Reviewed, UniProtKB/Swiss-Prot Q8TEW0 (PARD3_HUMAN)

Names and origin

Protein names

Recommended name:
    Partitioning defective 3 homolog
      Short name=PARD-3
      Short name=PAR-3
Alternative name(s):
    Atypical PKC isotype-specific-interacting protein
      Short name=ASIP
    CTCL tumor antigen se2-5
    PAR3-alpha

Gene names

Name:	PARD3
Synonyms:	PAR3, PAR3A

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Subunit structure	Interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI By similarity. Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Interacts with F11R/JAM1 By similarity. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with LIMK2. Ref.1 Ref.4 Ref.10 Ref.11 Ref.16
Subcellular location	Endomembrane system. Cell junction. Cell junction › tight junction. Cell membrane. Cytoplasm › cell cortex By similarity. Cytoplasm › cytoskeleton. Note: Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II By similarity.
Tissue specificity	Widely expressed. Ref.4
Domain	Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization By similarity.
Post-translational modification	Phosphorylated by PRKCZ. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2. Ref.16 Ref.12 Ref.13 Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24
Miscellaneous	Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.
Sequence similarities	Belongs to the PAR3 family. Contains 3 PDZ (DHR) domains.
Sequence caution	The sequence AAG33676.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Tight junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Traceable author statement. Source: UniProtKB asymmetric cell division Ref.1 Traceable author statement. Source: ProtInc axonogenesis Traceable author statement. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW establishment or maintenance of cell polarity Ref.1 Traceable author statement. Source: UniProtKB protein complex assembly Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell tight junction Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PARD6A	Q9NPB6	2	EBI-81968,EBI-81876
PARD6B	Q9BYG5	1	EBI-81968,EBI-295391
Pard6b	Q9JK83	2	EBI-81968,EBI-81861	From a different organism.
PARD6G	Q9BYG4	1	EBI-81968,EBI-295417
PNMA1	Q8ND90	1	EBI-81968,EBI-302345
PRKCI	P41743	1	EBI-81968,EBI-286199
STK11	Q15831	1	EBI-81968,EBI-306838
YWHAB	P31946	1	EBI-81968,EBI-359815
YWHAG	P61981	1	EBI-81968,EBI-359832
YWHAH	Q04917	1	EBI-81968,EBI-306940
YWHAZ	P63104	1	EBI-81968,EBI-347088

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEW0-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEW0-2)

Also known as: B; La;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.

Isoform 3 (identifier: Q8TEW0-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 4 (identifier: Q8TEW0-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1061: Missing.

Isoform 5 (identifier: Q8TEW0-5)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     857-857: I → S
     858-872: Missing.
     1025-1061: Missing.

Isoform 6 (identifier: Q8TEW0-6)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Isoform 7 (identifier: Q8TEW0-7)

Also known as: Lb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1061: Missing.

Isoform 8 (identifier: Q8TEW0-8)

Also known as: Sa;

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 9 (identifier: Q8TEW0-9)

Also known as: Sb;

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Isoform 10 (identifier: Q8TEW0-10)

