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Protein

Sushi, nidogen and EGF-like domain-containing protein 1

Gene

SNED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi, nidogen and EGF-like domain-containing protein 1
Alternative name(s):
Insulin-responsive sequence DNA-binding protein 1
Short name:
IRE-BP1
Gene namesi
Name:SNED1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24696. SNED1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25992.
OpenTargetsiENSG00000162804.
PharmGKBiPA134946370.

Polymorphism and mutation databases

BioMutaiSNED1.
DMDMi158563933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000029955425 – 1413Sushi, nidogen and EGF-like domain-containing protein 1Add BLAST1389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi272 ↔ 284By similarity
Disulfide bondi278 ↔ 297By similarity
Disulfide bondi299 ↔ 308By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi320 ↔ 335By similarity
Disulfide bondi337 ↔ 346By similarity
Disulfide bondi353 ↔ 364By similarity
Disulfide bondi358 ↔ 373By similarity
Disulfide bondi375 ↔ 384By similarity
Disulfide bondi391 ↔ 402By similarity
Disulfide bondi396 ↔ 411By similarity
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi413 ↔ 422By similarity
Disulfide bondi433 ↔ 444By similarity
Disulfide bondi438 ↔ 453By similarity
Disulfide bondi455 ↔ 464By similarity
Disulfide bondi472 ↔ 480By similarity
Disulfide bondi474 ↔ 488By similarity
Disulfide bondi490 ↔ 499By similarity
Disulfide bondi545 ↔ 556By similarity
Disulfide bondi550 ↔ 565By similarity
Disulfide bondi567 ↔ 576By similarity
Disulfide bondi584 ↔ 595By similarity
Disulfide bondi589 ↔ 604By similarity
Disulfide bondi606 ↔ 615By similarity
Disulfide bondi623 ↔ 634By similarity
Disulfide bondi628 ↔ 643By similarity
Disulfide bondi645 ↔ 654By similarity
Disulfide bondi661 ↔ 672By similarity
Disulfide bondi666 ↔ 681By similarity
Disulfide bondi683 ↔ 692By similarity
Disulfide bondi698 ↔ 739By similarity
Disulfide bondi724 ↔ 751By similarity
Disulfide bondi757 ↔ 768By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi779 ↔ 788By similarity
Disulfide bondi795 ↔ 806By similarity
Disulfide bondi800 ↔ 815By similarity
Disulfide bondi817 ↔ 826By similarity
Disulfide bondi833 ↔ 844By similarity
Disulfide bondi838 ↔ 853By similarity
Disulfide bondi855 ↔ 864By similarity
Disulfide bondi871 ↔ 882By similarity
Disulfide bondi876 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Glycosylationi977N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1311 ↔ 1322By similarity
Disulfide bondi1316 ↔ 1331By similarity
Disulfide bondi1333 ↔ 1342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TER0.
PeptideAtlasiQ8TER0.
PRIDEiQ8TER0.

PTM databases

iPTMnetiQ8TER0.
PhosphoSitePlusiQ8TER0.

Expressioni

Gene expression databases

BgeeiENSG00000162804.
CleanExiHS_SNED1.
ExpressionAtlasiQ8TER0. baseline and differential.
GenevisibleiQ8TER0. HS.

Organism-specific databases

HPAiHPA036414.
HPA036415.

Interactioni

Protein-protein interaction databases

IntActiQ8TER0. 1 interactor.
STRINGi9606.ENSP00000308893.

Structurei

3D structure databases

ProteinModelPortaliQ8TER0.
SMRiQ8TER0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 258NIDOPROSITE-ProRule annotationAdd BLAST156
Domaini268 – 309EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini311 – 347EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini349 – 385EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini352 – 374Follistatin-like 1Add BLAST23
Domaini387 – 423EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini429 – 465EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 500EGF-like 6PROSITE-ProRule annotationAdd BLAST33
Domaini507 – 530Follistatin-like 2Add BLAST24
Domaini541 – 577EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini580 – 616EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini619 – 655EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini657 – 693EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini696 – 753SushiPROSITE-ProRule annotationAdd BLAST58
Domaini753 – 789EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini791 – 827EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini829 – 865EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini867 – 903EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini908 – 1006Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini1007 – 1105Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini1106 – 1200Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini1307 – 1343EGF-like 15PROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Contains 15 EGF-like domains.PROSITE-ProRule annotation
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 follistatin-like domains.Curated
Contains 1 NIDO domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4291. Eukaryota.
ENOG410ZK2K. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG108495.
InParanoidiQ8TER0.
OrthoDBiEOG091G002A.
PhylomeDBiQ8TER0.
TreeFamiTF335195.

