Q8TEW0 (PARD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Partitioning defective 3 homolog
Short name=PAR-3
Short name=PARD-3

Alternative name(s):
Atypical PKC isotype-specific-interacting protein
Short name=ASIP
CTCL tumor antigen se2-5
PAR3-alpha

Gene names

Name:	PARD3
Synonyms:	PAR3, PAR3A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. Ref.18
Subunit structure	Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) By similarity. Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with ECT2 and FBF1. Ref.1 Ref.4 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15 Ref.18 Ref.20
Subcellular location	Endomembrane system. Cell junction. Cell junction › tight junction. Cell membrane. Cytoplasm › cell cortex By similarity. Cytoplasm › cytoskeleton. Note: Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II By similarity. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Ref.20
Tissue specificity	Widely expressed. Ref.4
Domain	Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization By similarity. The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids By similarity.
Post-translational modification	Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 By similarity. Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity.
Miscellaneous	Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.
Sequence similarities	Belongs to the PAR3 family. Contains 3 PDZ (DHR) domains.
Sequence caution	The sequence AAG33676.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA91366.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB55330.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Tight junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apical constriction Inferred from electronic annotation. Source: Compara asymmetric cell division Traceable author statement Ref.1. Source: ProtInc axonogenesis Traceable author statement PubMed 14676191. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW centrosome localization Inferred from electronic annotation. Source: Compara establishment of epithelial cell polarity Inferred from sequence or structural similarity. Source: UniProtKB microtubule cytoskeleton organization Inferred from electronic annotation. Source: Compara protein complex assembly Traceable author statement Ref.1. Source: ProtInc protein kinase C-activating G-protein coupled receptor signaling pathway Traceable author statement PubMed 11260256. Source: UniProtKB protein targeting to membrane Inferred from sequence or structural similarity. Source: UniProtKB regulation of actin filament-based process Inferred from electronic annotation. Source: Compara regulation of cellular localization Inferred from electronic annotation. Source: Compara tight junction assembly Inferred from sequence or structural similarity. Source: UniProtKB transforming growth factor beta receptor signaling pathway Traceable author statement. Source: Reactome wound healing, spreading of cells Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara axonal growth cone Inferred from electronic annotation. Source: Compara cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cell-cell adherens junction Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome spindle Inferred from electronic annotation. Source: Compara tight junction Inferred from direct assay PubMed 14676191. Source: UniProtKB
Molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol-3-phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol-4,5-bisphosphate binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PARD6A	Q9NPB6	7	EBI-81968,EBI-81876
PARD6B	Q9BYG5	4	EBI-81968,EBI-295391
Pard6b	Q9JK83	2	EBI-81968,EBI-81861	From a different organism.
PARD6G	Q9BYG4	3	EBI-81968,EBI-295417
PNMA1	Q8ND90	4	EBI-81968,EBI-302345
PRKCI	P41743	3	EBI-81968,EBI-286199
YWHAH	Q04917	6	EBI-81968,EBI-306940
YWHAZ	P63104	3	EBI-81968,EBI-347088

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEW0-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEW0-2)

Also known as: B; La;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.

Isoform 3 (identifier: Q8TEW0-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 4 (identifier: Q8TEW0-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1061: Missing.

Isoform 5 (identifier: Q8TEW0-5)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     857-857: I → S
     858-872: Missing.
     1025-1061: Missing.

Isoform 6 (identifier: Q8TEW0-6)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 7 (identifier: Q8TEW0-7)

Also known as: Lb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1061: Missing.

Isoform 8 (identifier: Q8TEW0-8)

Also known as: Sa;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 9 (identifier: Q8TEW0-9)

Also known as: Sb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 10 (identifier: Q8TEW0-10)

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     827-856: Missing.
     857-858: IA → T
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Note: No experimental confirmation available.

