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Q8TEU7

- RPGF6_HUMAN

UniProt

Q8TEU7 - RPGF6_HUMAN

Protein

Rap guanine nucleotide exchange factor 6

Gene

RAPGEF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi280 – 399120cNMPAdd
    BLAST

    GO - Molecular functioni

    1. GTP-dependent protein binding Source: UniProtKB
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB
    3. protein binding Source: IntAct
    4. Ras GTPase binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. Ras protein signal transduction Source: UniProtKB
    3. regulation of GTPase activity Source: UniProtKB
    4. regulation of small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 6
    Alternative name(s):
    PDZ domain-containing guanine nucleotide exchange factor 2
    Short name:
    PDZ-GEF2
    RA-GEF-2
    Gene namesi
    Name:RAPGEF6
    Synonyms:PDZGEF2
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20655. RAPGEF6.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication
    Note: Upon binding to M-Ras, it translocates to the plasma membrane.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134885793.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16011601Rap guanine nucleotide exchange factor 6PRO_0000068876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8TEU7.
    PaxDbiQ8TEU7.
    PRIDEiQ8TEU7.

    PTM databases

    PhosphoSiteiQ8TEU7.

    Expressioni

    Tissue specificityi

    Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ8TEU7.
    BgeeiQ8TEU7.
    CleanExiHS_RAPGEF6.
    GenevestigatoriQ8TEU7.

    Organism-specific databases

    HPAiHPA037982.
    HPA037983.

    Interactioni

    Subunit structurei

    Interacts with the second PDZ domain of human PTP1e.1 PublicationCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PTPN13Q129234EBI-2693017,EBI-355227

    Protein-protein interaction databases

    BioGridi119705. 7 interactions.
    IntActiQ8TEU7. 5 interactions.
    MINTiMINT-8283239.
    STRINGi9606.ENSP00000296859.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi267 – 27711
    Turni280 – 2823
    Helixi286 – 2927
    Turni293 – 2953
    Beta strandi296 – 3016
    Beta strandi303 – 3053
    Beta strandi307 – 3093
    Beta strandi317 – 3204
    Beta strandi326 – 3294
    Beta strandi331 – 3333
    Beta strandi335 – 3384
    Beta strandi343 – 3453
    Beta strandi348 – 3503
    Beta strandi357 – 37216
    Helixi373 – 3797
    Beta strandi1598 – 16014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D93NMR-A265-385[»]
    3LNYX-ray1.30B1596-1601[»]
    ProteinModelPortaliQ8TEU7.
    SMRiQ8TEU7. Positions 268-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TEU7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini412 – 526115N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini530 – 61586PDZCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini749 – 83587Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini860 – 1088229Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1229 – 1440212Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.CuratedPROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.CuratedPROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307777.
    HOVERGENiHBG056658.
    KOiK08020.
    OMAiQPSHPKL.
    OrthoDBiEOG71VSRT.
    PhylomeDBiQ8TEU7.
    TreeFamiTF313184.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to Basket

    Also known as: PDZ-GEF2A1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS     50
    ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG 100
    GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE 150
    RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG 200
    SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD 250
    LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV 300
    VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL 350
    DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH 400
    EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF 450
    LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE 500
    EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS 550
    EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN 600
    NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG 650
    DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ 700
    SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD 750
    QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV 800
    TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK 850
    ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL 900
    KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM 950
    FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL 1000
    SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV 1050
    VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK 1100
    LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS 1150
    AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD 1200
    PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY 1250
    TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV 1300
    PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ 1350
    EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI 1400
    AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV 1450
    KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR 1500
    YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP 1550
    PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA 1600
    V 1601
    Length:1,601
    Mass (Da):179,423
    Last modified:November 30, 2010 - v2
    Checksum:iCF4C5407EB61EEE2
    GO
    Isoform 2 (identifier: Q8TEU7-2) [UniParc]FASTAAdd to Basket

    Also known as: PDZ-GEF2B1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1249-1391: GYTLIPSAKS...PKSWDFLNSY → VGSIISDHSS...RFKSKRRKTL
         1392-1601: Missing.

    Show »
    Length:1,391
    Mass (Da):157,540
    Checksum:i479E95ACE48D3938
    GO
    Isoform 3 (identifier: Q8TEU7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         747-747: D → AVGFYY
         1067-1067: R → RKKRWRSLG
         1489-1593: Missing.

    Show »
    Length:1,509
    Mass (Da):169,500
    Checksum:i726CDBA718C65649
    GO
    Isoform 4 (identifier: Q8TEU7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1067-1067: R → RKKRWRSLG

    Note: No experimental confirmation available.

    Show »
    Length:1,609
    Mass (Da):180,435
    Checksum:i2674B9180DEB7FCC
    GO
    Isoform 5 (identifier: Q8TEU7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1067-1067: R → RKKRWRSLG
         1489-1593: Missing.

