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Q8TEP8

- CE192_HUMAN

UniProt

Q8TEP8 - CE192_HUMAN

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Protein

Centrosomal protein of 192 kDa

Gene

CEP192

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.2 Publications

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB

GO - Biological processi

  1. centrosome duplication Source: UniProtKB
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. mitotic cell cycle Source: Reactome
  4. negative regulation of phosphatase activity Source: UniProtKB
  5. spindle assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 192 kDa
Short name:
Cep192
Gene namesi
Name:CEP192
Synonyms:KIAA1569
ORF Names:PP8407
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:25515. CEP192.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 3 Publications
Note: Pericentriolar location in mitotic centrosomes.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1717 – 17171P → A: Increased presence on interphasic centrosomes, and decreased presence on mitotic centrosomes; no ubiquitination and unchanged levels in response to hypoxia. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19411941Centrosomal protein of 192 kDaPRO_0000312495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161Phosphoserine1 Publication
Modified residuei1159 – 11591Phosphoserine1 Publication
Modified residuei1502 – 15021Phosphoserine1 Publication
Modified residuei1514 – 15141Phosphoserine1 Publication
Modified residuei1717 – 17171Hydroxyproline1 Publication

Post-translational modificationi

Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.1 Publication
Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.1 Publication

Keywords - PTMi

Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8TEP8.
PaxDbiQ8TEP8.
PeptideAtlasiQ8TEP8.
PRIDEiQ8TEP8.

Expressioni

Gene expression databases

BgeeiQ8TEP8.
CleanExiHS_CEP192.
ExpressionAtlasiQ8TEP8. baseline and differential.
GenevestigatoriQ8TEP8.

Organism-specific databases

HPAiHPA039392.
HPA040503.

Interactioni

Subunit structurei

Interacts with SHBG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-2339778,EBI-357253

Protein-protein interaction databases

IntActiQ8TEP8. 10 interactions.
MINTiMINT-4989007.
STRINGi9606.ENSP00000317156.

Structurei

3D structure databases

ProteinModelPortaliQ8TEP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG82847.
GeneTreeiENSGT00510000048187.
HOGENOMiHOG000111525.
HOVERGENiHBG106621.
InParanoidiQ8TEP8.
KOiK16725.
PhylomeDBiQ8TEP8.

