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Q8TET4

- GANC_HUMAN

UniProt

Q8TET4 - GANC_HUMAN

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Protein

Neutral alpha-glucosidase C

Gene

GANC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Has alpha-glucosidase activity.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei511 – 5111NucleophilePROSITE-ProRule annotation
Active sitei514 – 5141By similarity
Active sitei587 – 5871Proton donorBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB
  2. carbohydrate binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral alpha-glucosidase C (EC:3.2.1.20)
Gene namesi
Name:GANC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:4139. GANC.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Neutral alpha-glucosidase CPRO_0000185364Add
BLAST

Proteomic databases

MaxQBiQ8TET4.
PaxDbiQ8TET4.
PRIDEiQ8TET4.

PTM databases

PhosphoSiteiQ8TET4.

Expressioni

Gene expression databases

BgeeiQ8TET4.
ExpressionAtlasiQ8TET4. baseline and differential.
GenevestigatoriQ8TET4.

Organism-specific databases

HPAiHPA016949.

Interactioni

Protein-protein interaction databases

BioGridi108866. 1 interaction.
STRINGi9606.ENSP00000326227.

Structurei

3D structure databases

ProteinModelPortaliQ8TET4.
SMRiQ8TET4. Positions 42-913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

eggNOGiCOG1501.
GeneTreeiENSGT00760000119229.
HOGENOMiHOG000115864.
HOVERGENiHBG051683.
InParanoidiQ8TET4.
KOiK12317.
OMAiLKCHITA.
OrthoDBiEOG7VQJDS.
PhylomeDBiQ8TET4.
TreeFamiTF300337.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TET4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV
60 70 80 90 100
TTDEDSTRFQ IINEASKVPL LAEIYGIEGN IFRLKINEET PLKPRFEVPD
110 120 130 140 150
VLTSKPSTVR LISCSGDTGS LILADGKGDL KCHITANPFK VDLVSEEEVV
160 170 180 190 200
ISINSLGQLY FEHLQILHKQ RAAKENEEET SVDTSQENQE DLGLWEEKFG
210 220 230 240 250
KFVDIKANGP SSIGLDFSLH GFEHLYGIPQ HAESHQLKNT GDGDAYRLYN
260 270 280 290 300
LDVYGYQIYD KMGIYGSVPY LLAHKLGRTI GIFWLNASET LVEINTEPAV
310 320 330 340 350
EYTLTQMGPV AAKQKVRSRT HVHWMSESGI IDVFLLTGPT PSDVFKQYSH
360 370 380 390 400
LTGTQAMPPL FSLGYHQCRW NYEDEQDVKA VDAGFDEHDI PYDAMWLDIE
410 420 430 440 450
HTEGKRYFTW DKNRFPNPKR MQELLRSKKR KLVVISDPHI KIDPDYSVYV
460 470 480 490 500
KAKDQGFFVK NQEGEDFEGV CWPGLSSYLD FTNPKVREWY SSLFAFPVYQ
510 520 530 540 550
GSTDILFLWN DMNEPSVFRG PEQTMQKNAI HHGNWEHREL HNIYGFYHQM
560 570 580 590 600
ATAEGLIKRS KGKERPFVLT RSFFAGSQKY GAVWTGDNTA EWSNLKISIP
610 620 630 640 650
MLLTLSITGI SFCGADIGGF IGNPETELLV RWYQAGAYQP FFRGHATMNT
660 670 680 690 700
KRREPWLFGE EHTRLIREAI RERYGLLPYW YSLFYHAHVA SQPVMRPLWV
710 720 730 740 750
EFPDELKTFD MEDEYMLGSA LLVHPVTEPK ATTVDVFLPG SNEVWYDYKT
760 770 780 790 800
FAHWEGGCTV KIPVALDTIP VFQRGGSVIP IKTTVGKSTG WMTESSYGLR
810 820 830 840 850
VALSTKGSSV GELYLDDGHS FQYLHQKQFL HRKFSFCSSV LINSFADQRG
860 870 880 890 900
HYPSKCVVEK ILVLGFRKEP SSVTTHSSDG KDQPVAFTYC AKTSILSLEK
910
LSLNIATDWE VRII
Length:914
Mass (Da):104,334
Last modified:May 18, 2010 - v3
Checksum:i7AA10E180DA7FDC2
GO

Sequence cautioni

The sequence BAB84863.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801T → A in AAO14993. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111L → V.3 Publications
Corresponds to variant rs8043515 [ dbSNP | Ensembl ].
VAR_018984
Natural varianti44 – 441Q → R.3 Publications
Corresponds to variant rs8024732 [ dbSNP | Ensembl ].
VAR_018985
Natural varianti153 – 1531I → M.1 Publication
Corresponds to variant rs75876980 [ dbSNP | Ensembl ].
VAR_018986
Natural varianti166 – 1661I → V.
Corresponds to variant rs16973015 [ dbSNP | Ensembl ].
VAR_056237
Natural varianti443 – 4431D → E.1 Publication
Corresponds to variant rs2578652 [ dbSNP | Ensembl ].
VAR_018987
Natural varianti845 – 8451F → S.1 Publication
Corresponds to variant rs7181742 [ dbSNP | Ensembl ].
VAR_018988
Natural varianti848 – 8481Q → R.1 Publication
Corresponds to variant rs7180279 [ dbSNP | Ensembl ].
VAR_018989

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545044 mRNA. Translation: AAN74755.1.
AF545045 mRNA. Translation: AAN74756.1.
AF545046 mRNA. Translation: AAN74757.1.
AK074037 mRNA. Translation: BAB84863.1. Different initiation.
AC012651 Genomic DNA. No translation available.
AC022468 Genomic DNA. No translation available.
BC059406 mRNA. Translation: AAH59406.1.
BC093833 mRNA. Translation: AAH93833.1.
AF525397 mRNA. Translation: AAO14993.1.
CCDSiCCDS10084.1.
RefSeqiNP_937784.2. NM_198141.2.
UniGeneiHs.730806.

Genome annotation databases

EnsembliENST00000318010; ENSP00000326227; ENSG00000214013.
GeneIDi2595.
KEGGihsa:2595.
UCSCiuc001zpi.3. human.

Polymorphism databases

DMDMi296439340.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545044 mRNA. Translation: AAN74755.1 .
AF545045 mRNA. Translation: AAN74756.1 .
AF545046 mRNA. Translation: AAN74757.1 .
AK074037 mRNA. Translation: BAB84863.1 . Different initiation.
AC012651 Genomic DNA. No translation available.
AC022468 Genomic DNA. No translation available.
BC059406 mRNA. Translation: AAH59406.1 .
BC093833 mRNA. Translation: AAH93833.1 .
AF525397 mRNA. Translation: AAO14993.1 .
CCDSi CCDS10084.1.
RefSeqi NP_937784.2. NM_198141.2.
UniGenei Hs.730806.

3D structure databases

ProteinModelPortali Q8TET4.
SMRi Q8TET4. Positions 42-913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108866. 1 interaction.
STRINGi 9606.ENSP00000326227.

Chemistry

BindingDBi Q8TET4.
ChEMBLi CHEMBL2520.
DrugBanki DB00491. Miglitol.

PTM databases

PhosphoSitei Q8TET4.

Polymorphism databases

DMDMi 296439340.

Proteomic databases

MaxQBi Q8TET4.
PaxDbi Q8TET4.
PRIDEi Q8TET4.

Protocols and materials databases

DNASUi 2595.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318010 ; ENSP00000326227 ; ENSG00000214013 .
GeneIDi 2595.
KEGGi hsa:2595.
UCSCi uc001zpi.3. human.

Organism-specific databases

CTDi 2595.
GeneCardsi GC15P042566.
HGNCi HGNC:4139. GANC.
HPAi HPA016949.
MIMi 104180. gene.
neXtProti NX_Q8TET4.
PharmGKBi PA28552.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1501.
GeneTreei ENSGT00760000119229.
HOGENOMi HOG000115864.
HOVERGENi HBG051683.
InParanoidi Q8TET4.
KOi K12317.
OMAi LKCHITA.
OrthoDBi EOG7VQJDS.
PhylomeDBi Q8TET4.
TreeFami TF300337.

Miscellaneous databases

ChiTaRSi GANC. human.
GeneWikii GANC.
GenomeRNAii 2595.
NextBioi 10263.
PROi Q8TET4.
SOURCEi Search...

Gene expression databases

Bgeei Q8TET4.
ExpressionAtlasi Q8TET4. baseline and differential.
Genevestigatori Q8TET4.

Family and domain databases

InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Computer assisted cloning of human neutral alpha glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31."
    Hirschhorn R., Huie M.L., Kasper J.S.
    Proc. Natl. Acad. Sci. U.S.A. 99:13642-13646(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-11; ARG-44; MET-153; GLU-443; SER-845 AND ARG-848, FUNCTION.
    Tissue: Lymphoid tissue.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Ohara O., Nagase T., Kikuno R., Okumura K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-11 AND ARG-44.
    Tissue: Spleen.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-11 AND ARG-44.
    Tissue: Colon and Placenta.
  5. Ben-Asher E.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 146-914.
    Tissue: Erythroid cell.

Entry informationi

Entry nameiGANC_HUMAN
AccessioniPrimary (citable) accession number: Q8TET4
Secondary accession number(s): Q52LQ4
, Q8IWZ0, Q8IZM4, Q8IZM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3