Q8TER0 (SNED1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sushi, nidogen and EGF-like domain-containing protein 1

Alternative name(s):
Insulin-responsive sequence DNA-binding protein 1
Short name=IRE-BP1

Gene names

Name:

SNED1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1413 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 15 EGF-like domains. Contains 3 fibronectin type-III domains. Contains 2 follistatin-like domains. Contains 1 NIDO domain. Contains 1 Sushi (CCP/SCR) domain.
Sequence caution	The sequence AAH27939.1 differs from that shown. Reason: Intron retention. The N-terminal region arises from intron retention. The sequence AAQ04558.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Sushi
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-matrix adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TER0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TER0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1306: QPTASAQLENMEEAPKRVSLALQLPEHGSKDIGN → H
     1375-1402: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TER0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1306: QPTASAQLENMEEAPKRVSLALQLPEHGSKDIGN → H
     1398-1398: K → L
     1399-1413: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8TER0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1306-1324: NVPGNCSENPCQNGGTCVP → SESAALVGTLGLTDCSQGP
     1325-1413: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 1413	1389	Sushi, nidogen and EGF-like domain-containing protein 1		PRO_0000299554
Regions
	Domain	103 – 258	156	NIDO
	Domain	268 – 309	42	EGF-like 1
	Domain	311 – 347	37	EGF-like 2
	Domain	349 – 385	37	EGF-like 3
	Domain	352 – 374	23	Follistatin-like 1
	Domain	387 – 423	37	EGF-like 4; calcium-binding Potential
	Domain	429 – 465	37	EGF-like 5
	Domain	468 – 500	33	EGF-like 6
	Domain	507 – 530	24	Follistatin-like 2
	Domain	541 – 577	37	EGF-like 7
	Domain	580 – 616	37	EGF-like 8
	Domain	619 – 655	37	EGF-like 9
	Domain	657 – 693	37	EGF-like 10
	Domain	696 – 753	58	Sushi
	Domain	753 – 789	37	EGF-like 11; calcium-binding Potential
	Domain	791 – 827	37	EGF-like 12; calcium-binding Potential
	Domain	829 – 865	37	EGF-like 13
	Domain	867 – 903	37	EGF-like 14
	Domain	905 – 1003	99	Fibronectin type-III 1
	Domain	1005 – 1096	92	Fibronectin type-III 2
	Domain	1104 – 1196	93	Fibronectin type-III 3
	Domain	1307 – 1343	37	EGF-like 15
Amino acid modifications
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Glycosylation	408	1	N-linked (GlcNAc...) Potential
	Glycosylation	977	1	N-linked (GlcNAc...) Potential
	Disulfide bond	272 ↔ 284		By similarity
	Disulfide bond	278 ↔ 297		By similarity
	Disulfide bond	299 ↔ 308		By similarity
	Disulfide bond	315 ↔ 326		By similarity
	Disulfide bond	320 ↔ 335		By similarity
	Disulfide bond	337 ↔ 346		By similarity
	Disulfide bond	353 ↔ 364		By similarity
	Disulfide bond	358 ↔ 373		By similarity
	Disulfide bond	375 ↔ 384		By similarity
	Disulfide bond	391 ↔ 402		By similarity
	Disulfide bond	396 ↔ 411		By similarity
	Disulfide bond	413 ↔ 422		By similarity
	Disulfide bond	433 ↔ 444		By similarity
	Disulfide bond	438 ↔ 453		By similarity
	Disulfide bond	455 ↔ 464		By similarity
	Disulfide bond	472 ↔ 480		By similarity
	Disulfide bond	474 ↔ 488		By similarity
	Disulfide bond	490 ↔ 499		By similarity
	Disulfide bond	545 ↔ 556		By similarity
	Disulfide bond	550 ↔ 565		By similarity
	Disulfide bond	567 ↔ 576		By similarity
	Disulfide bond	584 ↔ 595		By similarity
	Disulfide bond	589 ↔ 604		By similarity
	Disulfide bond	606 ↔ 615		By similarity
