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Q8TEQ6

- GEMI5_HUMAN

UniProt

Q8TEQ6 - GEMI5_HUMAN

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Protein
Gem-associated protein 5
Gene
GEMIN5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.3 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. snRNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA splicing, via spliceosome Source: UniProtKB
  4. ncRNA metabolic process Source: Reactome
  5. protein complex assembly Source: UniProtKB
  6. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_11066. snRNP Assembly.
SignaLinkiQ8TEQ6.

Names & Taxonomyi

Protein namesi
Recommended name:
Gem-associated protein 5
Short name:
Gemin5
Gene namesi
Name:GEMIN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20043. GEMIN5.

Subcellular locationi

Nucleusnucleoplasm. Nucleusgem. Cytoplasm
Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.1 Publication

GO - Cellular componenti

  1. Gemini of coiled bodies Source: UniProtKB-SubCell
  2. SMN complex Source: UniProtKB
  3. SMN-Sm protein complex Source: UniProtKB
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: UniProtKB
  6. nuclear body Source: UniProtKB
  7. nucleoplasm Source: UniProtKB
  8. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15081508Gem-associated protein 5
PRO_0000051004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine1 Publication
Modified residuei751 – 7511Phosphothreonine1 Publication
Modified residuei757 – 7571Phosphoserine1 Publication
Modified residuei770 – 7701Phosphoserine1 Publication
Modified residuei778 – 7781Phosphoserine3 Publications
Modified residuei847 – 8471Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TEQ6.
PaxDbiQ8TEQ6.
PRIDEiQ8TEQ6.

PTM databases

PhosphoSiteiQ8TEQ6.

Expressioni

Gene expression databases

ArrayExpressiQ8TEQ6.
BgeeiQ8TEQ6.
CleanExiHS_GEMIN5.
GenevestigatoriQ8TEQ6.

Organism-specific databases

HPAiHPA037393.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4EP067303EBI-443630,EBI-73440
SMN2Q166377EBI-443630,EBI-395421
SNRPEP623042EBI-443630,EBI-348082

Protein-protein interaction databases

BioGridi117429. 42 interactions.
IntActiQ8TEQ6. 13 interactions.
MINTiMINT-222419.
STRINGi9606.ENSP00000285873.

Structurei

3D structure databases

ProteinModelPortaliQ8TEQ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 10443WD 1
Add
BLAST
Repeati107 – 14842WD 2
Add
BLAST
Repeati150 – 18940WD 3
Add
BLAST
Repeati193 – 26472WD 4
Add
BLAST
Repeati280 – 32142WD 5
Add
BLAST
Repeati333 – 37442WD 6
Add
BLAST
Repeati377 – 41741WD 7
Add
BLAST
Repeati424 – 46441WD 8
Add
BLAST
Repeati468 – 50942WD 9
Add
BLAST
Repeati533 – 57341WD 10
Add
BLAST
Repeati576 – 62247WD 11
Add
BLAST
Repeati637 – 67741WD 12
Add
BLAST
Repeati680 – 72041WD 13
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1362 – 139332 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi738 – 7469Poly-Lys

Sequence similaritiesi

Belongs to the WD repeat gemin-5 family.
Contains 13 WD repeats.

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000231391.
HOVERGENiHBG051721.
InParanoidiQ8TEQ6.
KOiK13133.
OMAiAKQLCFQ.
OrthoDBiEOG7FXZXG.
PhylomeDBiQ8TEQ6.
TreeFamiTF328886.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 12 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG     50
TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT 100
VVTEHALHQH TISTLHWSPR VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE 150
PRTIFCLTCS PHHEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS 200
IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC YLATGSKDQT 250
IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV 300
SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ 350
LLLSTSMDRD VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG 400
DGMIRVWNTL SIKNNYDVKN FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK 450
VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPMSLGGE GDRPSLALYS 500
CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI 550
MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM 600
ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH 650
HDGRLVSASY DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS 700
GADDFCVHKW LTSMQDHSRP PQGKKSIELE KKRLSQPKAK PKKKKKPTLR 750
TPVKLESIDG NEEESMKENS GPVENGVSDQ EGEEQAREPE LPCGLAPAVS 800
REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI KKRKARSLLP 850
LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA 900
TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV 950
AMAPAAGYHV WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS 1000
NHFYREAIAI AKARLRPEDP VLKDLYLSWG TVLERDGHYA VAAKCYLGAT 1050
CAYDAAKVLA KKGDAASLRT AAELAAIVGE DELSASLALR CAQELLLANN 1100
WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK SSSSYHTWNT 1150
GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL 1200
LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF 1250
LPDGCDHLRD KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS 1300
VWVRAGHRTL SVEPSQQLDT ASTEETDPET SQPEPNRPSE LDLRLTEEGE 1350
RMLSTFKELF SEKHASLQNS QRTVAEVQET LAEMIRQHQK SQLCKSTANG 1400
PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE ANQRMAKFPE 1450
SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR 1500
RHCQTFCM 1508
Length:1,508
Mass (Da):168,589
Last modified:May 18, 2010 - v3
Checksum:iEA5293F395BBF14E
GO

