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Q8TEM1

- PO210_HUMAN

UniProt

Q8TEM1 - PO210_HUMAN

Protein

Nuclear pore membrane glycoprotein 210

Gene

NUP210

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.1 Publication

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. glucose transport Source: Reactome
    4. hexose transport Source: Reactome
    5. mitotic cell cycle Source: Reactome
    6. mitotic nuclear envelope disassembly Source: Reactome
    7. mRNA transport Source: UniProtKB-KW
    8. protein transport Source: UniProtKB-KW
    9. regulation of glucose transport Source: Reactome
    10. small molecule metabolic process Source: Reactome
    11. transmembrane transport Source: Reactome
    12. viral process Source: Reactome

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Short name:
    Nuclear pore protein gp210
    Alternative name(s):
    Nuclear envelope pore membrane protein POM 210
    Short name:
    POM210
    Nucleoporin Nup210
    Pore membrane protein of 210 kDa
    Gene namesi
    Name:NUP210
    Synonyms:KIAA0906
    ORF Names:PSEC0245
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30052. NUP210.

    Subcellular locationi

    Nucleusnuclear pore complex 1 Publication. Nucleus membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB
    3. nuclear envelope Source: Reactome
    4. nuclear membrane Source: UniProtKB-SubCell
    5. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 18871861Nuclear pore membrane glycoprotein 210PRO_0000236046Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)1 Publication
    Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi926 – 9261N-linked (GlcNAc...)1 Publication
    Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1116 – 11161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1135 – 11351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1362 – 13621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1441 – 14411N-linked (GlcNAc...)1 Publication
    Modified residuei1844 – 18441Phosphothreonine3 Publications
    Modified residuei1874 – 18741Phosphoserine3 Publications
    Modified residuei1881 – 18811Phosphoserine3 Publications
    Modified residuei1886 – 18861Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides By similarity.By similarity
    Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8TEM1.
    PaxDbiQ8TEM1.
    PRIDEiQ8TEM1.

    PTM databases

    PhosphoSiteiQ8TEM1.

    Expressioni

    Tissue specificityi

    Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ8TEM1.
    CleanExiHS_NUP210.
    GenevestigatoriQ8TEM1.

    Interactioni

    Subunit structurei

    Forms dimers and possibly higher-order oligomers.By similarity

    Protein-protein interaction databases

    BioGridi116831. 16 interactions.
    IntActiQ8TEM1. 11 interactions.
    MINTiMINT-4535557.
    STRINGi9606.ENSP00000254508.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEM1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 18081782LumenalCuratedAdd
    BLAST
    Topological domaini1830 – 188758CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1809 – 182921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi486 – 4916Poly-Ser

    Sequence similaritiesi

    Belongs to the NUP210 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG315446.
    HOGENOMiHOG000115312.
    HOVERGENiHBG082098.
    InParanoidiQ8TEM1.
    KOiK14314.
    OMAiPVWNQQE.
    OrthoDBiEOG7PS1DJ.
    PhylomeDBiQ8TEM1.
    TreeFamiTF313331.