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     827-856: Missing.
     857-858: IA → T
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1356	1356	Partitioning defective 3 homolog		PRO_0000185069
Regions
	Domain	271 – 359	89	PDZ 1
	Domain	461 – 546	86	PDZ 2
	Domain	590 – 677	88	PDZ 3
	Region	712 – 936	225	Interacts with PRKCZ By similarity
	Coiled coil	1049 – 1077	29	Potential
	Coiled coil	1151 – 1174	24	Potential
	Coiled coil	1201 – 1224	24	Potential
	Coiled coil	1280 – 1301	22	Potential
	Compositional bias	984 – 1042	59	Lys-rich
Amino acid modifications
	Modified residue	143	1	Phosphoserine Ref.20
	Modified residue	144	1	Phosphoserine Ref.15 Ref.20
	Modified residue	174	1	Phosphoserine Ref.22
	Modified residue	383	1	Phosphoserine Ref.12 Ref.18 Ref.20 Ref.21 Ref.24
	Modified residue	388	1	Phosphotyrosine Ref.23 Ref.24
	Modified residue	489	1	Phosphotyrosine Ref.17 Ref.23
	Modified residue	692	1	Phosphoserine Ref.21
	Modified residue	695	1	Phosphoserine Ref.20 Ref.21
	Modified residue	715	1	Phosphoserine Ref.20
	Modified residue	717	1	Phosphoserine Ref.20
	Modified residue	719	1	Phosphotyrosine Ref.23
	Modified residue	728	1	Phosphoserine Ref.20 Ref.21 Ref.24
	Modified residue	809	1	Phosphoserine Ref.21
	Modified residue	827	1	Phosphoserine By similarity
	Modified residue	852	1	Phosphoserine Ref.19 Ref.21 Ref.24
	Modified residue	873	1	Phosphoserine Ref.21
	Modified residue	1005	1	N6-acetyllysine Ref.25
	Modified residue	1080	1	Phosphotyrosine Ref.23
	Modified residue	1127	1	Phosphotyrosine Ref.16 Ref.13 Ref.23
Natural variations
	Alternative sequence	195 – 238	44	Missing in isoform 3 and isoform 5.		VSP_007462
	Alternative sequence	557 – 569	13	Missing in isoform 3, isoform 5, isoform 6, isoform 7 and isoform 9.		VSP_007463
	Alternative sequence	740 – 742	3	Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9 and isoform 10.		VSP_007464
	Alternative sequence	827 – 856	30	Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10.		VSP_007465
	Alternative sequence	857 – 858	2	IA → T in isoform 10.		VSP_007467
	Alternative sequence	857	1	I → S in isoform 5.		VSP_007466
	Alternative sequence	858 – 872	15	Missing in isoform 5.		VSP_007468
	Alternative sequence	1025 – 1061	37	Missing in isoform 4, isoform 5 and isoform 7.		VSP_007469
	Alternative sequence	1025 – 1034	10	RFGKHRKDDK → SLAKLKPEKR in isoform 8, isoform 9 and isoform 10.		VSP_007470
	Alternative sequence	1035 – 1356	322	Missing in isoform 8, isoform 9 and isoform 10.		VSP_007471
	Natural variant	107	1	E → D: dbSNP rs1436731.		VAR_015663
	Natural variant	575	1	D → N: dbSNP rs3758459.		VAR_050453
Experimental info
	Mutagenesis	1127	1	Y → F: Delayed epithelial tight junction assembly. Ref.16
	Sequence conflict	190	1	T → A in BAB55330. Ref.7
	Sequence conflict	233	1	L → Q in BAB55330. Ref.7
	Sequence conflict	594	1	N → S in BAB55330. Ref.7
	Sequence conflict	996 – 1000	5	GKEKK → VELHE in BAA91366. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified May 16, 2003. Version 2. Checksum: A4FD3F4F9AD8B92A	FASTA	1,356	151,423
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ ERIQAKTREF RERQARERDY 1090 1100 1110 1120 1130 1140 AEIQDFHRTF GCDDELMYGG VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP 1150 1160 1170 1180 1190 1200 VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE 1210 1220 1230 1240 1250 1260 VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS 1270 1280 1290 1300 1310 1320 SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS 1330 1340 1350 YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 2 (B) (La). Checksum: BC531577B9C31AE3	FASTA	1,353	151,150
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD 850 860 870 880 890 900 FVKTRKSKSM DLGIADETKL NTVDDQKAGS PSRDVGPSLG LKKSSSLESL QTAVAEVTLN 910 920 930 940 950 960 GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY DKPAVDDDDE GMETLEEDTE ESSRSGRESV 970 980 990 1000 1010 1020 STASDQPSHS LERQMNGNQE KGDKTDRKKD KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM 1030 1040 1050 1060 1070 1080 FRFGKHRKDD KIEKTGKIKI QESFTSEEER IRMKQEQERI QAKTREFRER QARERDYAEI 1090 1100 1110 1120 1130 1140 QDFHRTFGCD DELMYGGVSS YEGSMALNAR PQSPREGHMM DALYAQVKKP RNSKPSPVDS 1150 1160 1170 1180 1190 1200 NRSTPSNHDR IQRLRQEFQQ AKQDEDVEDR RRTYSFEQPW PNARPATQSG RHSVSVEVQM 1210 1220 1230 1240 1250 1260 QRQRQEERES SQQAQRQYSS LPRQSRKNAS SVSQDSWEQN YSPGEGFQSA KENPRYSSYQ 1270 1280 1290 1300 1310 1320 GSRNGYLGGH GFNARVMLET QELLRQEQRR KEQQMKKQPP SEGPSNYDSY KKVQDPSYAP 1330 1340 1350 PKGPFRQDVP PSPSQVARLN RLQTPEKGRP FYS
	Isoform 3 (C). Checksum: 92DF51B68081A4A2	FASTA	1,266	141,072
