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Q8TEM1 (PO210_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear pore membrane glycoprotein 210

Short name=Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name=POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene names
Name:NUP210
Synonyms:KIAA0906
ORF Names:PSEC0245
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1887 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Ref.8

Subunit structure

Forms dimers and possibly higher-order oligomers By similarity.

Subcellular location

Nucleusnuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.7.

Tissue specificity

Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle. Ref.4

Post-translational modification

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides By similarity.

Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase By similarity.

Miscellaneous

Recognized by antinuclear autoantibodies in primary biliary cirrhosis.

Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

Sequence similarities

Belongs to the NUP210 family.

Sequence caution

The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processmRNA transport
Protein transport
Translocation
Transport
   Cellular componentEndoplasmic reticulum
Membrane
Nuclear pore complex
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

glucose transport

Traceable author statement. Source: Reactome

hexose transport

Traceable author statement. Source: Reactome

mRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

mitotic cell cycle

Traceable author statement. Source: Reactome

mitotic nuclear envelope disassembly

Traceable author statement. Source: Reactome

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of glucose transport

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear envelope

Traceable author statement. Source: Reactome

nuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TEM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TEM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 18871861Nuclear pore membrane glycoprotein 210
PRO_0000236046

Regions

Topological domain27 – 18081782Lumenal Probable
Transmembrane1809 – 182921Helical; Potential
Topological domain1830 – 188758Cytoplasmic Probable
Compositional bias486 – 4916Poly-Ser

Amino acid modifications

Modified residue18441Phosphothreonine Ref.11 Ref.12 Ref.14
Modified residue18741Phosphoserine Ref.9 Ref.11 Ref.12
Modified residue18811Phosphoserine Ref.9 Ref.11 Ref.12
Modified residue18861Phosphoserine Ref.9
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation4051N-linked (GlcNAc...) Ref.10
Glycosylation4841N-linked (GlcNAc...) Potential
Glycosylation6811N-linked (GlcNAc...) Potential
Glycosylation8011N-linked (GlcNAc...) Potential
Glycosylation9261N-linked (GlcNAc...) Ref.10
Glycosylation10391N-linked (GlcNAc...) Potential
Glycosylation11161N-linked (GlcNAc...) Potential
Glycosylation11351N-linked (GlcNAc...) Potential
Glycosylation13621N-linked (GlcNAc...) Potential
Glycosylation14411N-linked (GlcNAc...) Ref.10

Natural variations

Alternative sequence947 – 96721HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2.
VSP_018567
Alternative sequence968 – 1887920Missing in isoform 2.
VSP_018568
Natural variant2971A → T.
Corresponds to variant rs7628051 [ dbSNP | Ensembl ].
VAR_028147
Natural variant6081I → V.
Corresponds to variant rs3732671 [ dbSNP | Ensembl ].
VAR_028148
Natural variant7551A → V.
Corresponds to variant rs6795271 [ dbSNP | Ensembl ].
VAR_028149
Natural variant7861R → L Polymorphism confirmed at protein level. Ref.3 Ref.15
Corresponds to variant rs2280084 [ dbSNP | Ensembl ].
VAR_026474
Natural variant8211P → A.
Corresponds to variant rs2280085 [ dbSNP | Ensembl ].
VAR_028150
Natural variant9441A → P.
Corresponds to variant rs433032 [ dbSNP | Ensembl ].
VAR_028151
Natural variant10961M → I.
Corresponds to variant rs2271505 [ dbSNP | Ensembl ].
VAR_028152
Natural variant14301D → E.
Corresponds to variant rs13081937 [ dbSNP | Ensembl ].
VAR_028153
Natural variant17521L → S. Ref.4 Ref.5 Ref.6
Corresponds to variant rs354479 [ dbSNP | Ensembl ].
VAR_026475
Natural variant17871V → M. Ref.4 Ref.5 Ref.6
Corresponds to variant rs354478 [ dbSNP | Ensembl ].
VAR_026476

Experimental info

Sequence conflict15121A → T in BAC11688. Ref.5
Sequence conflict17611P → S in BAC11688. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 70B5C35E685C8DF8

FASTA1,887205,111
        10         20         30         40         50         60 
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR 

        70         80         90        100        110        120 
PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED ITTGQVLRCD AIVDLIHDIQ 

       130        140        150        160        170        180 
IVSTTRELYL EDSPLELKIQ ALDSEGNTFS TLAGLVFEWT IVKDSEADRF SDSHNALRIL 

       190        200        210        220        230        240 
TFLESTYIPP SYISEMEKAA KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL 

       250        260        270        280        290        300 
ENILLNPAYD VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 

       310        320        330        340        350        360 
AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF TVHPGDRWVL 

       370        380        390        400        410        420 
ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL SSSQNGSYHR IRALKRGQTA 

       430        440        450        460        470        480 
IDAALTSVVD QDGGVHILQV PVWNQQEVEI HIPITLYPSI LTFPWQPKTG AYQYTIRAHG 

