Q8TEQ0 (SNX29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin-29

Alternative name(s):
RUN domain-containing protein 2A

Gene names

Name:	SNX29
Synonyms:	RUNDC2A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	813 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Contains 1 RUN domain.
Sequence caution	The sequence BAB14033.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     775-813: ITPPGEPVNSRPKAASRFPKLSRGQPRETRNVEPQSGDL → WISLFGNGRDSSREEFSSS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 813	813	Sorting nexin-29		PRO_0000297565
Regions
	Domain	36 – 180	145	RUN
	Domain	656 – 779	124	PX
	Coiled coil	466 – 545	80	Potential
Amino acid modifications
	Modified residue	641	1	Phosphothreonine By similarity
	Modified residue	642	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	775 – 813	39	ITPPG…QSGDL → WISLFGNGRDSSREEFSSS in isoform 2.		VSP_027281
Experimental info
	Sequence conflict	183	1	N → D in BAB14033. Ref.2
	Sequence conflict	344	1	S → G in BAB14033. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 19, 2011. Version 3. Checksum: A1868A682CCFBE0C	FASTA	813	91,254
	10 20 30 40 50 60 MSGSQNNDKR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE AVLQHGLKRS 70 80 90 100 110 120 RGLALTAAAI KQAAGFASKT ETEPVFWYYV KEVLNKHELQ RFYSLRHIAS DVGRGRAWLR 130 140 150 160 170 180 CALNEHSLER YLHMLLADRC RLSTFYEDWS FVMDEERSSM LPTMAAGLNS ILFAINIDNK 190 200 210 220 230 240 DLNGQSKFAP TVSDLLKEST QNVTSLLKES TQGVSSLFRE ITASSAVSIL IKPEQETDPL 250 260 270 280 290 300 PVVSRNVSAD AKCKKERKKK KKVTNIISFD DEEDEQNSGD VFKKTPGAGE SSEDNSDRSS 310 320 330 340 350 360 VNIMSAFESP FGPNSNGSQS SNSWKIDSLS LNGEFGYQKL DVKSIDDEDV DENEDDVYGN 370 380 390 400 410 420 SSGRKHRGHS ESPEKPLEGN TCLSQMHSWA PLKVLHNDSD ILFPVSGVGS YSPADAPLGS 430 440 450 460 470 480 LENGTGPEDH VLPDPGLRYS VEASSPGHGS PLSSLLPSAS VPESMTISEL RQATVAMMNR 490 500 510 520 530 540 KDELEEENRS LRNLLDGEME HSAALRQEVD TLKRKVAEQE ERQGMKVQAL ARENEVLKVQ 550 560 570 580 590 600 LKKYVGAVQM LKREGQTAEV PNLWSVDGEV TVAEQKPGEI AEELASSYER KLIEVAEMHG 610 620 630 640 650 660 ELIEFNERLH RALVAKEALV SQMRQELIDL RGPVPGDLSQ TSEDQSLSDF EISNRALINV 670 680 690 700 710 720 WIPSVFLRGK AANAFHVYQV YIRIKDDEWN IYRRYTEFRS LHHKLQNKYP QVRAYNFPPK 730 740 750 760 770 780 KAIGNKDAKF VEERRKQLQN YLRSVMNKVI QMVPEFAASP KKETLIQLMP FFVDITPPGE 790 800 810 PVNSRPKAAS RFPKLSRGQP RETRNVEPQS GDL
	Isoform 2 [UniParc]. Checksum: D6EA31956390331B	FASTA	793	89,144
	10 20 30 40 50 60 MSGSQNNDKR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE AVLQHGLKRS 70 80 90 100 110 120 RGLALTAAAI KQAAGFASKT ETEPVFWYYV KEVLNKHELQ RFYSLRHIAS DVGRGRAWLR 130 140 150 160 170 180 CALNEHSLER YLHMLLADRC RLSTFYEDWS FVMDEERSSM LPTMAAGLNS ILFAINIDNK 190 200 210 220 230 240 DLNGQSKFAP TVSDLLKEST QNVTSLLKES TQGVSSLFRE ITASSAVSIL IKPEQETDPL 250 260 270 280 290 300 PVVSRNVSAD AKCKKERKKK KKVTNIISFD DEEDEQNSGD VFKKTPGAGE SSEDNSDRSS 310 320 330 340 350 360 VNIMSAFESP FGPNSNGSQS SNSWKIDSLS LNGEFGYQKL DVKSIDDEDV DENEDDVYGN 370 380 390 400 410 420 SSGRKHRGHS ESPEKPLEGN TCLSQMHSWA PLKVLHNDSD ILFPVSGVGS YSPADAPLGS 430 440 450 460 470 480 LENGTGPEDH VLPDPGLRYS VEASSPGHGS PLSSLLPSAS VPESMTISEL RQATVAMMNR 490 500 510 520 530 540 KDELEEENRS LRNLLDGEME HSAALRQEVD TLKRKVAEQE ERQGMKVQAL ARENEVLKVQ 550 560 570 580 590 600 LKKYVGAVQM LKREGQTAEV PNLWSVDGEV TVAEQKPGEI AEELASSYER KLIEVAEMHG 610 620 630 640 650 660 ELIEFNERLH RALVAKEALV SQMRQELIDL RGPVPGDLSQ TSEDQSLSDF EISNRALINV 670 680 690 700 710 720 WIPSVFLRGK AANAFHVYQV YIRIKDDEWN IYRRYTEFRS LHHKLQNKYP QVRAYNFPPK 730 740 750 760 770 780 KAIGNKDAKF VEERRKQLQN YLRSVMNKVI QMVPEFAASP KKETLIQLMP FFVDWISLFG 790 NGRDSSREEF SSS

