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Protein

Rap guanine nucleotide exchange factor 6

Gene

RAPGEF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi280 – 399cNMPAdd BLAST120

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB
  • guanyl-nucleotide exchange factor activity Source: UniProtKB
  • phosphatidic acid binding Source: UniProtKB
  • Ras GTPase binding Source: UniProtKB

GO - Biological processi

  • microvillus assembly Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • Ras protein signal transduction Source: UniProtKB
  • regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNORiQ8TEU7.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 6
Alternative name(s):
PDZ domain-containing guanine nucleotide exchange factor 2
Short name:
PDZ-GEF2
RA-GEF-2
Gene namesi
Name:RAPGEF6
Synonyms:PDZGEF2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20655. RAPGEF6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication

  • Note: Upon binding to M-Ras, it translocates to the plasma membrane.

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cytosol Source: UniProtKB
  • endocytic vesicle Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51735.
OpenTargetsiENSG00000158987.
PharmGKBiPA134885793.

Polymorphism and mutation databases

BioMutaiRAPGEF6.
DMDMi313104174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688761 – 1601Rap guanine nucleotide exchange factor 6Add BLAST1601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TEU7.
MaxQBiQ8TEU7.
PaxDbiQ8TEU7.
PeptideAtlasiQ8TEU7.
PRIDEiQ8TEU7.

PTM databases

iPTMnetiQ8TEU7.
PhosphoSitePlusiQ8TEU7.

Expressioni

Tissue specificityi

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000158987.
CleanExiHS_RAPGEF6.
ExpressionAtlasiQ8TEU7. baseline and differential.
GenevisibleiQ8TEU7. HS.

Organism-specific databases

HPAiHPA037982.
HPA037983.

Interactioni

Subunit structurei

Interacts with the second PDZ domain of human PTP1e.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN13Q129234EBI-2693017,EBI-355227

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB
  • Ras GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119705. 18 interactors.
IntActiQ8TEU7. 12 interactors.
MINTiMINT-8283239.
STRINGi9606.ENSP00000296859.

Structurei

Secondary structure

11601
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi267 – 277Combined sources11
Turni280 – 282Combined sources3
Helixi286 – 292Combined sources7
Turni293 – 295Combined sources3
Beta strandi296 – 301Combined sources6
Beta strandi303 – 305Combined sources3
Beta strandi307 – 309Combined sources3
Beta strandi317 – 320Combined sources4
Beta strandi326 – 329Combined sources4
Beta strandi331 – 333Combined sources3
Beta strandi335 – 338Combined sources4
Beta strandi343 – 345Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi357 – 372Combined sources16
Helixi373 – 379Combined sources7
Beta strandi1598 – 1601Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D93NMR-A265-385[»]
3LNYX-ray1.30B1596-1601[»]
ProteinModelPortaliQ8TEU7.
SMRiQ8TEU7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TEU7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 526N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST115
Domaini530 – 615PDZPROSITE-ProRule annotationCuratedAdd BLAST86
Domaini749 – 835Ras-associatingPROSITE-ProRule annotationAdd BLAST87
Domaini860 – 1088Ras-GEFPROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1229 – 1440Ser-richAdd BLAST212

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotationCurated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiKOG3542. Eukaryota.
ENOG410XS6B. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000247009.
HOVERGENiHBG056658.
InParanoidiQ8TEU7.
KOiK08020.
OMAiQPSHPKL.
OrthoDBiEOG091G00NU.
PhylomeDBiQ8TEU7.
TreeFamiTF313184.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS
60 70 80 90 100
ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG
110 120 130 140 150
GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE
160 170 180 190 200
RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG
210 220 230 240 250
SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD
260 270 280 290 300
LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
310 320 330 340 350
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL
360 370 380 390 400
DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH
410 420 430 440 450
EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF
460 470 480 490 500
LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE
510 520 530 540 550
EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS
560 570 580 590 600
EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
610 620 630 640 650
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG
660 670 680 690 700
DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ
710 720 730 740 750
SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD
760 770 780 790 800
QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV
810 820 830 840 850
TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK
860 870 880 890 900
ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
910 920 930 940 950
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM
960 970 980 990 1000
FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL
1010 1020 1030 1040 1050
SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV
1060 1070 1080 1090 1100
VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK
1110 1120 1130 1140 1150
LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS
1160 1170 1180 1190 1200
AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
1210 1220 1230 1240 1250
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY
1260 1270 1280 1290 1300
TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV
1310 1320 1330 1340 1350
PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ
1360 1370 1380 1390 1400
EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI
1410 1420 1430 1440 1450
AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV
1460 1470 1480 1490 1500
KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
1510 1520 1530 1540 1550
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP
1560 1570 1580 1590 1600
PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA

V
Length:1,601
Mass (Da):179,423
Last modified:November 30, 2010 - v2
Checksum:iCF4C5407EB61EEE2
GO
Isoform 2 (identifier: Q8TEU7-2) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1391: GYTLIPSAKS...PKSWDFLNSY → VGSIISDHSS...RFKSKRRKTL
     1392-1601: Missing.

Show »
Length:1,391
Mass (Da):157,540
Checksum:i479E95ACE48D3938
GO
Isoform 3 (identifier: Q8TEU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     747-747: D → AVGFYY
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,509
Mass (Da):169,500
Checksum:i726CDBA718C65649
GO
Isoform 4 (identifier: Q8TEU7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG

Note: No experimental confirmation available.
Show »
Length:1,609
Mass (Da):180,435
Checksum:i2674B9180DEB7FCC
GO
Isoform 5 (identifier: Q8TEU7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,504
Mass (Da):168,914
Checksum:i52E76A090032E29F
GO
Isoform 6 (identifier: Q8TEU7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     828-1601: Missing.

Note: No experimental confirmation available.
Show »
Length:827
Mass (Da):93,442
Checksum:i2EF5931EDE350449
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti566K → E in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti566K → E in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti749P → A in AAI42965 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057168570S → A.Corresponds to variant rs3756293dbSNPEnsembl.1
Natural variantiVAR_057169594A → P.Corresponds to variant rs34112735dbSNPEnsembl.1
Natural variantiVAR_0571701353I → V.Corresponds to variant rs7717835dbSNPEnsembl.1
Natural variantiVAR_0597931452Q → R.3 PublicationsCorresponds to variant rs1291602dbSNPEnsembl.1
Natural variantiVAR_0571711559V → E.Corresponds to variant rs1064539dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050607747D → AVGFYY in isoform 3. 1 Publication1
Alternative sequenceiVSP_045027828 – 1601Missing in isoform 6. 1 PublicationAdd BLAST774
Alternative sequenceiVSP_0506081067R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0506101249 – 1391GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_0506111392 – 1601Missing in isoform 2. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_0506091489 – 1593Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA. Translation: AAL79915.1.
AF478469 mRNA. Translation: AAL79916.1.
AF478567 mRNA. Translation: AAM21637.1.
AF394782 mRNA. Translation: AAK83368.1.
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC133703 mRNA. Translation: AAI33704.1.
BC142964 mRNA. Translation: AAI42965.1.
BC144627 mRNA. Translation: AAI44628.1.
CCDSiCCDS34225.1. [Q8TEU7-1]
CCDS54897.1. [Q8TEU7-6]
CCDS54898.1. [Q8TEU7-2]
CCDS54899.1. [Q8TEU7-5]
CCDS54900.1. [Q8TEU7-4]
CCDS54901.1. [Q8TEU7-3]
RefSeqiNP_001157858.1. NM_001164386.1. [Q8TEU7-4]
NP_001157859.1. NM_001164387.1. [Q8TEU7-3]
NP_001157860.1. NM_001164388.1. [Q8TEU7-5]
NP_001157861.1. NM_001164389.1. [Q8TEU7-2]
NP_001157862.1. NM_001164390.1. [Q8TEU7-6]
NP_057424.3. NM_016340.5. [Q8TEU7-1]
UniGeneiHs.483329.

Genome annotation databases

EnsembliENST00000296859; ENSP00000296859; ENSG00000158987. [Q8TEU7-4]
ENST00000308008; ENSP00000311419; ENSG00000158987. [Q8TEU7-2]
ENST00000507093; ENSP00000426081; ENSG00000158987. [Q8TEU7-3]
ENST00000509018; ENSP00000421684; ENSG00000158987. [Q8TEU7-1]
ENST00000510071; ENSP00000425389; ENSG00000158987. [Q8TEU7-6]
ENST00000627212; ENSP00000487439; ENSG00000158987. [Q8TEU7-5]
GeneIDi51735.
KEGGihsa:51735.
UCSCiuc003kvn.2. human. [Q8TEU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA. Translation: AAL79915.1.
AF478469 mRNA. Translation: AAL79916.1.
AF478567 mRNA. Translation: AAM21637.1.
AF394782 mRNA. Translation: AAK83368.1.
AC004227 Genomic DNA. No translation available.
AC004622 Genomic DNA. No translation available.
AC008497 Genomic DNA. No translation available.
AC008695 Genomic DNA. No translation available.
AC026754 Genomic DNA. No translation available.
BC133703 mRNA. Translation: AAI33704.1.
BC142964 mRNA. Translation: AAI42965.1.
BC144627 mRNA. Translation: AAI44628.1.
CCDSiCCDS34225.1. [Q8TEU7-1]
CCDS54897.1. [Q8TEU7-6]
CCDS54898.1. [Q8TEU7-2]
CCDS54899.1. [Q8TEU7-5]
CCDS54900.1. [Q8TEU7-4]
CCDS54901.1. [Q8TEU7-3]
RefSeqiNP_001157858.1. NM_001164386.1. [Q8TEU7-4]
NP_001157859.1. NM_001164387.1. [Q8TEU7-3]
NP_001157860.1. NM_001164388.1. [Q8TEU7-5]
NP_001157861.1. NM_001164389.1. [Q8TEU7-2]
NP_001157862.1. NM_001164390.1. [Q8TEU7-6]
NP_057424.3. NM_016340.5. [Q8TEU7-1]
UniGeneiHs.483329.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D93NMR-A265-385[»]
3LNYX-ray1.30B1596-1601[»]
ProteinModelPortaliQ8TEU7.
SMRiQ8TEU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119705. 18 interactors.
IntActiQ8TEU7. 12 interactors.
MINTiMINT-8283239.
STRINGi9606.ENSP00000296859.

PTM databases

iPTMnetiQ8TEU7.
PhosphoSitePlusiQ8TEU7.

Polymorphism and mutation databases

BioMutaiRAPGEF6.
DMDMi313104174.

Proteomic databases

EPDiQ8TEU7.
MaxQBiQ8TEU7.
PaxDbiQ8TEU7.
PeptideAtlasiQ8TEU7.
PRIDEiQ8TEU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296859; ENSP00000296859; ENSG00000158987. [Q8TEU7-4]
ENST00000308008; ENSP00000311419; ENSG00000158987. [Q8TEU7-2]
ENST00000507093; ENSP00000426081; ENSG00000158987. [Q8TEU7-3]
ENST00000509018; ENSP00000421684; ENSG00000158987. [Q8TEU7-1]
ENST00000510071; ENSP00000425389; ENSG00000158987. [Q8TEU7-6]
ENST00000627212; ENSP00000487439; ENSG00000158987. [Q8TEU7-5]
GeneIDi51735.
KEGGihsa:51735.
UCSCiuc003kvn.2. human. [Q8TEU7-1]

Organism-specific databases

CTDi51735.
DisGeNETi51735.
GeneCardsiRAPGEF6.
H-InvDBHIX0005150.
HIX0078163.
HGNCiHGNC:20655. RAPGEF6.
HPAiHPA037982.
HPA037983.
MIMi610499. gene.
neXtProtiNX_Q8TEU7.
OpenTargetsiENSG00000158987.
PharmGKBiPA134885793.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3542. Eukaryota.
ENOG410XS6B. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000247009.
HOVERGENiHBG056658.
InParanoidiQ8TEU7.
KOiK08020.
OMAiQPSHPKL.
OrthoDBiEOG091G00NU.
PhylomeDBiQ8TEU7.
TreeFamiTF313184.

Enzyme and pathway databases

SIGNORiQ8TEU7.

Miscellaneous databases

ChiTaRSiRAPGEF6. human.
EvolutionaryTraceiQ8TEU7.
GeneWikiiRAPGEF6.
GenomeRNAii51735.
PROiQ8TEU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158987.
CleanExiHS_RAPGEF6.
ExpressionAtlasiQ8TEU7. baseline and differential.
GenevisibleiQ8TEU7. HS.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPGF6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEU7
Secondary accession number(s): A3KN82
, A5PLL6, B7ZML2, E9PDV7, Q8NI21, Q8TEU6, Q96PC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.