    Show »
    Length:1,504
    Mass (Da):168,914
    Checksum:i52E76A090032E29F
    GO
    Isoform 6 (identifier: Q8TEU7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         828-1601: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:827
    Mass (Da):93,442
    Checksum:i2EF5931EDE350449
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti566 – 5661K → E in AAL79915. (PubMed:12581858)Curated
    Sequence conflicti566 – 5661K → E in AAL79916. (PubMed:12581858)Curated
    Sequence conflicti619 – 6191L → P in AAL79915. (PubMed:12581858)Curated
    Sequence conflicti619 – 6191L → P in AAL79916. (PubMed:12581858)Curated
    Sequence conflicti637 – 6371E → K in AAL79915. (PubMed:12581858)Curated
    Sequence conflicti637 – 6371E → K in AAL79916. (PubMed:12581858)Curated
    Sequence conflicti669 – 6691V → A in AAL79915. (PubMed:12581858)Curated
    Sequence conflicti669 – 6691V → A in AAL79916. (PubMed:12581858)Curated
    Sequence conflicti749 – 7491P → A in AAI42965. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti570 – 5701S → A.
    Corresponds to variant rs3756293 [ dbSNP | Ensembl ].
    VAR_057168
    Natural varianti594 – 5941A → P.
    Corresponds to variant rs34112735 [ dbSNP | Ensembl ].
    VAR_057169
    Natural varianti1353 – 13531I → V.
    Corresponds to variant rs7717835 [ dbSNP | Ensembl ].
    VAR_057170
    Natural varianti1452 – 14521Q → R.3 Publications
    Corresponds to variant rs1291602 [ dbSNP | Ensembl ].
    VAR_059793
    Natural varianti1559 – 15591V → E.
    Corresponds to variant rs1064539 [ dbSNP | Ensembl ].
    VAR_057171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei747 – 7471D → AVGFYY in isoform 3. 1 PublicationVSP_050607
    Alternative sequencei828 – 1601774Missing in isoform 6. 1 PublicationVSP_045027Add
    BLAST
    Alternative sequencei1067 – 10671R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_050608
    Alternative sequencei1249 – 1391143GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationVSP_050610Add
    BLAST
    Alternative sequencei1392 – 1601210Missing in isoform 2. 1 PublicationVSP_050611Add
    BLAST
    Alternative sequencei1489 – 1593105Missing in isoform 3 and isoform 5. 2 PublicationsVSP_050609Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF478468 mRNA. Translation: AAL79915.1.
    AF478469 mRNA. Translation: AAL79916.1.
    AF478567 mRNA. Translation: AAM21637.1.
    AF394782 mRNA. Translation: AAK83368.1.
    AC004227 Genomic DNA. No translation available.
    AC004622 Genomic DNA. No translation available.
    AC008497 Genomic DNA. No translation available.
    AC008695 Genomic DNA. No translation available.
    AC026754 Genomic DNA. No translation available.
    BC133703 mRNA. Translation: AAI33704.1.
    BC142964 mRNA. Translation: AAI42965.1.
    BC144627 mRNA. Translation: AAI44628.1.
    CCDSiCCDS34225.1. [Q8TEU7-1]
    CCDS54897.1. [Q8TEU7-6]
    CCDS54898.1. [Q8TEU7-2]
    CCDS54899.1. [Q8TEU7-5]
    CCDS54900.1. [Q8TEU7-4]
    CCDS54901.1. [Q8TEU7-3]
    RefSeqiNP_001157858.1. NM_001164386.1. [Q8TEU7-4]
    NP_001157859.1. NM_001164387.1. [Q8TEU7-3]
    NP_001157860.1. NM_001164388.1. [Q8TEU7-5]
    NP_001157861.1. NM_001164389.1. [Q8TEU7-2]
    NP_001157862.1. NM_001164390.1. [Q8TEU7-6]
    NP_057424.3. NM_016340.5. [Q8TEU7-1]
    UniGeneiHs.483329.

    Genome annotation databases

    EnsembliENST00000296859; ENSP00000296859; ENSG00000158987. [Q8TEU7-4]
    ENST00000307984; ENSP00000309298; ENSG00000158987. [Q8TEU7-3]
    ENST00000308008; ENSP00000311419; ENSG00000158987. [Q8TEU7-2]
    ENST00000507093; ENSP00000426081; ENSG00000158987. [Q8TEU7-5]
    ENST00000509018; ENSP00000421684; ENSG00000158987. [Q8TEU7-1]
    ENST00000510071; ENSP00000425389; ENSG00000158987. [Q8TEU7-6]
    GeneIDi51735.
    KEGGihsa:51735.
    UCSCiuc003kvn.2. human. [Q8TEU7-1]
    uc003kvo.2. human. [Q8TEU7-3]
    uc003kvr.3. human. [Q8TEU7-2]
    uc010jdi.2. human. [Q8TEU7-4]
    uc010jdj.2. human. [Q8TEU7-5]