	Disulfide bond	623 ↔ 634		By similarity
	Disulfide bond	628 ↔ 643		By similarity
	Disulfide bond	645 ↔ 654		By similarity
	Disulfide bond	661 ↔ 672		By similarity
	Disulfide bond	666 ↔ 681		By similarity
	Disulfide bond	683 ↔ 692		By similarity
	Disulfide bond	698 ↔ 739		By similarity
	Disulfide bond	724 ↔ 751		By similarity
	Disulfide bond	757 ↔ 768		By similarity
	Disulfide bond	762 ↔ 777		By similarity
	Disulfide bond	779 ↔ 788		By similarity
	Disulfide bond	795 ↔ 806		By similarity
	Disulfide bond	800 ↔ 815		By similarity
	Disulfide bond	817 ↔ 826		By similarity
	Disulfide bond	833 ↔ 844		By similarity
	Disulfide bond	838 ↔ 853		By similarity
	Disulfide bond	855 ↔ 864		By similarity
	Disulfide bond	871 ↔ 882		By similarity
	Disulfide bond	876 ↔ 891		By similarity
	Disulfide bond	893 ↔ 902		By similarity
	Disulfide bond	1311 ↔ 1322		By similarity
	Disulfide bond	1316 ↔ 1331		By similarity
	Disulfide bond	1333 ↔ 1342		By similarity
Natural variations
	Alternative sequence	1273 – 1306	34	QPTAS…KDIGN → H in isoform 2 and isoform 3.		VSP_027749
	Alternative sequence	1306 – 1324	19	NVPGN…GTCVP → SESAALVGTLGLTDCSQGP in isoform 4.		VSP_027750
	Alternative sequence	1325 – 1413	89	Missing in isoform 4.		VSP_027751
	Alternative sequence	1375 – 1402	28	Missing in isoform 2.		VSP_027752
	Alternative sequence	1398	1	K → L in isoform 3.		VSP_027753
	Alternative sequence	1399 – 1413	15	Missing in isoform 3.		VSP_027754
	Natural variant	1228	1	L → P. Corresponds to variant rs17440466 [ dbSNP | Ensembl ].		VAR_034847
	Natural variant	1289	1	R → Q. Corresponds to variant rs6721345 [ dbSNP | Ensembl ].		VAR_034848
	Natural variant	1299	1	H → R. Corresponds to variant rs6708120 [ dbSNP | Ensembl ].		VAR_034849
	Natural variant	1362	1	A → S. Ref.4 Corresponds to variant rs2108485 [ dbSNP | Ensembl ].		VAR_034850
Experimental info
	Sequence conflict	546	1	D → N in AAQ04558. Ref.3
	Sequence conflict	653	1	H → Y in AAQ04558. Ref.3
	Sequence conflict	719	1	V → A in AAQ04558. Ref.3
	Sequence conflict	858	1	S → G in AAQ04558. Ref.3
	Sequence conflict	1186 – 1206	21	HSEPA…ADRRW → Q in AAQ04558. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 09BC8059234326D9	FASTA	1,413	152,204
	10 20 30 40 50 60 MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG SGLRPLSVPF 70 80 90 100 110 120 PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV VAAFWADVDN RRAGDVYYRE 130 140 150 160 170 180 ATDPAMLRRA TEDVRHYFPE LLDFNATWVF VATWYRVTFF GGSSSSPVNT FQTVLITDGK 190 200 210 220 230 240 LSFTIFNYES IVWTTGTHAS SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE 250 260 270 280 290 300 TTTNVGVPGR WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL 310 320 330 340 350 360 SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ SPCDTKECQH 370 380 390 400 410 420 GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG SCVDLVGNYT CLCAEPFKGL 430 440 450 460 470 480 RCETGDHPVP DACLSAPCHN GGTCVDADQG YVCECPEGFM GLDCRERVPD DCECRNGGRC 490 500 510 520 530 540 LGANTTLCQC PLGFFGLLCE FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS 550 560 570 580 590 600 LPSPCDSDPC FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG 610 620 630 640 650 660 EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS GRHCEIAPSP 670 680 690 700 710 720 CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP PEEVKHATLR FNGTRLGAVA 730 740 750 760 770 780 LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS 790 800 810 820 830 840 TGYEGAHCEL ERDECRAHPC RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH 850 860 870 880 890 900 GGRCESGGGA YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE 910 920 930 940 950 960 DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG SYRRTDFVDR 970 980 990 1000 1010 1020 TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL ARTRPRPVEG FEVTNVTAST 1030 1040 1050 1060 1070 1080 ISVQWALHRI RHATVSGVRV SIRHPEALRD QATDVDRSVD RFTFRALLPG KRYTIQLTTL 1090 1100 1110 1120 1130 1140 SGLRGEEHPT ESLATAPTHV WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV 1150 1160 1170 1180 1190 1200 TTSQSTKSRY VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD 1210 1220 1230 1240 1250 1260 GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV DGRGRVSARF 1270 1280 1290 1300 1310 1320 GGSPSKAATV RSQPTASAQL ENMEEAPKRV SLALQLPEHG SKDIGNVPGN CSENPCQNGG 1330 1340 1350 1360 1370 1380 TCVPGADAHS CDCGPGFKGR RCELACIKVS RPCTRLFSET KAFPVWEGGV CHHVYKRVYR 1390 1400 1410 VHQDICFKES CESTSLKKTP NRKQSKSQTL EKS
	Isoform 2 [UniParc]. Checksum: E6063435C0AA1CFD	FASTA	1,352	145,300
	10 20 30 40 50 60 MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG SGLRPLSVPF 70 80 90 100 110 120 PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV VAAFWADVDN RRAGDVYYRE 130 140 150 160 170 180 ATDPAMLRRA TEDVRHYFPE LLDFNATWVF VATWYRVTFF GGSSSSPVNT FQTVLITDGK 190 200 210 220 230 240 LSFTIFNYES IVWTTGTHAS SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE 250 260 270 280 290 300 TTTNVGVPGR WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL 310 320 330 340 350 360 SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ SPCDTKECQH 370 380 390 400 410 420 GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG SCVDLVGNYT CLCAEPFKGL 430 440 450 460 470 480 RCETGDHPVP DACLSAPCHN GGTCVDADQG YVCECPEGFM GLDCRERVPD DCECRNGGRC 490 500 510 520 530 540 LGANTTLCQC PLGFFGLLCE FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS 550 560 570 580 590 600 LPSPCDSDPC FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG 610 620 630 640 650 660 EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS GRHCEIAPSP 670 680 690 700 710 720 CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP PEEVKHATLR FNGTRLGAVA 730 740 750 760 770 780 LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS 790 800 810 820 830 840 TGYEGAHCEL ERDECRAHPC RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH 850 860 870 880 890 900 GGRCESGGGA YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE 910 920 930 940 950 960 DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG SYRRTDFVDR 970 980 990 1000 1010 1020 TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL ARTRPRPVEG FEVTNVTAST 1030 1040 1050 1060 1070 1080 ISVQWALHRI RHATVSGVRV SIRHPEALRD QATDVDRSVD RFTFRALLPG KRYTIQLTTL 1090 1100 1110 1120 1130 1140 SGLRGEEHPT ESLATAPTHV WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV 1150 1160 1170 1180 1190 1200 TTSQSTKSRY VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD 1210 1220 1230 1240 1250 1260 GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV DGRGRVSARF 1270 1280 1290 1300 1310 1320 GGSPSKAATV RSHVPGNCSE NPCQNGGTCV PGADAHSCDC GPGFKGRRCE LACIKVSRPC 1330 1340 1350 TRLFSETKAF PVWEGGVCHH VKQSKSQTLE KS
	Isoform 3 [UniParc]. Checksum: 346748DD68531BC3	FASTA	1,365	146,970