Family and domain databases

InterProiIPR028542. CEP192.
[Graphical view]
PANTHERiPTHR16029:SF10. PTHR16029:SF10. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TEP8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTSDLVPSF GYFIRSPEKR EPIALIRKSD VSRGNLEKEM AHLNHDLYSG
60 70 80 90 100
DLNEQSQAQL SEGSITLQVE AVESTSQVDE NDVTLTADKG KTEDTFFMSN
110 120 130 140 150
KPQRYKDKLP DSGDSMLRIS TIASAIAEAS VNTDPSQLAA MIKALSNKTR
160 170 180 190 200
DKTFQEDEKQ KDYSHVRHFL PNDLEKSNGS NALDMEKYLK KTEVSRYESA
210 220 230 240 250
LENFSRASMS DTWDLSLPKE QTTQDIHPVD LSATSVSVRA PEENTAAIVY
260 270 280 290 300
VENGESENQE SFRTINSSNS VTNRENNSAV VDVKTCSIDN KLQDVGNDEK
310 320 330 340 350
ATSISTPSDS YSSVRNPRIT SLCLLKDCEE IRDNRENQRQ NECVSEISNS
360 370 380 390 400
EKHVTFENHR IVSPKNSDLK NTSPEHGGRG SEDEQESFRP STSPLSHSSP
410 420 430 440 450
SEISGTSSSG CALESFGSAA QQQQPPCEQE LSPLVCSPAG VSRLTYVSEP
460 470 480 490 500
ESSYPTTATD DALEDRKSDI TSELSTTIIQ GSPAALEERA MEKLREKVPF
510 520 530 540 550
QNRGKGTLSS IIQNNSDTRK ATETTSLSSK PEYVKPDFRW SKDPSSKSGN
560 570 580 590 600
LLETSEVGWT SNPEELDPIR LALLGKSGLS CQVGSATSHP VSCQEPIDED
610 620 630 640 650
QRISPKDKST AGREFSGQVS HQTTSENQCT PIPSSTVHSS VADMQNMPAA
660 670 680 690 700
VHALLTQPSL SAAPFAQRYL GTLPSTGSTT LPQCHAGNAT VCGFSGGLPY
710 720 730 740 750
PAVAGEPVQN SVAVGICLGS NIGSGWMGTS SLCNPYSNTL NQNLLSTTKP
760 770 780 790 800
FPVPSVGTNC GIEPWDSGVT SGLGSVRVPE ELKLPHACCV GIASQTLLSV
810 820 830 840 850
LNPTDRWLQV SIGVLSISVN GEKVDLSTYR CLVFKNKAII RPHATEEIKV
860 870 880 890 900
LFIPSSPGVF RCTFSVASWP CSTDAETIVQ AEALASTVTL TAIAESPVIE
910 920 930 940 950
VETEKKDVLD FGDLTYGGWK ALPLKLINRT HATVPIRLII NANAVAWRCF
960 970 980 990 1000
TFSKESVRAP VEVAPCADVV TRLAGPSVVN HMMPASYDGQ DPEFLMIWVL
1010 1020 1030 1040 1050
FHSPKKQISS SDILDSAEEF SAKVDIEVDS PNPTPVLRSV SLRARAGIAR
1060 1070 1080 1090 1100
IHAPRDLQTM HFLAKVASSR KQHLPLKNAG NIEVYLDIKV PEQGSHFSVD
1110 1120 1130 1140 1150
PKNLLLKPGE EHEVIVSFTP KDPEACEERI LKIFVQPFGP QYEVVLKGEV
1160 1170 1180 1190 1200
ISSGSKPLSP GPCLDIPSIL SNKQFLAWGG VPLGRTQLQK LALRNNSAST
1210 1220 1230 1240 1250
TQHLRLLIRG QDQDCFQLQN TFGSEQRLTS NCEIRIHPKE DIFISVLFAP
1260 1270 1280 1290 1300
TRLSCMLARL EIKQLGNRSQ PGIKFTIPLS GYGGTSNLIL EGVKKLSDSY
1310 1320 1330 1340 1350
MVTVNGLVPG KESKIVFSVR NTGSRAAFVK AVGFKDSQKK VLLDPKVLRI
1360 1370 1380 1390 1400
FPDKFVLKER TQENVTLIYN PSDRGINNKT ATELSTVYLF GGDEISRQQY
1410 1420 1430 1440 1450
RRALLHKPEM IKQILPEHSV LQNINFVEAF QDELLVTEVY DLPQRPNDVQ
1460 1470 1480 1490 1500
LFYGSMCKII LSVIGEFRDC ISSREFLQPS SKASLESTSD LGASGKHGGN
1510 1520 1530 1540 1550
VSLDVLPVKG PQGSPLLSRA ARPPLDQLAS EEPWTVLPEH LILVAPSPCD
1560 1570 1580 1590 1600
MAKTGRFQIV NNSVRLLRFE LCWPAHCLTV TPQHGCVAPE SKLQILVSPN
1610 1620 1630 1640 1650
SSLSTKQSMF PWSGLIYIHC DDGQKKIVKV QIREDLTQVE LLTRLTSKPF
1660 1670 1680 1690 1700
GILSPVSEPS VSHLVKPMTK PPSTKVEIRN KSITFPTTEP GETSESCLEL
1710 1720 1730 1740 1750
ENHGTTDVKW HLSSLAPPYV KGVDESGDVF RATYAAFRCS PISGLLESHG
1760 1770 1780 1790 1800
IQKVSITFLP RGRGDYAQFW DVECHPLKEP HMKHTLRFQL SGQSIEAENE
1810 1820 1830 1840 1850
PENACLSTDS LIKIDHLVKP RRQAVSEASA RIPEQLDVTA RGVYAPEDVY
1860 1870 1880 1890 1900
RFRPTSVGES RTLKVNLRNN SFITHSLKFL SPREPFYVKH SKYSLRAQHY
1910 1920 1930 1940
INMPVQFKPK SAGKFEALLV IQTDEGKSIA IRLIGEALGK N
Length:1,941
Mass (Da):213,146
Last modified:December 4, 2007 - v2
Checksum:i0DA715D1FAABA8D4
GO
Isoform 2 (identifier: Q8TEP8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1403-1407: ALLHK → QGPAT
     1408-1941: Missing.