       490        500        510        520        530        540 
GSGNFSWSSS SHLVATVTVK GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF 

       550        560        570        580        590        600 
APCQVEARVG QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 

       610        620        630        640        650        660 
GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS VALVTLGSSK 

       670        680        690        700        710        720 
EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS RNYQQHWILV TCQALGEQVI 

       730        740        750        760        770        780 
ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS 

       790        800        810        820        830        840 
SHRNPRLDLA AYDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH 

       850        860        870        880        890        900 
GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 

       910        920        930        940        950        960 
EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL PGSSTIMIHD 

       970        980        990       1000       1010       1020 
LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR VLDLHKKPFL AKYFPFMDLK 

      1030       1040       1050       1060       1070       1080 
LRAASPIITL VALDEALDNY TITFLIRGVA IGQTSLTASV TNKAGQRINS APQQIEVFPP 

      1090       1100       1110       1120       1130       1140 
FRLMPRKVTL LIGATMQVTS EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG 

      1150       1160       1170       1180       1190       1200 
LVQAVDAETG KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS 

      1210       1220       1230       1240       1250       1260 
FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR TGLRVVVKAV 

      1270       1280       1290       1300       1310       1320 
DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM SPNSYIKLQT NRDGAASLSY 

      1330       1340       1350       1360       1370       1380 
RVLDGPEKVP VVHVDEKGFL ASGSMIGTST IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS 

      1390       1400       1410       1420       1430       1440 
MSPVLHTQNK EALVAVPLGM TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT 

      1450       1460       1470       1480       1490       1500 
NNTCVVRTVS VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS 

      1510       1520       1530       1540       1550       1560 
LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV VSVPQRIMAR 

      1570       1580       1590       1600       1610       1620 
HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI QALHPETLIS CQSQFKPAVF 

      1630       1640       1650       1660       1670       1680 
DFPSQDVFTV EPQFDTALGQ YFCSITMHRL TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ 

      1690       1700       1710       1720       1730       1740 
VGAEVPFSPG LFADQAEILL SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG 

      1750       1760       1770       1780       1790       1800 
WPSFITYTVG VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF 

      1810       1820       1830       1840       1850       1860 
QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG HSPHYFAASS 

      1870       1880 
PTSPNALPPA RKASPPSGLW SPAYASH 

« Hide

Isoform 2 [UniParc].

Checksum: 56A41738E2C8DEF1
Show »

FASTA967105,810

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Spleen.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1887 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1887 (ISOFORM 2), VARIANT LEU-786.
Tissue: Brain and Spleen.
[4]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787, TISSUE SPECIFICITY.
Tissue: Brain.
[5]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1405-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
Tissue: Ovary tumor.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1460-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
Tissue: Testis.
[7]"The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore."
Courvalin J.-C., Lassoued K., Bartnik E., Blobel G., Wozniak R.W.
J. Clin. Invest. 86:279-285(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Tissue: Cervix carcinoma.
[8]"Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans."
Cohen M., Feinstein N., Wilson K.L., Gruenbaum Y.
Mol. Biol. Cell 14:4230-4237(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1881 AND SER-1886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441.
Tissue: Liver.
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-786, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSCCDS33704.1. [Q8TEM1-1]
PIRT17289.
RefSeqNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneHs.475525.

3D structure databases

ProteinModelPortalQ8TEM1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116831. 15 interactions.
IntActQ8TEM1. 11 interactions.
MINTMINT-4535557.
STRING9606.ENSP00000254508.

PTM databases

PhosphoSiteQ8TEM1.

Polymorphism databases

DMDM116242720.

Proteomic databases

MaxQBQ8TEM1.
PaxDbQ8TEM1.
PRIDEQ8TEM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneID23225.
KEGGhsa:23225.
UCSCuc003bxv.1. human. [Q8TEM1-1]
uc003bxx.3. human. [Q8TEM1-2]

Organism-specific databases

CTD23225.
GeneCardsGC03M013420.
H-InvDBHIX0003074.
HIX0018493.
HIX0024491.
HGNCHGNC:30052. NUP210.
MIM607703. gene.
neXtProtNX_Q8TEM1.
PharmGKBPA128394614.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315446.
HOGENOMHOG000115312.
HOVERGENHBG082098.
InParanoidQ8TEM1.
KOK14314.
OMAPVWNQQE.
OrthoDBEOG7PS1DJ.
PhylomeDBQ8TEM1.
TreeFamTF313331.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21300. Mitotic M-M/G1 phases.
REACT_6900. Immune System.

Gene expression databases

BgeeQ8TEM1.
CleanExHS_NUP210.
GenevestigatorQ8TEM1.

Family and domain databases

InterProIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamPF02368. Big_2. 1 hit.
[Graphical view]
SMARTSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMSSF49373. SSF49373. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNUP210. human.
GenomeRNAi23225.
NextBio44833.
PROQ8TEM1.
SOURCESearch...

Entry information

Entry namePO210_HUMAN
AccessionPrimary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56 expand/collapse secondary AC list , O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM