM_001184788.1. [Q8TEW0-6]
NP_001171718.1. NM_001184789.1. [Q8TEW0-7]
NP_001171719.1. NM_001184790.1. [Q8TEW0-3]
NP_001171720.1. NM_001184791.1. [Q8TEW0-5]
NP_001171721.1. NM_001184792.1. [Q8TEW0-8]
NP_001171722.1. NM_001184793.1. [Q8TEW0-10]
NP_001171723.1. NM_001184794.1. [Q8TEW0-9]
NP_062565.2. NM_019619.3. [Q8TEW0-1]
UniGeneiHs.131489.

Genome annotation databases

EnsembliENST00000340077; ENSP00000341844; ENSG00000148498. [Q8TEW0-8]
ENST00000346874; ENSP00000340591; ENSG00000148498. [Q8TEW0-4]
ENST00000350537; ENSP00000311986; ENSG00000148498. [Q8TEW0-6]
ENST00000374776; ENSP00000363908; ENSG00000148498. [Q8TEW0-9]
ENST00000374788; ENSP00000363920; ENSG00000148498. [Q8TEW0-2]
ENST00000374789; ENSP00000363921; ENSG00000148498. [Q8TEW0-1]
ENST00000374794; ENSP00000363926; ENSG00000148498. [Q8TEW0-5]
ENST00000545260; ENSP00000440857; ENSG00000148498. [Q8TEW0-3]
ENST00000545693; ENSP00000443147; ENSG00000148498. [Q8TEW0-11]
GeneIDi56288.
KEGGihsa:56288.
UCSCiuc001ixq.3. human. [Q8TEW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252293 mRNA. Translation: AAF71530.1.
AF196185 mRNA. Translation: AAK27891.1.
AF196186 mRNA. Translation: AAK27892.1.
AF332592 mRNA. Translation: AAK69192.1.
AF332593 mRNA. Translation: AAK69193.1.
AB073671 mRNA. Translation: BAC54037.1.
AF467002 mRNA. Translation: AAL76042.1.
AF467003 mRNA. Translation: AAL76043.1.
AF467004 mRNA. Translation: AAL76044.1.
AF467005 mRNA. Translation: AAL76045.1.
AF467006 mRNA. Translation: AAL76046.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71161.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71162.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71163.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71165.1.
AL360233
, AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71166.1.
AL360233
, AL138768, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71167.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73524.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73525.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73526.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73528.1.
AL160409
, AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73529.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15036.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15037.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15038.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15039.1.
AL450337
, AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15040.1.
AL450337
, AL138768, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15041.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16985.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16986.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16987.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16988.1.
AL138768
, AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16989.1.
AL138768
, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16991.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17304.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17305.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17306.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17308.1.
AL390766
, AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17309.1.
AL390766
, AL138768, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17310.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17327.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17328.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17329.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17331.1.
AL392123
, AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17332.1.
AL392123
, AL138768, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17333.1.
CH471072 Genomic DNA. Translation: EAW85932.1.
CH471072 Genomic DNA. Translation: EAW85934.1.
BC011711 mRNA. Translation: AAH11711.2.
BC071566 mRNA. Translation: AAH71566.1.
AK000761 mRNA. Translation: BAA91366.1. Different initiation.
AK027735 mRNA. Translation: BAB55330.1. Different initiation.
AF177228 mRNA. Translation: AAG33676.1. Sequence problems.
CCDSiCCDS53509.1. [Q8TEW0-5]
CCDS53510.1. [Q8TEW0-3]
CCDS53511.1. [Q8TEW0-11]
CCDS53512.1. [Q8TEW0-6]
CCDS53513.1. [Q8TEW0-9]
CCDS53514.1. [Q8TEW0-4]
CCDS53515.1. [Q8TEW0-2]
CCDS53516.1. [Q8TEW0-8]
CCDS7178.1. [Q8TEW0-1]
RefSeqiNP_001171714.1. NM_001184785.1. [Q8TEW0-2]
NP_001171715.1. NM_001184786.1. [Q8TEW0-11]
NP_001171716.1. NM_001184787.1. [Q8TEW0-4]
NP_001171717.1. NM_001184788.1. [Q8TEW0-6]
NP_001171718.1. NM_001184789.1. [Q8TEW0-7]
NP_001171719.1. NM_001184790.1. [Q8TEW0-3]
NP_001171720.1. NM_001184791.1. [Q8TEW0-5]
NP_001171721.1. NM_001184792.1. [Q8TEW0-8]
NP_001171722.1. NM_001184793.1. [Q8TEW0-10]
NP_001171723.1. NM_001184794.1. [Q8TEW0-9]
NP_062565.2. NM_019619.3. [Q8TEW0-1]
UniGeneiHs.131489.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KOMNMR-A451-549[»]
ProteinModelPortaliQ8TEW0.
SMRiQ8TEW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121134. 66 interactors.
DIPiDIP-31315N.
IntActiQ8TEW0. 48 interactors.
MINTiMINT-7711810.
STRINGi9606.ENSP00000363921.