Isoform 11 (identifier: Q8TEW0-11)

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1356

1356

Partitioning defective 3 homolog

PRO_0000185069

Regions

Domain

271 – 359

89

PDZ 1

Domain

461 – 546

86

PDZ 2

Domain

590 – 677

88

PDZ 3

Region

712 – 936

225

Interacts with PRKCI and PRKCZ By similarity

Coiled coil

1049 – 1077

29

Potential

Coiled coil

1151 – 1174

24

Potential

Coiled coil

1201 – 1224

24

Potential

Coiled coil

1280 – 1301

22

Potential

Compositional bias

984 – 1042

59

Lys-rich

Amino acid modifications

Modified residue

144

1

Phosphoserine By similarity

Modified residue

383

1

Phosphoserine Ref.16 Ref.17 Ref.19 Ref.21 Ref.23

Modified residue

692

1

Phosphoserine Ref.17

Modified residue

695

1

Phosphoserine Ref.16 Ref.17

Modified residue

717

1

Phosphoserine By similarity

Modified residue

728

1

Phosphoserine Ref.17 Ref.19 Ref.21

Modified residue

809

1

Phosphoserine Ref.17

Modified residue

827

1

Phosphoserine By similarity

Modified residue

852

1

Phosphoserine Ref.17 Ref.19 Ref.21 Ref.23

Modified residue

873

1

Phosphoserine Ref.17 Ref.21 Ref.23

Modified residue

962

1

Phosphoserine; by AURKA Ref.18

Natural variations

Alternative sequence

195 – 238

44

Missing in isoform 3 and isoform 5.

VSP_007462

Alternative sequence

557 – 569

13

Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 11.

VSP_007463

Alternative sequence

740 – 742

3

Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11.

VSP_007464

Alternative sequence

827 – 856

30

Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10.

VSP_007465

Alternative sequence

857 – 858

2

IA → T in isoform 10.

VSP_007467

Alternative sequence

857

1

I → S in isoform 5.

VSP_007466

Alternative sequence

858 – 872

15

Missing in isoform 5.

VSP_007468

Alternative sequence

1025 – 1061

37

Missing in isoform 4, isoform 5 and isoform 7.

VSP_007469

Alternative sequence

1025 – 1034

10

RFGKHRKDDK → SLAKLKPEKR in isoform 8, isoform 9 and isoform 10.

VSP_007470

Alternative sequence

1035 – 1356

322

Missing in isoform 8, isoform 9 and isoform 10.

VSP_007471

Natural variant

107

1

E → D.
Corresponds to variant rs1436731 [ dbSNP | Ensembl ].

VAR_015663

Natural variant

575

1

D → N.
Corresponds to variant rs3758459 [ dbSNP | Ensembl ].

VAR_050453

Experimental info

Mutagenesis

962

1

S → A: Abolishes phosphorylation by AURKA. Ref.18

Mutagenesis

1127

1

Y → F: Delayed epithelial tight junction assembly.

Sequence conflict

190

1

T → A in BAB55330. Ref.8

Sequence conflict

233

1

L → Q in BAB55330. Ref.8

Sequence conflict

594

1

N → S in BAB55330. Ref.8

Sequence conflict

764

1

D → N in AAH71566. Ref.7

Sequence conflict

996 – 1000

5

GKEKK → VELHE in BAA91366. Ref.8

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1356

Helix Strand Turn

Details...