References

[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-375 (ISOFORM 1). Tissue: Mammary gland.
[3]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-813 (ISOFORM 1). Tissue: Spleen.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 512-813 (ISOFORM 2). Tissue: Brain.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007216 Genomic DNA. No translation available. AC007598 Genomic DNA. No translation available. AC007601 Genomic DNA. No translation available. AC010333 Genomic DNA. No translation available. AC092365 Genomic DNA. No translation available. AC131391 Genomic DNA. No translation available. AK022425 mRNA. Translation: BAB14033.1. Sequence problems. AK074072 mRNA. Translation: BAB84898.1. BC029857 mRNA. Translation: AAH29857.1.
IPI	IPI00166504. IPI00855845.
RefSeq	NP_115543.3. NM_032167.3.
UniGene	Hs.458401.
3D structure databases
ProteinModelPortal	Q8TEQ0.
SMR	Q8TEQ0. Positions 50-185, 658-772.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TEQ0. 2 interactions.
STRING	9606.ENSP00000306940.
PTM databases
PhosphoSite	Q8TEQ0.
Polymorphism databases
DMDM	296452885.
Proteomic databases
PaxDb	Q8TEQ0.
PRIDE	Q8TEQ0.
Protocols and materials databases
DNASU	92017.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000564791; ENSP00000457017; ENSG00000048471. ENST00000566228; ENSP00000456480; ENSG00000048471.
GeneID	92017.
KEGG	hsa:92017.
UCSC	uc002dbw.2. human. uc002dby.4. human.
Organism-specific databases
CTD	92017.
GeneCards	GC16P012146.
H-InvDB	HIX0012826.
HGNC	HGNC:30542. SNX29.
HPA	HPA008889.
neXtProt	NX_Q8TEQ0.
PharmGKB	PA142670962. PA162404312.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86473.
HOGENOM	HOG000170771.
HOVERGEN	HBG108498.
InParanoid	Q8TEQ0.
OrthoDB	EOG4BK53S.
Gene expression databases
ArrayExpress	Q8TEQ0.
Bgee	Q8TEQ0.
CleanEx	HS_RUNDC2A. HS_SNX29.
Genevestigator	Q8TEQ0.
Family and domain databases
Gene3D	3.30.1520.10. 1 hit.
InterPro	IPR001683. Phox. IPR004012. Run. [Graphical view]
Pfam	PF00787. PX. 1 hit. PF02759. RUN. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. SM00593. RUN. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. PS50826. RUN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SNX29. human.
GenomeRNAi	92017.
NextBio	77562.

Entry information

Entry name

SNX29_HUMAN

Accession

Primary (citable) accession number: Q8TEQ0
Secondary accession number(s): B5MDW2, Q8N2X2, Q9HA26

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 19, 2011
Last modified:	May 29, 2013
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.