    Polymorphism databases

    DMDMi313104174.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF478468 mRNA. Translation: AAL79915.1 .
    AF478469 mRNA. Translation: AAL79916.1 .
    AF478567 mRNA. Translation: AAM21637.1 .
    AF394782 mRNA. Translation: AAK83368.1 .
    AC004227 Genomic DNA. No translation available.
    AC004622 Genomic DNA. No translation available.
    AC008497 Genomic DNA. No translation available.
    AC008695 Genomic DNA. No translation available.
    AC026754 Genomic DNA. No translation available.
    BC133703 mRNA. Translation: AAI33704.1 .
    BC142964 mRNA. Translation: AAI42965.1 .
    BC144627 mRNA. Translation: AAI44628.1 .
    CCDSi CCDS34225.1. [Q8TEU7-1 ]
    CCDS54897.1. [Q8TEU7-6 ]
    CCDS54898.1. [Q8TEU7-2 ]
    CCDS54899.1. [Q8TEU7-5 ]
    CCDS54900.1. [Q8TEU7-4 ]
    CCDS54901.1. [Q8TEU7-3 ]
    RefSeqi NP_001157858.1. NM_001164386.1. [Q8TEU7-4 ]
    NP_001157859.1. NM_001164387.1. [Q8TEU7-3 ]
    NP_001157860.1. NM_001164388.1. [Q8TEU7-5 ]
    NP_001157861.1. NM_001164389.1. [Q8TEU7-2 ]
    NP_001157862.1. NM_001164390.1. [Q8TEU7-6 ]
    NP_057424.3. NM_016340.5. [Q8TEU7-1 ]
    UniGenei Hs.483329.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D93 NMR - A 265-385 [» ]
    3LNY X-ray 1.30 B 1596-1601 [» ]
    ProteinModelPortali Q8TEU7.
    SMRi Q8TEU7. Positions 268-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119705. 7 interactions.
    IntActi Q8TEU7. 5 interactions.
    MINTi MINT-8283239.
    STRINGi 9606.ENSP00000296859.

    PTM databases

    PhosphoSitei Q8TEU7.

    Polymorphism databases

    DMDMi 313104174.

    Proteomic databases

    MaxQBi Q8TEU7.
    PaxDbi Q8TEU7.
    PRIDEi Q8TEU7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296859 ; ENSP00000296859 ; ENSG00000158987 . [Q8TEU7-4 ]
    ENST00000307984 ; ENSP00000309298 ; ENSG00000158987 . [Q8TEU7-3 ]
    ENST00000308008 ; ENSP00000311419 ; ENSG00000158987 . [Q8TEU7-2 ]
    ENST00000507093 ; ENSP00000426081 ; ENSG00000158987 . [Q8TEU7-5 ]
    ENST00000509018 ; ENSP00000421684 ; ENSG00000158987 . [Q8TEU7-1 ]
    ENST00000510071 ; ENSP00000425389 ; ENSG00000158987 . [Q8TEU7-6 ]
    GeneIDi 51735.
    KEGGi hsa:51735.
    UCSCi uc003kvn.2. human. [Q8TEU7-1 ]
    uc003kvo.2. human. [Q8TEU7-3 ]
    uc003kvr.3. human. [Q8TEU7-2 ]
    uc010jdi.2. human. [Q8TEU7-4 ]
    uc010jdj.2. human. [Q8TEU7-5 ]

    Organism-specific databases

    CTDi 51735.
    GeneCardsi GC05M130759.
    H-InvDB HIX0005150.
    HIX0078163.
    HGNCi HGNC:20655. RAPGEF6.
    HPAi HPA037982.
    HPA037983.
    MIMi 610499. gene.
    neXtProti NX_Q8TEU7.
    PharmGKBi PA134885793.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307777.
    HOVERGENi HBG056658.
    KOi K08020.
    OMAi QPSHPKL.
    OrthoDBi EOG71VSRT.
    PhylomeDBi Q8TEU7.
    TreeFami TF313184.

    Miscellaneous databases

    ChiTaRSi RAPGEF6. human.
    EvolutionaryTracei Q8TEU7.
    GeneWikii RAPGEF6.
    GenomeRNAii 51735.
    NextBioi 55804.
    PROi Q8TEU7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEU7.
    Bgeei Q8TEU7.
    CleanExi HS_RAPGEF6.
    Genevestigatori Q8TEU7.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2."
      Kuiperij H.B., de Rooij J., Rehmann H., van Triest M., Wittinghofer A., Bos J.L., Zwartkruis F.J.T.
      Biochim. Biophys. Acta 1593:141-149(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, VARIANT ARG-1452.
    2. "A PDZ domain containing guanine exchange factor (GEF) interacts with the second PDZ domain of human PTP1e."
      Banville D., Murthy K., Shen S., Clark K., Fortin Y.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, VARIANT ARG-1452.
    3. "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras."
      Gao X., Satoh T., Liao Y., Song C., Hu C.-D., Kariya K., Kataoka T.
      J. Biol. Chem. 276:42219-42225(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-1452.
      Tissue: Fetal brain1 Publication.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
      Tissue: Brain.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Solution structure of the cNMP-binding domain of human Rap guanine nucleotide exchange factor 6."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 265-386.

    Entry informationi

    Entry nameiRPGF6_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEU7
    Secondary accession number(s): A3KN82
    , A5PLL6, B7ZML2, E9PDV7, Q8NI21, Q8TEU6, Q96PC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3