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Q8TEP8

- CE192_HUMAN

UniProt

Q8TEP8 - CE192_HUMAN

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Protein
Centrosomal protein of 192 kDa
Gene
CEP192, KIAA1569, PP8407
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.2 Publications

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. centrosome duplication Source: UniProtKB
  3. mitotic cell cycle Source: Reactome
  4. negative regulation of phosphatase activity Source: UniProtKB
  5. spindle assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 192 kDa
Short name:
Cep192
Gene namesi
Name:CEP192
Synonyms:KIAA1569
ORF Names:PP8407
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:25515. CEP192.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole
Note: Pericentriolar location in mitotic centrosomes.3 Publications

GO - Cellular componenti

  1. centriole Source: UniProtKB-SubCell
  2. centrosome Source: UniProtKB
  3. cytoplasm Source: HPA
  4. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1717 – 17171P → A: Increased presence on interphasic centrosomes, and decreased presence on mitotic centrosomes; no ubiquitination and unchanged levels in response to hypoxia. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19411941Centrosomal protein of 192 kDa
PRO_0000312495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161Phosphoserine1 Publication
Modified residuei1159 – 11591Phosphoserine1 Publication
Modified residuei1502 – 15021Phosphoserine1 Publication
Modified residuei1514 – 15141Phosphoserine1 Publication
Modified residuei1717 – 17171Hydroxyproline

Post-translational modificationi

Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.
Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.1 Publication

Keywords - PTMi

Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8TEP8.
PaxDbiQ8TEP8.
PeptideAtlasiQ8TEP8.
PRIDEiQ8TEP8.

Expressioni

Gene expression databases

ArrayExpressiQ8TEP8.
BgeeiQ8TEP8.
CleanExiHS_CEP192.
GenevestigatoriQ8TEP8.

Organism-specific databases

HPAiHPA039392.
HPA040503.

Interactioni

Subunit structurei

Interacts with SHBG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-2339778,EBI-357253

Protein-protein interaction databases

IntActiQ8TEP8. 10 interactions.
MINTiMINT-4989007.
STRINGi9606.ENSP00000317156.

Structurei

3D structure databases

ProteinModelPortaliQ8TEP8.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG82847.
HOGENOMiHOG000111525.
HOVERGENiHBG106621.
InParanoidiQ8TEP8.
PhylomeDBiQ8TEP8.

Family and domain databases

InterProiIPR028542. CEP192.
[Graphical view]
PANTHERiPTHR16029:SF10. PTHR16029:SF10. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TEP8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKTSDLVPSF GYFIRSPEKR EPIALIRKSD VSRGNLEKEM AHLNHDLYSG     50
DLNEQSQAQL SEGSITLQVE AVESTSQVDE NDVTLTADKG KTEDTFFMSN 100
KPQRYKDKLP DSGDSMLRIS TIASAIAEAS VNTDPSQLAA MIKALSNKTR 150
DKTFQEDEKQ KDYSHVRHFL PNDLEKSNGS NALDMEKYLK KTEVSRYESA 200
LENFSRASMS DTWDLSLPKE QTTQDIHPVD LSATSVSVRA PEENTAAIVY 250
VENGESENQE SFRTINSSNS VTNRENNSAV VDVKTCSIDN KLQDVGNDEK 300
ATSISTPSDS YSSVRNPRIT SLCLLKDCEE IRDNRENQRQ NECVSEISNS 350
EKHVTFENHR IVSPKNSDLK NTSPEHGGRG SEDEQESFRP STSPLSHSSP 400
SEISGTSSSG CALESFGSAA QQQQPPCEQE LSPLVCSPAG VSRLTYVSEP 450
ESSYPTTATD DALEDRKSDI TSELSTTIIQ GSPAALEERA MEKLREKVPF 500
QNRGKGTLSS IIQNNSDTRK ATETTSLSSK PEYVKPDFRW SKDPSSKSGN 550
LLETSEVGWT SNPEELDPIR LALLGKSGLS CQVGSATSHP VSCQEPIDED 600
QRISPKDKST AGREFSGQVS HQTTSENQCT PIPSSTVHSS VADMQNMPAA 650
VHALLTQPSL SAAPFAQRYL GTLPSTGSTT LPQCHAGNAT VCGFSGGLPY 700
PAVAGEPVQN SVAVGICLGS NIGSGWMGTS SLCNPYSNTL NQNLLSTTKP 750
FPVPSVGTNC GIEPWDSGVT SGLGSVRVPE ELKLPHACCV GIASQTLLSV 800
LNPTDRWLQV SIGVLSISVN GEKVDLSTYR CLVFKNKAII RPHATEEIKV 850
LFIPSSPGVF RCTFSVASWP CSTDAETIVQ AEALASTVTL TAIAESPVIE 900
VETEKKDVLD FGDLTYGGWK ALPLKLINRT HATVPIRLII NANAVAWRCF 950
TFSKESVRAP VEVAPCADVV TRLAGPSVVN HMMPASYDGQ DPEFLMIWVL 1000
FHSPKKQISS SDILDSAEEF SAKVDIEVDS PNPTPVLRSV SLRARAGIAR 1050
IHAPRDLQTM HFLAKVASSR KQHLPLKNAG NIEVYLDIKV PEQGSHFSVD 1100
PKNLLLKPGE EHEVIVSFTP KDPEACEERI LKIFVQPFGP QYEVVLKGEV 1150
ISSGSKPLSP GPCLDIPSIL SNKQFLAWGG VPLGRTQLQK LALRNNSAST 1200
TQHLRLLIRG QDQDCFQLQN TFGSEQRLTS NCEIRIHPKE DIFISVLFAP 1250
TRLSCMLARL EIKQLGNRSQ PGIKFTIPLS GYGGTSNLIL EGVKKLSDSY 1300
MVTVNGLVPG KESKIVFSVR NTGSRAAFVK AVGFKDSQKK VLLDPKVLRI 1350
FPDKFVLKER TQENVTLIYN PSDRGINNKT ATELSTVYLF GGDEISRQQY 1400
RRALLHKPEM IKQILPEHSV LQNINFVEAF QDELLVTEVY DLPQRPNDVQ 1450
LFYGSMCKII LSVIGEFRDC ISSREFLQPS SKASLESTSD LGASGKHGGN 1500
VSLDVLPVKG PQGSPLLSRA ARPPLDQLAS EEPWTVLPEH LILVAPSPCD 1550
MAKTGRFQIV NNSVRLLRFE LCWPAHCLTV TPQHGCVAPE SKLQILVSPN 1600
SSLSTKQSMF PWSGLIYIHC DDGQKKIVKV QIREDLTQVE LLTRLTSKPF 1650
GILSPVSEPS VSHLVKPMTK PPSTKVEIRN KSITFPTTEP GETSESCLEL 1700
ENHGTTDVKW HLSSLAPPYV KGVDESGDVF RATYAAFRCS PISGLLESHG 1750
IQKVSITFLP RGRGDYAQFW DVECHPLKEP HMKHTLRFQL SGQSIEAENE 1800
PENACLSTDS LIKIDHLVKP RRQAVSEASA RIPEQLDVTA RGVYAPEDVY 1850
RFRPTSVGES RTLKVNLRNN SFITHSLKFL SPREPFYVKH SKYSLRAQHY 1900
INMPVQFKPK SAGKFEALLV IQTDEGKSIA IRLIGEALGK N 1941
Length:1,941
Mass (Da):213,146
Last modified:December 4, 2007 - v2
Checksum:i0DA715D1FAABA8D4
GO
Isoform 2 (identifier: Q8TEP8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1403-1407: ALLHK → QGPAT
     1408-1941: Missing.

