Q8TER5 (ARH40_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho guanine nucleotide exchange factor 40

Alternative name(s):
Protein SOLO

Gene names

Name:	ARHGEF40
Synonyms:	SOLO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1519 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a guanine nucleotide exchange factor (GEF) By similarity.
Subcellular location	Cytoplasm. Note: Concentrated in the perinuclear region. Ref.5
Tissue specificity	Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level). Ref.5
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain.
Sequence caution	The sequence BAA91563.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15753.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB84883.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TER5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TER5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-714: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TER5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1415-1519: AARTRASVAV...RALSDPTTPL → GEGQGAGGWP...HPGLRGRVIL

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8TER5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1415-1462: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1519	1519	Rho guanine nucleotide exchange factor 40		PRO_0000314822
Regions
	Domain	1085 – 1253	169	DH
	Domain	1265 – 1372	108	PH
	Coiled coil	828 – 871	44	Potential
	Coiled coil	934 – 961	28	Potential
	Compositional bias	276 – 395	120	Gly-rich
	Compositional bias	706 – 711	6	Poly-Glu
	Compositional bias	966 – 969	4	Poly-Arg
Amino acid modifications
	Modified residue	262	1	Phosphoserine Ref.7 Ref.8
	Modified residue	371	1	Phosphothreonine Ref.7
	Modified residue	931	1	Phosphoserine Ref.6
	Modified residue	961	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 714	714	Missing in isoform 2.		VSP_030381
	Alternative sequence	1415 – 1519	105	AARTR…PTTPL → GEGQGAGGWPPGVKTLTMRI QRGGMVESQERHLVPKSVGL AGRPSVRLRVIPGSQEGFPT PAPHPPLPTLCSRPHPGLRG RVIL in isoform 3.		VSP_030382
	Alternative sequence	1415 – 1462	48	Missing in isoform 4.		VSP_030383
	Natural variant	956	1	V → L. Ref.1 Ref.4 Corresponds to variant rs7143633 [ dbSNP | Ensembl ].		VAR_038061
	Natural variant	1189	1	L → S. Ref.1 Ref.3 Ref.4 Corresponds to variant rs1958396 [ dbSNP | Ensembl ].		VAR_038062
	Natural variant	1312	1	M → T. Corresponds to variant rs943992 [ dbSNP | Ensembl ].		VAR_038063
	Natural variant	1418	1	T → P. Ref.3 Corresponds to variant rs17855344 [ dbSNP | Ensembl ].		VAR_060541
Experimental info
	Sequence conflict	293	1	K → E in BAB15753. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: E59DD53AE399E2E6	FASTA	1,519	164,658
	10 20 30 40 50 60 MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD FLVPAKHLLA 70 80 90 100 110 120 KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL RPGDFYLQVV PSAAQAPRLA 130 140 150 160 170 180 LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL QGINKDRPTG RLSTCLLSAP SGIQRLPWAE 190 200 210 220 230 240 LICPRFVHKE GLMVGHQPST LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG 250 260 270 280 290 300 EYVELLEVTL PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ 310 320 330 340 350 360 DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL RPGELRGGGG 370 380 390 400 410 420 GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL SPGDKEDASH QEALGNLPSP 430 440 450 460 470 480 SEHKLPECHL VKEEYEGSGK PESEPKELKT AGEKEPQLSE ACGPTEEGAG ERELEGPGLL 490 500 510 520 530 540 CMAGHTGPEG PLSDTPTPPL ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG 550 560 570 580 590 600 GVDQSGRALL TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL 610 620 630 640 650 660 PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK RVAKPEELQW 670 680 690 700 710 720 ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE LEGAAEPEEE EAVGMPKPLQ 730 740 750 760 770 780 KVLADPRLTA LQRDGGAILM RLRSTPSSKL EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ 790 800 810 820 830 840 EQRQCLRRLQ QVLQWLSGPG EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE 850 860 870 880 890 900 ALALEENATS QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE 910 920 930 940 950 960 AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER RIQQHVGEEA 970 980 990 1000 1010 1020 SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP RPAPSHCSLA PCGEDYEEEG 1030 1040 1050 1060 1070 1080 PELAPEAEGR PPRAVLIRGL EVTSTEVVDR TCSPREHVLL GRARGPDGPW GVGTPRMERK 1090 1100 1110 1120 1130 1140 RSISAQQRLV SELIACEQDY VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH 1150 1160 1170 1180 1190 1200 FLRELQGCAT HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL 1210 1220 1230 1240 1250 1260 PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG RDLLAVEAVR 1270 1280 1290 1300 1310 1320 GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF SKLKGPEGGS EMFVYKQAFK 1330 1340 1350 1360 1370 1380 TADMGLTENI GDSGLCFELW FRRRRAREAY TLQATSPEIK LKWTSSIAQL LWRQAAHNKE 1390 1400 1410 1420 1430 1440 LRVQQMVSMG IGNKPFLDIK ALGERTLSAL LTGRAARTRA SVAVSSFEHA GPSLPGLSPG 1450 1460 1470 1480 1490 1500 ACSLPARVEE EAWDLDVKQI SLAPETLDSS GDVSPGPRNS PSLQPPHPGS STPTLASRGI 1510 LGLSRQSHAR ALSDPTTPL
	Isoform 2 [UniParc]. Checksum: 7DA3D9DEED3284A3	FASTA	805	88,758
	10 20 30 40 50 60 MPKPLQKVLA DPRLTALQRD GGAILMRLRS TPSSKLEGQG PATLYQEVDE AIHQLVRLSN 70 80 90 100 110 120 LHVQQQEQRQ CLRRLQQVLQ WLSGPGEEQL ASFAMPGDTL SALQETELRF RAFSAEVQER 130 140 150 160 170 180 LAQAREALAL EENATSQKVL DIFEQRLEQV ESGLHRALRL QRFFQQAHEW VDEGFARLAG 190 200 210 220 230 240 AGPGREAVLA ALALRRAPEP SAGTFQEMRA LALDLGSPAA LREWGRCQAR CQELERRIQQ 250 260 270 280 290 300 HVGEEASPRG YRRRRADGAS SGGAQWGPRS PSPSLSSLLL PSSPGPRPAP SHCSLAPCGE 310 320 330 340 350 360 DYEEEGPELA PEAEGRPPRA VLIRGLEVTS TEVVDRTCSP REHVLLGRAR GPDGPWGVGT 370 380 390 400 410 420 PRMERKRSIS AQQRLVSELI ACEQDYVATL SEPVPPPGPE LTPELRGTWA AALSARERLR 430 440 450 460 470 480 SFHRTHFLRE LQGCATHPLR IGACFLRHGD QFSLYAQYVK HRHKLENGLA ALSPLSKGSM 490 500 510 520 530 540 EAGPYLPRAL QQPLEQLTRY GRLLEELLRE AGPELSSECR ALGAAVQLLR EQEARGRDLL 550 560 570 580 590 600 AVEAVRGCEI DLKEQGQLLH RDPFTVICGR KKCLRHVFLF EHLLLFSKLK GPEGGSEMFV 610 620 630 640 650 660 YKQAFKTADM GLTENIGDSG LCFELWFRRR RAREAYTLQA TSPEIKLKWT SSIAQLLWRQ 670 680 690 700 710 720 AAHNKELRVQ QMVSMGIGNK PFLDIKALGE RTLSALLTGR AARTRASVAV SSFEHAGPSL 730 740 750 760 770 780 PGLSPGACSL PARVEEEAWD LDVKQISLAP ETLDSSGDVS PGPRNSPSLQ PPHPGSSTPT 790 800 LASRGILGLS RQSHARALSD PTTPL
	Isoform 3 [UniParc]. Checksum: 43FB91E06285706E	FASTA	1,498	162,800