Beta strand

458 – 465

8

Beta strand

473 – 476

4

Beta strand

481 – 485

5

Beta strand

488 – 493

6

Helix

498 – 501

4

Beta strand

507 – 514

8

Helix

524 – 533

10

Beta strand

539 – 546

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified May 16, 2003. Version 2. Checksum: A4FD3F4F9AD8B92A	FASTA	1,356	151,423
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ ERIQAKTREF RERQARERDY 1090 1100 1110 1120 1130 1140 AEIQDFHRTF GCDDELMYGG VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP 1150 1160 1170 1180 1190 1200 VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE 1210 1220 1230 1240 1250 1260 VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS 1270 1280 1290 1300 1310 1320 SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS 1330 1340 1350 YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 2 (B) (La) [UniParc]. Checksum: BC531577B9C31AE3	FASTA	1,353	151,150
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD 850 860 870 880 890 900 FVKTRKSKSM DLGIADETKL NTVDDQKAGS PSRDVGPSLG LKKSSSLESL QTAVAEVTLN 910 920 930 940 950 960 GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY DKPAVDDDDE GMETLEEDTE ESSRSGRESV 970 980 990 1000 1010 1020 STASDQPSHS LERQMNGNQE KGDKTDRKKD KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM 1030 1040 1050 1060 1070 1080 FRFGKHRKDD KIEKTGKIKI QESFTSEEER IRMKQEQERI QAKTREFRER QARERDYAEI 1090 1100 1110 1120 1130 1140 QDFHRTFGCD DELMYGGVSS YEGSMALNAR PQSPREGHMM DALYAQVKKP RNSKPSPVDS 1150 1160 1170 1180 1190 1200 NRSTPSNHDR IQRLRQEFQQ AKQDEDVEDR RRTYSFEQPW PNARPATQSG RHSVSVEVQM 1210 1220 1230 1240 1250 1260 QRQRQEERES SQQAQRQYSS LPRQSRKNAS SVSQDSWEQN YSPGEGFQSA KENPRYSSYQ 1270 1280 1290 1300 1310 1320 GSRNGYLGGH GFNARVMLET QELLRQEQRR KEQQMKKQPP SEGPSNYDSY KKVQDPSYAP 1330 1340 1350 PKGPFRQDVP PSPSQVARLN RLQTPEKGRP FYS
	Isoform 3 (C) [UniParc]. Checksum: 92DF51B68081A4A2	FASTA	1,266	141,072
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQIADE TKLNTVDDQK 790 800 810 820 830 840 AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV TLNGDIPFHR PRPRIIRGRG CNESFRAAID 850 860 870 880 890 900 KSYDKPAVDD DDEGMETLEE DTEESSRSGR ESVSTASDQP SHSLERQMNG NQEKGDKTDR 910 920 930 940 950 960 KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE 970 980 990 1000 1010 1020 EERIRMKQEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG VSSYEGSMAL 1030 1040 1050 1060 1070 1080 NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV 1090 1100 1110 1120 1130 1140 EDRRRTYSFE QPWPNARPAT QSGRHSVSVE VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK 1150 1160 1170 1180 1190 1200 NASSVSQDSW EQNYSPGEGF QSAKENPRYS SYQGSRNGYL GGHGFNARVM LETQELLRQE 1210 1220 1230 1240 1250 1260 QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 4 (D) [UniParc]. Checksum: F5FBF3CE4E67163B	FASTA	1,319	146,877
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRIQAKT REFRERQARE RDYAEIQDFH RTFGCDDELM YGGVSSYEGS MALNARPQSP 1090 1100 1110 1120 1130 1140 REGHMMDALY AQVKKPRNSK PSPVDSNRST PSNHDRIQRL RQEFQQAKQD EDVEDRRRTY 1150 1160 1170 1180 1190 1200 SFEQPWPNAR PATQSGRHSV SVEVQMQRQR QEERESSQQA QRQYSSLPRQ SRKNASSVSQ 1210 1220 1230 1240 1250 1260 DSWEQNYSPG EGFQSAKENP RYSSYQGSRN GYLGGHGFNA RVMLETQELL RQEQRRKEQQ 1270 1280 1290 1300 1310 MKKQPPSEGP SNYDSYKKVQ DPSYAPPKGP FRQDVPPSPS QVARLNRLQT PEKGRPFYS
	Isoform 5 (E) [UniParc]. Checksum: C3C156C8811D49C2	FASTA	1,244	138,332
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 790 800 810 820 830 840 QLDFVKTRKS KSMDLGSSPS RDVGPSLGLK KSSSLESLQT AVAEVTLNGD IPFHRPRPRI 850 860 870 880 890 900 IRGRGCNESF RAAIDKSYDK PAVDDDDEGM ETLEEDTEES SRSGRESVST ASDQPSHSLE 910 920 930 940 950 960 RQMNGNQEKG DKTDRKKDKT GKEKKKDRDK EKDKMKAKKG MLKGLGDMFR IQAKTREFRE 970 980 990 1000 1010 1020 RQARERDYAE IQDFHRTFGC DDELMYGGVS SYEGSMALNA RPQSPREGHM MDALYAQVKK 1030 1040 1050 1060 1070 1080 PRNSKPSPVD SNRSTPSNHD RIQRLRQEFQ QAKQDEDVED RRRTYSFEQP WPNARPATQS 1090 1100 1110 1120 1130 1140 GRHSVSVEVQ MQRQRQEERE SSQQAQRQYS SLPRQSRKNA SSVSQDSWEQ NYSPGEGFQS 1150 1160 1170 1180 1190 1200 AKENPRYSSY QGSRNGYLGG HGFNARVMLE TQELLRQEQR RKEQQMKKQP PSEGPSNYDS 1210 1220 1230 1240 YKKVQDPSYA PPKGPFRQDV PPSPSQVARL NRLQTPEKGR PFYS
	Isoform 6 (F) [UniParc]. Checksum: 57361092A273AC60	FASTA	1,310	146,276
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 990 1000 1010 1020 KDKMKAKKGM LKGLGDMFRF GKHRKDDKIE KTGKIKIQES FTSEEERIRM KQEQERIQAK 1030 1040 1050 1060 1070 1080 TREFRERQAR ERDYAEIQDF HRTFGCDDEL MYGGVSSYEG SMALNARPQS PREGHMMDAL 1090 1100 1110 1120 1130 1140 YAQVKKPRNS KPSPVDSNRS TPSNHDRIQR LRQEFQQAKQ DEDVEDRRRT YSFEQPWPNA 1150 1160 1170 1180 1190 1200 RPATQSGRHS VSVEVQMQRQ RQEERESSQQ AQRQYSSLPR QSRKNASSVS QDSWEQNYSP 1210 1220 1230 1240 1250 1260 GEGFQSAKEN PRYSSYQGSR NGYLGGHGFN ARVMLETQEL LRQEQRRKEQ QMKKQPPSEG 1270 1280 1290 1300 1310 PSNYDSYKKV QDPSYAPPKG PFRQDVPPSP SQVARLNRLQ TPEKGRPFYS
