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Protein

Neutral alpha-glucosidase C

Gene

GANC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has alpha-glucosidase activity.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei511NucleophilePROSITE-ProRule annotation1
Active sitei514By similarity1
Active sitei587Proton donorBy similarity1

GO - Molecular functioni

  • alpha-1,4-glucosidase activity Source: UniProtKB
  • carbohydrate binding Source: InterPro
  • maltose alpha-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS08394-MONOMER.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral alpha-glucosidase C (EC:3.2.1.20)
Gene namesi
Name:GANC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:4139. GANC.

Pathology & Biotechi

Organism-specific databases

DisGeNETi2595.
OpenTargetsiENSG00000214013.
PharmGKBiPA28552.

Chemistry databases

ChEMBLiCHEMBL2520.
DrugBankiDB00491. Miglitol.

Polymorphism and mutation databases

BioMutaiGANC.
DMDMi296439340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853641 – 914Neutral alpha-glucosidase CAdd BLAST914

Proteomic databases

EPDiQ8TET4.
MaxQBiQ8TET4.
PaxDbiQ8TET4.
PeptideAtlasiQ8TET4.
PRIDEiQ8TET4.

PTM databases

iPTMnetiQ8TET4.
PhosphoSitePlusiQ8TET4.

Expressioni

Gene expression databases

BgeeiENSG00000214013.
ExpressionAtlasiQ8TET4. baseline and differential.
GenevisibleiQ8TET4. HS.

Organism-specific databases

HPAiHPA016949.

Interactioni

Protein-protein interaction databases

BioGridi108866. 2 interactors.
IntActiQ8TET4. 2 interactors.
STRINGi9606.ENSP00000326227.

Chemistry databases

BindingDBiQ8TET4.

Structurei

3D structure databases

ProteinModelPortaliQ8TET4.
SMRiQ8TET4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
HOGENOMiHOG000115864.
HOVERGENiHBG051683.
InParanoidiQ8TET4.
KOiK12317.
OMAiMQKNAIH.
OrthoDBiEOG091G01CC.
PhylomeDBiQ8TET4.
TreeFamiTF300337.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TET4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV
60 70 80 90 100
TTDEDSTRFQ IINEASKVPL LAEIYGIEGN IFRLKINEET PLKPRFEVPD
110 120 130 140 150
VLTSKPSTVR LISCSGDTGS LILADGKGDL KCHITANPFK VDLVSEEEVV
160 170 180 190 200
ISINSLGQLY FEHLQILHKQ RAAKENEEET SVDTSQENQE DLGLWEEKFG
210 220 230 240 250
KFVDIKANGP SSIGLDFSLH GFEHLYGIPQ HAESHQLKNT GDGDAYRLYN
260 270 280 290 300
LDVYGYQIYD KMGIYGSVPY LLAHKLGRTI GIFWLNASET LVEINTEPAV
310 320 330 340 350
EYTLTQMGPV AAKQKVRSRT HVHWMSESGI IDVFLLTGPT PSDVFKQYSH
360 370 380 390 400
LTGTQAMPPL FSLGYHQCRW NYEDEQDVKA VDAGFDEHDI PYDAMWLDIE
410 420 430 440 450
HTEGKRYFTW DKNRFPNPKR MQELLRSKKR KLVVISDPHI KIDPDYSVYV
460 470 480 490 500
KAKDQGFFVK NQEGEDFEGV CWPGLSSYLD FTNPKVREWY SSLFAFPVYQ
510 520 530 540 550
GSTDILFLWN DMNEPSVFRG PEQTMQKNAI HHGNWEHREL HNIYGFYHQM
560 570 580 590 600
ATAEGLIKRS KGKERPFVLT RSFFAGSQKY GAVWTGDNTA EWSNLKISIP
610 620 630 640 650
MLLTLSITGI SFCGADIGGF IGNPETELLV RWYQAGAYQP FFRGHATMNT
660 670 680 690 700
KRREPWLFGE EHTRLIREAI RERYGLLPYW YSLFYHAHVA SQPVMRPLWV
710 720 730 740 750
EFPDELKTFD MEDEYMLGSA LLVHPVTEPK ATTVDVFLPG SNEVWYDYKT
760 770 780 790 800
FAHWEGGCTV KIPVALDTIP VFQRGGSVIP IKTTVGKSTG WMTESSYGLR
810 820 830 840 850
VALSTKGSSV GELYLDDGHS FQYLHQKQFL HRKFSFCSSV LINSFADQRG
860 870 880 890 900
HYPSKCVVEK ILVLGFRKEP SSVTTHSSDG KDQPVAFTYC AKTSILSLEK
910
LSLNIATDWE VRII
Length:914
Mass (Da):104,334
Last modified:May 18, 2010 - v3
Checksum:i7AA10E180DA7FDC2
GO

Sequence cautioni

The sequence BAB84863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180T → A in AAO14993 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01898411L → V.3 PublicationsCorresponds to variant rs8043515dbSNPEnsembl.1
Natural variantiVAR_01898544Q → R.3 PublicationsCorresponds to variant rs8024732dbSNPEnsembl.1
Natural variantiVAR_018986153I → M.1 PublicationCorresponds to variant rs75876980dbSNPEnsembl.1
Natural variantiVAR_056237166I → V.Corresponds to variant rs16973015dbSNPEnsembl.1
Natural variantiVAR_018987443D → E.1 PublicationCorresponds to variant rs2578652dbSNPEnsembl.1
Natural variantiVAR_018988845F → S.1 PublicationCorresponds to variant rs7181742dbSNPEnsembl.1
Natural variantiVAR_018989848Q → R.1 PublicationCorresponds to variant rs7180279dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545044 mRNA. Translation: AAN74755.1.
AF545045 mRNA. Translation: AAN74756.1.
AF545046 mRNA. Translation: AAN74757.1.
AK074037 mRNA. Translation: BAB84863.1. Different initiation.
AC012651 Genomic DNA. No translation available.
AC022468 Genomic DNA. No translation available.
BC059406 mRNA. Translation: AAH59406.1.
BC093833 mRNA. Translation: AAH93833.1.
AF525397 mRNA. Translation: AAO14993.1.
CCDSiCCDS10084.1.
RefSeqiNP_937784.2. NM_198141.2.
UniGeneiHs.730806.

Genome annotation databases

EnsembliENST00000318010; ENSP00000326227; ENSG00000214013.
GeneIDi2595.
KEGGihsa:2595.
UCSCiuc001zpi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545044 mRNA. Translation: AAN74755.1.
AF545045 mRNA. Translation: AAN74756.1.
AF545046 mRNA. Translation: AAN74757.1.
AK074037 mRNA. Translation: BAB84863.1. Different initiation.
AC012651 Genomic DNA. No translation available.
AC022468 Genomic DNA. No translation available.
BC059406 mRNA. Translation: AAH59406.1.
BC093833 mRNA. Translation: AAH93833.1.
AF525397 mRNA. Translation: AAO14993.1.
CCDSiCCDS10084.1.
RefSeqiNP_937784.2. NM_198141.2.
UniGeneiHs.730806.

3D structure databases

ProteinModelPortaliQ8TET4.
SMRiQ8TET4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108866. 2 interactors.
IntActiQ8TET4. 2 interactors.
STRINGi9606.ENSP00000326227.

Chemistry databases

BindingDBiQ8TET4.
ChEMBLiCHEMBL2520.
DrugBankiDB00491. Miglitol.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

PTM databases

iPTMnetiQ8TET4.
PhosphoSitePlusiQ8TET4.

Polymorphism and mutation databases

BioMutaiGANC.
DMDMi296439340.

Proteomic databases

EPDiQ8TET4.
MaxQBiQ8TET4.
PaxDbiQ8TET4.
PeptideAtlasiQ8TET4.
PRIDEiQ8TET4.

Protocols and materials databases

DNASUi2595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318010; ENSP00000326227; ENSG00000214013.
GeneIDi2595.
KEGGihsa:2595.
UCSCiuc001zpi.4. human.

Organism-specific databases

CTDi2595.
DisGeNETi2595.
GeneCardsiGANC.
HGNCiHGNC:4139. GANC.
HPAiHPA016949.
MIMi104180. gene.
neXtProtiNX_Q8TET4.
OpenTargetsiENSG00000214013.
PharmGKBiPA28552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
HOGENOMiHOG000115864.
HOVERGENiHBG051683.
InParanoidiQ8TET4.
KOiK12317.
OMAiMQKNAIH.
OrthoDBiEOG091G01CC.
PhylomeDBiQ8TET4.
TreeFamiTF300337.

Enzyme and pathway databases

BioCyciZFISH:HS08394-MONOMER.

Miscellaneous databases

ChiTaRSiGANC. human.
GeneWikiiGANC.
GenomeRNAii2595.
PROiQ8TET4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214013.
ExpressionAtlasiQ8TET4. baseline and differential.
GenevisibleiQ8TET4. HS.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGANC_HUMAN
AccessioniPrimary (citable) accession number: Q8TET4
Secondary accession number(s): Q52LQ4
, Q8IWZ0, Q8IZM4, Q8IZM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.