Show »
Length:1,407
Mass (Da):153,582
Checksum:i2B078D93D54C537E
GO
Isoform 3 (identifier: Q8TEP8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MKTSDLV → MEDFRGIAEE...CLGGGNNVKR

Show »
Length:2,537
Mass (Da):279,111
Checksum:iCA0A92F264280C3B
GO

Sequence cautioni

The sequence CAB66752.1 differs from that shown. Reason: Frameshift at positions 1196 and 1239.
The sequence AAL55870.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB66752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti806 – 8061R → L in BAB84900. (PubMed:12693554)Curated
Sequence conflicti857 – 8571P → A in AAL55870. (PubMed:15498874)Curated
Sequence conflicti1519 – 15191R → Q(PubMed:11230166)Curated
Isoform 3 (identifier: Q8TEP8-3)
Sequence conflicti357 – 3571V → I in AIA61642. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti457 – 4571T → A.
Corresponds to variant rs10048340 [ dbSNP | Ensembl ].
VAR_037514
Natural varianti513 – 5131Q → P.
Corresponds to variant rs11080623 [ dbSNP | Ensembl ].
VAR_050782
Natural varianti769 – 7691V → M.1 Publication
Corresponds to variant rs2282542 [ dbSNP | Ensembl ].
VAR_037515
Natural varianti948 – 9481R → H.2 Publications
Corresponds to variant rs7228940 [ dbSNP | Ensembl ].
VAR_050783
Natural varianti956 – 9561S → P.3 Publications
Corresponds to variant rs578208 [ dbSNP | Ensembl ].
VAR_050784
Natural varianti1105 – 11051L → F.3 Publications
Corresponds to variant rs6505780 [ dbSNP | Ensembl ].
VAR_050785
Natural varianti1455 – 14551S → N.1 Publication
Corresponds to variant rs2027698 [ dbSNP | Ensembl ].
VAR_050786
Natural varianti1525 – 15251L → P.3 Publications
Corresponds to variant rs474337 [ dbSNP | Ensembl ].
VAR_050787
Natural varianti1675 – 16751K → E.1 Publication
Corresponds to variant rs3737379 [ dbSNP | Ensembl ].
VAR_050788
Natural varianti1853 – 18531R → L.3 Publications
Corresponds to variant rs1786263 [ dbSNP | Ensembl ].
VAR_050789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MKTSDLV → MEDFRGIAEESFPSFLTNSL FGNSGILENVTLSSNLGLPV AVSTLARDRSSTDNRYPDIQ ASYLVEGRFSVPSGSSPGSQ SDAEPRERLQLSFQDDDSIS RKKSYVESQRLSNALSKQSA LQMETAGPEEEPAGATESLQ GQDLFNRASPLEQAQDSPID FHLQSWMNNKEPKIVVLDAG KHFEDKTLKSDLSHTSLLEN EKLILPTSLEDSSDDDIDDE MFYDDHLEAYFEQLAIPGMI YEDLEGPEPPEKGFKLPTNG LRQANENGSLNCKFQSENNS SLISLDSHSSETTHKESEES QVICLPGTSNSIGTGDSRRY TDGMLPFSSGTWGTEKEIEN LKGIVPDLNSECASKDVLVK TLRAIDVKLNSDNFHDANAN RGGFDLTDPVKQGAECPHQN KTVLHMDGCLDTETPTVSIQ ENVDVASLKPISDSGINFTD AIWSPTCERRTCECHESIEK NKDKTDLPQSVVYQNEEGRW VTDLAYYTSFNSKQNLNVSL SDEMNEDFRSGSEAFDLIAQ DEEEFNKEHQFIQEENIDAH NTSVALGDTSWGATINYSLL RKSRSTSDLDKDDASYLRLS LGEFFAQRSEALGCLGGGNN VKR in isoform 3. 1 PublicationVSP_055678
Alternative sequencei1403 – 14075ALLHK → QGPAT in isoform 2. 1 PublicationVSP_029845
Alternative sequencei1408 – 1941534Missing in isoform 2. 1 PublicationVSP_029846Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KJ567064 mRNA. Translation: AIA61642.1.
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
AK074074 mRNA. Translation: BAB84900.1.
AF318363 mRNA. Translation: AAL55870.1. Different initiation.
AK001214 mRNA. Translation: BAA91559.1. Different initiation.
CCDSiCCDS32792.2. [Q8TEP8-3]
UniGeneiHs.100914.