	10 20 30 40 50 60 MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD FLVPAKHLLA 70 80 90 100 110 120 KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL RPGDFYLQVV PSAAQAPRLA 130 140 150 160 170 180 LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL QGINKDRPTG RLSTCLLSAP SGIQRLPWAE 190 200 210 220 230 240 LICPRFVHKE GLMVGHQPST LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG 250 260 270 280 290 300 EYVELLEVTL PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ 310 320 330 340 350 360 DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL RPGELRGGGG 370 380 390 400 410 420 GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL SPGDKEDASH QEALGNLPSP 430 440 450 460 470 480 SEHKLPECHL VKEEYEGSGK PESEPKELKT AGEKEPQLSE ACGPTEEGAG ERELEGPGLL 490 500 510 520 530 540 CMAGHTGPEG PLSDTPTPPL ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG 550 560 570 580 590 600 GVDQSGRALL TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL 610 620 630 640 650 660 PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK RVAKPEELQW 670 680 690 700 710 720 ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE LEGAAEPEEE EAVGMPKPLQ 730 740 750 760 770 780 KVLADPRLTA LQRDGGAILM RLRSTPSSKL EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ 790 800 810 820 830 840 EQRQCLRRLQ QVLQWLSGPG EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE 850 860 870 880 890 900 ALALEENATS QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE 910 920 930 940 950 960 AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER RIQQHVGEEA 970 980 990 1000 1010 1020 SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP RPAPSHCSLA PCGEDYEEEG 1030 1040 1050 1060 1070 1080 PELAPEAEGR PPRAVLIRGL EVTSTEVVDR TCSPREHVLL GRARGPDGPW GVGTPRMERK 1090 1100 1110 1120 1130 1140 RSISAQQRLV SELIACEQDY VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH 1150 1160 1170 1180 1190 1200 FLRELQGCAT HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL 1210 1220 1230 1240 1250 1260 PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG RDLLAVEAVR 1270 1280 1290 1300 1310 1320 GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF SKLKGPEGGS EMFVYKQAFK 1330 1340 1350 1360 1370 1380 TADMGLTENI GDSGLCFELW FRRRRAREAY TLQATSPEIK LKWTSSIAQL LWRQAAHNKE 1390 1400 1410 1420 1430 1440 LRVQQMVSMG IGNKPFLDIK ALGERTLSAL LTGRGEGQGA GGWPPGVKTL TMRIQRGGMV 1450 1460 1470 1480 1490 ESQERHLVPK SVGLAGRPSV RLRVIPGSQE GFPTPAPHPP LPTLCSRPHP GLRGRVIL
	Isoform 4 [UniParc]. Checksum: 5FC596887113AA2C	FASTA	1,471	159,698
	10 20 30 40 50 60 MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD FLVPAKHLLA 70 80 90 100 110 120 KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL RPGDFYLQVV PSAAQAPRLA 130 140 150 160 170 180 LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL QGINKDRPTG RLSTCLLSAP SGIQRLPWAE 190 200 210 220 230 240 LICPRFVHKE GLMVGHQPST LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG 250 260 270 280 290 300 EYVELLEVTL PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ 310 320 330 340 350 360 DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL RPGELRGGGG 370 380 390 400 410 420 GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL SPGDKEDASH QEALGNLPSP 430 440 450 460 470 480 SEHKLPECHL VKEEYEGSGK PESEPKELKT AGEKEPQLSE ACGPTEEGAG ERELEGPGLL 490 500 510 520 530 540 CMAGHTGPEG PLSDTPTPPL ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG 550 560 570 580 590 600 GVDQSGRALL TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL 610 620 630 640 650 660 PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK RVAKPEELQW 670 680 690 700 710 720 ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE LEGAAEPEEE EAVGMPKPLQ 730 740 750 760 770 780 KVLADPRLTA LQRDGGAILM RLRSTPSSKL EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ 790 800 810 820 830 840 EQRQCLRRLQ QVLQWLSGPG EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE 850 860 870 880 890 900 ALALEENATS QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE 910 920 930 940 950 960 AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER RIQQHVGEEA 970 980 990 1000 1010 1020 SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP RPAPSHCSLA PCGEDYEEEG 1030 1040 1050 1060 1070 1080 PELAPEAEGR PPRAVLIRGL EVTSTEVVDR TCSPREHVLL GRARGPDGPW GVGTPRMERK 1090 1100 1110 1120 1130 1140 RSISAQQRLV SELIACEQDY VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH 1150 1160 1170 1180 1190 1200 FLRELQGCAT HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL 1210 1220 1230 1240 1250 1260 PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG RDLLAVEAVR 1270 1280 1290 1300 1310 1320 GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF SKLKGPEGGS EMFVYKQAFK 1330 1340 1350 1360 1370 1380 TADMGLTENI GDSGLCFELW FRRRRAREAY TLQATSPEIK LKWTSSIAQL LWRQAAHNKE 1390 1400 1410 1420 1430 1440 LRVQQMVSMG IGNKPFLDIK ALGERTLSAL LTGRAPETLD SSGDVSPGPR NSPSLQPPHP 1450 1460 1470 GSSTPTLASR GILGLSRQSH ARALSDPTTP L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1172-1519 (ISOFORM 4), VARIANTS LEU-956 AND SER-1189. Tissue: Spleen and Teratocarcinoma.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-1189 AND PRO-1418. Tissue: Kidney.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 841-1519 (ISOFORM 3), VARIANTS LEU-956 AND SER-1189. Tissue: Testis.
[5]	"Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain." Tse S.-W., Broderick J.A., Wei M.-L., Luo M.-H., Smith D., McCaffery P., Stamm S., Andreadis A. Gene 359:63-72(2005) [PubMed: 16143467] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-931, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262 AND THR-371, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262 AND SER-961, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001219 mRNA. Translation: BAA91563.1. Different initiation. AK024463 mRNA. Translation: BAB15753.1. Different initiation. AK074057 mRNA. Translation: BAB84883.1. Different initiation. AL161668 Genomic DNA. No translation available. BC000084 mRNA. Translation: AAH00084.4. BC142692 mRNA. Translation: AAI42693.1. AL137291 mRNA. Translation: CAB70682.1.
IPI	IPI00018134. IPI00790107. IPI00878303. IPI00878685.
PIR	T46359.
RefSeq	NP_060541.3. NM_018071.3.
UniGene	Hs.35125.
3D structure databases
HSSP	HSSP built from PDB template 1RJ2 based on UniProtKB Q63406.
ProteinModelPortal	Q8TER5.
SMR	Q8TER5. Positions 1077-1375.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TER5. 3 interactions.
MINT	MINT-1409884.
PTM databases
PhosphoSite	Q8TER5.
Polymorphism databases
DMDM	296452953.
Proteomic databases
PRIDE	Q8TER5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298694; ENSP00000298694; ENSG00000165801.
GeneID	55701.
KEGG	hsa:55701.
UCSC	uc001vzo.1. human. uc001vzp.1. human.
Organism-specific databases
CTD	55701.
GeneCards	GC14P021539.
H-InvDB	HIX0001353. HIX0011501.
HGNC	HGNC:25516. ARHGEF40.
HPA	HPA030746. HPA030757.
MIM	610018. gene.
neXtProt	NX_Q8TER5.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000077135.
HOGENOM	HBG282401.
HOVERGEN	HBG108500.
InParanoid	Q8TER5.
OMA	RMERKRS.
OrthoDB	EOG4J117G.
PhylomeDB	Q8TER5.
Gene expression databases
ArrayExpress	Q8TER5.
Bgee	Q8TER5.
Genevestigator	Q8TER5.
Family and domain databases
InterPro	IPR000219. DH-domain. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	60542.
SOURCE	Search...

Entry information

Entry name

ARH40_HUMAN

Accession

Primary (citable) accession number: Q8TER5
Secondary accession number(s): A5PL07 , Q9BWP5, Q9H7L6, Q9NTF9, Q9NW24

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.