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Q8TEU7

- RPGF6_HUMAN

UniProt

Q8TEU7 - RPGF6_HUMAN

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Protein

Rap guanine nucleotide exchange factor 6

Gene

RAPGEF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi280 – 399120cNMPAdd
BLAST

GO - Molecular functioni

  1. GTP-dependent protein binding Source: UniProtKB
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. Ras GTPase binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. Ras protein signal transduction Source: UniProtKB
  3. regulation of GTPase activity Source: UniProtKB
  4. regulation of small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 6
Alternative name(s):
PDZ domain-containing guanine nucleotide exchange factor 2
Short name:
PDZ-GEF2
RA-GEF-2
Gene namesi
Name:RAPGEF6
Synonyms:PDZGEF2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:20655. RAPGEF6.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication
Note: Upon binding to M-Ras, it translocates to the plasma membrane.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16011601Rap guanine nucleotide exchange factor 6PRO_0000068876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8TEU7.
PaxDbiQ8TEU7.
PRIDEiQ8TEU7.

PTM databases

PhosphoSiteiQ8TEU7.

Expressioni

Tissue specificityi

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ8TEU7.
CleanExiHS_RAPGEF6.
ExpressionAtlasiQ8TEU7. baseline and differential.
GenevestigatoriQ8TEU7.

Organism-specific databases

HPAiHPA037982.
HPA037983.

Interactioni

Subunit structurei

Interacts with the second PDZ domain of human PTP1e.1 PublicationCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN13Q129234EBI-2693017,EBI-355227

Protein-protein interaction databases

BioGridi119705. 7 interactions.
IntActiQ8TEU7. 5 interactions.
MINTiMINT-8283239.
STRINGi9606.ENSP00000296859.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi267 – 27711Combined sources
Turni280 – 2823Combined sources
Helixi286 – 2927Combined sources
Turni293 – 2953Combined sources
Beta strandi296 – 3016Combined sources
Beta strandi303 – 3053Combined sources
Beta strandi307 – 3093Combined sources
Beta strandi317 – 3204Combined sources
Beta strandi326 – 3294Combined sources
Beta strandi331 – 3333Combined sources
Beta strandi335 – 3384Combined sources
Beta strandi343 – 3453Combined sources
Beta strandi348 – 3503Combined sources
Beta strandi357 – 37216Combined sources
Helixi373 – 3797Combined sources
Beta strandi1598 – 16014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D93NMR-A265-385[»]
3LNYX-ray1.30B1596-1601[»]
ProteinModelPortaliQ8TEU7.
SMRiQ8TEU7. Positions 268-386.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TEU7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini412 – 526115N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini530 – 61586PDZCuratedPROSITE-ProRule annotationAdd
BLAST
Domaini749 – 83587Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini860 – 1088229Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1229 – 1440212Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.CuratedPROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.CuratedPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG307777.
GeneTreeiENSGT00770000120448.
HOVERGENiHBG056658.
InParanoidiQ8TEU7.
KOiK08020.
OMAiQPSHPKL.
OrthoDBiEOG71VSRT.
PhylomeDBiQ8TEU7.
TreeFamiTF313184.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to Basket

Also known as: PDZ-GEF2A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS
60 70 80 90 100
ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG
110 120 130 140 150
GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE
160 170 180 190 200
RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG
210 220 230 240 250
SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD
260 270 280 290 300
LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
310 320 330 340 350
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL
360 370 380 390 400
DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH
410 420 430 440 450
EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF
460 470 480 490 500
LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE
510 520 530 540 550
EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS
560 570 580 590 600
EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
610 620 630 640 650
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG
660 670 680 690 700
DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ
710 720 730 740 750
SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD
760 770 780 790 800
QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV
810 820 830 840 850
TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK
860 870 880 890 900
ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
910 920 930 940 950
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM
960 970 980 990 1000
FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL
1010 1020 1030 1040 1050
SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV
1060 1070 1080 1090 1100
VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK
1110 1120 1130 1140 1150
LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS
1160 1170 1180 1190 1200
AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
1210 1220 1230 1240 1250
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY
1260 1270 1280 1290 1300
TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV
1310 1320 1330 1340 1350
PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ
1360 1370 1380 1390 1400
EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI
1410 1420 1430 1440 1450
AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV
1460 1470 1480 1490 1500
KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
1510 1520 1530 1540 1550
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP
1560 1570 1580 1590 1600
PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA

V
Length:1,601
Mass (Da):179,423
Last modified:November 30, 2010 - v2
Checksum:iCF4C5407EB61EEE2
GO
Isoform 2 (identifier: Q8TEU7-2) [UniParc]FASTAAdd to Basket

Also known as: PDZ-GEF2B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1391: GYTLIPSAKS...PKSWDFLNSY → VGSIISDHSS...RFKSKRRKTL
     1392-1601: Missing.