Genome annotation databases

EnsembliENST00000506447; ENSP00000427550; ENSG00000101639. [Q8TEP8-3]
KEGGihsa:55125.
UCSCiuc002krs.1. human. [Q8TEP8-2]

Polymorphism databases

DMDMi162416230.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KJ567064 mRNA. Translation: AIA61642.1 .
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1 . Sequence problems.
AK074074 mRNA. Translation: BAB84900.1 .
AF318363 mRNA. Translation: AAL55870.1 . Different initiation.
AK001214 mRNA. Translation: BAA91559.1 . Different initiation.
CCDSi CCDS32792.2. [Q8TEP8-3 ]
UniGenei Hs.100914.

3D structure databases

ProteinModelPortali Q8TEP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8TEP8. 10 interactions.
MINTi MINT-4989007.
STRINGi 9606.ENSP00000317156.

Polymorphism databases

DMDMi 162416230.

Proteomic databases

MaxQBi Q8TEP8.
PaxDbi Q8TEP8.
PeptideAtlasi Q8TEP8.
PRIDEi Q8TEP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000506447 ; ENSP00000427550 ; ENSG00000101639 . [Q8TEP8-3 ]
KEGGi hsa:55125.
UCSCi uc002krs.1. human. [Q8TEP8-2 ]

Organism-specific databases

CTDi 55125.
GeneCardsi GC18P012998.
HGNCi HGNC:25515. CEP192.
HPAi HPA039392.
HPA040503.
neXtProti NX_Q8TEP8.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82847.
GeneTreei ENSGT00510000048187.
HOGENOMi HOG000111525.
HOVERGENi HBG106621.
InParanoidi Q8TEP8.
KOi K16725.
PhylomeDBi Q8TEP8.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

GenomeRNAii 55125.
NextBioi 58782.
PROi Q8TEP8.

Gene expression databases

Bgeei Q8TEP8.
CleanExi HS_CEP192.
ExpressionAtlasi Q8TEP8. baseline and differential.
Genevestigatori Q8TEP8.

Family and domain databases

InterProi IPR028542. CEP192.
[Graphical view ]
PANTHERi PTHR16029:SF10. PTHR16029:SF10. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Cep192-organized Aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly."
    Joukov V., Walter J.C., De Nicolo A.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1941 (ISOFORM 1), VARIANTS MET-769; HIS-948; PRO-956; PHE-1105; PRO-1525 AND LEU-1853.
    Tissue: Testis.
  4. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-1941 (ISOFORM 1), VARIANTS PRO-956; PHE-1105; ASN-1455; PRO-1525; GLU-1675 AND LEU-1853.
    Tissue: Spleen.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 857-1941 (ISOFORM 2), VARIANTS HIS-948; PRO-956 AND PHE-1105.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1362-1941 (ISOFORM 1), VARIANTS PRO-1525 AND LEU-1853.
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  8. "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin."
    Pope S.N., Lee I.R.
    J. Steroid Biochem. Mol. Biol. 94:203-208(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHBG.
  9. "Human Cep192 is required for mitotic centrosome and spindle assembly."
    Gomez-Ferreria M.A., Rath U., Buster D.W., Chanda S.K., Caldwell J.S., Rines D.R., Sharp D.J.
    Curr. Biol. 17:1960-1966(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-1159; SER-1502 AND SER-1514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192."
    Moser S.C., Bensaddek D., Ortmann B., Maure J.F., Mudie S., Blow J.J., Lamond A.I., Swedlow J.R., Rocha S.
    Dev. Cell 26:381-392(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: HYDROXYLATION AT PRO-1717, UBIQUITINATION, MUTAGENESIS OF PRO-1717.

Entry informationi

Entry nameiCE192_HUMAN
AccessioniPrimary (citable) accession number: Q8TEP8
Secondary accession number(s): A0A060A9S4
, E9PF99, Q8WYT8, Q9H0F4, Q9NW27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3