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Q8TEU8

- WFKN2_HUMAN

UniProt

Q8TEU8 - WFKN2_HUMAN

Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Gene

WFIKKN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei140 – 1412Reactive bondPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase inhibitor activity Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. transforming growth factor beta receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI02.954.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
    Alternative name(s):
    Growth and differentiation factor-associated serum protein 1
    Short name:
    GASP-1
    Short name:
    hGASP-1
    WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein
    WFIKKN-related protein
    Gene namesi
    Name:WFIKKN2
    Synonyms:GASP1, WFIKKNRP
    ORF Names:UNQ9235/PRO31996
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30916. WFIKKN2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434By similarityAdd
    BLAST
    Chaini35 – 576542WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2PRO_0000307820Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 79By similarity
    Disulfide bondi62 ↔ 83By similarity
    Disulfide bondi66 ↔ 78By similarity
    Disulfide bondi72 ↔ 88By similarity
    Disulfide bondi134 ↔ 164By similarity
    Disulfide bondi138 ↔ 157By similarity
    Disulfide bondi146 ↔ 175By similarity
    Disulfide bondi231 ↔ 287By similarity
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 378By similarity
    Disulfide bondi337 ↔ 361By similarity
    Disulfide bondi353 ↔ 374By similarity
    Disulfide bondi386 ↔ 436By similarity
    Disulfide bondi395 ↔ 419By similarity
    Disulfide bondi411 ↔ 432By similarity
    Disulfide bondi445 ↔ 515By similarity
    Disulfide bondi448 ↔ 517By similarity
    Disulfide bondi459 ↔ 566By similarity
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TEU8.
    PRIDEiQ8TEU8.

    PTM databases

    PhosphoSiteiQ8TEU8.

    Expressioni

    Tissue specificityi

    Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8TEU8.
    BgeeiQ8TEU8.
    CleanExiHS_WFIKKN2.
    GenevestigatoriQ8TEU8.

    Organism-specific databases

    HPAiCAB025621.
    HPA010953.
    HPA011561.

    Interactioni

    Subunit structurei

    Interacts with both mature and propeptide myostatin/MSTN.1 Publication

    Protein-protein interaction databases

    IntActiQ8TEU8. 7 interactions.
    MINTiMINT-8044275.
    STRINGi9606.ENSP00000311184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEU8.
    SMRiQ8TEU8. Positions 129-173, 187-294, 337-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 9254WAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini126 – 17752Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini210 – 30394Ig-like C2-typeAdd
    BLAST
    Domaini328 – 37851BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 43651BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 566122NTRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WFIKKN family.Curated
    Contains 2 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation
    Contains 1 WAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG261628.
    HOGENOMiHOG000154855.
    HOVERGENiHBG108676.
    InParanoidiQ8TEU8.
    OMAiCPNVCGT.
    OrthoDBiEOG754HSR.
    PhylomeDBiQ8TEU8.
    TreeFamiTF315349.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    4.10.410.10. 2 hits.
    4.10.75.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR002350. Kazal_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR008993. TIMP-like_OB-fold.
    IPR008197. WAP.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF07648. Kazal_2. 1 hit.
    PF00014. Kunitz_BPTI. 2 hits.
    PF01759. NTR. 1 hit.
    PF00095. WAP. 1 hit.
    [Graphical view]
    PRINTSiPR00759. BASICPTASE.
    SMARTiSM00408. IGc2. 1 hit.
    SM00280. KAZAL. 1 hit.
    SM00131. KU. 2 hits.
    SM00217. WAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF57256. SSF57256. 1 hit.
    SSF57362. SSF57362. 2 hits.
    PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 2 hits.
    PS50835. IG_LIKE. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    PS50189. NTR. 1 hit.
    PS51390. WAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TEU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWAPRCRRFW SRWEQVAALL LLLLLLGVPP RSLALPPIRY SHAGICPNDM    50
    NPNLWVDAQS TCRRECETDQ ECETYEKCCP NVCGTKSCVA ARYMDVKGKK 100
    GPVGMPKEAT CDHFMCLQQG SECDIWDGQP VCKCKDRCEK EPSFTCASDG 150
    LTYYNRCYMD AEACSKGITL AVVTCRYHFT WPNTSPPPPE TTMHPTTASP 200
    ETPELDMAAP ALLNNPVHQS VTMGETVSFL CDVVGRPRPE ITWEKQLEDR 250
    ENVVMRPNHV RGNVVVTNIA QLVIYNAQLQ DAGIYTCTAR NVAGVLRADF 300
    PLSVVRGHQA AATSESSPNG TAFPAAECLK PPDSEDCGEE QTRWHFDAQA 350
    NNCLTFTFGH CHRNLNHFET YEACMLACMS GPLAACSLPA LQGPCKAYAP 400
    RWAYNSQTGQ CQSFVYGGCE GNGNNFESRE ACEESCPFPR GNQRCRACKP 450
    RQKLVTSFCR SDFVILGRVS ELTEEPDSGR ALVTVDEVLK DEKMGLKFLG 500
    QEPLEVTLLH VDWACPCPNV TVSEMPLIIM GEVDGGMAML RPDSFVGASS 550
    ARRVRKLREV MHKKTCDVLK EFLGLH 576
    Length:576
    Mass (Da):63,941
    Last modified:June 1, 2002 - v1
    Checksum:i08B4F2EDBE121F81
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311R → Q.1 Publication
    Corresponds to variant rs55700534 [ dbSNP | Ensembl ].
    VAR_061984
    Natural varianti96 – 961V → M.
    Corresponds to variant rs35300894 [ dbSNP | Ensembl ].
    VAR_036692

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468657 mRNA. Translation: AAL77058.1.
    AY358142 mRNA. Translation: AAQ88509.1.
    CCDSiCCDS11575.1.
    RefSeqiNP_783165.1. NM_175575.5.
    UniGeneiHs.211475.

    Genome annotation databases

    EnsembliENST00000311378; ENSP00000311184; ENSG00000173714.
    GeneIDi124857.
    KEGGihsa:124857.
    UCSCiuc002isv.4. human.

    Polymorphism databases

    DMDMi74716081.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468657 mRNA. Translation: AAL77058.1 .
    AY358142 mRNA. Translation: AAQ88509.1 .
    CCDSi CCDS11575.1.
    RefSeqi NP_783165.1. NM_175575.5.
    UniGenei Hs.211475.

    3D structure databases

    ProteinModelPortali Q8TEU8.
    SMRi Q8TEU8. Positions 129-173, 187-294, 337-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8TEU8. 7 interactions.
    MINTi MINT-8044275.
    STRINGi 9606.ENSP00000311184.

    Protein family/group databases

    MEROPSi I02.954.

    PTM databases

    PhosphoSitei Q8TEU8.

    Polymorphism databases

    DMDMi 74716081.

    Proteomic databases

    PaxDbi Q8TEU8.
    PRIDEi Q8TEU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311378 ; ENSP00000311184 ; ENSG00000173714 .
    GeneIDi 124857.
    KEGGi hsa:124857.
    UCSCi uc002isv.4. human.

    Organism-specific databases

    CTDi 124857.
    GeneCardsi GC17P048912.
    HGNCi HGNC:30916. WFIKKN2.
    HPAi CAB025621.
    HPA010953.
    HPA011561.
    MIMi 610895. gene.
    neXtProti NX_Q8TEU8.
    PharmGKBi PA134864812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261628.
    HOGENOMi HOG000154855.
    HOVERGENi HBG108676.
    InParanoidi Q8TEU8.
    OMAi CPNVCGT.
    OrthoDBi EOG754HSR.
    PhylomeDBi Q8TEU8.
    TreeFami TF315349.

    Miscellaneous databases

    GenomeRNAii 124857.
    NextBioi 81402.
    PROi Q8TEU8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEU8.
    Bgeei Q8TEU8.
    CleanExi HS_WFIKKN2.
    Genevestigatori Q8TEU8.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    4.10.410.10. 2 hits.
    4.10.75.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR002350. Kazal_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR008993. TIMP-like_OB-fold.
    IPR008197. WAP.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF07648. Kazal_2. 1 hit.
    PF00014. Kunitz_BPTI. 2 hits.
    PF01759. NTR. 1 hit.
    PF00095. WAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00759. BASICPTASE.
    SMARTi SM00408. IGc2. 1 hit.
    SM00280. KAZAL. 1 hit.
    SM00131. KU. 2 hits.
    SM00217. WAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF57256. SSF57256. 1 hit.
    SSF57362. SSF57362. 2 hits.
    PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 2 hits.
    PS50835. IG_LIKE. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    PS50189. NTR. 1 hit.
    PS51390. WAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules."
      Trexler M., Banyai L., Patthy L.
      Biol. Chem. 383:223-228(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-31.
    3. "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains."
      Hill J.J., Qiu Y., Hewick R.M., Wolfman N.M.
      Mol. Endocrinol. 17:1144-1154(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH MSTN.

    Entry informationi

    Entry nameiWFKN2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEU8
    Secondary accession number(s): Q6UXZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3