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Protein

Centrosomal protein of 192 kDa

Gene

CEP192

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.2 Publications

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

GO - Biological processi

  • centrosome duplication Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • negative regulation of phosphatase activity Source: UniProtKB
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101639-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 192 kDa
Short name:
Cep192
Gene namesi
Name:CEP192
Synonyms:KIAA1569
ORF Names:PP8407
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25515. CEP192.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB-SubCell
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • pericentriolar material Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1717P → A: Increased presence on interphasic centrosomes, and decreased presence on mitotic centrosomes; no ubiquitination and unchanged levels in response to hypoxia. 1 Publication1

Organism-specific databases

DisGeNETi55125.
OpenTargetsiENSG00000101639.
PharmGKBiPA142672129.

Polymorphism and mutation databases

DMDMi162416230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003124951 – 1941Centrosomal protein of 192 kDaAdd BLAST1941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1502PhosphoserineCombined sources1
Modified residuei1514PhosphoserineCombined sources1
Modified residuei1717Hydroxyproline1 Publication1

Post-translational modificationi

Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.1 Publication
Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.1 Publication

Keywords - PTMi

Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TEP8.
MaxQBiQ8TEP8.
PaxDbiB7ZMF0.
Q8TEP8.
PeptideAtlasiQ8TEP8.
PRIDEiQ8TEP8.

PTM databases

iPTMnetiQ8TEP8.
PhosphoSitePlusiQ8TEP8.

Expressioni

Gene expression databases

BgeeiENSG00000101639.
CleanExiHS_CEP192.
ExpressionAtlasiQ8TEP8. baseline and differential.
GenevisibleiQ8TEP8. HS.

Organism-specific databases

HPAiHPA039392.
HPA040503.

Interactioni

Subunit structurei

Interacts with SHBG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-2339778,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-52779N.
IntActiQ8TEP8. 42 interactors.
MINTiMINT-4989007.
STRINGi9606.ENSP00000427550.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N7ZX-ray2.85B538-595[»]
ProteinModelPortaliQ8TEP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG8G. Eukaryota.
ENOG4110RMB. LUCA.
GeneTreeiENSGT00510000048187.
HOGENOMiHOG000111525.
HOVERGENiHBG106621.
InParanoidiQ8TEP8.
OMAiEPHMKHT.
OrthoDBiEOG091G00BY.
PhylomeDBiQ8TEP8.