Show »
Length:1,407
Mass (Da):153,582
Checksum:i2B078D93D54C537E
GO
Isoform 3 (identifier: Q8TEP8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MKTSDLV → MEDFRGIAEE...CLGGGNNVKR

Show »
Length:2,537
Mass (Da):279,111
Checksum:iCA0A92F264280C3B
GO

Sequence cautioni

The sequence CAB66752.1 differs from that shown. Reason: Frameshift at positions 1196 and 1239.
The sequence AAL55870.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB66752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti457 – 4571T → A.
Corresponds to variant rs10048340 [ dbSNP | Ensembl ].
VAR_037514
Natural varianti513 – 5131Q → P.
Corresponds to variant rs11080623 [ dbSNP | Ensembl ].
VAR_050782
Natural varianti769 – 7691V → M.1 Publication
Corresponds to variant rs2282542 [ dbSNP | Ensembl ].
VAR_037515
Natural varianti948 – 9481R → H.2 Publications
Corresponds to variant rs7228940 [ dbSNP | Ensembl ].
VAR_050783
Natural varianti956 – 9561S → P.3 Publications
Corresponds to variant rs578208 [ dbSNP | Ensembl ].
VAR_050784
Natural varianti1105 – 11051L → F.3 Publications
Corresponds to variant rs6505780 [ dbSNP | Ensembl ].
VAR_050785
Natural varianti1455 – 14551S → N.1 Publication
Corresponds to variant rs2027698 [ dbSNP | Ensembl ].
VAR_050786
Natural varianti1525 – 15251L → P.3 Publications
Corresponds to variant rs474337 [ dbSNP | Ensembl ].
VAR_050787
Natural varianti1675 – 16751K → E.1 Publication
Corresponds to variant rs3737379 [ dbSNP | Ensembl ].
VAR_050788
Natural varianti1853 – 18531R → L.3 Publications
Corresponds to variant rs1786263 [ dbSNP | Ensembl ].
VAR_050789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MKTSDLV → MEDFRGIAEESFPSFLTNSL FGNSGILENVTLSSNLGLPV AVSTLARDRSSTDNRYPDIQ ASYLVEGRFSVPSGSSPGSQ SDAEPRERLQLSFQDDDSIS RKKSYVESQRLSNALSKQSA LQMETAGPEEEPAGATESLQ GQDLFNRASPLEQAQDSPID FHLQSWMNNKEPKIVVLDAG KHFEDKTLKSDLSHTSLLEN EKLILPTSLEDSSDDDIDDE MFYDDHLEAYFEQLAIPGMI YEDLEGPEPPEKGFKLPTNG LRQANENGSLNCKFQSENNS SLISLDSHSSETTHKESEES QVICLPGTSNSIGTGDSRRY TDGMLPFSSGTWGTEKEIEN LKGIVPDLNSECASKDVLVK TLRAIDVKLNSDNFHDANAN RGGFDLTDPVKQGAECPHQN KTVLHMDGCLDTETPTVSIQ ENVDVASLKPISDSGINFTD AIWSPTCERRTCECHESIEK NKDKTDLPQSVVYQNEEGRW VTDLAYYTSFNSKQNLNVSL SDEMNEDFRSGSEAFDLIAQ DEEEFNKEHQFIQEENIDAH NTSVALGDTSWGATINYSLL RKSRSTSDLDKDDASYLRLS LGEFFAQRSEALGCLGGGNN VKR in isoform 3.
VSP_055678
Alternative sequencei1403 – 14075ALLHK → QGPAT in isoform 2.
VSP_029845
Alternative sequencei1408 – 1941534Missing in isoform 2.
VSP_029846Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti806 – 8061R → L in BAB84900. 1 Publication
Sequence conflicti857 – 8571P → A in AAL55870. 1 Publication
Sequence conflicti1519 – 15191R → Q1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KJ567064 mRNA. No translation available.
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
AK074074 mRNA. Translation: BAB84900.1.
AF318363 mRNA. Translation: AAL55870.1. Different initiation.
AK001214 mRNA. Translation: BAA91559.1. Different initiation.
UniGeneiHs.100914.