Family and domain databases

CDDicd00033. CCP. 1 hit.
cd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003886. NIDO_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 11 hits.
PF00041. fn3. 3 hits.
PF12661. hEGF. 3 hits.
PF06119. NIDO. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 14 hits.
SM00060. FN3. 3 hits.
SM00539. NIDO. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 13 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 3 hits.
PS50853. FN3. 3 hits.
PS51220. NIDO. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TER0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG
60 70 80 90 100
SGLRPLSVPF PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV
110 120 130 140 150
VAAFWADVDN RRAGDVYYRE ATDPAMLRRA TEDVRHYFPE LLDFNATWVF
160 170 180 190 200
VATWYRVTFF GGSSSSPVNT FQTVLITDGK LSFTIFNYES IVWTTGTHAS
210 220 230 240 250
SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE TTTNVGVPGR
260 270 280 290 300
WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL
310 320 330 340 350
SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ
360 370 380 390 400
SPCDTKECQH GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG
410 420 430 440 450
SCVDLVGNYT CLCAEPFKGL RCETGDHPVP DACLSAPCHN GGTCVDADQG
460 470 480 490 500
YVCECPEGFM GLDCRERVPD DCECRNGGRC LGANTTLCQC PLGFFGLLCE
510 520 530 540 550
FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS LPSPCDSDPC
560 570 580 590 600
FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG
610 620 630 640 650
EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS
660 670 680 690 700
GRHCEIAPSP CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP
710 720 730 740 750
PEEVKHATLR FNGTRLGAVA LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ
760 770 780 790 800
CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS TGYEGAHCEL ERDECRAHPC
810 820 830 840 850
RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH GGRCESGGGA
860 870 880 890 900
YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE
910 920 930 940 950
DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG
960 970 980 990 1000
SYRRTDFVDR TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL
1010 1020 1030 1040 1050
ARTRPRPVEG FEVTNVTAST ISVQWALHRI RHATVSGVRV SIRHPEALRD
1060 1070 1080 1090 1100
QATDVDRSVD RFTFRALLPG KRYTIQLTTL SGLRGEEHPT ESLATAPTHV
1110 1120 1130 1140 1150
WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV TTSQSTKSRY
1160 1170 1180 1190 1200
VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD
1210 1220 1230 1240 1250
GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV
1260 1270 1280 1290 1300
DGRGRVSARF GGSPSKAATV RSQPTASAQL ENMEEAPKRV SLALQLPEHG
1310 1320 1330 1340 1350
SKDIGNVPGN CSENPCQNGG TCVPGADAHS CDCGPGFKGR RCELACIKVS
1360 1370 1380 1390 1400
RPCTRLFSET KAFPVWEGGV CHHVYKRVYR VHQDICFKES CESTSLKKTP
1410
NRKQSKSQTL EKS
Length:1,413
Mass (Da):152,204
Last modified:September 11, 2007 - v2
Checksum:i09BC8059234326D9
GO
Isoform 2 (identifier: Q8TER0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1306: QPTASAQLENMEEAPKRVSLALQLPEHGSKDIGN → H
     1375-1402: Missing.

Note: No experimental confirmation available.
Show »
Length:1,352
Mass (Da):145,300
Checksum:iE6063435C0AA1CFD
GO
Isoform 3 (identifier: Q8TER0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1306: QPTASAQLENMEEAPKRVSLALQLPEHGSKDIGN → H
     1398-1398: K → L
     1399-1413: Missing.

Note: No experimental confirmation available.
Show »
Length:1,365
Mass (Da):146,970
Checksum:i346748DD68531BC3
GO
Isoform 4 (identifier: Q8TER0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1306-1324: NVPGNCSENPCQNGGTCVP → SESAALVGTLGLTDCSQGP
     1325-1413: Missing.

Note: No experimental confirmation available.
Show »
Length:1,324
Mass (Da):142,073
Checksum:iAA7A732F74E755D6
GO

Sequence cautioni

The sequence AAH27939 differs from that shown. Intron retention. The N-terminal region arises from intron retention.Curated
The sequence AAQ04558 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti546D → N in AAQ04558 (PubMed:15194686).Curated1
Sequence conflicti653H → Y in AAQ04558 (PubMed:15194686).Curated1
Sequence conflicti719V → A in AAQ04558 (PubMed:15194686).Curated1
Sequence conflicti858S → G in AAQ04558 (PubMed:15194686).Curated1
Sequence conflicti1186 – 1206HSEPA…ADRRW → Q in AAQ04558 (PubMed:15194686).CuratedAdd BLAST21

