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Q8TEP8

- CE192_HUMAN

UniProt

Q8TEP8 - CE192_HUMAN

Protein

Centrosomal protein of 192 kDa

Gene

CEP192

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.2 Publications

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. centrosome duplication Source: UniProtKB
    2. G2/M transition of mitotic cell cycle Source: Reactome
    3. mitotic cell cycle Source: Reactome
    4. negative regulation of phosphatase activity Source: UniProtKB
    5. spindle assembly Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 192 kDa
    Short name:
    Cep192
    Gene namesi
    Name:CEP192
    Synonyms:KIAA1569
    ORF Names:PP8407
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:25515. CEP192.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 3 Publications
    Note: Pericentriolar location in mitotic centrosomes.

    GO - Cellular componenti

    1. centriole Source: UniProtKB-SubCell
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: HPA
    4. cytosol Source: Reactome
    5. pericentriolar material Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1717 – 17171P → A: Increased presence on interphasic centrosomes, and decreased presence on mitotic centrosomes; no ubiquitination and unchanged levels in response to hypoxia. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19411941Centrosomal protein of 192 kDaPRO_0000312495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161Phosphoserine1 Publication
    Modified residuei1159 – 11591Phosphoserine1 Publication
    Modified residuei1502 – 15021Phosphoserine1 Publication
    Modified residuei1514 – 15141Phosphoserine1 Publication
    Modified residuei1717 – 17171Hydroxyproline1 Publication

    Post-translational modificationi

    Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.1 Publication
    Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.1 Publication

    Keywords - PTMi

    Hydroxylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8TEP8.
    PaxDbiQ8TEP8.
    PeptideAtlasiQ8TEP8.
    PRIDEiQ8TEP8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TEP8.
    BgeeiQ8TEP8.
    CleanExiHS_CEP192.
    GenevestigatoriQ8TEP8.

    Organism-specific databases

    HPAiHPA039392.
    HPA040503.

    Interactioni

    Subunit structurei

    Interacts with SHBG.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CAP621362EBI-2339778,EBI-357253

    Protein-protein interaction databases

    IntActiQ8TEP8. 10 interactions.
    MINTiMINT-4989007.
    STRINGi9606.ENSP00000317156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG82847.
    HOGENOMiHOG000111525.
    HOVERGENiHBG106621.
    InParanoidiQ8TEP8.
    PhylomeDBiQ8TEP8.

