Q8TEM1 (PO210_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore membrane glycoprotein 210
Short name=Nuclear pore protein gp210

Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name=POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa

Gene names

Name:	NUP210
Synonyms:	KIAA0906
ORF Names:	PSEC0245

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1887 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Ref.8
Subunit structure	Forms dimers and possibly higher-order oligomers By similarity.
Subcellular location	Nucleus › nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.7.
Tissue specificity	Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle. Ref.4
Post-translational modification	N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides By similarity. Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase By similarity.
Miscellaneous	Recognized by antinuclear autoantibodies in primary biliary cirrhosis. Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
Sequence similarities	Belongs to the NUP210 family.
Sequence caution	The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Endoplasmic reticulum Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Traceable author statement. Source: Reactome nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 1887	1861	Nuclear pore membrane glycoprotein 210		PRO_0000236046
Regions
	Topological domain	27 – 1808	1782	Lumenal Probable
	Transmembrane	1809 – 1829	21	Helical; Potential
	Topological domain	1830 – 1887	58	Cytoplasmic Probable
	Compositional bias	486 – 491	6	Poly-Ser
Amino acid modifications
	Modified residue	1844	1	Phosphothreonine Ref.11 Ref.12 Ref.14
	Modified residue	1874	1	Phosphoserine Ref.9 Ref.11 Ref.12
	Modified residue	1881	1	Phosphoserine Ref.9 Ref.11 Ref.12
	Modified residue	1886	1	Phosphoserine Ref.9
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
	Glycosylation	337	1	N-linked (GlcNAc...) Potential
	Glycosylation	405	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	484	1	N-linked (GlcNAc...) Potential
	Glycosylation	681	1	N-linked (GlcNAc...) Potential
	Glycosylation	801	1	N-linked (GlcNAc...) Potential
	Glycosylation	926	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	1039	1	N-linked (GlcNAc...) Potential
	Glycosylation	1116	1	N-linked (GlcNAc...) Potential
	Glycosylation	1135	1	N-linked (GlcNAc...) Potential
	Glycosylation	1362	1	N-linked (GlcNAc...) Potential
	Glycosylation	1441	1	N-linked (GlcNAc...) Ref.10
Natural variations
	Alternative sequence	947 – 967	21	HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2.		VSP_018567
	Alternative sequence	968 – 1887	920	Missing in isoform 2.		VSP_018568
	Natural variant	297	1	A → T. Corresponds to variant rs7628051 [ dbSNP | Ensembl ].		VAR_028147
	Natural variant	608	1	I → V. Corresponds to variant rs3732671 [ dbSNP | Ensembl ].		VAR_028148
	Natural variant	755	1	A → V. Corresponds to variant rs6795271 [ dbSNP | Ensembl ].		VAR_028149
	Natural variant	786	1	R → L Polymorphism confirmed at protein level. Ref.3 Ref.15 Corresponds to variant rs2280084 [ dbSNP | Ensembl ].		VAR_026474
	Natural variant	821	1	P → A. Corresponds to variant rs2280085 [ dbSNP | Ensembl ].		VAR_028150
	Natural variant	944	1	A → P. Corresponds to variant rs433032 [ dbSNP | Ensembl ].		VAR_028151
	Natural variant	1096	1	M → I. Corresponds to variant rs2271505 [ dbSNP | Ensembl ].		VAR_028152
	Natural variant	1430	1	D → E. Corresponds to variant rs13081937 [ dbSNP | Ensembl ].		VAR_028153
	Natural variant	1752	1	L → S. Ref.4 Ref.5 Ref.6 Corresponds to variant rs354479 [ dbSNP | Ensembl ].		VAR_026475
	Natural variant	1787	1	V → M. Ref.4 Ref.5 Ref.6 Corresponds to variant rs354478 [ dbSNP | Ensembl ].		VAR_026476
Experimental info
	Sequence conflict	1512	1	A → T in BAC11688. Ref.5
	Sequence conflict	1761	1	P → S in BAC11688. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 70B5C35E685C8DF8	FASTA	1,887	205,111
	10 20 30 40 50 60 MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR 70 80 90 100 110 120 PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED ITTGQVLRCD AIVDLIHDIQ 130 140 150 160 170 180 IVSTTRELYL EDSPLELKIQ ALDSEGNTFS TLAGLVFEWT IVKDSEADRF SDSHNALRIL 190 200 210 220 230 240 TFLESTYIPP SYISEMEKAA KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL 250 260 270 280 290 300 ENILLNPAYD VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 310 320 330 340 350 360 AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF TVHPGDRWVL 370 380 390 400 410 420 ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL SSSQNGSYHR IRALKRGQTA 430 440 450 460 470 480 IDAALTSVVD QDGGVHILQV PVWNQQEVEI HIPITLYPSI LTFPWQPKTG AYQYTIRAHG 490 500 510 520 530 540 GSGNFSWSSS SHLVATVTVK GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF 550 560 570 580 590 600 APCQVEARVG QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 610 620 630 640 650 660 GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS VALVTLGSSK 670 680 690 700 710 720 EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS RNYQQHWILV TCQALGEQVI 730 740 750 760 770 780 ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS 790 800 810 820 830 840 SHRNPRLDLA AYDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH 850 860 870 880 890 900 GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 910 920 930 940 950 960 EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL PGSSTIMIHD 970 980 990 1000 1010 1020 LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR VLDLHKKPFL AKYFPFMDLK 1030 1040 1050 1060 1070 1080 LRAASPIITL VALDEALDNY TITFLIRGVA IGQTSLTASV TNKAGQRINS APQQIEVFPP 1090 1100 1110 1120 1130 1140 FRLMPRKVTL LIGATMQVTS EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG 1150 1160 1170 1180 1190 1200 LVQAVDAETG KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS 1210 1220 1230 1240 1250 1260 FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR TGLRVVVKAV 1270 1280 1290 1300 1310 1320 DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM SPNSYIKLQT NRDGAASLSY 1330 1340 1350 1360 1370 1380 RVLDGPEKVP VVHVDEKGFL ASGSMIGTST IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS 1390 1400 1410 1420 1430 1440 MSPVLHTQNK EALVAVPLGM TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT 1450 1460 1470 1480 1490 1500 NNTCVVRTVS VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS 1510 1520 1530 1540 1550 1560 LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV VSVPQRIMAR 1570 1580 1590 1600 1610 1620 HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI QALHPETLIS CQSQFKPAVF 1630 1640 1650 1660 1670 1680 DFPSQDVFTV EPQFDTALGQ YFCSITMHRL TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ 1690 1700 1710 1720 1730 1740 VGAEVPFSPG LFADQAEILL SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG 1750 1760 1770 1780 1790 1800 WPSFITYTVG VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF 1810 1820 1830 1840 1850 1860 QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG HSPHYFAASS 1870 1880 PTSPNALPPA RKASPPSGLW SPAYASH
	Isoform 2 [UniParc]. Checksum: 56A41738E2C8DEF1	FASTA	967	105,810
	10 20 30 40 50 60 MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR 70 80 90 100 110 120 PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED ITTGQVLRCD AIVDLIHDIQ 130 140 150 160 170 180 IVSTTRELYL EDSPLELKIQ ALDSEGNTFS TLAGLVFEWT IVKDSEADRF SDSHNALRIL 190 200 210 220 230 240 TFLESTYIPP SYISEMEKAA KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL 250 260 270 280 290 300 ENILLNPAYD VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 310 320 330 340 350 360 AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF TVHPGDRWVL 370 380 390 400 410 420 ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL SSSQNGSYHR IRALKRGQTA 430 440 450 460 470 480 IDAALTSVVD QDGGVHILQV PVWNQQEVEI HIPITLYPSI LTFPWQPKTG AYQYTIRAHG 490 500 510 520 530 540 GSGNFSWSSS SHLVATVTVK GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF 550 560 570 580 590 600 APCQVEARVG QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 610 620 630 640 650 660 GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS VALVTLGSSK 670 680 690 700 710 720 EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS RNYQQHWILV TCQALGEQVI 730 740 750 760 770 780 ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS 790 800 810 820 830 840 SHRNPRLDLA AYDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH 850 860 870 880 890 900 GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 910 920 930 940 950 960 EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVSLGH RSPLLVFIPY LGCCVVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1887 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1887 (ISOFORM 2), VARIANT LEU-786. Tissue: Brain and Spleen.
[4]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787, TISSUE SPECIFICITY. Tissue: Brain.
[5]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1405-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787. Tissue: Ovary tumor.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1460-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787. Tissue: Testis.
[7]	"The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore." Courvalin J.-C., Lassoued K., Bartnik E., Blobel G., Wozniak R.W. J. Clin. Invest. 86:279-285(1990) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Tissue: Cervix carcinoma.
[8]	"Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans." Cohen M., Feinstein N., Wilson K.L., Gruenbaum Y. Mol. Biol. Cell 14:4230-4237(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1881 AND SER-1886, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441, MASS SPECTROMETRY. Tissue: Liver.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, MASS SPECTROMETRY.
[15]	"Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data." Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr. J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-786, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC027124 Genomic DNA. No translation available. AC069246 Genomic DNA. No translation available. BC067089 mRNA. Translation: AAH67089.1. AK026042 mRNA. Translation: BAB15332.1. Different initiation. AK074101 mRNA. Translation: BAB84927.1. AB020713 mRNA. Translation: BAA74929.1. AK075545 mRNA. Translation: BAC11688.1. Different initiation. AL117527 mRNA. Translation: CAB55979.2.
IPI	IPI00291755. IPI00871723.
PIR	T17289.
RefSeq	NP_079199.2. NM_024923.2.
UniGene	Hs.475525.
3D structure databases
ProteinModelPortal	Q8TEM1.
SMR	Q8TEM1. Positions 471-538, 1091-1142, 1322-1355, 1507-1538.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TEM1. 11 interactions.
STRING	9606.ENSP00000254508.
PTM databases
PhosphoSite	Q8TEM1.
Polymorphism databases
DMDM	116242720.
Proteomic databases
PaxDb	Q8TEM1.
PRIDE	Q8TEM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254508; ENSP00000254508; ENSG00000132182.
GeneID	23225.
KEGG	hsa:23225.
UCSC	uc003bxv.1. human. uc003bxx.3. human.
Organism-specific databases
CTD	23225.
GeneCards	GC03M013332.
H-InvDB	HIX0003074. HIX0018493. HIX0024491.
HGNC	HGNC:30052. NUP210.
MIM	607703. gene.
neXtProt	NX_Q8TEM1.
PharmGKB	PA128394614.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315446.
HOGENOM	HOG000115312.
HOVERGEN	HBG082098.
InParanoid	Q8TEM1.
KO	K14314.
OMA	EDITTGQ.
OrthoDB	EOG4RJG0P.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
Bgee	Q8TEM1.
CleanEx	HS_NUP210.
Genevestigator	Q8TEM1.
GermOnline	ENSG00000132182. Homo sapiens.
Family and domain databases
InterPro	IPR003343. Big_2. IPR008964. Invasin/intimin_cell_adhesion. [Graphical view]
Pfam	PF02368. Big_2. 1 hit. [Graphical view]
SMART	SM00635. BID_2. 1 hit. [Graphical view]
SUPFAM	SSF49373. Invasin_intimin. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	NUP210. human.
GenomeRNAi	23225.
NextBio	44833.
SOURCE	Search...

Entry information

Entry name

PO210_HUMAN

Accession

Primary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56 , O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 88 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.