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Protein

Nuclear pore membrane glycoprotein 210

Gene

NUP210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.1 Publication

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. gene expression Source: Reactome
  4. glucose transport Source: Reactome
  5. hexose transport Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear envelope disassembly Source: Reactome
  8. mRNA transport Source: UniProtKB-KW
  9. pathogenesis Source: Reactome
  10. protein transport Source: UniProtKB-KW
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral life cycle Source: Reactome
  15. viral process Source: Reactome
  16. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:NUP210
Synonyms:KIAA0906
ORF Names:PSEC0245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30052. NUP210.

Subcellular locationi

  1. Nucleusnuclear pore complex 1 Publication
  2. Nucleus membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  3. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 18081782LumenalCuratedAdd
BLAST
Transmembranei1809 – 182921HelicalSequence AnalysisAdd
BLAST
Topological domaini1830 – 188758CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB
  3. nuclear envelope Source: Reactome
  4. nuclear membrane Source: UniProtKB-SubCell
  5. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394614.

Polymorphism and mutation databases

BioMutaiNUP210.
DMDMi116242720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 18871861Nuclear pore membrane glycoprotein 210PRO_0000236046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi405 – 4051N-linked (GlcNAc...)1 Publication
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi926 – 9261N-linked (GlcNAc...)1 Publication
Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1116 – 11161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1135 – 11351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1362 – 13621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1441 – 14411N-linked (GlcNAc...)1 Publication
Modified residuei1844 – 18441Phosphothreonine4 Publications
Modified residuei1874 – 18741Phosphoserine3 Publications
Modified residuei1881 – 18811Phosphoserine3 Publications
Modified residuei1886 – 18861Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).By similarity
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8TEM1.
PaxDbiQ8TEM1.
PRIDEiQ8TEM1.

PTM databases

PhosphoSiteiQ8TEM1.

Expressioni

Tissue specificityi

Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8TEM1.
CleanExiHS_NUP210.
GenevestigatoriQ8TEM1.

Organism-specific databases

HPAiHPA066888.

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers.By similarity

Protein-protein interaction databases

BioGridi116831. 18 interactions.
IntActiQ8TEM1. 11 interactions.
MINTiMINT-4535557.
STRINGi9606.ENSP00000254508.

Structurei

3D structure databases

ProteinModelPortaliQ8TEM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4916Poly-Ser

Sequence similaritiesi

Belongs to the NUP210 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315446.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ8TEM1.
KOiK14314.
OMAiFPWQPKT.
OrthoDBiEOG7PS1DJ.
PhylomeDBiQ8TEM1.
TreeFamiTF313331.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS
60 70 80 90 100
EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED
110 120 130 140 150
ITTGQVLRCD AIVDLIHDIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS
160 170 180 190 200
TLAGLVFEWT IVKDSEADRF SDSHNALRIL TFLESTYIPP SYISEMEKAA
210 220 230 240 250
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD
260 270 280 290 300
VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV
310 320 330 340 350
AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF
360 370 380 390 400
TVHPGDRWVL ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL
410 420 430 440 450
SSSQNGSYHR IRALKRGQTA IDAALTSVVD QDGGVHILQV PVWNQQEVEI
460 470 480 490 500
HIPITLYPSI LTFPWQPKTG AYQYTIRAHG GSGNFSWSSS SHLVATVTVK
510 520 530 540 550
GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF APCQVEARVG
560 570 580 590 600
QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP
610 620 630 640 650
GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS
660 670 680 690 700
VALVTLGSSK EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS
710 720 730 740 750
RNYQQHWILV TCQALGEQVI ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS
760 770 780 790 800
RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS SHRNPRLDLA AYDQEGRRFD
810 820 830 840 850
NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA
860 870 880 890 900
SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE
910 920 930 940 950
EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL
960 970 980 990 1000
PGSSTIMIHD LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR
1010 1020 1030 1040 1050
VLDLHKKPFL AKYFPFMDLK LRAASPIITL VALDEALDNY TITFLIRGVA
1060 1070 1080 1090 1100
IGQTSLTASV TNKAGQRINS APQQIEVFPP FRLMPRKVTL LIGATMQVTS
1110 1120 1130 1140 1150
EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG LVQAVDAETG
1160 1170 1180 1190 1200
KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS
1210 1220 1230 1240 1250
FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR
1260 1270 1280 1290 1300
TGLRVVVKAV DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM
1310 1320 1330 1340 1350
SPNSYIKLQT NRDGAASLSY RVLDGPEKVP VVHVDEKGFL ASGSMIGTST
1360 1370 1380 1390 1400
IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS MSPVLHTQNK EALVAVPLGM
1410 1420 1430 1440 1450
TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT NNTCVVRTVS
1460 1470 1480 1490 1500
VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS
1510 1520 1530 1540 1550
LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV
1560 1570 1580 1590 1600
VSVPQRIMAR HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI
1610 1620 1630 1640 1650
QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL
1660 1670 1680 1690 1700
TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSPG LFADQAEILL
1710 1720 1730 1740 1750
SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG WPSFITYTVG
1760 1770 1780 1790 1800
VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF
1810 1820 1830 1840 1850
QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG
1860 1870 1880
HSPHYFAASS PTSPNALPPA RKASPPSGLW SPAYASH
Length:1,887
Mass (Da):205,111
Last modified:October 17, 2006 - v3
Checksum:i70B5C35E685C8DF8
GO
Isoform 2 (identifier: Q8TEM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Show »
Length:967
Mass (Da):105,810
Checksum:i56A41738E2C8DEF1
GO

Sequence cautioni

The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1512 – 15121A → T in BAC11688 (PubMed:16303743).Curated
Sequence conflicti1761 – 17611P → S in BAC11688 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti297 – 2971A → T.
Corresponds to variant rs7628051 [ dbSNP | Ensembl ].
VAR_028147
Natural varianti608 – 6081I → V.
Corresponds to variant rs3732671 [ dbSNP | Ensembl ].
VAR_028148
Natural varianti755 – 7551A → V.
Corresponds to variant rs6795271 [ dbSNP | Ensembl ].
VAR_028149
Natural varianti786 – 7861R → L Polymorphism confirmed at protein level. 2 Publications
Corresponds to variant rs2280084 [ dbSNP | Ensembl ].
VAR_026474
Natural varianti821 – 8211P → A.
Corresponds to variant rs2280085 [ dbSNP | Ensembl ].
VAR_028150
Natural varianti944 – 9441A → P.
Corresponds to variant rs433032 [ dbSNP | Ensembl ].
VAR_028151
Natural varianti1096 – 10961M → I.
Corresponds to variant rs2271505 [ dbSNP | Ensembl ].
VAR_028152
Natural varianti1430 – 14301D → E.
Corresponds to variant rs13081937 [ dbSNP | Ensembl ].
VAR_028153
Natural varianti1752 – 17521L → S.3 Publications
Corresponds to variant rs354479 [ dbSNP | Ensembl ].
VAR_026475
Natural varianti1787 – 17871V → M.3 Publications
Corresponds to variant rs354478 [ dbSNP | Ensembl ].
VAR_026476

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei947 – 96721HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2. 2 PublicationsVSP_018567Add
BLAST
Alternative sequencei968 – 1887920Missing in isoform 2. 2 PublicationsVSP_018568Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSiCCDS33704.1. [Q8TEM1-1]
PIRiT17289.
RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneiHs.475525.

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneIDi23225.
KEGGihsa:23225.
UCSCiuc003bxv.1. human. [Q8TEM1-1]
uc003bxx.3. human. [Q8TEM1-2]

Polymorphism and mutation databases

BioMutaiNUP210.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSiCCDS33704.1. [Q8TEM1-1]
PIRiT17289.
RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneiHs.475525.

3D structure databases

ProteinModelPortaliQ8TEM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116831. 18 interactions.
IntActiQ8TEM1. 11 interactions.
MINTiMINT-4535557.
STRINGi9606.ENSP00000254508.

PTM databases

PhosphoSiteiQ8TEM1.

Polymorphism and mutation databases

BioMutaiNUP210.
DMDMi116242720.

Proteomic databases

MaxQBiQ8TEM1.
PaxDbiQ8TEM1.
PRIDEiQ8TEM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneIDi23225.
KEGGihsa:23225.
UCSCiuc003bxv.1. human. [Q8TEM1-1]
uc003bxx.3. human. [Q8TEM1-2]

Organism-specific databases

CTDi23225.
GeneCardsiGC03M013548.
H-InvDBHIX0003074.
HIX0018493.
HIX0024491.
HGNCiHGNC:30052. NUP210.
HPAiHPA066888.
MIMi607703. gene.
neXtProtiNX_Q8TEM1.
PharmGKBiPA128394614.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315446.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ8TEM1.
KOiK14314.
OMAiFPWQPKT.
OrthoDBiEOG7PS1DJ.
PhylomeDBiQ8TEM1.
TreeFamiTF313331.

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

ChiTaRSiNUP210. human.
GenomeRNAii23225.
NextBioi44833.
PROiQ8TEM1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TEM1.
CleanExiHS_NUP210.
GenevestigatoriQ8TEM1.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1887 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1887 (ISOFORM 2), VARIANT LEU-786.
    Tissue: Brain and Spleen.
  4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787, TISSUE SPECIFICITY.
    Tissue: Brain.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1405-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
    Tissue: Ovary tumor.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1460-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
    Tissue: Testis.
  7. "The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore."
    Courvalin J.-C., Lassoued K., Bartnik E., Blobel G., Wozniak R.W.
    J. Clin. Invest. 86:279-285(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma.
  8. "Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans."
    Cohen M., Feinstein N., Wilson K.L., Gruenbaum Y.
    Mol. Biol. Cell 14:4230-4237(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1881 AND SER-1886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441.
    Tissue: Liver.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
    Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
    J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-786, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPO210_HUMAN
AccessioniPrimary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56
, O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.