    Family and domain databases

    InterProiIPR028542. CEP192.
    [Graphical view]
    PANTHERiPTHR16029:SF10. PTHR16029:SF10. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TEP8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTSDLVPSF GYFIRSPEKR EPIALIRKSD VSRGNLEKEM AHLNHDLYSG     50
    DLNEQSQAQL SEGSITLQVE AVESTSQVDE NDVTLTADKG KTEDTFFMSN 100
    KPQRYKDKLP DSGDSMLRIS TIASAIAEAS VNTDPSQLAA MIKALSNKTR 150
    DKTFQEDEKQ KDYSHVRHFL PNDLEKSNGS NALDMEKYLK KTEVSRYESA 200
    LENFSRASMS DTWDLSLPKE QTTQDIHPVD LSATSVSVRA PEENTAAIVY 250
    VENGESENQE SFRTINSSNS VTNRENNSAV VDVKTCSIDN KLQDVGNDEK 300
    ATSISTPSDS YSSVRNPRIT SLCLLKDCEE IRDNRENQRQ NECVSEISNS 350
    EKHVTFENHR IVSPKNSDLK NTSPEHGGRG SEDEQESFRP STSPLSHSSP 400
    SEISGTSSSG CALESFGSAA QQQQPPCEQE LSPLVCSPAG VSRLTYVSEP 450
    ESSYPTTATD DALEDRKSDI TSELSTTIIQ GSPAALEERA MEKLREKVPF 500
    QNRGKGTLSS IIQNNSDTRK ATETTSLSSK PEYVKPDFRW SKDPSSKSGN 550
    LLETSEVGWT SNPEELDPIR LALLGKSGLS CQVGSATSHP VSCQEPIDED 600
    QRISPKDKST AGREFSGQVS HQTTSENQCT PIPSSTVHSS VADMQNMPAA 650
    VHALLTQPSL SAAPFAQRYL GTLPSTGSTT LPQCHAGNAT VCGFSGGLPY 700
    PAVAGEPVQN SVAVGICLGS NIGSGWMGTS SLCNPYSNTL NQNLLSTTKP 750
    FPVPSVGTNC GIEPWDSGVT SGLGSVRVPE ELKLPHACCV GIASQTLLSV 800
    LNPTDRWLQV SIGVLSISVN GEKVDLSTYR CLVFKNKAII RPHATEEIKV 850
    LFIPSSPGVF RCTFSVASWP CSTDAETIVQ AEALASTVTL TAIAESPVIE 900
    VETEKKDVLD FGDLTYGGWK ALPLKLINRT HATVPIRLII NANAVAWRCF 950
    TFSKESVRAP VEVAPCADVV TRLAGPSVVN HMMPASYDGQ DPEFLMIWVL 1000
    FHSPKKQISS SDILDSAEEF SAKVDIEVDS PNPTPVLRSV SLRARAGIAR 1050
    IHAPRDLQTM HFLAKVASSR KQHLPLKNAG NIEVYLDIKV PEQGSHFSVD 1100
    PKNLLLKPGE EHEVIVSFTP KDPEACEERI LKIFVQPFGP QYEVVLKGEV 1150
    ISSGSKPLSP GPCLDIPSIL SNKQFLAWGG VPLGRTQLQK LALRNNSAST 1200
    TQHLRLLIRG QDQDCFQLQN TFGSEQRLTS NCEIRIHPKE DIFISVLFAP 1250
    TRLSCMLARL EIKQLGNRSQ PGIKFTIPLS GYGGTSNLIL EGVKKLSDSY 1300
    MVTVNGLVPG KESKIVFSVR NTGSRAAFVK AVGFKDSQKK VLLDPKVLRI 1350
    FPDKFVLKER TQENVTLIYN PSDRGINNKT ATELSTVYLF GGDEISRQQY 1400
    RRALLHKPEM IKQILPEHSV LQNINFVEAF QDELLVTEVY DLPQRPNDVQ 1450
    LFYGSMCKII LSVIGEFRDC ISSREFLQPS SKASLESTSD LGASGKHGGN 1500
    VSLDVLPVKG PQGSPLLSRA ARPPLDQLAS EEPWTVLPEH LILVAPSPCD 1550
    MAKTGRFQIV NNSVRLLRFE LCWPAHCLTV TPQHGCVAPE SKLQILVSPN 1600
    SSLSTKQSMF PWSGLIYIHC DDGQKKIVKV QIREDLTQVE LLTRLTSKPF 1650
    GILSPVSEPS VSHLVKPMTK PPSTKVEIRN KSITFPTTEP GETSESCLEL 1700
    ENHGTTDVKW HLSSLAPPYV KGVDESGDVF RATYAAFRCS PISGLLESHG 1750
    IQKVSITFLP RGRGDYAQFW DVECHPLKEP HMKHTLRFQL SGQSIEAENE 1800
    PENACLSTDS LIKIDHLVKP RRQAVSEASA RIPEQLDVTA RGVYAPEDVY 1850
    RFRPTSVGES RTLKVNLRNN SFITHSLKFL SPREPFYVKH SKYSLRAQHY 1900
    INMPVQFKPK SAGKFEALLV IQTDEGKSIA IRLIGEALGK N 1941
    Length:1,941
    Mass (Da):213,146
    Last modified:December 4, 2007 - v2
    Checksum:i0DA715D1FAABA8D4
    GO
    Isoform 2 (identifier: Q8TEP8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1403-1407: ALLHK → QGPAT
         1408-1941: Missing.