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQIADE TKLNTVDDQK 790 800 810 820 830 840 AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV TLNGDIPFHR PRPRIIRGRG CNESFRAAID 850 860 870 880 890 900 KSYDKPAVDD DDEGMETLEE DTEESSRSGR ESVSTASDQP SHSLERQMNG NQEKGDKTDR 910 920 930 940 950 960 KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE 970 980 990 1000 1010 1020 EERIRMKQEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG VSSYEGSMAL 1030 1040 1050 1060 1070 1080 NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV 1090 1100 1110 1120 1130 1140 EDRRRTYSFE QPWPNARPAT QSGRHSVSVE VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK 1150 1160 1170 1180 1190 1200 NASSVSQDSW EQNYSPGEGF QSAKENPRYS SYQGSRNGYL GGHGFNARVM LETQELLRQE 1210 1220 1230 1240 1250 1260 QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
	Isoform 4 (D). Checksum: F5FBF3CE4E67163B	FASTA	1,319	146,877
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 790 800 810 820 830 840 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 850 860 870 880 890 900 QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 910 920 930 940 950 960 TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 970 980 990 1000 1010 1020 ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 1030 1040 1050 1060 1070 1080 GDMFRIQAKT REFRERQARE RDYAEIQDFH RTFGCDDELM YGGVSSYEGS MALNARPQSP 1090 1100 1110 1120 1130 1140 REGHMMDALY AQVKKPRNSK PSPVDSNRST PSNHDRIQRL RQEFQQAKQD EDVEDRRRTY 1150 1160 1170 1180 1190 1200 SFEQPWPNAR PATQSGRHSV SVEVQMQRQR QEERESSQQA QRQYSSLPRQ SRKNASSVSQ 1210 1220 1230 1240 1250 1260 DSWEQNYSPG EGFQSAKENP RYSSYQGSRN GYLGGHGFNA RVMLETQELL RQEQRRKEQQ 1270 1280 1290 1300 1310 MKKQPPSEGP SNYDSYKKVQ DPSYAPPKGP FRQDVPPSPS QVARLNRLQT PEKGRPFYS
	Isoform 5 (E). Checksum: C3C156C8811D49C2	FASTA	1,244	138,332
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL 250 260 270 280 290 300 GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF 310 320 330 340 350 360 RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR 370 380 390 400 410 420 APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL 430 440 450 460 470 480 KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ 490 500 510 520 530 540 EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG 550 560 570 580 590 600 SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD 610 620 630 640 650 660 AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS 670 680 690 700 710 720 LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 730 740 750 760 770 780 SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 790 800 810 820 830 840 QLDFVKTRKS KSMDLGSSPS RDVGPSLGLK KSSSLESLQT AVAEVTLNGD IPFHRPRPRI 850 860 870 880 890 900 IRGRGCNESF RAAIDKSYDK PAVDDDDEGM ETLEEDTEES SRSGRESVST ASDQPSHSLE 910 920 930 940 950 960 RQMNGNQEKG DKTDRKKDKT GKEKKKDRDK EKDKMKAKKG MLKGLGDMFR IQAKTREFRE 970 980 990 1000 1010 1020 RQARERDYAE IQDFHRTFGC DDELMYGGVS SYEGSMALNA RPQSPREGHM MDALYAQVKK 1030 1040 1050 1060 1070 1080 PRNSKPSPVD SNRSTPSNHD RIQRLRQEFQ QAKQDEDVED RRRTYSFEQP WPNARPATQS 1090 1100 1110 1120 1130 1140 GRHSVSVEVQ MQRQRQEERE SSQQAQRQYS SLPRQSRKNA SSVSQDSWEQ NYSPGEGFQS 1150 1160 1170 1180 1190 1200 AKENPRYSSY QGSRNGYLGG HGFNARVMLE TQELLRQEQR RKEQQMKKQP PSEGPSNYDS 1210 1220 1230 1240 YKKVQDPSYA PPKGPFRQDV PPSPSQVARL NRLQTPEKGR PFYS
	Isoform 6 (F). Checksum: 57361092A273AC60	FASTA	1,310	146,276
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 990 1000 1010 1020 KDKMKAKKGM LKGLGDMFRF GKHRKDDKIE KTGKIKIQES FTSEEERIRM KQEQERIQAK 1030 1040 1050 1060 1070 1080 TREFRERQAR ERDYAEIQDF HRTFGCDDEL MYGGVSSYEG SMALNARPQS PREGHMMDAL 1090 1100 1110 1120 1130 1140 YAQVKKPRNS KPSPVDSNRS TPSNHDRIQR LRQEFQQAKQ DEDVEDRRRT YSFEQPWPNA 1150 1160 1170 1180 1190 1200 RPATQSGRHS VSVEVQMQRQ RQEERESSQQ AQRQYSSLPR QSRKNASSVS QDSWEQNYSP 1210 1220 1230 1240 1250 1260 GEGFQSAKEN PRYSSYQGSR NGYLGGHGFN ARVMLETQEL LRQEQRRKEQ QMKKQPPSEG 1270 1280 1290 1300 1310 PSNYDSYKKV QDPSYAPPKG PFRQDVPPSP SQVARLNRLQ TPEKGRPFYS
	Isoform 7 (Lb). Checksum: 53C1A94D8CB7341E	FASTA	1,273	141,730
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 990 1000 1010 1020 KDKMKAKKGM LKGLGDMFRI QAKTREFRER QARERDYAEI QDFHRTFGCD DELMYGGVSS 1030 1040 1050 1060 1070 1080 YEGSMALNAR PQSPREGHMM DALYAQVKKP RNSKPSPVDS NRSTPSNHDR IQRLRQEFQQ 1090 1100 1110 1120 1130 1140 AKQDEDVEDR RRTYSFEQPW PNARPATQSG RHSVSVEVQM QRQRQEERES SQQAQRQYSS 1150 1160 1170 1180 1190 1200 LPRQSRKNAS SVSQDSWEQN YSPGEGFQSA KENPRYSSYQ GSRNGYLGGH GFNARVMLET 1210 1220 1230 1240 1250 1260 QELLRQEQRR KEQQMKKQPP SEGPSNYDSY KKVQDPSYAP PKGPFRQDVP PSPSQVARLN 1270 RLQTPEKGRP FYS