Show »
Length:1,391
Mass (Da):157,540
Checksum:i479E95ACE48D3938
GO
Isoform 3 (identifier: Q8TEU7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     747-747: D → AVGFYY
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,509
Mass (Da):169,500
Checksum:i726CDBA718C65649
GO
Isoform 4 (identifier: Q8TEU7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG

Note: No experimental confirmation available.

Show »
Length:1,609
Mass (Da):180,435
Checksum:i2674B9180DEB7FCC
GO
Isoform 5 (identifier: Q8TEU7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,504
Mass (Da):168,914
Checksum:i52E76A090032E29F
GO
Isoform 6 (identifier: Q8TEU7-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     828-1601: Missing.

Note: No experimental confirmation available.

Show »
Length:827
Mass (Da):93,442
Checksum:i2EF5931EDE350449
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti566 – 5661K → E in AAL79915. (PubMed:12581858)Curated
Sequence conflicti566 – 5661K → E in AAL79916. (PubMed:12581858)Curated
Sequence conflicti619 – 6191L → P in AAL79915. (PubMed:12581858)Curated
Sequence conflicti619 – 6191L → P in AAL79916. (PubMed:12581858)Curated
Sequence conflicti637 – 6371E → K in AAL79915. (PubMed:12581858)Curated
Sequence conflicti637 – 6371E → K in AAL79916. (PubMed:12581858)Curated
Sequence conflicti669 – 6691V → A in AAL79915. (PubMed:12581858)Curated
Sequence conflicti669 – 6691V → A in AAL79916. (PubMed:12581858)Curated
Sequence conflicti749 – 7491P → A in AAI42965. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti570 – 5701S → A.
Corresponds to variant rs3756293 [ dbSNP | Ensembl ].
VAR_057168
Natural varianti594 – 5941A → P.
Corresponds to variant rs34112735 [ dbSNP | Ensembl ].
VAR_057169
Natural varianti1353 – 13531I → V.
Corresponds to variant rs7717835 [ dbSNP | Ensembl ].
VAR_057170
Natural varianti1452 – 14521Q → R.3 Publications
Corresponds to variant rs1291602 [ dbSNP | Ensembl ].
VAR_059793
Natural varianti1559 – 15591V → E.
Corresponds to variant rs1064539 [ dbSNP | Ensembl ].
VAR_057171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei747 – 7471D → AVGFYY in isoform 3. 1 PublicationVSP_050607
Alternative sequencei828 – 1601774Missing in isoform 6. 1 PublicationVSP_045027Add
BLAST
Alternative sequencei1067 – 10671R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_050608
Alternative sequencei1249 – 1391143GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationVSP_050610Add
BLAST
Alternative sequencei1392 – 1601210Missing in isoform 2. 1 PublicationVSP_050611Add
BLAST
Alternative sequencei1489 – 1593105Missing in isoform 3 and isoform 5. 2 PublicationsVSP_050609Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA. Translation: AAL79915.1.
AF478469 mRNA. Translation: AAL79916.1.
AF478567 mRNA. Translation: AAM21637.1.
AF394782 mRNA. Translation: AAK83368.1.
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC133703 mRNA. Translation: AAI33704.1.
BC142964 mRNA. Translation: AAI42965.1.
BC144627 mRNA. Translation: AAI44628.1.
CCDSiCCDS34225.1. [Q8TEU7-1]
CCDS54897.1. [Q8TEU7-6]
CCDS54898.1. [Q8TEU7-2]
CCDS54899.1. [Q8TEU7-5]
CCDS54900.1. [Q8TEU7-4]
RefSeqiNP_001157858.1. NM_001164386.1. [Q8TEU7-4]
NP_001157859.1. NM_001164387.1. [Q8TEU7-3]
NP_001157860.1. NM_001164388.1. [Q8TEU7-5]
NP_001157861.1. NM_001164389.1. [Q8TEU7-2]
NP_001157862.1. NM_001164390.1. [Q8TEU7-6]
NP_057424.3. NM_016340.5. [Q8TEU7-1]
UniGeneiHs.483329.