PTM databases

iPTMnetiQ8TEW0.
PhosphoSitePlusiQ8TEW0.

Polymorphism and mutation databases

BioMutaiPARD3.
DMDMi30913162.

Proteomic databases

EPDiQ8TEW0.
MaxQBiQ8TEW0.
PaxDbiQ8TEW0.
PeptideAtlasiQ8TEW0.
PRIDEiQ8TEW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340077; ENSP00000341844; ENSG00000148498. [Q8TEW0-8]
ENST00000346874; ENSP00000340591; ENSG00000148498. [Q8TEW0-4]
ENST00000350537; ENSP00000311986; ENSG00000148498. [Q8TEW0-6]
ENST00000374776; ENSP00000363908; ENSG00000148498. [Q8TEW0-9]
ENST00000374788; ENSP00000363920; ENSG00000148498. [Q8TEW0-2]
ENST00000374789; ENSP00000363921; ENSG00000148498. [Q8TEW0-1]
ENST00000374794; ENSP00000363926; ENSG00000148498. [Q8TEW0-5]
ENST00000545260; ENSP00000440857; ENSG00000148498. [Q8TEW0-3]
ENST00000545693; ENSP00000443147; ENSG00000148498. [Q8TEW0-11]
GeneIDi56288.
KEGGihsa:56288.
UCSCiuc001ixq.3. human. [Q8TEW0-1]

Organism-specific databases

CTDi56288.
DisGeNETi56288.
GeneCardsiPARD3.
HGNCiHGNC:16051. PARD3.
HPAiHPA030443.
MIMi606745. gene.
neXtProtiNX_Q8TEW0.
OpenTargetsiENSG00000148498.
PharmGKBiPA32936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITAJ. Eukaryota.
ENOG410ZDVK. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.
InParanoidiQ8TEW0.
KOiK04237.
OMAiFQRDNAR.
OrthoDBiEOG091G04AU.
PhylomeDBiQ8TEW0.
TreeFamiTF323729.

Enzyme and pathway databases

ReactomeiR-HSA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-HSA-420029. Tight junction interactions.
SignaLinkiQ8TEW0.
SIGNORiQ8TEW0.

Miscellaneous databases

ChiTaRSiPARD3. human.
EvolutionaryTraceiQ8TEW0.
GeneWikiiPARD3.
GenomeRNAii56288.
PROiQ8TEW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148498.
ExpressionAtlasiQ8TEW0. baseline and differential.
GenevisibleiQ8TEW0. HS.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARD3_HUMAN
AccessioniPrimary (citable) accession number: Q8TEW0
Secondary accession number(s): F5H5T0
, Q5T2U1, Q5VUA2, Q5VUA3, Q5VWV0, Q5VWV1, Q5VWV3, Q5VWV4, Q5VWV5, Q6IQ47, Q8TCZ9, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.