	Isoform 8 (Sa). Checksum: 40DD593636EAE999	FASTA	1,031	113,419
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD 850 860 870 880 890 900 FVKTRKSKSM DLGIADETKL NTVDDQKAGS PSRDVGPSLG LKKSSSLESL QTAVAEVTLN 910 920 930 940 950 960 GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY DKPAVDDDDE GMETLEEDTE ESSRSGRESV 970 980 990 1000 1010 1020 STASDQPSHS LERQMNGNQE KGDKTDRKKD KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM 1030 FSLAKLKPEK R
	Isoform 9 (Sb). Checksum: 89F2139B096F7F7F	FASTA	988	108,545
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELKAED EDIVLTPDGT REFLTFEVPL NDSGSAGLGV SVKGNRSKEN 610 620 630 640 650 660 HADLGIFVKS IINGGAASKD GRLRVNDQLI AVNGESLLGK TNQDAMETLR RSMSTEGNKR 670 680 690 700 710 720 GMIQLIVARR ISKCNELKSP GSPPGPELPI ETALDDRERR ISHSLYSGIE GLDESPSRNA 730 740 750 760 770 780 ALSRIMGKYQ LSPTVNMPQD DTVIIEDDRL PVLPPHLSDQ SSSSSHDDVG FVTADAGTWA 790 800 810 820 830 840 KAAISDSADC SLSPDVDPVL AFQREGFGRQ IADETKLNTV DDQKAGSPSR DVGPSLGLKK 850 860 870 880 890 900 SSSLESLQTA VAEVTLNGDI PFHRPRPRII RGRGCNESFR AAIDKSYDKP AVDDDDEGME 910 920 930 940 950 960 TLEEDTEESS RSGRESVSTA SDQPSHSLER QMNGNQEKGD KTDRKKDKTG KEKKKDRDKE 970 980 KDKMKAKKGM LKGLGDMFSL AKLKPEKR
	Isoform 10. Checksum: 135A54F80C144606	FASTA	1,000	109,917
	10 20 30 40 50 60 MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 70 80 90 100 110 120 LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 130 140 150 160 170 180 ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 190 200 210 220 230 240 KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 250 260 270 280 290 300 DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 310 320 330 340 350 360 LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 370 380 390 400 410 420 ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 430 440 450 460 470 480 LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 490 500 510 520 530 540 TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 550 560 570 580 590 600 SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 610 620 630 640 650 660 LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 670 680 690 700 710 720 TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 730 740 750 760 770 780 GIEGLDESPS RNAALSRIMG KYQLSPTVNM PQDDTVIIED DRLPVLPPHL SDQSSSSSHD 790 800 810 820 830 840 DVGFVTADAG TWAKAAISDS ADCSLSPDVD PVLAFQREGF GRQTDETKLN TVDDQKAGSP 850 860 870 880 890 900 SRDVGPSLGL KKSSSLESLQ TAVAEVTLNG DIPFHRPRPR IIRGRGCNES FRAAIDKSYD 910 920 930 940 950 960 KPAVDDDDEG METLEEDTEE SSRSGRESVS TASDQPSHSL ERQMNGNQEK GDKTDRKKDK 970 980 990 1000 TGKEKKKDRD KEKDKMKAKK GMLKGLGDMF SLAKLKPEKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42." Joberty G., Petersen C., Gao L., Macara I.G. Nat. Cell Biol. 2:531-539(2000) [PubMed: 10934474] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH PARD6B. Tissue: Kidney.
[2]	"Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas." Fang C.M., Xu Y.H. Cell Res. 11:223-229(2001) [PubMed: 11642408] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 7; 8 AND 9).
[3]	"PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions." Kohjima M., Noda Y., Takeya R., Saito N., Takeuchi K., Sumimoto H. Biochem. Biophys. Res. Commun. 299:641-646(2002) [PubMed: 12459187] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[4]	"Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties." Gao L., Macara I.G., Joberty G. Gene 294:99-107(2002) [PubMed: 12234671] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), INTERACTION WITH PARD6B AND PRKCZ, TISSUE SPECIFICITY.
[5]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-1356 (ISOFORM 10). Tissue: Hepatoma and Ovarian carcinoma.
[8]	"Serological detection of cutaneous T-cell lymphoma-associated antigens." Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed: 11149944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 313-992. Tissue: Testis.
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 860-1356. Tissue: Lung.
[10]	"The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1." Johansson A.-S., Driessens M., Aspenstroem P. J. Cell Sci. 113:3267-3275(2000) [PubMed: 10954424] [Abstract] Cited for: INTERACTION WITH PARD6A.
[11]	"Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures." Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S. J. Cell Biol. 152:1183-1196(2001) [PubMed: 11257119] [Abstract] Cited for: SUBUNIT OF A COMPLEX CONTAINING PARD6B AND PRKCI. Tissue: Kidney.
[12]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, MASS SPECTROMETRY. Tissue: Epithelium.