	Isoform 7 (Lb) [UniParc]. Checksum: 53C1A94D8CB7341E	FASTA	1,273	141,730
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 990 1000 1010 1020 KDKMKAKKGM LKGLGDMFRI QAKTREFRER QARERDYAEI QDFHRTFGCD DELMYGGVSS 1030 1040 1050 1060 1070 1080 YEGSMALNAR PQSPREGHMM DALYAQVKKP RNSKPSPVDS NRSTPSNHDR IQRLRQEFQQ 1090 1100 1110 1120 1130 1140 AKQDEDVEDR RRTYSFEQPW PNARPATQSG RHSVSVEVQM QRQRQEERES SQQAQRQYSS 1150 1160 1170 1180 1190 1200 LPRQSRKNAS SVSQDSWEQN YSPGEGFQSA KENPRYSSYQ GSRNGYLGGH GFNARVMLET 1210 1220 1230 1240 1250 1260 QELLRQEQRR KEQQMKKQPP SEGPSNYDSY KKVQDPSYAP PKGPFRQDVP PSPSQVARLN 1270 RLQTPEKGRP FYS
	Isoform 8 (Sa) [UniParc]. Checksum: 40DD593636EAE999	FASTA	1,031	113,419
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD 850 860 870 880 890 900 FVKTRKSKSM DLGIADETKL NTVDDQKAGS PSRDVGPSLG LKKSSSLESL QTAVAEVTLN 910 920 930 940 950 960 GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY DKPAVDDDDE GMETLEEDTE ESSRSGRESV 970 980 990 1000 1010 1020 STASDQPSHS LERQMNGNQE KGDKTDRKKD KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM 1030 FSLAKLKPEK R
	Isoform 9 (Sb) [UniParc]. Checksum: 89F2139B096F7F7F	FASTA	988	108,545
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 KDKMKAKKGM LKGLGDMFSL AKLKPEKR
	Isoform 10 [UniParc]. Checksum: 135A54F80C144606	FASTA	1,000	109,917
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQTDETKLN TVDDQKAGSP 850 860 870 880 890 900 SRDVGPSLGL KKSSSLESLQ TAVAEVTLNG DIPFHRPRPR IIRGRGCNES FRAAIDKSYD 910 920 930 940 950 960 KPAVDDDDEG METLEEDTEE SSRSGRESVS TASDQPSHSL ERQMNGNQEK GDKTDRKKDK 970 980 990 1000 TGKEKKKDRD KEKDKMKAKK GMLKGLGDMF SLAKLKPEKR
	Isoform 11 [UniParc]. Checksum: 3DAB16557C6BBA86	FASTA	1,340	149,695
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ SMSEKRTKQF SDASQLDFVK TRKSKSMDLG 850 860 870 880 890 900 IADETKLNTV DDQKAGSPSR DVGPSLGLKK SSSLESLQTA VAEVTLNGDI PFHRPRPRII 910 920 930 940 950 960 RGRGCNESFR AAIDKSYDKP AVDDDDEGME TLEEDTEESS RSGRESVSTA SDQPSHSLER 970 980 990 1000 1010 1020 QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE KDKMKAKKGM LKGLGDMFRF GKHRKDDKIE 1030 1040 1050 1060 1070 1080 KTGKIKIQES FTSEEERIRM KQEQERIQAK TREFRERQAR ERDYAEIQDF HRTFGCDDEL 1090 1100 1110 1120 1130 1140 MYGGVSSYEG SMALNARPQS PREGHMMDAL YAQVKKPRNS KPSPVDSNRS TPSNHDRIQR 1150 1160 1170 1180 1190 1200 LRQEFQQAKQ DEDVEDRRRT YSFEQPWPNA RPATQSGRHS VSVEVQMQRQ RQEERESSQQ 1210 1220 1230 1240 1250 1260 AQRQYSSLPR QSRKNASSVS QDSWEQNYSP GEGFQSAKEN PRYSSYQGSR NGYLGGHGFN 1270 1280 1290 1300 1310 1320 ARVMLETQEL LRQEQRRKEQ QMKKQPPSEG PSNYDSYKKV QDPSYAPPKG PFRQDVPPSP 1330 1340 SQVARLNRLQ TPEKGRPFYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42." Joberty G., Petersen C., Gao L., Macara I.G. Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH PARD6B. Tissue: Kidney.
[2]	"Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas." Fang C.M., Xu Y.H. Cell Res. 11:223-229(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 7; 8 AND 9).
[3]	"PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions." Kohjima M., Noda Y., Takeya R., Saito N., Takeuchi K., Sumimoto H. Biochem. Biophys. Res. Commun. 299:641-646(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[4]	"Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties." Gao L., Macara I.G., Joberty G. Gene 294:99-107(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), INTERACTION WITH PARD6B AND PRKCZ, TISSUE SPECIFICITY.
[5]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 860-1356 (ISOFORM 1). Tissue: Lung and Placenta.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 955-1356 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-1356 (ISOFORM 10). Tissue: Hepatoma and Ovarian carcinoma.
[9]	"Serological detection of cutaneous T-cell lymphoma-associated antigens." Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 313-992. Tissue: Testis.
[10]	"The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1." Johansson A.-S., Driessens M., Aspenstroem P. J. Cell Sci. 113:3267-3275(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PARD6A.
[11]	"Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures." Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S. J. Cell Biol. 152:1183-1196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT OF A COMPLEX CONTAINING PARD6B AND PRKCI. Tissue: Kidney.
[12]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[13]	"Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity." Liu X.F., Ishida H., Raziuddin R., Miki T. Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ECT2.
[14]	"A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells." Wells C.D., Fawcett J.P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Metalnikov P., Pawson T. Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH ARHGAP17; AMOT; MPP5 AND INADL.