    Family and domain databases

    InterProiIPR003343. Big_2.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view]
    PfamiPF02368. Big_2. 1 hit.
    [Graphical view]
    SMARTiSM00635. BID_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49373. SSF49373. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TEM1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS     50
    EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED 100
    ITTGQVLRCD AIVDLIHDIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS 150
    TLAGLVFEWT IVKDSEADRF SDSHNALRIL TFLESTYIPP SYISEMEKAA 200
    KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD 250
    VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 300
    AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF 350
    TVHPGDRWVL ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL 400
    SSSQNGSYHR IRALKRGQTA IDAALTSVVD QDGGVHILQV PVWNQQEVEI 450
    HIPITLYPSI LTFPWQPKTG AYQYTIRAHG GSGNFSWSSS SHLVATVTVK 500
    GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF APCQVEARVG 550
    QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 600
    GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS 650
    VALVTLGSSK EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS 700
    RNYQQHWILV TCQALGEQVI ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS 750
    RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS SHRNPRLDLA AYDQEGRRFD 800
    NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA 850
    SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 900
    EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL 950
    PGSSTIMIHD LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR 1000
    VLDLHKKPFL AKYFPFMDLK LRAASPIITL VALDEALDNY TITFLIRGVA 1050
    IGQTSLTASV TNKAGQRINS APQQIEVFPP FRLMPRKVTL LIGATMQVTS 1100
    EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG LVQAVDAETG 1150
    KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS 1200
    FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR 1250
    TGLRVVVKAV DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM 1300
    SPNSYIKLQT NRDGAASLSY RVLDGPEKVP VVHVDEKGFL ASGSMIGTST 1350
    IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS MSPVLHTQNK EALVAVPLGM 1400
    TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT NNTCVVRTVS 1450
    VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS 1500
    LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV 1550
    VSVPQRIMAR HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI 1600
    QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL 1650
    TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSPG LFADQAEILL 1700
    SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG WPSFITYTVG 1750
    VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF 1800
    QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG 1850
    HSPHYFAASS PTSPNALPPA RKASPPSGLW SPAYASH 1887
    Length:1,887
    Mass (Da):205,111
    Last modified:October 17, 2006 - v3
    Checksum:i70B5C35E685C8DF8
    GO
    Isoform 2 (identifier: Q8TEM1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
         968-1887: Missing.

    Show »
    Length:967
    Mass (Da):105,810
    Checksum:i56A41738E2C8DEF1
    GO

    Sequence cautioni

    The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1512 – 15121A → T in BAC11688. (PubMed:16303743)Curated
    Sequence conflicti1761 – 17611P → S in BAC11688. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti297 – 2971A → T.
    Corresponds to variant rs7628051 [ dbSNP | Ensembl ].
    VAR_028147
    Natural varianti608 – 6081I → V.
    Corresponds to variant rs3732671 [ dbSNP | Ensembl ].
    VAR_028148
    Natural varianti755 – 7551A → V.
    Corresponds to variant rs6795271 [ dbSNP | Ensembl ].
    VAR_028149
    Natural varianti786 – 7861R → L Polymorphism confirmed at protein level. 2 Publications
    Corresponds to variant rs2280084 [ dbSNP | Ensembl ].
    VAR_026474
    Natural varianti821 – 8211P → A.
    Corresponds to variant rs2280085 [ dbSNP | Ensembl ].
    VAR_028150
    Natural varianti944 – 9441A → P.
    Corresponds to variant rs433032 [ dbSNP | Ensembl ].
    VAR_028151
    Natural varianti1096 – 10961M → I.
    Corresponds to variant rs2271505 [ dbSNP | Ensembl ].
    VAR_028152
    Natural varianti1430 – 14301D → E.
    Corresponds to variant rs13081937 [ dbSNP | Ensembl ].
    VAR_028153
    Natural varianti1752 – 17521L → S.3 Publications
    Corresponds to variant rs354479 [ dbSNP | Ensembl ].
    VAR_026475
    Natural varianti1787 – 17871V → M.3 Publications
    Corresponds to variant rs354478 [ dbSNP | Ensembl ].
    VAR_026476

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei947 – 96721HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2. 2 PublicationsVSP_018567Add
    BLAST
    Alternative sequencei968 – 1887920Missing in isoform 2. 2 PublicationsVSP_018568Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC027124 Genomic DNA. No translation available.
    AC069246 Genomic DNA. No translation available.
    BC067089 mRNA. Translation: AAH67089.1.
    AK026042 mRNA. Translation: BAB15332.1. Different initiation.
    AK074101 mRNA. Translation: BAB84927.1.
    AB020713 mRNA. Translation: BAA74929.1.
    AK075545 mRNA. Translation: BAC11688.1. Different initiation.
    AL117527 mRNA. Translation: CAB55979.2.
    CCDSiCCDS33704.1. [Q8TEM1-1]
    PIRiT17289.
    RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
    UniGeneiHs.475525.

