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Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Gene

WFIKKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei140 – 141Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.954

Names & Taxonomyi

Protein namesi
Recommended name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Alternative name(s):
Growth and differentiation factor-associated serum protein 1
Short name:
GASP-1
Short name:
hGASP-1
WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein
WFIKKN-related protein
Gene namesi
Name:WFIKKN2
Synonyms:GASP1, WFIKKNRP
ORF Names:UNQ9235/PRO31996
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173714.7
HGNCiHGNC:30916 WFIKKN2
MIMi610895 gene
neXtProtiNX_Q8TEU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173714
PharmGKBiPA134864812

Polymorphism and mutation databases

BioMutaiWFIKKN2
DMDMi74716081

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34By similarityAdd BLAST34
ChainiPRO_000030782035 – 576WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 79By similarity
Disulfide bondi62 ↔ 83By similarity
Disulfide bondi66 ↔ 78By similarity
Disulfide bondi72 ↔ 88By similarity
Disulfide bondi134 ↔ 164By similarity
Disulfide bondi138 ↔ 157By similarity
Disulfide bondi146 ↔ 175By similarity
Disulfide bondi231 ↔ 287By similarity
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi328 ↔ 378By similarity
Disulfide bondi337 ↔ 361By similarity
Disulfide bondi353 ↔ 374By similarity
Disulfide bondi386 ↔ 436By similarity
Disulfide bondi395 ↔ 419By similarity
Disulfide bondi411 ↔ 432By similarity
Disulfide bondi445 ↔ 515By similarity
Disulfide bondi448 ↔ 517By similarity
Disulfide bondi459 ↔ 566By similarity
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TEU8
PeptideAtlasiQ8TEU8
PRIDEiQ8TEU8

PTM databases

iPTMnetiQ8TEU8
PhosphoSitePlusiQ8TEU8

Expressioni

Tissue specificityi

Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.1 Publication

Gene expression databases

BgeeiENSG00000173714
CleanExiHS_WFIKKN2
ExpressionAtlasiQ8TEU8 baseline and differential
GenevisibleiQ8TEU8 HS

Interactioni

Subunit structurei

Interacts with both mature and propeptide myostatin/MSTN.1 Publication

GO - Molecular functioni

  • receptor antagonist activity Source: UniProtKB
  • transforming growth factor beta binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ8TEU8, 7 interactors
MINTiQ8TEU8
STRINGi9606.ENSP00000311184

Structurei

3D structure databases

ProteinModelPortaliQ8TEU8
SMRiQ8TEU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 92WAPPROSITE-ProRule annotationAdd BLAST54
Domaini126 – 177Kazal-likePROSITE-ProRule annotationAdd BLAST52
Domaini210 – 303Ig-like C2-typeAdd BLAST94
Domaini328 – 378BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini386 – 436BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini445 – 566NTRPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the WFIKKN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410ITYX Eukaryota
ENOG410XRTD LUCA
GeneTreeiENSGT00740000114929
HOGENOMiHOG000154855
HOVERGENiHBG108676
InParanoidiQ8TEU8
OMAiCPNVCGT
OrthoDBiEOG091G09P2
PhylomeDBiQ8TEU8
TreeFamiTF315349

Family and domain databases

CDDicd00109 KU, 2 hits
Gene3Di2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033639 WFIKKN2
PANTHERiPTHR10083:SF87 PTHR10083:SF87, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00014 Kunitz_BPTI, 2 hits
PF01759 NTR, 1 hit
PF00095 WAP, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00131 KU, 2 hits
SM00217 WAP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF50242 SSF50242, 1 hit
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS51465 KAZAL_2, 1 hit
PS50189 NTR, 1 hit
PS51390 WAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TEU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWAPRCRRFW SRWEQVAALL LLLLLLGVPP RSLALPPIRY SHAGICPNDM
60 70 80 90 100
NPNLWVDAQS TCRRECETDQ ECETYEKCCP NVCGTKSCVA ARYMDVKGKK
110 120 130 140 150
GPVGMPKEAT CDHFMCLQQG SECDIWDGQP VCKCKDRCEK EPSFTCASDG
160 170 180 190 200
LTYYNRCYMD AEACSKGITL AVVTCRYHFT WPNTSPPPPE TTMHPTTASP
210 220 230 240 250
ETPELDMAAP ALLNNPVHQS VTMGETVSFL CDVVGRPRPE ITWEKQLEDR
260 270 280 290 300
ENVVMRPNHV RGNVVVTNIA QLVIYNAQLQ DAGIYTCTAR NVAGVLRADF
310 320 330 340 350
PLSVVRGHQA AATSESSPNG TAFPAAECLK PPDSEDCGEE QTRWHFDAQA
360 370 380 390 400
NNCLTFTFGH CHRNLNHFET YEACMLACMS GPLAACSLPA LQGPCKAYAP
410 420 430 440 450
RWAYNSQTGQ CQSFVYGGCE GNGNNFESRE ACEESCPFPR GNQRCRACKP
460 470 480 490 500
RQKLVTSFCR SDFVILGRVS ELTEEPDSGR ALVTVDEVLK DEKMGLKFLG
510 520 530 540 550
QEPLEVTLLH VDWACPCPNV TVSEMPLIIM GEVDGGMAML RPDSFVGASS
560 570
ARRVRKLREV MHKKTCDVLK EFLGLH
Length:576
Mass (Da):63,941
Last modified:June 1, 2002 - v1
Checksum:i08B4F2EDBE121F81
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06198431R → Q1 PublicationCorresponds to variant dbSNP:rs55700534Ensembl.1
Natural variantiVAR_03669296V → M. Corresponds to variant dbSNP:rs35300894Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468657 mRNA Translation: AAL77058.1
AY358142 mRNA Translation: AAQ88509.1
CCDSiCCDS11575.1
RefSeqiNP_001317270.1, NM_001330341.1
NP_783165.1, NM_175575.5
UniGeneiHs.211475

Genome annotation databases

EnsembliENST00000311378; ENSP00000311184; ENSG00000173714
GeneIDi124857
KEGGihsa:124857
UCSCiuc002isv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWFKN2_HUMAN
AccessioniPrimary (citable) accession number: Q8TEU8
Secondary accession number(s): Q6UXZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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