Family and domain databases

InterProiIPR028542. CEP192.
[Graphical view]
PANTHERiPTHR16029:SF10. PTHR16029:SF10. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTSDLVPSF GYFIRSPEKR EPIALIRKSD VSRGNLEKEM AHLNHDLYSG
60 70 80 90 100
DLNEQSQAQL SEGSITLQVE AVESTSQVDE NDVTLTADKG KTEDTFFMSN
110 120 130 140 150
KPQRYKDKLP DSGDSMLRIS TIASAIAEAS VNTDPSQLAA MIKALSNKTR
160 170 180 190 200
DKTFQEDEKQ KDYSHVRHFL PNDLEKSNGS NALDMEKYLK KTEVSRYESA
210 220 230 240 250
LENFSRASMS DTWDLSLPKE QTTQDIHPVD LSATSVSVRA PEENTAAIVY
260 270 280 290 300
VENGESENQE SFRTINSSNS VTNRENNSAV VDVKTCSIDN KLQDVGNDEK
310 320 330 340 350
ATSISTPSDS YSSVRNPRIT SLCLLKDCEE IRDNRENQRQ NECVSEISNS
360 370 380 390 400
EKHVTFENHR IVSPKNSDLK NTSPEHGGRG SEDEQESFRP STSPLSHSSP
410 420 430 440 450
SEISGTSSSG CALESFGSAA QQQQPPCEQE LSPLVCSPAG VSRLTYVSEP
460 470 480 490 500
ESSYPTTATD DALEDRKSDI TSELSTTIIQ GSPAALEERA MEKLREKVPF
510 520 530 540 550
QNRGKGTLSS IIQNNSDTRK ATETTSLSSK PEYVKPDFRW SKDPSSKSGN
560 570 580 590 600
LLETSEVGWT SNPEELDPIR LALLGKSGLS CQVGSATSHP VSCQEPIDED
610 620 630 640 650
QRISPKDKST AGREFSGQVS HQTTSENQCT PIPSSTVHSS VADMQNMPAA
660 670 680 690 700
VHALLTQPSL SAAPFAQRYL GTLPSTGSTT LPQCHAGNAT VCGFSGGLPY
710 720 730 740 750
PAVAGEPVQN SVAVGICLGS NIGSGWMGTS SLCNPYSNTL NQNLLSTTKP
760 770 780 790 800
FPVPSVGTNC GIEPWDSGVT SGLGSVRVPE ELKLPHACCV GIASQTLLSV
810 820 830 840 850
LNPTDRWLQV SIGVLSISVN GEKVDLSTYR CLVFKNKAII RPHATEEIKV
860 870 880 890 900
LFIPSSPGVF RCTFSVASWP CSTDAETIVQ AEALASTVTL TAIAESPVIE
910 920 930 940 950
VETEKKDVLD FGDLTYGGWK ALPLKLINRT HATVPIRLII NANAVAWRCF
960 970 980 990 1000
TFSKESVRAP VEVAPCADVV TRLAGPSVVN HMMPASYDGQ DPEFLMIWVL
1010 1020 1030 1040 1050
FHSPKKQISS SDILDSAEEF SAKVDIEVDS PNPTPVLRSV SLRARAGIAR
1060 1070 1080 1090 1100
IHAPRDLQTM HFLAKVASSR KQHLPLKNAG NIEVYLDIKV PEQGSHFSVD
1110 1120 1130 1140 1150
PKNLLLKPGE EHEVIVSFTP KDPEACEERI LKIFVQPFGP QYEVVLKGEV
1160 1170 1180 1190 1200
ISSGSKPLSP GPCLDIPSIL SNKQFLAWGG VPLGRTQLQK LALRNNSAST
1210 1220 1230 1240 1250
TQHLRLLIRG QDQDCFQLQN TFGSEQRLTS NCEIRIHPKE DIFISVLFAP
1260 1270 1280 1290 1300
TRLSCMLARL EIKQLGNRSQ PGIKFTIPLS GYGGTSNLIL EGVKKLSDSY
1310 1320 1330 1340 1350
MVTVNGLVPG KESKIVFSVR NTGSRAAFVK AVGFKDSQKK VLLDPKVLRI
1360 1370 1380 1390 1400
FPDKFVLKER TQENVTLIYN PSDRGINNKT ATELSTVYLF GGDEISRQQY
1410 1420 1430 1440 1450
RRALLHKPEM IKQILPEHSV LQNINFVEAF QDELLVTEVY DLPQRPNDVQ
1460 1470 1480 1490 1500
LFYGSMCKII LSVIGEFRDC ISSREFLQPS SKASLESTSD LGASGKHGGN
1510 1520 1530 1540 1550
VSLDVLPVKG PQGSPLLSRA ARPPLDQLAS EEPWTVLPEH LILVAPSPCD
1560 1570 1580 1590 1600
MAKTGRFQIV NNSVRLLRFE LCWPAHCLTV TPQHGCVAPE SKLQILVSPN
1610 1620 1630 1640 1650
SSLSTKQSMF PWSGLIYIHC DDGQKKIVKV QIREDLTQVE LLTRLTSKPF
1660 1670 1680 1690 1700
GILSPVSEPS VSHLVKPMTK PPSTKVEIRN KSITFPTTEP GETSESCLEL
1710 1720 1730 1740 1750
ENHGTTDVKW HLSSLAPPYV KGVDESGDVF RATYAAFRCS PISGLLESHG
1760 1770 1780 1790 1800
IQKVSITFLP RGRGDYAQFW DVECHPLKEP HMKHTLRFQL SGQSIEAENE
1810 1820 1830 1840 1850
PENACLSTDS LIKIDHLVKP RRQAVSEASA RIPEQLDVTA RGVYAPEDVY
1860 1870 1880 1890 1900
RFRPTSVGES RTLKVNLRNN SFITHSLKFL SPREPFYVKH SKYSLRAQHY
1910 1920 1930 1940
INMPVQFKPK SAGKFEALLV IQTDEGKSIA IRLIGEALGK N
Length:1,941
Mass (Da):213,146
Last modified:December 4, 2007 - v2
Checksum:i0DA715D1FAABA8D4
GO
Isoform 2 (identifier: Q8TEP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1403-1407: ALLHK → QGPAT
     1408-1941: Missing.

