Reviewed, UniProtKB/Swiss-Prot Q8TEW0 (PARD3_HUMAN)

Names and origin

Protein names

Recommended name:
    Partitioning-defective 3 homolog
      Short name=PARD-3
      Short name=PAR-3
Alternative name(s):
    Atypical PKC isotype-specific-interacting protein
      Short name=ASIP
    CTCL tumor antigen se2-5
    PAR3-alpha

Gene names

Name:	PARD3
Synonyms:	PAR3, PAR3A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Subunit structure	Interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI By similarity. Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Interacts with F11R/JAM1 By similarity. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with LIMK2.
Subcellular location	Intracytoplasmic membrane. Cell junction › tight junction. Cell membrane. Note= Partially localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions.
Tissue specificity	Widely expressed.
Post-translational modification	Phosphorylated by PRKCZ. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2.
Miscellaneous	Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.
Sequence similarities	Belongs to the PAR3 family. Contains 3 PDZ (DHR) domains.
Sequence caution	The sequence AAG33676.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell junction Cell membrane Membrane Tight junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	activation of protein kinase C activity Traceable author statement. Source: UniProtKB asymmetric cell division Ref.1 Traceable author statement. Source: ProtInc axonogenesis Traceable author statement. Source: UniProtKB establishment or maintenance of cell polarity Ref.1 Traceable author statement. Source: UniProtKB protein complex assembly Ref.1 Traceable author statement. Source: ProtInc
Cellular component	tight junction Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PARD6A	Q9NPB6	2	EBI-81968,EBI-81876
PARD6B	Q9BYG5	1	EBI-81968,EBI-295391
Pard6b	Q9JK83	2	EBI-81968,EBI-81861	From a different organism.
PNMA1	Q8ND90	1	EBI-81968,EBI-302345
PRKCI	P41743	1	EBI-81968,EBI-286199
YWHAB	P31946	1	EBI-81968,EBI-359815
YWHAG	P61981	1	EBI-81968,EBI-359832
YWHAH	Q04917	1	EBI-81968,EBI-306940
YWHAZ	P63104	1	EBI-81968,EBI-347088

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEW0-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEW0-2)

Also known as: B; La;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.

Isoform 3 (identifier: Q8TEW0-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 4 (identifier: Q8TEW0-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1061: Missing.

Isoform 5 (identifier: Q8TEW0-5)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     857-857: I → S
     858-872: Missing.
     1025-1061: Missing.

Isoform 6 (identifier: Q8TEW0-6)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 7 (identifier: Q8TEW0-7)

Also known as: Lb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1061: Missing.

Isoform 8 (identifier: Q8TEW0-8)

Also known as: Sa;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 9 (identifier: Q8TEW0-9)

Also known as: Sb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 10 (identifier: Q8TEW0-10)