[13]	"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M. Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed: 15951569] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1127, MASS SPECTROMETRY. Tissue: Epithelium.
[14]	"A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells." Wells C.D., Fawcett J.P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Metalnikov P., Pawson T. Cell 125:535-548(2006) [PubMed: 16678097] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH ARHGAP17; AMOT; MPP5 AND INADL.
[15]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, MASS SPECTROMETRY. Tissue: Epithelium.
[16]	"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling." Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z. EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1127, MASS SPECTROMETRY, INTERACTION WITH LIMK2, MUTAGENESIS OF TYR-1127.
[17]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-489, MASS SPECTROMETRY.
[18]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, MASS SPECTROMETRY. Tissue: Epithelium.
[19]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852, MASS SPECTROMETRY. Tissue: Platelet.
[20]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-144; SER-383; SER-695; SER-715; SER-717 AND SER-728, MASS SPECTROMETRY.
[21]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-692; SER-695; SER-728; SER-809; SER-852 AND SER-873, MASS SPECTROMETRY.
[22]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, MASS SPECTROMETRY.
[23]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-388; TYR-489; TYR-719; TYR-1080 AND TYR-1127, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[24]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; TYR-388; SER-728 AND SER-852, MASS SPECTROMETRY. Tissue: T-cell.
[25]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1005, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF252293 mRNA. Translation: AAF71530.1.
AF196185 mRNA. Translation: AAK27891.1.
AF196186 mRNA. Translation: AAK27892.1.
AF332592 mRNA. Translation: AAK69192.1.
AF332593 mRNA. Translation: AAK69193.1.
AB073671 mRNA. Translation: BAC54037.1.
AF467002 mRNA. Translation: AAL76042.1.
AF467003 mRNA. Translation: AAL76043.1.
AF467004 mRNA. Translation: AAL76044.1.
AF467005 mRNA. Translation: AAL76045.1.
AF467006 mRNA. Translation: AAL76046.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71161.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71162.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71163.1.
AL360233 , AL138768, AL160409, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71166.1.
AL360233 , AL138768, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH71167.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73524.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73525.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73526.1.
AL160409 , AL138768, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAH73529.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15036.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15037.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15038.1.
AL450337 , AL138768, AL160409, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15040.1.
AL450337 , AL138768, AL360233, AL390766, AL392123 Genomic DNA. Translation: CAI15041.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16985.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16986.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16987.1.
AL138768 , AL160409, AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16989.1.
AL138768 , AL360233, AL390766, AL392123, AL450337 Genomic DNA. Translation: CAI16991.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17304.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17305.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17306.1.
AL390766 , AL138768, AL160409, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17309.1.
AL390766 , AL138768, AL360233, AL392123, AL450337 Genomic DNA. Translation: CAI17310.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17327.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17328.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17329.1.
AL392123 , AL138768, AL160409, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17332.1.
AL392123 , AL138768, AL360233, AL390766, AL450337 Genomic DNA. Translation: CAI17333.1.
AK000761 mRNA. Translation: BAA91366.1. Different initiation.
AK027735 mRNA. Translation: BAB55330.1. Different initiation.
AF177228 mRNA. Translation: AAG33676.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW85932.1.
BC011711 mRNA. Translation: AAH11711.2.

IPI

IPI00045423.
IPI00154915.
IPI00163607.
IPI00163608.
IPI00165621.
IPI00179063.
IPI00294934.
IPI00301595.
IPI00301597.
IPI00301605.

RefSeq

NP_062565.2.

UniGene

Hs.131489

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KOM	NMR	-	A	451-549	[»]

SMR

Q8TEW0. Positions 2-83, 269-363, 279-549, 458-682, 582-685.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8TEW0. 18 interactions.

STRING

Q8TEW0.

PTM databases

PhosphoSite

Q8TEW0.

Proteomic databases

PRIDE

Q8TEW0.

Genome annotation databases

Ensembl

ENST00000374789; ENSP00000363921; ENSG00000148498; Homo sapiens. [Genome view]

GeneID

56288.

KEGG

hsa:56288.

UCSC

uc001ixg.1. human.
uc001ixh.1. human.
uc001ixi.1. human.
uc001ixk.1. human.
uc001ixl.1. human.
uc001ixm.1. human.
uc001ixn.1. human.
uc001ixp.1. human.
uc001ixq.1. human.
uc001ixr.1. human.

Organism-specific databases

CTD

56288.

GeneCards

GC10M034438.

H-InvDB

HIX0008758.
HIX0035395.

HGNC

HGNC:16051. PARD3.

MIM

606745. gene.

PharmGKB

PA32936.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q8TEW0.

InParanoid

Q8TEW0.

OMA

RTKQFSD.

PhylomeDB

Q8TEW0.

Enzyme and pathway databases

Reactome

REACT_20676. Cell junction organization.

Gene expression databases

ArrayExpress

Q8TEW0.

Bgee

Q8TEW0.

Genevestigator

Q8TEW0.

GermOnline

ENSG00000148498. Homo sapiens.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
[Graphical view]

Pfam

PF00595. PDZ. 3 hits.
[Graphical view]

SMART

SM00228. PDZ. 3 hits.
[Graphical view]

PROSITE

PS50106. PDZ. 3 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

61959.

SOURCE

Search...

Entry information

Entry name

PARD3_HUMAN

Accession

Primary (citable) accession number: Q8TEW0
Secondary accession number(s): Q5T2U1 , Q5VWV0, Q5VWV3, Q5VWV4, Q5VWV5, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 16, 2003
Last modified:	February 9, 2010
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.