	10 20 30 40 50 60 MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG SGLRPLSVPF 70 80 90 100 110 120 PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV VAAFWADVDN RRAGDVYYRE 130 140 150 160 170 180 ATDPAMLRRA TEDVRHYFPE LLDFNATWVF VATWYRVTFF GGSSSSPVNT FQTVLITDGK 190 200 210 220 230 240 LSFTIFNYES IVWTTGTHAS SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE 250 260 270 280 290 300 TTTNVGVPGR WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL 310 320 330 340 350 360 SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ SPCDTKECQH 370 380 390 400 410 420 GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG SCVDLVGNYT CLCAEPFKGL 430 440 450 460 470 480 RCETGDHPVP DACLSAPCHN GGTCVDADQG YVCECPEGFM GLDCRERVPD DCECRNGGRC 490 500 510 520 530 540 LGANTTLCQC PLGFFGLLCE FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS 550 560 570 580 590 600 LPSPCDSDPC FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG 610 620 630 640 650 660 EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS GRHCEIAPSP 670 680 690 700 710 720 CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP PEEVKHATLR FNGTRLGAVA 730 740 750 760 770 780 LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS 790 800 810 820 830 840 TGYEGAHCEL ERDECRAHPC RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH 850 860 870 880 890 900 GGRCESGGGA YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE 910 920 930 940 950 960 DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG SYRRTDFVDR 970 980 990 1000 1010 1020 TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL ARTRPRPVEG FEVTNVTAST 1030 1040 1050 1060 1070 1080 ISVQWALHRI RHATVSGVRV SIRHPEALRD QATDVDRSVD RFTFRALLPG KRYTIQLTTL 1090 1100 1110 1120 1130 1140 SGLRGEEHPT ESLATAPTHV WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV 1150 1160 1170 1180 1190 1200 TTSQSTKSRY VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD 1210 1220 1230 1240 1250 1260 GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV DGRGRVSARF 1270 1280 1290 1300 1310 1320 GGSPSKAATV RSHVPGNCSE NPCQNGGTCV PGADAHSCDC GPGFKGRRCE LACIKVSRPC 1330 1340 1350 1360 TRLFSETKAF PVWEGGVCHH VYKRVYRVHQ DICFKESCES TSLKL
	Isoform 4 [UniParc]. Checksum: AA7A732F74E755D6	FASTA	1,324	142,073
	10 20 30 40 50 60 MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG SGLRPLSVPF 70 80 90 100 110 120 PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV VAAFWADVDN RRAGDVYYRE 130 140 150 160 170 180 ATDPAMLRRA TEDVRHYFPE LLDFNATWVF VATWYRVTFF GGSSSSPVNT FQTVLITDGK 190 200 210 220 230 240 LSFTIFNYES IVWTTGTHAS SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE 250 260 270 280 290 300 TTTNVGVPGR WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL 310 320 330 340 350 360 SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ SPCDTKECQH 370 380 390 400 410 420 GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG SCVDLVGNYT CLCAEPFKGL 430 440 450 460 470 480 RCETGDHPVP DACLSAPCHN GGTCVDADQG YVCECPEGFM GLDCRERVPD DCECRNGGRC 490 500 510 520 530 540 LGANTTLCQC PLGFFGLLCE FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS 550 560 570 580 590 600 LPSPCDSDPC FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG 610 620 630 640 650 660 EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS GRHCEIAPSP 670 680 690 700 710 720 CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP PEEVKHATLR FNGTRLGAVA 730 740 750 760 770 780 LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS 790 800 810 820 830 840 TGYEGAHCEL ERDECRAHPC RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH 850 860 870 880 890 900 GGRCESGGGA YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE 910 920 930 940 950 960 DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG SYRRTDFVDR 970 980 990 1000 1010 1020 TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL ARTRPRPVEG FEVTNVTAST 1030 1040 1050 1060 1070 1080 ISVQWALHRI RHATVSGVRV SIRHPEALRD QATDVDRSVD