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     827-856: Missing.
     857-858: IA → T
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1356	1356	Partitioning-defective 3 homolog
Regions
	Domain	271 – 359	89	PDZ 1
	Domain	461 – 546	86	PDZ 2
	Domain	590 – 677	88	PDZ 3
	Region	712 – 936	225	Interacts with PRKCZ By similarity
	Coiled coil	1049 – 1077	29	Potential
	Coiled coil	1151 – 1174	24	Potential
	Coiled coil	1201 – 1224	24	Potential
	Coiled coil	1280 – 1301	22	Potential
	Compositional bias	984 – 1042	59	Lys-rich
Amino acid modifications
	Modified residue	143	1	Phosphoserine
	Modified residue	144	1	Phosphoserine
	Modified residue	383	1	Phosphoserine
	Modified residue	489	1	Phosphotyrosine
	Modified residue	695	1	Phosphoserine
	Modified residue	715	1	Phosphoserine
	Modified residue	717	1	Phosphoserine
	Modified residue	728	1	Phosphoserine
	Modified residue	827	1	Phosphoserine By similarity
	Modified residue	852	1	Phosphoserine
	Modified residue	1080	1	Phosphotyrosine By similarity
	Modified residue	1127	1	Phosphotyrosine
Natural variations
	Alternative sequence	195 – 238	44	Missing in isoform 3 and isoform 5.
	Alternative sequence	557 – 569	13	Missing in isoform 3, isoform 5, isoform 6, isoform 7 and isoform 9.
	Alternative sequence	740 – 742	3	Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9 and isoform 10.
	Alternative sequence	827 – 856	30	Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10.
	Alternative sequence	857 – 858	2	IA → T in isoform 10.
	Alternative sequence	857	1	I → S in isoform 5.
	Alternative sequence	858 – 872	15	Missing in isoform 5.
	Alternative sequence	1025 – 1061	37	Missing in isoform 4, isoform 5 and isoform 7.
	Alternative sequence	1025 – 1034	10	RFGKHRKDDK → SLAKLKPEKR in isoform 8, isoform 9 and isoform 10.
	Alternative sequence	1035 – 1356	322	Missing in isoform 8, isoform 9 and isoform 10.
	Natural variant	107	1	E → D: dbSNP rs1436731.
Experimental info
	Mutagenesis	1127	1	Y → F: Delayed epithelial tight junction assembly
	Sequence conflict	190	1	T → A in BAB55330. Ref.5
	Sequence conflict	233	1	L → Q in BAB55330. Ref.5
	Sequence conflict	594	1	N → S in BAB55330. Ref.5
	Sequence conflict	996 – 1000	5	GKEKK → VELHE in BAA91366. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified May 16, 2003. Version 2. Checksum: A4FD3F4F9AD8B92A	FASTA	1,356	151,423
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ ERIQAKTREF RERQARERDY 1090 1100 1110 1120 1130 1140 AEIQDFHRTF GCDDELMYGG VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP 1150 1160 1170 1180 1190 1200 VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE 1210 1220 1230 1240 1250 1260 VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS 1270 1280 1290 1300 1310 1320 SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS 1330 1340 1350 YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 2 (B) (La) [UniParc]. Checksum: BC531577B9C31AE3		1,353	151,150
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD 850 860 870 880 890 900 FVKTRKSKSM DLGIADETKL NTVDDQKAGS PSRDVGPSLG LKKSSSLESL QTAVAEVTLN 910 920 930 940 950 960 GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY DKPAVDDDDE GMETLEEDTE ESSRSGRESV 970 980 990 1000 1010 1020 STASDQPSHS LERQMNGNQE KGDKTDRKKD KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM 1030 1040 1050 1060 1070 1080 FRFGKHRKDD KIEKTGKIKI QESFTSEEER IRMKQEQERI QAKTREFRER QARERDYAEI 1090 1100 1110 1120 1130 1140 QDFHRTFGCD DELMYGGVSS YEGSMALNAR PQSPREGHMM DALYAQVKKP RNSKPSPVDS 1150 1160 1170 1180 1190 1200 NRSTPSNHDR IQRLRQEFQQ AKQDEDVEDR RRTYSFEQPW PNARPATQSG RHSVSVEVQM 1210 1220 1230 1240 1250 1260 QRQRQEERES SQQAQRQYSS LPRQSRKNAS SVSQDSWEQN YSPGEGFQSA KENPRYSSYQ 1270 1280 1290 1300 1310 1320 GSRNGYLGGH GFNARVMLET QELLRQEQRR KEQQMKKQPP SEGPSNYDSY KKVQDPSYAP 1330 1340 1350 PKGPFRQDVP PSPSQVARLN RLQTPEKGRP FYS