Sequence cautioni

The sequence BAB84892.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti682 – 6821R → Q.5 Publications
Corresponds to variant rs1974777 [ dbSNP | Ensembl ].
VAR_033807
Natural varianti1155 – 11551P → S.
Corresponds to variant rs6865950 [ dbSNP | Ensembl ].
VAR_057604

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991L → P in BAB14222. 1 Publication
Sequence conflicti456 – 4561T → A in BAB14222. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY063750 mRNA. Translation: AAL38980.1.
AK074066 mRNA. Translation: BAB84892.2. Different initiation.
AC008421 Genomic DNA. No translation available.
BC008776 mRNA. Translation: AAH08776.2.
BC014147 mRNA. Translation: AAH14147.2.
BC113614 mRNA. Translation: AAI13615.1.
AK022748 mRNA. Translation: BAB14222.1.
AL117665 mRNA. Translation: CAB56035.2.
CCDSiCCDS4330.1.
PIRiT17345.
RefSeqiNP_001239085.1. NM_001252156.1.
NP_056280.2. NM_015465.4.
UniGeneiHs.483921.

Genome annotation databases

EnsembliENST00000285873; ENSP00000285873; ENSG00000082516.
GeneIDi25929.
KEGGihsa:25929.
UCSCiuc003lvx.3. human.

Polymorphism databases

DMDMi296439335.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY063750 mRNA. Translation: AAL38980.1 .
AK074066 mRNA. Translation: BAB84892.2 . Different initiation.
AC008421 Genomic DNA. No translation available.
BC008776 mRNA. Translation: AAH08776.2 .
BC014147 mRNA. Translation: AAH14147.2 .
BC113614 mRNA. Translation: AAI13615.1 .
AK022748 mRNA. Translation: BAB14222.1 .
AL117665 mRNA. Translation: CAB56035.2 .
CCDSi CCDS4330.1.
PIRi T17345.
RefSeqi NP_001239085.1. NM_001252156.1.
NP_056280.2. NM_015465.4.
UniGenei Hs.483921.

3D structure databases

ProteinModelPortali Q8TEQ6.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117429. 42 interactions.
IntActi Q8TEQ6. 13 interactions.
MINTi MINT-222419.
STRINGi 9606.ENSP00000285873.

PTM databases

PhosphoSitei Q8TEQ6.

Polymorphism databases

DMDMi 296439335.

Proteomic databases

MaxQBi Q8TEQ6.
PaxDbi Q8TEQ6.
PRIDEi Q8TEQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285873 ; ENSP00000285873 ; ENSG00000082516 .
GeneIDi 25929.
KEGGi hsa:25929.
UCSCi uc003lvx.3. human.

Organism-specific databases

CTDi 25929.
GeneCardsi GC05M154247.
H-InvDB HIX0005347.
HGNCi HGNC:20043. GEMIN5.
HPAi HPA037393.
MIMi 607005. gene.
neXtProti NX_Q8TEQ6.
PharmGKBi PA134945791.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000231391.
HOVERGENi HBG051721.
InParanoidi Q8TEQ6.
KOi K13133.
OMAi AKQLCFQ.
OrthoDBi EOG7FXZXG.
PhylomeDBi Q8TEQ6.
TreeFami TF328886.

Enzyme and pathway databases

Reactomei REACT_11066. snRNP Assembly.
SignaLinki Q8TEQ6.

Miscellaneous databases

GeneWikii GEMIN5.
GenomeRNAii 25929.
NextBioi 47472.
PROi Q8TEQ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TEQ6.
Bgeei Q8TEQ6.
CleanExi HS_GEMIN5.
Genevestigatori Q8TEQ6.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 12 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins."
    Gubitz A.K., Mourelatos Z., Abel L., Rappsilber J., Mann M., Dreyfuss G.
    J. Biol. Chem. 277:5631-5636(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, INTERACTION WITH SMN1; SNRPB; SNRPD1; SNRPD2; SNRPD3 AND SNRPE, SUBCELLULAR LOCATION, VARIANT GLN-682.
    Tissue: Cervix carcinoma.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-682.
    Tissue: Spleen.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-682.
    Tissue: Cerebellum and Lymph.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-737, VARIANT GLN-682.
    Tissue: Teratocarcinoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1508, VARIANT GLN-682.
    Tissue: Uterus.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "The Gemin5 protein of the SMN complex identifies snRNAs."
    Battle D.J., Lau C.-K., Wan L., Deng H., Lotti F., Dreyfuss G.
    Mol. Cell 23:273-279(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
    Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
    Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN SMN-SM COMPLEX.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; THR-751; SER-770; SER-778 AND SER-847, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757 AND SER-778, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGEMI5_HUMAN
AccessioniPrimary (citable) accession number: Q8TEQ6
Secondary accession number(s): Q14CV0
, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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