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0348471228L → P.Corresponds to variant rs17440466dbSNPEnsembl.1
Natural variantiVAR_0348481289R → Q.Corresponds to variant rs6721345dbSNPEnsembl.1
Natural variantiVAR_0348491299H → R.Corresponds to variant rs6708120dbSNPEnsembl.1
Natural variantiVAR_0348501362A → S.1 PublicationCorresponds to variant rs2108485dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0277491273 – 1306QPTAS…KDIGN → H in isoform 2 and isoform 3. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_0277501306 – 1324NVPGN…GTCVP → SESAALVGTLGLTDCSQGP in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0277511325 – 1413Missing in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0277521375 – 1402Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0277531398K → L in isoform 3. 1 Publication1
Alternative sequenceiVSP_0277541399 – 1413Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005237 Genomic DNA. No translation available.
AC093585 Genomic DNA. No translation available.
AC104809 Genomic DNA. No translation available.
AK074062 mRNA. Translation: BAB84888.1.
AK074075 mRNA. Translation: BAB84901.1.
AF439717 mRNA. Translation: AAQ04558.1. Different initiation.
AF439718 mRNA. Translation: AAQ04563.1.
BC027939 mRNA. Translation: AAH27939.1. Sequence problems.
CCDSiCCDS46562.1. [Q8TER0-1]
RefSeqiNP_001073906.1. NM_001080437.1. [Q8TER0-1]
UniGeneiHs.471834.

Genome annotation databases

EnsembliENST00000310397; ENSP00000308893; ENSG00000162804. [Q8TER0-1]
ENST00000401884; ENSP00000384871; ENSG00000162804. [Q8TER0-5]
ENST00000405547; ENSP00000386007; ENSG00000162804. [Q8TER0-3]
GeneIDi25992.
KEGGihsa:25992.
UCSCiuc002wah.2. human. [Q8TER0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005237 Genomic DNA. No translation available.
AC093585 Genomic DNA. No translation available.
AC104809 Genomic DNA. No translation available.
AK074062 mRNA. Translation: BAB84888.1.
AK074075 mRNA. Translation: BAB84901.1.
AF439717 mRNA. Translation: AAQ04558.1. Different initiation.
AF439718 mRNA. Translation: AAQ04563.1.
BC027939 mRNA. Translation: AAH27939.1. Sequence problems.
CCDSiCCDS46562.1. [Q8TER0-1]
RefSeqiNP_001073906.1. NM_001080437.1. [Q8TER0-1]
UniGeneiHs.471834.

3D structure databases

ProteinModelPortaliQ8TER0.
SMRiQ8TER0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TER0. 1 interactor.
STRINGi9606.ENSP00000308893.

PTM databases

iPTMnetiQ8TER0.
PhosphoSitePlusiQ8TER0.

Polymorphism and mutation databases

BioMutaiSNED1.
DMDMi158563933.

Proteomic databases

PaxDbiQ8TER0.
PeptideAtlasiQ8TER0.
PRIDEiQ8TER0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310397; ENSP00000308893; ENSG00000162804. [Q8TER0-1]
ENST00000401884; ENSP00000384871; ENSG00000162804. [Q8TER0-5]
ENST00000405547; ENSP00000386007; ENSG00000162804. [Q8TER0-3]
GeneIDi25992.
KEGGihsa:25992.
UCSCiuc002wah.2. human. [Q8TER0-1]

Organism-specific databases

CTDi25992.
DisGeNETi25992.
GeneCardsiSNED1.
H-InvDBHIX0002988.
HGNCiHGNC:24696. SNED1.
HPAiHPA036414.
HPA036415.
MIMi616634. gene.
neXtProtiNX_Q8TER0.
OpenTargetsiENSG00000162804.
PharmGKBiPA134946370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4291. Eukaryota.
ENOG410ZK2K. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG108495.
InParanoidiQ8TER0.
OrthoDBiEOG091G002A.
PhylomeDBiQ8TER0.
TreeFamiTF335195.

Miscellaneous databases

ChiTaRSiSNED1. human.
GenomeRNAii25992.
PROiQ8TER0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162804.
CleanExiHS_SNED1.
ExpressionAtlasiQ8TER0. baseline and differential.
GenevisibleiQ8TER0. HS.

Family and domain databases

CDDicd00033. CCP. 1 hit.
cd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003886. NIDO_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 11 hits.
PF00041. fn3. 3 hits.
PF12661. hEGF. 3 hits.
PF06119. NIDO. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 14 hits.
SM00060. FN3. 3 hits.
SM00539. NIDO. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 13 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 3 hits.
PS50853. FN3. 3 hits.
PS51220. NIDO. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNED1_HUMAN
AccessioniPrimary (citable) accession number: Q8TER0
Secondary accession number(s): B5MDC3
, B7WNK6, B7WPM0, Q336F4, Q336F5, Q8N369, Q8TEP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.