Show »
Length:1,407
Mass (Da):153,582
Checksum:i2B078D93D54C537E
GO
Isoform 3 (identifier: Q8TEP8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MKTSDLV → MEDFRGIAEE...CLGGGNNVKR

Show »
Length:2,537
Mass (Da):279,111
Checksum:iCA0A92F264280C3B
GO

Sequence cautioni

The sequence AAL55870 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91559 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66752 differs from that shown. Reason: Frameshift at positions 1196 and 1239.Curated
The sequence CAB66752 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti806R → L in BAB84900 (PubMed:12693554).Curated1
Sequence conflicti857P → A in AAL55870 (PubMed:15498874).Curated1
Sequence conflicti1519R → Q (PubMed:11230166).Curated1
Sequence conflicti1519R → Q in AAI44482 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q8TEP8-3)
Sequence conflicti357V → I in AIA61642 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037514457T → A.Corresponds to variant rs10048340dbSNPEnsembl.1
Natural variantiVAR_050782513Q → P.Corresponds to variant rs11080623dbSNPEnsembl.1
Natural variantiVAR_037515769V → M.1 PublicationCorresponds to variant rs2282542dbSNPEnsembl.1
Natural variantiVAR_050783948R → H.2 PublicationsCorresponds to variant rs7228940dbSNPEnsembl.1
Natural variantiVAR_050784956S → P.4 PublicationsCorresponds to variant rs578208dbSNPEnsembl.1
Natural variantiVAR_0507851105L → F.4 PublicationsCorresponds to variant rs6505780dbSNPEnsembl.1
Natural variantiVAR_0507861455S → N.1 PublicationCorresponds to variant rs2027698dbSNPEnsembl.1
Natural variantiVAR_0507871525L → P.4 PublicationsCorresponds to variant rs474337dbSNPEnsembl.1
Natural variantiVAR_0507881675K → E.1 PublicationCorresponds to variant rs3737379dbSNPEnsembl.1
Natural variantiVAR_0507891853R → L.4 PublicationsCorresponds to variant rs1786263dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556781 – 7MKTSDLV → MEDFRGIAEESFPSFLTNSL FGNSGILENVTLSSNLGLPV AVSTLARDRSSTDNRYPDIQ ASYLVEGRFSVPSGSSPGSQ SDAEPRERLQLSFQDDDSIS RKKSYVESQRLSNALSKQSA LQMETAGPEEEPAGATESLQ GQDLFNRASPLEQAQDSPID FHLQSWMNNKEPKIVVLDAG KHFEDKTLKSDLSHTSLLEN EKLILPTSLEDSSDDDIDDE MFYDDHLEAYFEQLAIPGMI YEDLEGPEPPEKGFKLPTNG LRQANENGSLNCKFQSENNS SLISLDSHSSETTHKESEES QVICLPGTSNSIGTGDSRRY TDGMLPFSSGTWGTEKEIEN LKGIVPDLNSECASKDVLVK TLRAIDVKLNSDNFHDANAN RGGFDLTDPVKQGAECPHQN KTVLHMDGCLDTETPTVSIQ ENVDVASLKPISDSGINFTD AIWSPTCERRTCECHESIEK NKDKTDLPQSVVYQNEEGRW VTDLAYYTSFNSKQNLNVSL SDEMNEDFRSGSEAFDLIAQ DEEEFNKEHQFIQEENIDAH NTSVALGDTSWGATINYSLL RKSRSTSDLDKDDASYLRLS LGEFFAQRSEALGCLGGGNN VKR in isoform 3. 1 Publication7
Alternative sequenceiVSP_0298451403 – 1407ALLHK → QGPAT in isoform 2. 1 Publication5
Alternative sequenceiVSP_0298461408 – 1941Missing in isoform 2. 1 PublicationAdd BLAST534

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ567064 mRNA. Translation: AIA61642.1.
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
AK074074 mRNA. Translation: BAB84900.1.
AF318363 mRNA. Translation: AAL55870.1. Different initiation.
AK001214 mRNA. Translation: BAA91559.1. Different initiation.
BC144481 mRNA. Translation: AAI44482.1.
CCDSiCCDS32792.2. [Q8TEP8-3]
RefSeqiNP_115518.3. NM_032142.3. [Q8TEP8-3]
UniGeneiHs.100914.

Genome annotation databases

EnsembliENST00000506447; ENSP00000427550; ENSG00000101639. [Q8TEP8-3]
GeneIDi55125.
UCSCiuc010xac.3. human. [Q8TEP8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ567064 mRNA. Translation: AIA61642.1.
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
AK074074 mRNA. Translation: BAB84900.1.
AF318363 mRNA. Translation: AAL55870.1. Different initiation.
AK001214 mRNA. Translation: BAA91559.1. Different initiation.
BC144481 mRNA. Translation: AAI44482.1.
CCDSiCCDS32792.2. [Q8TEP8-3]
RefSeqiNP_115518.3. NM_032142.3. [Q8TEP8-3]
UniGeneiHs.100914.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N7ZX-ray2.85B538-595[»]
ProteinModelPortaliQ8TEP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-52779N.
IntActiQ8TEP8. 42 interactors.
MINTiMINT-4989007.
STRINGi9606.ENSP00000427550.

PTM databases

iPTMnetiQ8TEP8.
PhosphoSitePlusiQ8TEP8.

Polymorphism and mutation databases

DMDMi162416230.

Proteomic databases

EPDiQ8TEP8.
MaxQBiQ8TEP8.
PaxDbiB7ZMF0.
Q8TEP8.
PeptideAtlasiQ8TEP8.
PRIDEiQ8TEP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506447; ENSP00000427550; ENSG00000101639. [Q8TEP8-3]
GeneIDi55125.
UCSCiuc010xac.3. human. [Q8TEP8-1]

Organism-specific databases

CTDi55125.
DisGeNETi55125.
GeneCardsiCEP192.
HGNCiHGNC:25515. CEP192.
HPAiHPA039392.
HPA040503.
MIMi616426. gene.
neXtProtiNX_Q8TEP8.
OpenTargetsiENSG00000101639.
PharmGKBiPA142672129.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG8G. Eukaryota.
ENOG4110RMB. LUCA.
GeneTreeiENSGT00510000048187.
HOGENOMiHOG000111525.
HOVERGENiHBG106621.
InParanoidiQ8TEP8.
OMAiEPHMKHT.
OrthoDBiEOG091G00BY.
PhylomeDBiQ8TEP8.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101639-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiCEP192. human.
PROiQ8TEP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101639.
CleanExiHS_CEP192.
ExpressionAtlasiQ8TEP8. baseline and differential.
GenevisibleiQ8TEP8. HS.

Family and domain databases

InterProiIPR028542. CEP192.
[Graphical view]
PANTHERiPTHR16029:SF10. PTHR16029:SF10. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCE192_HUMAN
AccessioniPrimary (citable) accession number: Q8TEP8
Secondary accession number(s): A0A060A9S4
, B7ZMF0, E9PF99, Q8WYT8, Q9H0F4, Q9NW27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.