RFTFRALLPG KRYTIQLTTL 1090 1100 1110 1120 1130 1140 SGLRGEEHPT ESLATAPTHV WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV 1150 1160 1170 1180 1190 1200 TTSQSTKSRY VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD 1210 1220 1230 1240 1250 1260 GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV DGRGRVSARF 1270 1280 1290 1300 1310 1320 GGSPSKAATV RSQPTASAQL ENMEEAPKRV SLALQLPEHG SKDIGSESAA LVGTLGLTDC SQGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-1413 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 831-1413 (ISOFORM 2). Tissue: Spleen.
[3]	"Insulin-response element-binding protein 1: a novel Akt substrate involved in transcriptional action of insulin." Villafuerte B.C., Phillips L.S., Rane M.J., Zhao W. J. Biol. Chem. 279:36650-36659(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 367-1413 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 938-1413 (ISOFORM 4).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 791-1413 (ISOFORM 3), VARIANT SER-1362. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005237 Genomic DNA. No translation available. AC093585 Genomic DNA. No translation available. AC104809 Genomic DNA. No translation available. AK074062 mRNA. Translation: BAB84888.1. AK074075 mRNA. Translation: BAB84901.1. AF439717 mRNA. Translation: AAQ04558.1. Different initiation. AF439718 mRNA. Translation: AAQ04563.1. BC027939 mRNA. Translation: AAH27939.1. Sequence problems.
IPI	IPI00152789. IPI00827714. IPI00855880. IPI00856022.
RefSeq	NP_001073906.1. NM_001080437.1.
UniGene	Hs.471834.
3D structure databases
HSSP	HSSP built from PDB template 1EDM based on UniProtKB P00740.
ProteinModelPortal	Q8TER0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308893.
PTM databases
PhosphoSite	Q8TER0.
Polymorphism databases
DMDM	158563933.
Proteomic databases
PaxDb	Q8TER0.
PRIDE	Q8TER0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310397; ENSP00000308893; ENSG00000162804. ENST00000401884; ENSP00000384871; ENSG00000162804. ENST00000405547; ENSP00000386007; ENSG00000162804.
GeneID	25992.
KEGG	hsa:25992.
UCSC	uc002wah.1. human.
Organism-specific databases
CTD	25992.
GeneCards	GC02P241938.
H-InvDB	HIX0002988.
HGNC	HGNC:24696. SNED1.
HPA	HPA036414. HPA036415.
neXtProt	NX_Q8TER0.
PharmGKB	PA134946370.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242910.
HOVERGEN	HBG108495.
InParanoid	Q8TER0.
OrthoDB	EOG4K0QMM.
Gene expression databases
ArrayExpress	Q8TER0.
Bgee	Q8TER0.
CleanEx	HS_SNED1.
Genevestigator	Q8TER0.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR003961. Fibronectin_type3. IPR003645. Fol_N. IPR013783. Ig-like_fold. IPR003886. Nidogen_extracell_dom. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00008. EGF. 10 hits. PF00041. fn3. 3 hits. PF12661. hEGF. 2 hits. PF06119. NIDO. 1 hit. [Graphical view]
SMART	SM00032. CCP. 1 hit. SM00181. EGF. 10 hits. SM00179. EGF_CA. 5 hits. SM00060. FN3. 3 hits. SM00274. FOLN. 2 hits. SM00539. NIDO. 1 hit. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 1 hit. SSF49265. FN_III-like. 3 hits.
PROSITE	PS00010. ASX_HYDROXYL. 5 hits. PS00022. EGF_1. 15 hits. PS01186. EGF_2. 13 hits. PS50026. EGF_3. 15 hits. PS01187. EGF_CA. 3 hits. PS50853. FN3. 3 hits. PS51220. NIDO. 1 hit. PS50923. SUSHI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25992.
NextBio	47694.

Entry information

Entry name

SNED1_HUMAN

Accession

Primary (citable) accession number: Q8TER0
Secondary accession number(s): B5MDC3 , B7WNK6, B7WPM0, Q336F4, Q336F5, Q8N369, Q8TEP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.