[15]	"The keratin-binding protein Albatross regulates polarization of epithelial cells." Sugimoto M., Inoko A., Shiromizu T., Nakayama M., Zou P., Yonemura S., Hayashi Y., Izawa I., Sasoh M., Uji Y., Kaibuchi K., Kiyono T., Inagaki M. J. Cell Biol. 183:19-28(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FBF1.
[16]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND SER-695, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-692; SER-695; SER-728; SER-809; SER-852 AND SER-873, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity." Khazaei M.R., Puschel A.W. J. Biol. Chem. 284:33571-33579(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AURKA AND AURKB, FUNCTION, MUTAGENESIS OF SER-962, PHOSPHORYLATION AT SER-962.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-728 AND SER-852, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[20]	"CCM1 regulates vascular-lumen organization by inducing endothelial polarity." Lampugnani M.G., Orsenigo F., Rudini N., Maddaluno L., Boulday G., Chapon F., Dejana E. J. Cell Sci. 123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT.
[21]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-728; SER-852 AND SER-873, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[22]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[23]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-852 AND SER-873, MASS SPECTROMETRY.
[24]	"Rapid, robotic, small-scale protein production for NMR screening and structure determination." Jensen D.R., Woytovich C., Li M., Duvnjak P., Cassidy M.S., Frederick R.O., Bergeman L.F., Peterson F.C., Volkman B.F. Protein Sci. 19:570-578(2010) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 451-549.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF252293 mRNA. Translation: AAF71530.1.
AF196185 mRNA. Translation: AAK27891.1.
AF196186 mRNA. Translation: AAK27892.1.
AF332592 mRNA. Translation: AAK69192.1.
AF332593 mRNA. Translation: AAK69193.1.
AB073671 mRNA. Translation: BAC54037.1.
AF467002 mRNA. Translation: AAL76042.1.
AF467003 mRNA. Translation: AAL76043.1.
AF467004 mRNA. Translation: AAL76044.1.
AF467005 mRNA. Translation: AAL76045.1.
AF467006 mRNA. Translation: AAL76046.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71161.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71162.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71163.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71165.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71166.1.
AL360233 , AL138768, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71167.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73524.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73525.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73526.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73528.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73529.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15036.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15037.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15038.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15039.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15040.1.
AL450337 , AL138768, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15041.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16985.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16986.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16987.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16988.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16989.1.
AL138768 , AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16991.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17304.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17305.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17306.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17308.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17309.1.
AL390766 , AL138768, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17310.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17327.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17328.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17329.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17331.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17332.1.
AL392123 , AL138768, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17333.1.
CH471072 Genomic DNA. Translation: EAW85932.1.
CH471072 Genomic DNA. Translation: EAW85934.1.
BC011711 mRNA. Translation: AAH11711.2.
BC071566 mRNA. Translation: AAH71566.1.
AK000761 mRNA. Translation: BAA91366.1. Different initiation.
AK027735 mRNA. Translation: BAB55330.1. Different initiation.
AF177228 mRNA. Translation: AAG33676.1. Sequence problems.