    Show »
    Length:1,407
    Mass (Da):153,582
    Checksum:i2B078D93D54C537E
    GO
    Isoform 3 (identifier: Q8TEP8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MKTSDLV → MEDFRGIAEE...CLGGGNNVKR

    Show »
    Length:2,537
    Mass (Da):279,111
    Checksum:iCA0A92F264280C3B
    GO

    Sequence cautioni

    The sequence CAB66752.1 differs from that shown. Reason: Frameshift at positions 1196 and 1239.
    The sequence AAL55870.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAB66752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti806 – 8061R → L in BAB84900. (PubMed:12693554)Curated
    Sequence conflicti857 – 8571P → A in AAL55870. (PubMed:15498874)Curated
    Sequence conflicti1519 – 15191R → Q(PubMed:11230166)Curated
    Isoform 3 (identifier: Q8TEP8-3)
    Sequence conflicti357 – 3571V → I in AIA61642. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti457 – 4571T → A.
    Corresponds to variant rs10048340 [ dbSNP | Ensembl ].
    VAR_037514
    Natural varianti513 – 5131Q → P.
    Corresponds to variant rs11080623 [ dbSNP | Ensembl ].
    VAR_050782
    Natural varianti769 – 7691V → M.1 Publication
    Corresponds to variant rs2282542 [ dbSNP | Ensembl ].
    VAR_037515
    Natural varianti948 – 9481R → H.2 Publications
    Corresponds to variant rs7228940 [ dbSNP | Ensembl ].
    VAR_050783
    Natural varianti956 – 9561S → P.3 Publications
    Corresponds to variant rs578208 [ dbSNP | Ensembl ].
    VAR_050784
    Natural varianti1105 – 11051L → F.3 Publications
    Corresponds to variant rs6505780 [ dbSNP | Ensembl ].
    VAR_050785
    Natural varianti1455 – 14551S → N.1 Publication
    Corresponds to variant rs2027698 [ dbSNP | Ensembl ].
    VAR_050786
    Natural varianti1525 – 15251L → P.3 Publications
    Corresponds to variant rs474337 [ dbSNP | Ensembl ].
    VAR_050787
    Natural varianti1675 – 16751K → E.1 Publication
    Corresponds to variant rs3737379 [ dbSNP | Ensembl ].
    VAR_050788
    Natural varianti1853 – 18531R → L.3 Publications
    Corresponds to variant rs1786263 [ dbSNP | Ensembl ].
    VAR_050789

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MKTSDLV → MEDFRGIAEESFPSFLTNSL FGNSGILENVTLSSNLGLPV AVSTLARDRSSTDNRYPDIQ ASYLVEGRFSVPSGSSPGSQ SDAEPRERLQLSFQDDDSIS RKKSYVESQRLSNALSKQSA LQMETAGPEEEPAGATESLQ GQDLFNRASPLEQAQDSPID FHLQSWMNNKEPKIVVLDAG KHFEDKTLKSDLSHTSLLEN EKLILPTSLEDSSDDDIDDE MFYDDHLEAYFEQLAIPGMI YEDLEGPEPPEKGFKLPTNG LRQANENGSLNCKFQSENNS SLISLDSHSSETTHKESEES QVICLPGTSNSIGTGDSRRY TDGMLPFSSGTWGTEKEIEN LKGIVPDLNSECASKDVLVK TLRAIDVKLNSDNFHDANAN RGGFDLTDPVKQGAECPHQN KTVLHMDGCLDTETPTVSIQ ENVDVASLKPISDSGINFTD AIWSPTCERRTCECHESIEK NKDKTDLPQSVVYQNEEGRW VTDLAYYTSFNSKQNLNVSL SDEMNEDFRSGSEAFDLIAQ DEEEFNKEHQFIQEENIDAH NTSVALGDTSWGATINYSLL RKSRSTSDLDKDDASYLRLS LGEFFAQRSEALGCLGGGNN VKR in isoform 3. 1 PublicationVSP_055678
    Alternative sequencei1403 – 14075ALLHK → QGPAT in isoform 2. 1 PublicationVSP_029845
    Alternative sequencei1408 – 1941534Missing in isoform 2. 1 PublicationVSP_029846Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KJ567064 mRNA. Translation: AIA61642.1.
    AP001357 Genomic DNA. No translation available.
    AP002449 Genomic DNA. No translation available.
    AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
    AK074074 mRNA. Translation: BAB84900.1.
    AF318363 mRNA. Translation: AAL55870.1. Different initiation.
    AK001214 mRNA. Translation: BAA91559.1. Different initiation.
    UniGeneiHs.100914.

