Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8TEP8 (CE192_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrosomal protein of 192 kDa

Short name=Cep192
Gene names
Name:CEP192
Synonyms:KIAA1569
ORF Names:PP8407
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1941 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Ref.8 Ref.9

Subunit structure

Interacts with SHBG. Ref.7

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Note: Pericentriolar location in mitotic centrosomes. Ref.6 Ref.8 Ref.9

Post-translational modification

Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.

Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation. Ref.13

Sequence caution

The sequence AAL55870.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA91559.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB66752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAB66752.1 differs from that shown. Reason: Frameshift at positions 1196 and 1239.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP1CAP621362EBI-2339778,EBI-357253

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TEP8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TEP8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1403-1407: ALLHK → QGPAT
     1408-1941: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19411941Centrosomal protein of 192 kDa
PRO_0000312495

Amino acid modifications

Modified residue2161Phosphoserine Ref.12
Modified residue11591Phosphoserine Ref.12
Modified residue15021Phosphoserine Ref.12
Modified residue15141Phosphoserine Ref.12
Modified residue17171Hydroxyproline

Natural variations

Alternative sequence1403 – 14075ALLHK → QGPAT in isoform 2.
VSP_029845
Alternative sequence1408 – 1941534Missing in isoform 2.
VSP_029846
Natural variant4571T → A.
Corresponds to variant rs10048340 [ dbSNP | Ensembl ].
VAR_037514
Natural variant5131Q → P.
Corresponds to variant rs11080623 [ dbSNP | Ensembl ].
VAR_050782
Natural variant7691V → M. Ref.2
Corresponds to variant rs2282542 [ dbSNP | Ensembl ].
VAR_037515
Natural variant9481R → H. Ref.2 Ref.4
Corresponds to variant rs7228940 [ dbSNP | Ensembl ].
VAR_050783
Natural variant9561S → P. Ref.2 Ref.3 Ref.4
Corresponds to variant rs578208 [ dbSNP | Ensembl ].
VAR_050784
Natural variant11051L → F. Ref.2 Ref.3 Ref.4
Corresponds to variant rs6505780 [ dbSNP | Ensembl ].
VAR_050785
Natural variant14551S → N. Ref.3
Corresponds to variant rs2027698 [ dbSNP | Ensembl ].
VAR_050786
Natural variant15251L → P. Ref.2 Ref.3 Ref.5
Corresponds to variant rs474337 [ dbSNP | Ensembl ].
VAR_050787
Natural variant16751K → E. Ref.3
Corresponds to variant rs3737379 [ dbSNP | Ensembl ].
VAR_050788
Natural variant18531R → L. Ref.2 Ref.3 Ref.5
Corresponds to variant rs1786263 [ dbSNP | Ensembl ].
VAR_050789

Experimental info

Mutagenesis17171P → A: Increased presence on interphasic centrosomes, and decreased presence on mitotic centrosomes; no ubiquitination and unchanged levels in response to hypoxia. Ref.13
Sequence conflict8061R → L in BAB84900. Ref.3
Sequence conflict8571P → A in AAL55870. Ref.4
Sequence conflict15191R → Q Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 0DA715D1FAABA8D4

FASTA1,941213,146
        10         20         30         40         50         60 
MKTSDLVPSF GYFIRSPEKR EPIALIRKSD VSRGNLEKEM AHLNHDLYSG DLNEQSQAQL 

        70         80         90        100        110        120 
SEGSITLQVE AVESTSQVDE NDVTLTADKG KTEDTFFMSN KPQRYKDKLP DSGDSMLRIS 

       130        140        150        160        170        180 
TIASAIAEAS VNTDPSQLAA MIKALSNKTR DKTFQEDEKQ KDYSHVRHFL PNDLEKSNGS 

       190        200        210        220        230        240 
NALDMEKYLK KTEVSRYESA LENFSRASMS DTWDLSLPKE QTTQDIHPVD LSATSVSVRA 

       250        260        270        280        290        300 
PEENTAAIVY VENGESENQE SFRTINSSNS VTNRENNSAV VDVKTCSIDN KLQDVGNDEK 

       310        320        330        340        350        360 
ATSISTPSDS YSSVRNPRIT SLCLLKDCEE IRDNRENQRQ NECVSEISNS EKHVTFENHR 

       370        380        390        400        410        420 
IVSPKNSDLK NTSPEHGGRG SEDEQESFRP STSPLSHSSP SEISGTSSSG CALESFGSAA 

