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Q8TEQ6

- GEMI5_HUMAN

UniProt

Q8TEQ6 - GEMI5_HUMAN

Protein

Gem-associated protein 5

Gene

GEMIN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.3 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. snRNA binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. ncRNA metabolic process Source: Reactome
    4. protein complex assembly Source: UniProtKB
    5. RNA metabolic process Source: Reactome
    6. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_11066. snRNP Assembly.
    SignaLinkiQ8TEQ6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gem-associated protein 5
    Short name:
    Gemin5
    Gene namesi
    Name:GEMIN5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20043. GEMIN5.

    Subcellular locationi

    Nucleusnucleoplasm 1 Publication. Nucleusgem 1 Publication. Cytoplasm 1 Publication
    Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. Gemini of coiled bodies Source: UniProtKB-SubCell
    4. membrane Source: UniProtKB
    5. nuclear body Source: UniProtKB
    6. nucleoplasm Source: UniProtKB
    7. nucleus Source: HPA
    8. SMN complex Source: UniProtKB
    9. SMN-Sm protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15081508Gem-associated protein 5PRO_0000051004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 481Phosphoserine1 Publication
    Modified residuei751 – 7511Phosphothreonine1 Publication
    Modified residuei757 – 7571Phosphoserine1 Publication
    Modified residuei770 – 7701Phosphoserine1 Publication
    Modified residuei778 – 7781Phosphoserine3 Publications
    Modified residuei847 – 8471Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TEQ6.
    PaxDbiQ8TEQ6.
    PRIDEiQ8TEQ6.

    PTM databases

    PhosphoSiteiQ8TEQ6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TEQ6.
    BgeeiQ8TEQ6.
    CleanExiHS_GEMIN5.
    GenevestigatoriQ8TEQ6.

    Organism-specific databases

    HPAiHPA037393.

    Interactioni

    Subunit structurei

    Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF4EP067303EBI-443630,EBI-73440
    SMN2Q166377EBI-443630,EBI-395421
    SNRPEP623042EBI-443630,EBI-348082

    Protein-protein interaction databases

    BioGridi117429. 42 interactions.
    IntActiQ8TEQ6. 13 interactions.
    MINTiMINT-222419.
    STRINGi9606.ENSP00000285873.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati62 – 10443WD 1Add
    BLAST
    Repeati107 – 14842WD 2Add
    BLAST
    Repeati150 – 18940WD 3Add
    BLAST
    Repeati193 – 26472WD 4Add
    BLAST
    Repeati280 – 32142WD 5Add
    BLAST
    Repeati333 – 37442WD 6Add
    BLAST
    Repeati377 – 41741WD 7Add
    BLAST
    Repeati424 – 46441WD 8Add
    BLAST
    Repeati468 – 50942WD 9Add
    BLAST
    Repeati533 – 57341WD 10Add
    BLAST
    Repeati576 – 62247WD 11Add
    BLAST
    Repeati637 – 67741WD 12Add
    BLAST
    Repeati680 – 72041WD 13Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1362 – 139332Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi738 – 7469Poly-Lys

    Sequence similaritiesi

    Belongs to the WD repeat gemin-5 family.Curated
    Contains 13 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000231391.
    HOVERGENiHBG051721.
    InParanoidiQ8TEQ6.
    KOiK13133.
    OMAiAKQLCFQ.
    OrthoDBiEOG7FXZXG.
    PhylomeDBiQ8TEQ6.
    TreeFamiTF328886.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 12 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    SSF50998. SSF50998. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TEQ6-1 [UniParc]FASTAAdd to Basket

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    MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG     50
    TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT 100
    VVTEHALHQH TISTLHWSPR VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE 150
    PRTIFCLTCS PHHEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS 200
    IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC YLATGSKDQT 250
    IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV 300
    SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ 350
    LLLSTSMDRD VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG 400
    DGMIRVWNTL SIKNNYDVKN FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK 450
    VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPMSLGGE GDRPSLALYS 500
    CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI 550
    MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM 600
    ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH 650
    HDGRLVSASY DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS 700
    GADDFCVHKW LTSMQDHSRP PQGKKSIELE KKRLSQPKAK PKKKKKPTLR 750
    TPVKLESIDG NEEESMKENS GPVENGVSDQ EGEEQAREPE LPCGLAPAVS 800
    REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI KKRKARSLLP 850
    LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA 900
    TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV 950
    AMAPAAGYHV WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS 1000
    NHFYREAIAI AKARLRPEDP VLKDLYLSWG TVLERDGHYA VAAKCYLGAT 1050
    CAYDAAKVLA KKGDAASLRT AAELAAIVGE DELSASLALR CAQELLLANN 1100
    WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK SSSSYHTWNT 1150
    GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL 1200
    LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF 1250
    LPDGCDHLRD KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS 1300
    VWVRAGHRTL SVEPSQQLDT ASTEETDPET SQPEPNRPSE LDLRLTEEGE 1350
    RMLSTFKELF SEKHASLQNS QRTVAEVQET LAEMIRQHQK SQLCKSTANG 1400
    PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE ANQRMAKFPE 1450
    SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR 1500
    RHCQTFCM 1508
    Length:1,508
    Mass (Da):168,589
    Last modified:May 18, 2010 - v3
    Checksum:iEA5293F395BBF14E
    GO

    Sequence cautioni

    The sequence BAB84892.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991L → P in BAB14222. (PubMed:14702039)Curated
    Sequence conflicti456 – 4561T → A in BAB14222. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti682 – 6821R → Q.5 Publications
    Corresponds to variant rs1974777 [ dbSNP | Ensembl ].
    VAR_033807
    Natural varianti1155 – 11551P → S.
    Corresponds to variant rs6865950 [ dbSNP | Ensembl ].
    VAR_057604

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY063750 mRNA. Translation: AAL38980.1.
    AK074066 mRNA. Translation: BAB84892.2. Different initiation.
    AC008421 Genomic DNA. No translation available.
    BC008776 mRNA. Translation: AAH08776.2.
    BC014147 mRNA. Translation: AAH14147.2.
    BC113614 mRNA. Translation: AAI13615.1.
    AK022748 mRNA. Translation: BAB14222.1.
    AL117665 mRNA. Translation: CAB56035.2.
    CCDSiCCDS4330.1.
    PIRiT17345.
    RefSeqiNP_001239085.1. NM_001252156.1.
    NP_056280.2. NM_015465.4.
    UniGeneiHs.483921.

    Genome annotation databases

    EnsembliENST00000285873; ENSP00000285873; ENSG00000082516.
    GeneIDi25929.
    KEGGihsa:25929.
    UCSCiuc003lvx.3. human.

    Polymorphism databases

    DMDMi296439335.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY063750 mRNA. Translation: AAL38980.1 .
    AK074066 mRNA. Translation: BAB84892.2 . Different initiation.
    AC008421 Genomic DNA. No translation available.
    BC008776 mRNA. Translation: AAH08776.2 .
    BC014147 mRNA. Translation: AAH14147.2 .
    BC113614 mRNA. Translation: AAI13615.1 .
    AK022748 mRNA. Translation: BAB14222.1 .
    AL117665 mRNA. Translation: CAB56035.2 .
    CCDSi CCDS4330.1.
    PIRi T17345.
    RefSeqi NP_001239085.1. NM_001252156.1.
    NP_056280.2. NM_015465.4.
    UniGenei Hs.483921.

    3D structure databases

    ProteinModelPortali Q8TEQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117429. 42 interactions.
    IntActi Q8TEQ6. 13 interactions.
    MINTi MINT-222419.
    STRINGi 9606.ENSP00000285873.

    PTM databases

    PhosphoSitei Q8TEQ6.

    Polymorphism databases

    DMDMi 296439335.

    Proteomic databases

    MaxQBi Q8TEQ6.
    PaxDbi Q8TEQ6.
    PRIDEi Q8TEQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285873 ; ENSP00000285873 ; ENSG00000082516 .
    GeneIDi 25929.
    KEGGi hsa:25929.
    UCSCi uc003lvx.3. human.

    Organism-specific databases

    CTDi 25929.
    GeneCardsi GC05M154247.
    H-InvDB HIX0005347.
    HGNCi HGNC:20043. GEMIN5.
    HPAi HPA037393.
    MIMi 607005. gene.
    neXtProti NX_Q8TEQ6.
    PharmGKBi PA134945791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000231391.
    HOVERGENi HBG051721.
    InParanoidi Q8TEQ6.
    KOi K13133.
    OMAi AKQLCFQ.
    OrthoDBi EOG7FXZXG.
    PhylomeDBi Q8TEQ6.
    TreeFami TF328886.

    Enzyme and pathway databases

    Reactomei REACT_11066. snRNP Assembly.
    SignaLinki Q8TEQ6.

    Miscellaneous databases

    GeneWikii GEMIN5.
    GenomeRNAii 25929.
    NextBioi 47472.
    PROi Q8TEQ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEQ6.
    Bgeei Q8TEQ6.
    CleanExi HS_GEMIN5.
    Genevestigatori Q8TEQ6.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 12 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    SSF50998. SSF50998. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins."
      Gubitz A.K., Mourelatos Z., Abel L., Rappsilber J., Mann M., Dreyfuss G.
      J. Biol. Chem. 277:5631-5636(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, INTERACTION WITH SMN1; SNRPB; SNRPD1; SNRPD2; SNRPD3 AND SNRPE, SUBCELLULAR LOCATION, VARIANT GLN-682.
      Tissue: Cervix carcinoma.
    2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-682.
      Tissue: Spleen.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-682.
      Tissue: Cerebellum and Lymph.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-737, VARIANT GLN-682.
      Tissue: Teratocarcinoma.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1508, VARIANT GLN-682.
      Tissue: Uterus.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "The Gemin5 protein of the SMN complex identifies snRNAs."
      Battle D.J., Lau C.-K., Wan L., Deng H., Lotti F., Dreyfuss G.
      Mol. Cell 23:273-279(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
      Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
      Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN SMN-SM COMPLEX.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; THR-751; SER-770; SER-778 AND SER-847, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757 AND SER-778, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGEMI5_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEQ6
    Secondary accession number(s): Q14CV0
    , Q8WWV4, Q969W4, Q9H9K3, Q9UFI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3