ID   SNX29_HUMAN             Reviewed;         813 AA.
AC   Q8TEQ0; B5MDW2; Q8N2X2; Q9HA26;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 3.
DT   27-MAR-2024, entry version 142.
DE   RecName: Full=Sorting nexin-29;
DE   AltName: Full=RUN domain-containing protein 2A;
GN   Name=SNX29; Synonyms=RUNDC2A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-375 (ISOFORM 1).
RC   TISSUE=Mammary gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-813 (ISOFORM 1).
RC   TISSUE=Spleen;
RX   PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA   Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA   Ohara O.;
RT   "Characterization of long cDNA clones from human adult spleen. II. The
RT   complete sequences of 81 cDNA clones.";
RL   DNA Res. 10:49-57(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 512-813 (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268 AND SER-330, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8TEQ0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TEQ0-2; Sequence=VSP_027281;
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB14033.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR   EMBL; AC007216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK022425; BAB14033.1; ALT_SEQ; mRNA.
DR   EMBL; AK074072; BAB84898.1; -; mRNA.
DR   EMBL; BC029857; AAH29857.1; -; mRNA.
DR   CCDS; CCDS10553.2; -. [Q8TEQ0-1]
DR   RefSeq; NP_115543.3; NM_032167.4. [Q8TEQ0-1]
DR   AlphaFoldDB; Q8TEQ0; -.
DR   SMR; Q8TEQ0; -.
DR   BioGRID; 124903; 45.
DR   IntAct; Q8TEQ0; 10.
DR   STRING; 9606.ENSP00000456480; -.
DR   TCDB; 3.A.34.1.1; the sorting nexins of the escrt complexes (sn-escrt).
DR   GlyCosmos; Q8TEQ0; 1 site, 1 glycan.
DR   GlyGen; Q8TEQ0; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8TEQ0; -.
DR   PhosphoSitePlus; Q8TEQ0; -.
DR   BioMuta; SNX29; -.
DR   DMDM; 353526314; -.
DR   EPD; Q8TEQ0; -.
DR   jPOST; Q8TEQ0; -.
DR   MassIVE; Q8TEQ0; -.
DR   MaxQB; Q8TEQ0; -.
DR   PaxDb; 9606-ENSP00000456480; -.
DR   PeptideAtlas; Q8TEQ0; -.
DR   ProteomicsDB; 74476; -. [Q8TEQ0-1]
DR   ProteomicsDB; 74477; -. [Q8TEQ0-2]
DR   Pumba; Q8TEQ0; -.
DR   Antibodypedia; 2225; 146 antibodies from 19 providers.
DR   DNASU; 92017; -.
DR   Ensembl; ENST00000566228.6; ENSP00000456480.1; ENSG00000048471.14. [Q8TEQ0-1]
DR   GeneID; 92017; -.
DR   KEGG; hsa:92017; -.
DR   MANE-Select; ENST00000566228.6; ENSP00000456480.1; NM_032167.5; NP_115543.3.
DR   UCSC; uc002dby.6; human. [Q8TEQ0-1]
DR   AGR; HGNC:30542; -.
DR   CTD; 92017; -.
DR   DisGeNET; 92017; -.
DR   GeneCards; SNX29; -.
DR   HGNC; HGNC:30542; SNX29.
DR   HPA; ENSG00000048471; Low tissue specificity.
DR   neXtProt; NX_Q8TEQ0; -.
DR   OpenTargets; ENSG00000048471; -.
DR   PharmGKB; PA162404312; -.
DR   VEuPathDB; HostDB:ENSG00000048471; -.
DR   eggNOG; KOG2101; Eukaryota.
DR   eggNOG; KOG4381; Eukaryota.
DR   GeneTree; ENSGT00730000110975; -.
DR   HOGENOM; CLU_020563_1_0_1; -.
DR   InParanoid; Q8TEQ0; -.
DR   OMA; TIPHVKL; -.