       430        440        450        460        470        480 
QQQQPPCEQE LSPLVCSPAG VSRLTYVSEP ESSYPTTATD DALEDRKSDI TSELSTTIIQ 

       490        500        510        520        530        540 
GSPAALEERA MEKLREKVPF QNRGKGTLSS IIQNNSDTRK ATETTSLSSK PEYVKPDFRW 

       550        560        570        580        590        600 
SKDPSSKSGN LLETSEVGWT SNPEELDPIR LALLGKSGLS CQVGSATSHP VSCQEPIDED 

       610        620        630        640        650        660 
QRISPKDKST AGREFSGQVS HQTTSENQCT PIPSSTVHSS VADMQNMPAA VHALLTQPSL 

       670        680        690        700        710        720 
SAAPFAQRYL GTLPSTGSTT LPQCHAGNAT VCGFSGGLPY PAVAGEPVQN SVAVGICLGS 

       730        740        750        760        770        780 
NIGSGWMGTS SLCNPYSNTL NQNLLSTTKP FPVPSVGTNC GIEPWDSGVT SGLGSVRVPE 

       790        800        810        820        830        840 
ELKLPHACCV GIASQTLLSV LNPTDRWLQV SIGVLSISVN GEKVDLSTYR CLVFKNKAII 

       850        860        870        880        890        900 
RPHATEEIKV LFIPSSPGVF RCTFSVASWP CSTDAETIVQ AEALASTVTL TAIAESPVIE 

       910        920        930        940        950        960 
VETEKKDVLD FGDLTYGGWK ALPLKLINRT HATVPIRLII NANAVAWRCF TFSKESVRAP 

       970        980        990       1000       1010       1020 
VEVAPCADVV TRLAGPSVVN HMMPASYDGQ DPEFLMIWVL FHSPKKQISS SDILDSAEEF 

      1030       1040       1050       1060       1070       1080 
SAKVDIEVDS PNPTPVLRSV SLRARAGIAR IHAPRDLQTM HFLAKVASSR KQHLPLKNAG 

      1090       1100       1110       1120       1130       1140 
NIEVYLDIKV PEQGSHFSVD PKNLLLKPGE EHEVIVSFTP KDPEACEERI LKIFVQPFGP 

      1150       1160       1170       1180       1190       1200 
QYEVVLKGEV ISSGSKPLSP GPCLDIPSIL SNKQFLAWGG VPLGRTQLQK LALRNNSAST 

      1210       1220       1230       1240       1250       1260 
TQHLRLLIRG QDQDCFQLQN TFGSEQRLTS NCEIRIHPKE DIFISVLFAP TRLSCMLARL 

      1270       1280       1290       1300       1310       1320 
EIKQLGNRSQ PGIKFTIPLS GYGGTSNLIL EGVKKLSDSY MVTVNGLVPG KESKIVFSVR 

      1330       1340       1350       1360       1370       1380 
NTGSRAAFVK AVGFKDSQKK VLLDPKVLRI FPDKFVLKER TQENVTLIYN PSDRGINNKT 

      1390       1400       1410       1420       1430       1440 
ATELSTVYLF GGDEISRQQY RRALLHKPEM IKQILPEHSV LQNINFVEAF QDELLVTEVY 

      1450       1460       1470       1480       1490       1500 
DLPQRPNDVQ LFYGSMCKII LSVIGEFRDC ISSREFLQPS SKASLESTSD LGASGKHGGN 

      1510       1520       1530       1540       1550       1560 
VSLDVLPVKG PQGSPLLSRA ARPPLDQLAS EEPWTVLPEH LILVAPSPCD MAKTGRFQIV 

      1570       1580       1590       1600       1610       1620 
NNSVRLLRFE LCWPAHCLTV TPQHGCVAPE SKLQILVSPN SSLSTKQSMF PWSGLIYIHC 

      1630       1640       1650       1660       1670       1680 
DDGQKKIVKV QIREDLTQVE LLTRLTSKPF GILSPVSEPS VSHLVKPMTK PPSTKVEIRN 

      1690       1700       1710       1720       1730       1740 
KSITFPTTEP GETSESCLEL ENHGTTDVKW HLSSLAPPYV KGVDESGDVF RATYAAFRCS 

      1750       1760       1770       1780       1790       1800 
PISGLLESHG IQKVSITFLP RGRGDYAQFW DVECHPLKEP HMKHTLRFQL SGQSIEAENE 

      1810       1820       1830       1840       1850       1860 
PENACLSTDS LIKIDHLVKP RRQAVSEASA RIPEQLDVTA RGVYAPEDVY RFRPTSVGES 

      1870       1880       1890       1900       1910       1920 
RTLKVNLRNN SFITHSLKFL SPREPFYVKH SKYSLRAQHY INMPVQFKPK SAGKFEALLV 

      1930       1940 
IQTDEGKSIA IRLIGEALGK N 

« Hide

Isoform 2 [UniParc].

Checksum: 2B078D93D54C537E
Show »

FASTA1,407153,582

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1941 (ISOFORM 1), VARIANTS MET-769; HIS-948; PRO-956; PHE-1105; PRO-1525 AND LEU-1853.
Tissue: Testis.
[3]"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-1941 (ISOFORM 1), VARIANTS PRO-956; PHE-1105; ASN-1455; PRO-1525; GLU-1675 AND LEU-1853.
Tissue: Spleen.
[4]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 857-1941 (ISOFORM 2), VARIANTS HIS-948; PRO-956 AND PHE-1105.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1362-1941 (ISOFORM 1), VARIANTS PRO-1525 AND LEU-1853.
[6]"Proteomic characterization of the human centrosome by protein correlation profiling."
Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Lymphoblast.
[7]"Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin."
Pope S.N., Lee I.R.
J. Steroid Biochem. Mol. Biol. 94:203-208(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SHBG.
[8]"Human Cep192 is required for mitotic centrosome and spindle assembly."
Gomez-Ferreria M.A., Rath U., Buster D.W., Chanda S.K., Caldwell J.S., Rines D.R., Sharp D.J.
Curr. Biol. 17:1960-1966(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]"The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis."
Zhu F., Lawo S., Bird A., Pinchev D., Ralph A., Richter C., Mueller-Reichert T., Kittler R., Hyman A.A., Pelletier L.
Curr. Biol. 18:136-141(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-1159; SER-1502 AND SER-1514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192."
Moser S.C., Bensaddek D., Ortmann B., Maure J.F., Mudie S., Blow J.J., Lamond A.I., Swedlow J.R., Rocha S.
Dev. Cell 26:381-392(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: HYDROXYLATION AT PRO-1717, UBIQUITINATION, MUTAGENESIS OF PRO-1717.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP001357 Genomic DNA. No translation available.
AP002449 Genomic DNA. No translation available.
AL136818 mRNA. Translation: CAB66752.1. Sequence problems.
AK074074 mRNA. Translation: BAB84900.1.
AF318363 mRNA. Translation: AAL55870.1. Different initiation.
AK001214 mRNA. Translation: BAA91559.1. Different initiation.
UniGeneHs.100914.

3D structure databases

ProteinModelPortalQ8TEP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8TEP8. 10 interactions.
MINTMINT-4989007.
STRING9606.ENSP00000317156.

Polymorphism databases

DMDM162416230.

Proteomic databases

PaxDbQ8TEP8.
PeptideAtlasQ8TEP8.
PRIDEQ8TEP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325971; ENSP00000317156; ENSG00000101639. [Q8TEP8-1]
UCSCuc002krs.1. human. [Q8TEP8-2]

Organism-specific databases

GeneCardsGC18P012998.
HGNCHGNC:25515. CEP192.
HPAHPA039392.
HPA040503.
neXtProtNX_Q8TEP8.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82847.
HOGENOMHOG000111525.
HOVERGENHBG106621.
InParanoidQ8TEP8.
PhylomeDBQ8TEP8.

Enzyme and pathway databases

ReactomeREACT_115566. Cell Cycle.

Gene expression databases

ArrayExpressQ8TEP8.
BgeeQ8TEP8.
CleanExHS_CEP192.
GenevestigatorQ8TEP8.

Family and domain databases

InterProIPR028542. CEP192.
[Graphical view]
PANTHERPTHR16029:SF5. PTHR16029:SF5. 1 hit.
ProtoNetSearch...

Other

PROQ8TEP8.

Entry information

Entry nameCE192_HUMAN
AccessionPrimary (citable) accession number: Q8TEP8
Secondary accession number(s): Q8WYT8, Q9H0F4, Q9NW27
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM