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Protein

Nuclear pore membrane glycoprotein 210

Gene

NUP210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:NUP210
Synonyms:KIAA0906
ORF Names:PSEC0245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30052. NUP210.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1808LumenalCuratedAdd BLAST1782
Transmembranei1809 – 1829HelicalSequence analysisAdd BLAST21
Topological domaini1830 – 1887CytoplasmicCuratedAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23225.
OpenTargetsiENSG00000132182.
PharmGKBiPA128394614.

Polymorphism and mutation databases

BioMutaiNUP210.
DMDMi116242720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000023604627 – 1887Nuclear pore membrane glycoprotein 210Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1
Glycosylationi405N-linked (GlcNAc...)1 Publication1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi681N-linked (GlcNAc...)Sequence analysis1
Glycosylationi801N-linked (GlcNAc...)Sequence analysis1
Glycosylationi926N-linked (GlcNAc...)1 Publication1
Glycosylationi1039N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1441N-linked (GlcNAc...)1 Publication1
Modified residuei1844PhosphothreonineCombined sources1
Modified residuei1874PhosphoserineCombined sources1
Modified residuei1877PhosphoserineCombined sources1
Modified residuei1881PhosphoserineCombined sources1
Modified residuei1886PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).By similarity
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8TEM1.
MaxQBiQ8TEM1.
PaxDbiQ8TEM1.
PeptideAtlasiQ8TEM1.
PRIDEiQ8TEM1.

PTM databases

iPTMnetiQ8TEM1.
PhosphoSitePlusiQ8TEM1.

Expressioni

Tissue specificityi

Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000132182.
CleanExiHS_NUP210.
GenevisibleiQ8TEM1. HS.

Organism-specific databases

HPAiHPA058611.
HPA066888.

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers.By similarity

Protein-protein interaction databases

BioGridi116831. 35 interactors.
IntActiQ8TEM1. 22 interactors.
MINTiMINT-4535557.
STRINGi9606.ENSP00000254508.

Structurei

3D structure databases

ProteinModelPortaliQ8TEM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi486 – 491Poly-Ser6

Sequence similaritiesi

Belongs to the NUP210 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1833. Eukaryota.
ENOG410XNNU. LUCA.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ8TEM1.
KOiK14314.
OMAiLVFEWTI.
OrthoDBiEOG091G006N.
PhylomeDBiQ8TEM1.
TreeFamiTF313331.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS
60 70 80 90 100
EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED
110 120 130 140 150
ITTGQVLRCD AIVDLIHDIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS
160 170 180 190 200
TLAGLVFEWT IVKDSEADRF SDSHNALRIL TFLESTYIPP SYISEMEKAA
210 220 230 240 250
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD
260 270 280 290 300
VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV
310 320 330 340 350
AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF
360 370 380 390 400
TVHPGDRWVL ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL
410 420 430 440 450
SSSQNGSYHR IRALKRGQTA IDAALTSVVD QDGGVHILQV PVWNQQEVEI
460 470 480 490 500
HIPITLYPSI LTFPWQPKTG AYQYTIRAHG GSGNFSWSSS SHLVATVTVK
510 520 530 540 550
GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF APCQVEARVG
560 570 580 590 600
QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP
610 620 630 640 650
GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS
660 670 680 690 700
VALVTLGSSK EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS
710 720 730 740 750
RNYQQHWILV TCQALGEQVI ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS
760 770 780 790 800
RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS SHRNPRLDLA AYDQEGRRFD
810 820 830 840 850
NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA
860 870 880 890 900
SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE
910 920 930 940 950
EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL
960 970 980 990 1000
PGSSTIMIHD LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR
1010 1020 1030 1040 1050
VLDLHKKPFL AKYFPFMDLK LRAASPIITL VALDEALDNY TITFLIRGVA
1060 1070 1080 1090 1100
IGQTSLTASV TNKAGQRINS APQQIEVFPP FRLMPRKVTL LIGATMQVTS
1110 1120 1130 1140 1150
EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG LVQAVDAETG
1160 1170 1180 1190 1200
KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS
1210 1220 1230 1240 1250
FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR
1260 1270 1280 1290 1300
TGLRVVVKAV DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM
1310 1320 1330 1340 1350
SPNSYIKLQT NRDGAASLSY RVLDGPEKVP VVHVDEKGFL ASGSMIGTST
1360 1370 1380 1390 1400
IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS MSPVLHTQNK EALVAVPLGM
1410 1420 1430 1440 1450
TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT NNTCVVRTVS
1460 1470 1480 1490 1500
VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS
1510 1520 1530 1540 1550
LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV
1560 1570 1580 1590 1600
VSVPQRIMAR HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI
1610 1620 1630 1640 1650
QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL
1660 1670 1680 1690 1700
TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSPG LFADQAEILL
1710 1720 1730 1740 1750
SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG WPSFITYTVG
1760 1770 1780 1790 1800
VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF
1810 1820 1830 1840 1850
QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG
1860 1870 1880
HSPHYFAASS PTSPNALPPA RKASPPSGLW SPAYASH
Length:1,887
Mass (Da):205,111
Last modified:October 17, 2006 - v3
Checksum:i70B5C35E685C8DF8
GO
Isoform 2 (identifier: Q8TEM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Show »
Length:967
Mass (Da):105,810
Checksum:i56A41738E2C8DEF1
GO