DR   OrthoDB; 5481180at2759; -.
DR   PhylomeDB; Q8TEQ0; -.
DR   PathwayCommons; Q8TEQ0; -.
DR   SignaLink; Q8TEQ0; -.
DR   BioGRID-ORCS; 92017; 11 hits in 1153 CRISPR screens.
DR   ChiTaRS; SNX29; human.
DR   GenomeRNAi; 92017; -.
DR   Pharos; Q8TEQ0; Tbio.
DR   PRO; PR:Q8TEQ0; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q8TEQ0; Protein.
DR   Bgee; ENSG00000048471; Expressed in kidney epithelium and 181 other cell types or tissues.
DR   ExpressionAtlas; Q8TEQ0; baseline and differential.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd07277; PX_RUN; 1.
DR   CDD; cd17689; RUN_SNX29; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR047329; RUN_SNX29.
DR   InterPro; IPR037916; SNX29_PX.
DR   PANTHER; PTHR47194:SF4; SORTING NEXIN-29; 1.
DR   PANTHER; PTHR47194; SORTING NEXIN-29-RELATED; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   Genevisible; Q8TEQ0; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..813
FT                   /note="Sorting nexin-29"
FT                   /id="PRO_0000297565"
FT   DOMAIN          36..180
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT   DOMAIN          656..779
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   REGION          269..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          778..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          466..545
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        357..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         268
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         291
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         292
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         330
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         445
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         450
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         639
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         641
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         642
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   MOD_RES         646
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3S3"
FT   VAR_SEQ         775..813
FT                   /note="ITPPGEPVNSRPKAASRFPKLSRGQPRETRNVEPQSGDL -> WISLFGNGR
FT                   DSSREEFSSS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027281"
FT   CONFLICT        183
FT                   /note="N -> D (in Ref. 2; BAB14033)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        344
FT                   /note="S -> G (in Ref. 2; BAB14033)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   813 AA;  91254 MW;  A1868A682CCFBE0C CRC64;
     MSGSQNNDKR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE AVLQHGLKRS
     RGLALTAAAI KQAAGFASKT ETEPVFWYYV KEVLNKHELQ RFYSLRHIAS DVGRGRAWLR
     CALNEHSLER YLHMLLADRC RLSTFYEDWS FVMDEERSSM LPTMAAGLNS ILFAINIDNK
     DLNGQSKFAP TVSDLLKEST QNVTSLLKES TQGVSSLFRE ITASSAVSIL IKPEQETDPL
     PVVSRNVSAD AKCKKERKKK KKVTNIISFD DEEDEQNSGD VFKKTPGAGE SSEDNSDRSS
     VNIMSAFESP FGPNSNGSQS SNSWKIDSLS LNGEFGYQKL DVKSIDDEDV DENEDDVYGN
     SSGRKHRGHS ESPEKPLEGN TCLSQMHSWA PLKVLHNDSD ILFPVSGVGS YSPADAPLGS
     LENGTGPEDH VLPDPGLRYS VEASSPGHGS PLSSLLPSAS VPESMTISEL RQATVAMMNR
     KDELEEENRS LRNLLDGEME HSAALRQEVD TLKRKVAEQE ERQGMKVQAL ARENEVLKVQ
     LKKYVGAVQM LKREGQTAEV PNLWSVDGEV TVAEQKPGEI AEELASSYER KLIEVAEMHG
     ELIEFNERLH RALVAKEALV SQMRQELIDL RGPVPGDLSQ TSEDQSLSDF EISNRALINV
     WIPSVFLRGK AANAFHVYQV YIRIKDDEWN IYRRYTEFRS LHHKLQNKYP QVRAYNFPPK
     KAIGNKDAKF VEERRKQLQN YLRSVMNKVI QMVPEFAASP KKETLIQLMP FFVDITPPGE
     PVNSRPKAAS RFPKLSRGQP RETRNVEPQS GDL
//