Genome annotation databases

EnsembliENST00000325971; ENSP00000317156; ENSG00000101639. [Q8TEP8-1]
UCSCiuc002krs.1. human. [Q8TEP8-2]

Polymorphism databases

DMDMi162416230.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KJ567064 mRNA. No translation available.
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1 . Sequence problems.
AK074074 mRNA. Translation: BAB84900.1 .
AF318363 mRNA. Translation: AAL55870.1 . Different initiation.
AK001214 mRNA. Translation: BAA91559.1 . Different initiation.
UniGenei Hs.100914.

3D structure databases

ProteinModelPortali Q8TEP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8TEP8. 10 interactions.
MINTi MINT-4989007.
STRINGi 9606.ENSP00000317156.

Polymorphism databases

DMDMi 162416230.

Proteomic databases

MaxQBi Q8TEP8.
PaxDbi Q8TEP8.
PeptideAtlasi Q8TEP8.
PRIDEi Q8TEP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325971 ; ENSP00000317156 ; ENSG00000101639 . [Q8TEP8-1 ]
UCSCi uc002krs.1. human. [Q8TEP8-2 ]

Organism-specific databases

GeneCardsi GC18P012998.
HGNCi HGNC:25515. CEP192.
HPAi HPA039392.
HPA040503.
neXtProti NX_Q8TEP8.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82847.
HOGENOMi HOG000111525.
HOVERGENi HBG106621.
InParanoidi Q8TEP8.
PhylomeDBi Q8TEP8.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

PROi Q8TEP8.

Gene expression databases

ArrayExpressi Q8TEP8.
Bgeei Q8TEP8.
CleanExi HS_CEP192.
Genevestigatori Q8TEP8.

Family and domain databases

InterProi IPR028542. CEP192.
[Graphical view ]
PANTHERi PTHR16029:SF10. PTHR16029:SF10. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Cep192-organized Aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly."
    Joukov V., Walter J.C., De Nicolo A.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1941 (ISOFORM 1), VARIANTS MET-769; HIS-948; PRO-956; PHE-1105; PRO-1525 AND LEU-1853.
    Tissue: Testis.
  4. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-1941 (ISOFORM 1), VARIANTS PRO-956; PHE-1105; ASN-1455; PRO-1525; GLU-1675 AND LEU-1853.
    Tissue: Spleen.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 857-1941 (ISOFORM 2), VARIANTS HIS-948; PRO-956 AND PHE-1105.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1362-1941 (ISOFORM 1), VARIANTS PRO-1525 AND LEU-1853.
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  8. "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin."
    Pope S.N., Lee I.R.
    J. Steroid Biochem. Mol. Biol. 94:203-208(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHBG.
  9. "Human Cep192 is required for mitotic centrosome and spindle assembly."
    Gomez-Ferreria M.A., Rath U., Buster D.W., Chanda S.K., Caldwell J.S., Rines D.R., Sharp D.J.
    Curr. Biol. 17:1960-1966(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-1159; SER-1502 AND SER-1514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192."
    Moser S.C., Bensaddek D., Ortmann B., Maure J.F., Mudie S., Blow J.J., Lamond A.I., Swedlow J.R., Rocha S.
    Dev. Cell 26:381-392(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: HYDROXYLATION AT PRO-1717, UBIQUITINATION, MUTAGENESIS OF PRO-1717.

Entry informationi

Entry nameiCE192_HUMAN
AccessioniPrimary (citable) accession number: Q8TEP8
Secondary accession number(s): E9PF99
, Q8WYT8, Q9H0F4, Q9NW27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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