IPI

IPI00045423.
IPI00154915.
IPI00163607.
IPI00163608.
IPI00165621.
IPI00179063.
IPI00294934.
IPI00301595.
IPI00301597.
IPI00301605.
IPI00984283.

RefSeq

NP_001171714.1. NM_001184785.1.
NP_001171715.1. NM_001184786.1.
NP_001171716.1. NM_001184787.1.
NP_001171717.1. NM_001184788.1.
NP_001171718.1. NM_001184789.1.
NP_001171719.1. NM_001184790.1.
NP_001171720.1. NM_001184791.1.
NP_001171721.1. NM_001184792.1.
NP_001171722.1. NM_001184793.1.
NP_001171723.1. NM_001184794.1.
NP_062565.2. NM_019619.3.

UniGene

Hs.131489.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KOM	NMR	-	A	451-549	[»]

ProteinModelPortal

Q8TEW0.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31315N.

IntAct

Q8TEW0. 17 interactions.

MINT

MINT-1342655.

PTM databases

PhosphoSite

Q8TEW0.

Polymorphism databases

DMDM

30913162.

Proteomic databases

PaxDb

Q8TEW0.

PRIDE

Q8TEW0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000340077; ENSP00000341844; ENSG00000148498.
ENST00000346874; ENSP00000340591; ENSG00000148498.
ENST00000350537; ENSP00000311986; ENSG00000148498.
ENST00000374776; ENSP00000363908; ENSG00000148498.
ENST00000374788; ENSP00000363920; ENSG00000148498.
ENST00000374789; ENSP00000363921; ENSG00000148498.
ENST00000374794; ENSP00000363926; ENSG00000148498.
ENST00000545260; ENSP00000440857; ENSG00000148498.
ENST00000545693; ENSP00000443147; ENSG00000148498.

GeneID

56288.

KEGG

hsa:56288.

UCSC

uc001ixp.2. human.
uc001ixq.2. human.
uc001ixr.2. human.
uc010qej.2. human.
uc010qek.2. human.
uc010qel.2. human.
uc010qen.2. human.
uc010qeo.2. human.
uc010qep.2. human.
uc010qeq.2. human.

Organism-specific databases

CTD

56288.

GeneCards

GC10M034438.

HGNC

HGNC:16051. PARD3.

HPA

HPA030443.

MIM

606745. gene.

neXtProt

NX_Q8TEW0.

PharmGKB

PA32936.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG268288.

HOVERGEN

HBG053508.

InParanoid

Q8TEW0.

KO

K04237.

OMA

DEQDPHH.

OrthoDB

EOG4C2H8V.

PhylomeDB

Q8TEW0.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpress

Q8TEW0.

Bgee

Q8TEW0.

Genevestigator

Q8TEW0.

GermOnline

ENSG00000148498. Homo sapiens.

Family and domain databases

InterPro

IPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]

Pfam

PF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]

SMART

SM00228. PDZ. 3 hits.
[Graphical view]

SUPFAM

SSF50156. PDZ. 3 hits.

PROSITE

PS50106. PDZ. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PARD3. human.

EvolutionaryTrace

Q8TEW0.

GenomeRNAi

56288.

NextBio

61959.

SOURCE

Search...

Entry information

Entry name

PARD3_HUMAN

Accession

Primary (citable) accession number: Q8TEW0
Secondary accession number(s): F5H5T0 , Q5T2U1, Q5VUA2, Q5VUA3, Q5VWV0, Q5VWV1, Q5VWV3, Q5VWV4, Q5VWV5, Q6IQ47, Q8TCZ9, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 16, 2003
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.