Genome annotation databases

GeneIDi51735.
KEGGihsa:51735.
UCSCiuc003kvn.2. human. [Q8TEU7-1]
uc003kvo.2. human. [Q8TEU7-3]
uc003kvr.3. human. [Q8TEU7-2]
uc010jdi.2. human. [Q8TEU7-4]
uc010jdj.2. human. [Q8TEU7-5]

Polymorphism databases

DMDMi313104174.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA. Translation: AAL79915.1 .
AF478469 mRNA. Translation: AAL79916.1 .
AF478567 mRNA. Translation: AAM21637.1 .
AF394782 mRNA. Translation: AAK83368.1 .
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC133703 mRNA. Translation: AAI33704.1 .
BC142964 mRNA. Translation: AAI42965.1 .
BC144627 mRNA. Translation: AAI44628.1 .
CCDSi CCDS34225.1. [Q8TEU7-1 ]
CCDS54897.1. [Q8TEU7-6 ]
CCDS54898.1. [Q8TEU7-2 ]
CCDS54899.1. [Q8TEU7-5 ]
CCDS54900.1. [Q8TEU7-4 ]
RefSeqi NP_001157858.1. NM_001164386.1. [Q8TEU7-4 ]
NP_001157859.1. NM_001164387.1. [Q8TEU7-3 ]
NP_001157860.1. NM_001164388.1. [Q8TEU7-5 ]
NP_001157861.1. NM_001164389.1. [Q8TEU7-2 ]
NP_001157862.1. NM_001164390.1. [Q8TEU7-6 ]
NP_057424.3. NM_016340.5. [Q8TEU7-1 ]
UniGenei Hs.483329.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D93 NMR - A 265-385 [» ]
3LNY X-ray 1.30 B 1596-1601 [» ]
ProteinModelPortali Q8TEU7.
SMRi Q8TEU7. Positions 268-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119705. 7 interactions.
IntActi Q8TEU7. 5 interactions.
MINTi MINT-8283239.
STRINGi 9606.ENSP00000296859.

PTM databases

PhosphoSitei Q8TEU7.

Polymorphism databases

DMDMi 313104174.

Proteomic databases

MaxQBi Q8TEU7.
PaxDbi Q8TEU7.
PRIDEi Q8TEU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 51735.
KEGGi hsa:51735.
UCSCi uc003kvn.2. human. [Q8TEU7-1 ]
uc003kvo.2. human. [Q8TEU7-3 ]
uc003kvr.3. human. [Q8TEU7-2 ]
uc010jdi.2. human. [Q8TEU7-4 ]
uc010jdj.2. human. [Q8TEU7-5 ]

Organism-specific databases

CTDi 51735.
GeneCardsi GC05M130759.
H-InvDB HIX0005150.
HIX0078163.
HGNCi HGNC:20655. RAPGEF6.
HPAi HPA037982.
HPA037983.
MIMi 610499. gene.
neXtProti NX_Q8TEU7.
PharmGKBi PA134885793.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307777.
GeneTreei ENSGT00770000120448.
HOVERGENi HBG056658.
InParanoidi Q8TEU7.
KOi K08020.
OMAi QPSHPKL.
OrthoDBi EOG71VSRT.
PhylomeDBi Q8TEU7.
TreeFami TF313184.

Miscellaneous databases

ChiTaRSi RAPGEF6. human.
EvolutionaryTracei Q8TEU7.
GeneWikii RAPGEF6.
GenomeRNAii 51735.
NextBioi 55804.
PROi Q8TEU7.
SOURCEi Search...

Gene expression databases

Bgeei Q8TEU7.
CleanExi HS_RAPGEF6.
ExpressionAtlasi Q8TEU7. baseline and differential.
Genevestigatori Q8TEU7.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 2 hits.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2."
    Kuiperij H.B., de Rooij J., Rehmann H., van Triest M., Wittinghofer A., Bos J.L., Zwartkruis F.J.T.
    Biochim. Biophys. Acta 1593:141-149(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, VARIANT ARG-1452.
  2. "A PDZ domain containing guanine exchange factor (GEF) interacts with the second PDZ domain of human PTP1e."
    Banville D., Murthy K., Shen S., Clark K., Fortin Y.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, VARIANT ARG-1452.
  3. "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras."
    Gao X., Satoh T., Liao Y., Song C., Hu C.-D., Kariya K., Kataoka T.
    J. Biol. Chem. 276:42219-42225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-1452.
    Tissue: Fetal brain1 Publication.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    Tissue: Brain.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of the cNMP-binding domain of human Rap guanine nucleotide exchange factor 6."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 265-386.

Entry informationi

Entry nameiRPGF6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEU7
Secondary accession number(s): A3KN82
, A5PLL6, B7ZML2, E9PDV7, Q8NI21, Q8TEU6, Q96PC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3