	Isoform 3 (C) [UniParc]. Checksum: 92DF51B68081A4A2		1,266	141,072
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQIADE TKLNTVDDQK 790 800 810 820 830 840 AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV TLNGDIPFHR PRPRIIRGRG CNESFRAAID 850 860 870 880 890 900 KSYDKPAVDD DDEGMETLEE DTEESSRSGR ESVSTASDQP SHSLERQMNG NQEKGDKTDR 910 920 930 940 950 960 KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE 970 980 990 1000 1010 1020 EERIRMKQEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG VSSYEGSMAL 1030 1040 1050 1060 1070 1080 NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV 1090 1100 1110 1120 1130 1140 EDRRRTYSFE QPWPNARPAT QSGRHSVSVE VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK 1150 1160 1170 1180 1190 1200 NASSVSQDSW EQNYSPGEGF QSAKENPRYS SYQGSRNGYL GGHGFNARVM LETQELLRQE 1210 1220 1230 1240 1250 1260 QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 4 (D) [UniParc]. Checksum: F5FBF3CE4E67163B		1,319	146,877
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRIQAKT REFRERQARE RDYAEIQDFH RTFGCDDELM YGGVSSYEGS MALNARPQSP 1090 1100 1110 1120 1130 1140 REGHMMDALY AQVKKPRNSK PSPVDSNRST PSNHDRIQRL RQEFQQAKQD EDVEDRRRTY 1150 1160 1170 1180 1190 1200 SFEQPWPNAR PATQSGRHSV SVEVQMQRQR QEERESSQQA QRQYSSLPRQ SRKNASSVSQ 1210 1220 1230 1240 1250 1260 DSWEQNYSPG EGFQSAKENP RYSSYQGSRN GYLGGHGFNA RVMLETQELL RQEQRRKEQQ 1270 1280 1290 1300 1310 MKKQPPSEGP SNYDSYKKVQ DPSYAPPKGP FRQDVPPSPS QVARLNRLQT PEKGRPFYS
	Isoform 5 (E) [UniParc]. Checksum: C3C156C8811D49C2		1,244	138,332
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 790 800 810 820 830 840 QLDFVKTRKS KSMDLGSSPS RDVGPSLGLK KSSSLESLQT AVAEVTLNGD IPFHRPRPRI 850 860 870 880 890 900 IRGRGCNESF RAAIDKSYDK PAVDDDDEGM ETLEEDTEES SRSGRESVST ASDQPSHSLE 910 920 930 940 950 960 RQMNGNQEKG DKTDRKKDKT GKEKKKDRDK EKDKMKAKKG MLKGLGDMFR IQAKTREFRE 970 980 990 1000 1010 1020 RQARERDYAE IQDFHRTFGC DDELMYGGVS SYEGSMALNA RPQSPREGHM MDALYAQVKK 1030 1040 1050 1060 1070 1080 PRNSKPSPVD SNRSTPSNHD RIQRLRQEFQ QAKQDEDVED RRRTYSFEQP WPNARPATQS 1090 1100 1110 1120 1130 1140 GRHSVSVEVQ MQRQRQEERE SSQQAQRQYS SLPRQSRKNA SSVSQDSWEQ NYSPGEGFQS 1150 1160 1170 1180 1190 1200 AKENPRYSSY QGSRNGYLGG HGFNARVMLE TQELLRQEQR RKEQQMKKQP PSEGPSNYDS 1210 1220 1230 1240 YKKVQDPSYA PPKGPFRQDV PPSPSQVARL NRLQTPEKGR PFYS
	Isoform 6 (F) [UniParc]. Checksum: 57361092A273AC60		1,310	146,276
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 990 1000 1010 1020 KDKMKAKKGM LKGLGDMFRF GKHRKDDKIE KTGKIKIQES FTSEEERIRM KQEQERIQAK 1030 1040 1050 1060 1070 1080 TREFRERQAR ERDYAEIQDF HRTFGCDDEL MYGGVSSYEG SMALNARPQS PREGHMMDAL 1090 1100 1110 1120 1130 1140 YAQVKKPRNS KPSPVDSNRS TPSNHDRIQR LRQEFQQAKQ DEDVEDRRRT YSFEQPWPNA 1150 1160 1170 1180 1190 1200 RPATQSGRHS VSVEVQMQRQ RQEERESSQQ AQRQYSSLPR QSRKNASSVS QDSWEQNYSP 1210 1220 1230 1240 1250 1260 GEGFQSAKEN PRYSSYQGSR NGYLGGHGFN ARVMLETQEL LRQEQRRKEQ QMKKQPPSEG 1270 1280 1290 1300 1310 PSNYDSYKKV QDPSYAPPKG PFRQDVPPSP SQVARLNRLQ TPEKGRPFYS
	Isoform 7 (Lb) [UniParc]. Checksum: 53C1A94D8CB7341E		1,273	141,730
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE