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Protein

Fas-binding factor 1

Gene

FBF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.2 Publications

GO - Biological processi

  • apical junction assembly Source: UniProtKB
  • cilium assembly Source: UniProtKB
  • establishment of epithelial cell polarity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:G66-33883-MONOMER.
ReactomeiR-HSA-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Fas-binding factor 1
Short name:
FBF-1
Alternative name(s):
Protein albatross
Gene namesi
Name:FBF1
Synonyms:ALB, KIAA1863
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24674. FBF1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-SubCell
  • centriole Source: UniProtKB
  • centrosome Source: HPA
  • ciliary transition fiber Source: MGI
  • cytosol Source: Reactome
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi85302.
OpenTargetsiENSG00000188878.

Polymorphism and mutation databases

BioMutaiFBF1.
DMDMi156630449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976461 – 1133Fas-binding factor 1Add BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TES7.
MaxQBiQ8TES7.
PaxDbiQ8TES7.
PeptideAtlasiQ8TES7.
PRIDEiQ8TES7.

PTM databases

iPTMnetiQ8TES7.
PhosphoSitePlusiQ8TES7.

Expressioni

Tissue specificityi

Present in various epithelial cells (at protein level).

Gene expression databases

BgeeiENSG00000188878.
CleanExiHS_FBF1.
ExpressionAtlasiQ8TES7. baseline and differential.
GenevisibleiQ8TES7. HS.

Organism-specific databases

HPAiHPA023677.

Interactioni

Subunit structurei

May interact with FAS cytoplasmic domain (By similarity). Interacts with PARD3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI3Q9P2A43EBI-10244131,EBI-742038
AESQ081173EBI-10244131,EBI-717810
BLZF1Q9H2G93EBI-10244131,EBI-2548012
CALCOCO2Q131373EBI-10244131,EBI-739580
CCDC102BA1A4H13EBI-10244131,EBI-10171570
CCDC67E9PJR53EBI-10244131,EBI-10177066
CCDC67Q05D603EBI-10244131,EBI-748597
CEP55D3DR373EBI-10244131,EBI-10173536
CEP63Q96MT83EBI-10244131,EBI-741977
CINPQ9BW663EBI-10244131,EBI-739784
FAM208BQ5VWN6-23EBI-10244131,EBI-10172380
GATA1P159763EBI-10244131,EBI-3909284
GOLGA2Q083793EBI-10244131,EBI-618309
IKZF3Q9UKT93EBI-10244131,EBI-747204
KRT13A1A4E93EBI-10244131,EBI-10171552
KRT31Q153233EBI-10244131,EBI-948001
KRT40Q6A1623EBI-10244131,EBI-10171697
LZTS2Q9BRK43EBI-10244131,EBI-741037
MEOX2A4D1273EBI-10244131,EBI-10172134
MID2Q9UJV3-23EBI-10244131,EBI-10172526
MIPOL1Q8TD103EBI-10244131,EBI-2548751
PNMA1Q8ND903EBI-10244131,EBI-302345
RBPMSQ930623EBI-10244131,EBI-740322
SSX2IPQ9Y2D83EBI-10244131,EBI-2212028
SUMO1P631653EBI-10244131,EBI-80140
TADA2AO754783EBI-10244131,EBI-742268
TEX11Q8IYF33EBI-10244131,EBI-742397
TMCC2Q7Z6C63EBI-10244131,EBI-10177480
TRAF1Q130773EBI-10244131,EBI-359224
TRIM23P364063EBI-10244131,EBI-740098
TRIM27P143733EBI-10244131,EBI-719493
TRIM54Q9BYV23EBI-10244131,EBI-2130429
TSGA10Q9BZW73EBI-10244131,EBI-744794
TTC32Q5I0X73EBI-10244131,EBI-8636434
USHBP1Q8N6Y03EBI-10244131,EBI-739895
VPS37BQ9H9H43EBI-10244131,EBI-4400866

Protein-protein interaction databases

BioGridi124465. 146 interactors.
IntActiQ8TES7. 128 interactors.
MINTiMINT-1413885.
STRINGi9606.ENSP00000324292.

Structurei

3D structure databases

ProteinModelPortaliQ8TES7.
SMRiQ8TES7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili577 – 727Sequence analysisAdd BLAST151
Coiled coili773 – 870Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi999 – 1045Gln-richAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFRT. Eukaryota.
ENOG4111RN4. LUCA.
GeneTreeiENSGT00720000108861.
HOGENOMiHOG000060115.
HOVERGENiHBG071428.
InParanoidiQ8TES7.
KOiK16471.
OrthoDBiEOG091G02RR.
PhylomeDBiQ8TES7.
TreeFamiTF328742.

Family and domain databases

InterProiIPR033561. FBF1.
[Graphical view]
PANTHERiPTHR33689:SF1. PTHR33689:SF1. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TES7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR TKSLLGDDVF
60 70 80 90 100
STMAGLEEAD AEVSGISEAD PQALLQAMKD LDGMDADILG LKKSNSAPSK
110 120 130 140 150
KAAKDPGKGE LPNHPKPAGG AIPTKKSLPS PSSSGHQNRR FSSEDLEDPL
160 170 180 190 200
RGLLSYDEGG ITKQPPVTQS KTASDKSPST VRDQGPSIPL TPGDTPIRKK
210 220 230 240 250
EELLFDDGDD IMATLGFGDS PKAEKRQIGD QEGPRPARST LDELLGRGMA
260 270 280 290 300
TKLLARPGTG EHREFKLDKK YQRPQDSEDM WGDEDFTFGA YQPTVVSSEG
310 320 330 340 350
RQSRRQSVSR FFADSGADPK GEPGSKQSPP MASSPIQPRK GGADWLGLKD
360 370 380 390 400
EDLDLFPASP TREAHRESSV PVTPSVPPPA SQHSTPAGLP PSRAKPPTEG
410 420 430 440 450
AGSPAKASQA SKLRASKEEK EDWLSHALSR KKSQGLAREQ HAGTSEGLHL
460 470 480 490 500
AGTAGHPPSG SQPLTSTQGL EHAAAGGSSG TTARERPCVR PGVSGSPVTQ
510 520 530 540 550
NHAASALPTG SPKRGTAPGD LSATEPATCF PSTQKPTEPS VPVQPLLPES
560 570 580 590 600
LARSLLPSTE YQKQLLAAQV QLQCSPAELQ AELLHSQARL AELEAQVRKL
610 620 630 640 650
ELERAQHELL LGSLQQQHQA DLELIESAHR SRIKVLETSY QQREERLRRE
660 670 680 690 700
NEELSARYLS QCQEAEQARA ELTAQHQRRL AAIAQEKDQE MERLRELQRA
710 720 730 740 750
SILDMRRDHE EQLQRLKLLK DREVDAATSA TSHTRSLNSI IHQMEKFSSS
760 770 780 790 800
LHELSSRVEA SHLTTSQERE LGIRQRDEQL RALQERLGQQ QRDMEEERSR
810 820 830 840 850
QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ SKAESMQRAL EEQRKVTAQQ
860 870 880 890 900
MAMERAELER AKSALLEEQK SVMLKCGEER RRLAAEWAEF SAQQKLSKER
910 920 930 940 950
AEREAERALQ VDTQREGTLI SLAKQAELKI RASELRAEEK QLAAERAALE
960 970 980 990 1000
QERQELRLEK ERINATALRV KLRAEEVESM SKVASEKYEE GERALREAQQ
1010 1020 1030 1040 1050
VQAEQQARLQ AVQQQQERLR KQEQHMHQEH LSLAQQRLQL DRARQDLPSS
1060 1070 1080 1090 1100
LVGLFPRAQG PAASSQSALM PPAPTTRWCS QPPTGLDPSP LHLHARLALL
1110 1120 1130
RHMAEQDRDF LENEQFFLET LKKGSYNLTS HSA
Length:1,133
Mass (Da):125,446
Last modified:August 21, 2007 - v2
Checksum:i58FA2446CBA3C6B7
GO
Isoform 2 (identifier: Q8TES7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     897-899: SKE → RAG
     900-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:899
Mass (Da):98,643
Checksum:i3C216940C6ED257C
GO
Isoform 3 (identifier: Q8TES7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-662: KLELERAQHE...ELSARYLSQC → GSGAVGAGGR...AEAGARTGPA
     663-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):69,178
Checksum:i46F943597FC16193
GO
Isoform 4 (identifier: Q8TES7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-517: QPLTSTQGLE...PTGSPKRGTA → LTWAFCHLHL...VSGLVSRGPL
     518-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):54,791
Checksum:iEC7D6EF77AE2AE30
GO
Isoform 5 (identifier: Q8TES7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-309: Missing.
     924-924: K → KE

Note: No experimental confirmation available.
Show »
Length:1,133
Mass (Da):125,488
Checksum:i0FA5464A6C80D1A4
GO
Isoform 6 (identifier: Q8TES7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: V → GSIDDFLGDLLGDDM
     924-924: K → KE

Show »
Length:1,148
Mass (Da):127,041
Checksum:i030249D5E297C457
GO

Sequence cautioni

The sequence BAB71400 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB84871 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti801Q → R in BAB71400 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03465965G → V.1 PublicationCorresponds to variant rs1135889dbSNPEnsembl.1
Natural variantiVAR_034660151R → G.2 PublicationsCorresponds to variant rs2305913dbSNPEnsembl.1
Natural variantiVAR_034661371P → S.Corresponds to variant rs7218738dbSNPEnsembl.1
Natural variantiVAR_034662574C → S.Corresponds to variant rs7213548dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04155511V → GSIDDFLGDLLGDDM in isoform 6. 1 Publication1
Alternative sequenceiVSP_040769309Missing in isoform 5. Curated1
Alternative sequenceiVSP_027318462 – 517QPLTS…KRGTA → LTWAFCHLHLERCLSSANLS PAHKGLSTQLLEGVLEQLHE KDRVSGLVSRGPL in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_027319518 – 1133Missing in isoform 4. 1 PublicationAdd BLAST616
Alternative sequenceiVSP_027320599 – 662KLELE…YLSQC → GSGAVGAGGRVATGGDTESG WKLPQEGGRAVGTGQRGVQP PPLPGCWPSCCLPGAEAGAR TGPA in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_027321663 – 1133Missing in isoform 3. 1 PublicationAdd BLAST471
Alternative sequenceiVSP_027322897 – 899SKE → RAG in isoform 2. 1 Publication3
Alternative sequenceiVSP_027323900 – 1133Missing in isoform 2. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_040770924K → KE in isoform 5 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB354594 mRNA. Translation: BAG71501.1.
AK057261 mRNA. Translation: BAB71400.1. Different initiation.
AK074045 mRNA. Translation: BAB84871.1. Different initiation.
AC087289 Genomic DNA. No translation available.
AB058766 mRNA. Translation: BAB47492.1.
BC007570 mRNA. Translation: AAH07570.1.
CCDSiCCDS45779.2. [Q8TES7-6]
RefSeqiNP_001306122.1. NM_001319193.1. [Q8TES7-6]
UniGeneiHs.720068.

Genome annotation databases

EnsembliENST00000586717; ENSP00000465132; ENSG00000188878. [Q8TES7-1]
ENST00000627351; ENSP00000486708; ENSG00000188878. [Q8TES7-5]
ENST00000636174; ENSP00000490726; ENSG00000188878. [Q8TES7-6]
GeneIDi85302.
KEGGihsa:85302.
UCSCiuc002jqd.2. human. [Q8TES7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB354594 mRNA. Translation: BAG71501.1.
AK057261 mRNA. Translation: BAB71400.1. Different initiation.
AK074045 mRNA. Translation: BAB84871.1. Different initiation.
AC087289 Genomic DNA. No translation available.
AB058766 mRNA. Translation: BAB47492.1.
BC007570 mRNA. Translation: AAH07570.1.
CCDSiCCDS45779.2. [Q8TES7-6]
RefSeqiNP_001306122.1. NM_001319193.1. [Q8TES7-6]
UniGeneiHs.720068.

3D structure databases

ProteinModelPortaliQ8TES7.
SMRiQ8TES7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124465. 146 interactors.
IntActiQ8TES7. 128 interactors.
MINTiMINT-1413885.
STRINGi9606.ENSP00000324292.

PTM databases

iPTMnetiQ8TES7.
PhosphoSitePlusiQ8TES7.

Polymorphism and mutation databases

BioMutaiFBF1.
DMDMi156630449.

Proteomic databases

EPDiQ8TES7.
MaxQBiQ8TES7.
PaxDbiQ8TES7.
PeptideAtlasiQ8TES7.
PRIDEiQ8TES7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586717; ENSP00000465132; ENSG00000188878. [Q8TES7-1]
ENST00000627351; ENSP00000486708; ENSG00000188878. [Q8TES7-5]
ENST00000636174; ENSP00000490726; ENSG00000188878. [Q8TES7-6]
GeneIDi85302.
KEGGihsa:85302.
UCSCiuc002jqd.2. human. [Q8TES7-1]

Organism-specific databases

CTDi85302.
DisGeNETi85302.
GeneCardsiFBF1.
HGNCiHGNC:24674. FBF1.
HPAiHPA023677.
neXtProtiNX_Q8TES7.
OpenTargetsiENSG00000188878.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFRT. Eukaryota.
ENOG4111RN4. LUCA.
GeneTreeiENSGT00720000108861.
HOGENOMiHOG000060115.
HOVERGENiHBG071428.
InParanoidiQ8TES7.
KOiK16471.
OrthoDBiEOG091G02RR.
PhylomeDBiQ8TES7.
TreeFamiTF328742.

Enzyme and pathway databases

BioCyciZFISH:G66-33883-MONOMER.
ReactomeiR-HSA-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

GenomeRNAii85302.
PROiQ8TES7.

Gene expression databases

BgeeiENSG00000188878.
CleanExiHS_FBF1.
ExpressionAtlasiQ8TES7. baseline and differential.
GenevisibleiQ8TES7. HS.

Family and domain databases

InterProiIPR033561. FBF1.
[Graphical view]
PANTHERiPTHR33689:SF1. PTHR33689:SF1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBF1_HUMAN
AccessioniPrimary (citable) accession number: Q8TES7
Secondary accession number(s): B5MEM5
, Q96IF6, Q96JG4, Q96MA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.