    Genome annotation databases

    EnsembliENST00000325971; ENSP00000317156; ENSG00000101639. [Q8TEP8-1]
    ENST00000506447; ENSP00000427550; ENSG00000101639. [Q8TEP8-3]
    UCSCiuc002krs.1. human. [Q8TEP8-2]

    Polymorphism databases

    DMDMi162416230.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KJ567064 mRNA. Translation: AIA61642.1 .
    AP001357 Genomic DNA. No translation available.
    AP002449 Genomic DNA. No translation available.
    AL136818 mRNA. Translation: CAB66752.1 . Sequence problems.
    AK074074 mRNA. Translation: BAB84900.1 .
    AF318363 mRNA. Translation: AAL55870.1 . Different initiation.
    AK001214 mRNA. Translation: BAA91559.1 . Different initiation.
    UniGenei Hs.100914.

    3D structure databases

    ProteinModelPortali Q8TEP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8TEP8. 10 interactions.
    MINTi MINT-4989007.
    STRINGi 9606.ENSP00000317156.

    Polymorphism databases

    DMDMi 162416230.

    Proteomic databases

    MaxQBi Q8TEP8.
    PaxDbi Q8TEP8.
    PeptideAtlasi Q8TEP8.
    PRIDEi Q8TEP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325971 ; ENSP00000317156 ; ENSG00000101639 . [Q8TEP8-1 ]
    ENST00000506447 ; ENSP00000427550 ; ENSG00000101639 . [Q8TEP8-3 ]
    UCSCi uc002krs.1. human. [Q8TEP8-2 ]

    Organism-specific databases

    CTDi 55125.
    GeneCardsi GC18P012998.
    HGNCi HGNC:25515. CEP192.
    HPAi HPA039392.
    HPA040503.
    neXtProti NX_Q8TEP8.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82847.
    HOGENOMi HOG000111525.
    HOVERGENi HBG106621.
    InParanoidi Q8TEP8.
    PhylomeDBi Q8TEP8.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    PROi Q8TEP8.

    Gene expression databases

    ArrayExpressi Q8TEP8.
    Bgeei Q8TEP8.
    CleanExi HS_CEP192.
    Genevestigatori Q8TEP8.

    Family and domain databases

    InterProi IPR028542. CEP192.
    [Graphical view ]
    PANTHERi PTHR16029:SF10. PTHR16029:SF10. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Cep192-organized Aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly."
      Joukov V., Walter J.C., De Nicolo A.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1941 (ISOFORM 1), VARIANTS MET-769; HIS-948; PRO-956; PHE-1105; PRO-1525 AND LEU-1853.
      Tissue: Testis.
    4. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-1941 (ISOFORM 1), VARIANTS PRO-956; PHE-1105; ASN-1455; PRO-1525; GLU-1675 AND LEU-1853.
      Tissue: Spleen.
    5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 857-1941 (ISOFORM 2), VARIANTS HIS-948; PRO-956 AND PHE-1105.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1362-1941 (ISOFORM 1), VARIANTS PRO-1525 AND LEU-1853.
    7. "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
      Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Lymphoblast.
    8. "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin."
      Pope S.N., Lee I.R.
      J. Steroid Biochem. Mol. Biol. 94:203-208(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SHBG.
    9. "Human Cep192 is required for mitotic centrosome and spindle assembly."
      Gomez-Ferreria M.A., Rath U., Buster D.W., Chanda S.K., Caldwell J.S., Rines D.R., Sharp D.J.
      Curr. Biol. 17:1960-1966(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-1159; SER-1502 AND SER-1514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192."
      Moser S.C., Bensaddek D., Ortmann B., Maure J.F., Mudie S., Blow J.J., Lamond A.I., Swedlow J.R., Rocha S.
      Dev. Cell 26:381-392(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: HYDROXYLATION AT PRO-1717, UBIQUITINATION, MUTAGENESIS OF PRO-1717.

    Entry informationi

    Entry nameiCE192_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEP8
    Secondary accession number(s): A0A060A9S4
    , E9PF99, Q8WYT8, Q9H0F4, Q9NW27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3