Sequence cautioni

The sequence BAB15332 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11688 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1512A → T in BAC11688 (PubMed:16303743).Curated1
Sequence conflicti1761P → S in BAC11688 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028147297A → T.Corresponds to variant rs7628051dbSNPEnsembl.1
Natural variantiVAR_028148608I → V.Corresponds to variant rs3732671dbSNPEnsembl.1
Natural variantiVAR_028149755A → V.Corresponds to variant rs6795271dbSNPEnsembl.1
Natural variantiVAR_026474786R → L Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant rs2280084dbSNPEnsembl.1
Natural variantiVAR_028150821P → A.Corresponds to variant rs2280085dbSNPEnsembl.1
Natural variantiVAR_028151944A → P.Corresponds to variant rs433032dbSNPEnsembl.1
Natural variantiVAR_0281521096M → I.Corresponds to variant rs2271505dbSNPEnsembl.1
Natural variantiVAR_0281531430D → E.Corresponds to variant rs13081937dbSNPEnsembl.1
Natural variantiVAR_0264751752L → S.3 PublicationsCorresponds to variant rs354479dbSNPEnsembl.1
Natural variantiVAR_0264761787V → M.3 PublicationsCorresponds to variant rs354478dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018567947 – 967HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_018568968 – 1887Missing in isoform 2. 2 PublicationsAdd BLAST920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSiCCDS33704.1. [Q8TEM1-1]
PIRiT17289.
RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneiHs.475525.

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneIDi23225.
KEGGihsa:23225.
UCSCiuc003bxv.3. human. [Q8TEM1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSiCCDS33704.1. [Q8TEM1-1]
PIRiT17289.
RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneiHs.475525.

3D structure databases

ProteinModelPortaliQ8TEM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116831. 35 interactors.
IntActiQ8TEM1. 22 interactors.
MINTiMINT-4535557.
STRINGi9606.ENSP00000254508.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ8TEM1.
PhosphoSitePlusiQ8TEM1.

Polymorphism and mutation databases

BioMutaiNUP210.
DMDMi116242720.

Proteomic databases

EPDiQ8TEM1.
MaxQBiQ8TEM1.
PaxDbiQ8TEM1.
PeptideAtlasiQ8TEM1.
PRIDEiQ8TEM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneIDi23225.
KEGGihsa:23225.
UCSCiuc003bxv.3. human. [Q8TEM1-1]

Organism-specific databases

CTDi23225.
DisGeNETi23225.
GeneCardsiNUP210.
H-InvDBHIX0003074.
HIX0018493.
HIX0024491.
HGNCiHGNC:30052. NUP210.
HPAiHPA058611.
HPA066888.
MIMi607703. gene.
neXtProtiNX_Q8TEM1.
OpenTargetsiENSG00000132182.
PharmGKBiPA128394614.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1833. Eukaryota.
ENOG410XNNU. LUCA.
GeneTreeiENSGT00390000009491.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ8TEM1.
KOiK14314.
OMAiLVFEWTI.
OrthoDBiEOG091G006N.
PhylomeDBiQ8TEM1.
TreeFamiTF313331.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Miscellaneous databases

ChiTaRSiNUP210. human.
GenomeRNAii23225.
PROiQ8TEM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132182.
CleanExiHS_NUP210.
GenevisibleiQ8TEM1. HS.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPO210_HUMAN
AccessioniPrimary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56
, O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.