    Genome annotation databases

    EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
    GeneIDi23225.
    KEGGihsa:23225.
    UCSCiuc003bxv.1. human. [Q8TEM1-1]
    uc003bxx.3. human. [Q8TEM1-2]

    Polymorphism databases

    DMDMi116242720.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC027124 Genomic DNA. No translation available.
    AC069246 Genomic DNA. No translation available.
    BC067089 mRNA. Translation: AAH67089.1 .
    AK026042 mRNA. Translation: BAB15332.1 . Different initiation.
    AK074101 mRNA. Translation: BAB84927.1 .
    AB020713 mRNA. Translation: BAA74929.1 .
    AK075545 mRNA. Translation: BAC11688.1 . Different initiation.
    AL117527 mRNA. Translation: CAB55979.2 .
    CCDSi CCDS33704.1. [Q8TEM1-1 ]
    PIRi T17289.
    RefSeqi NP_079199.2. NM_024923.3. [Q8TEM1-1 ]
    UniGenei Hs.475525.

    3D structure databases

    ProteinModelPortali Q8TEM1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116831. 16 interactions.
    IntActi Q8TEM1. 11 interactions.
    MINTi MINT-4535557.
    STRINGi 9606.ENSP00000254508.

    PTM databases

    PhosphoSitei Q8TEM1.

    Polymorphism databases

    DMDMi 116242720.

    Proteomic databases

    MaxQBi Q8TEM1.
    PaxDbi Q8TEM1.
    PRIDEi Q8TEM1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254508 ; ENSP00000254508 ; ENSG00000132182 . [Q8TEM1-1 ]
    GeneIDi 23225.
    KEGGi hsa:23225.
    UCSCi uc003bxv.1. human. [Q8TEM1-1 ]
    uc003bxx.3. human. [Q8TEM1-2 ]

    Organism-specific databases

    CTDi 23225.
    GeneCardsi GC03M013420.
    H-InvDB HIX0003074.
    HIX0018493.
    HIX0024491.
    HGNCi HGNC:30052. NUP210.
    MIMi 607703. gene.
    neXtProti NX_Q8TEM1.
    PharmGKBi PA128394614.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315446.
    HOGENOMi HOG000115312.
    HOVERGENi HBG082098.
    InParanoidi Q8TEM1.
    KOi K14314.
    OMAi PVWNQQE.
    OrthoDBi EOG7PS1DJ.
    PhylomeDBi Q8TEM1.
    TreeFami TF313331.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Miscellaneous databases

    ChiTaRSi NUP210. human.
    GenomeRNAii 23225.
    NextBioi 44833.
    PROi Q8TEM1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TEM1.
    CleanExi HS_NUP210.
    Genevestigatori Q8TEM1.

    Family and domain databases

    InterProi IPR003343. Big_2.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view ]
    Pfami PF02368. Big_2. 1 hit.
    [Graphical view ]
    SMARTi SM00635. BID_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49373. SSF49373. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1887 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1887 (ISOFORM 2), VARIANT LEU-786.
      Tissue: Brain and Spleen.
    4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787, TISSUE SPECIFICITY.
      Tissue: Brain.
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1405-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
      Tissue: Ovary tumor.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1460-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
      Tissue: Testis.
    7. "The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore."
      Courvalin J.-C., Lassoued K., Bartnik E., Blobel G., Wozniak R.W.
      J. Clin. Invest. 86:279-285(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Tissue: Cervix carcinoma.
    8. "Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans."
      Cohen M., Feinstein N., Wilson K.L., Gruenbaum Y.
      Mol. Biol. Cell 14:4230-4237(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1881 AND SER-1886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441.
      Tissue: Liver.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
      Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
      J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-786, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPO210_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEM1
    Secondary accession number(s): A6NN56
    , O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
    Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3