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Q8TEM1

- PO210_HUMAN

UniProt

Q8TEM1 - PO210_HUMAN

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Protein
Nuclear pore membrane glycoprotein 210
Gene
NUP210, KIAA0906, PSEC0245
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.1 Publication

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. glucose transport Source: Reactome
  4. hexose transport Source: Reactome
  5. mRNA transport Source: UniProtKB-KW
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear envelope disassembly Source: Reactome
  8. protein transport Source: UniProtKB-KW
  9. regulation of glucose transport Source: Reactome
  10. small molecule metabolic process Source: Reactome
  11. transmembrane transport Source: Reactome
  12. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:NUP210
Synonyms:KIAA0906
ORF Names:PSEC0245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30052. NUP210.

Subcellular locationi

Nucleusnuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 18081782Lumenal Inferred
Add
BLAST
Transmembranei1809 – 182921Helical; Reviewed prediction
Add
BLAST
Topological domaini1830 – 188758Cytoplasmic Inferred
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. nuclear envelope Source: Reactome
  3. nuclear membrane Source: UniProtKB-SubCell
  4. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Chaini27 – 18871861Nuclear pore membrane glycoprotein 210
PRO_0000236046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi405 – 4051N-linked (GlcNAc...)1 Publication
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi801 – 8011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi926 – 9261N-linked (GlcNAc...)1 Publication
Glycosylationi1039 – 10391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1116 – 11161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1135 – 11351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1362 – 13621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1441 – 14411N-linked (GlcNAc...)1 Publication
Modified residuei1844 – 18441Phosphothreonine3 Publications
Modified residuei1874 – 18741Phosphoserine3 Publications
Modified residuei1881 – 18811Phosphoserine3 Publications
Modified residuei1886 – 18861Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides By similarity.
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8TEM1.
PaxDbiQ8TEM1.
PRIDEiQ8TEM1.

PTM databases

PhosphoSiteiQ8TEM1.

Expressioni

Tissue specificityi

Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8TEM1.
CleanExiHS_NUP210.
GenevestigatoriQ8TEM1.

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers By similarity.

Protein-protein interaction databases

BioGridi116831. 16 interactions.
IntActiQ8TEM1. 11 interactions.
MINTiMINT-4535557.
STRINGi9606.ENSP00000254508.

Structurei

3D structure databases

ProteinModelPortaliQ8TEM1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4916Poly-Ser

Sequence similaritiesi

Belongs to the NUP210 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315446.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ8TEM1.
KOiK14314.
OMAiPVWNQQE.
OrthoDBiEOG7PS1DJ.
PhylomeDBiQ8TEM1.
TreeFamiTF313331.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TEM1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS     50
EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED 100
ITTGQVLRCD AIVDLIHDIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS 150
TLAGLVFEWT IVKDSEADRF SDSHNALRIL TFLESTYIPP SYISEMEKAA 200
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD 250
VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 300
AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF 350
TVHPGDRWVL ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL 400
SSSQNGSYHR IRALKRGQTA IDAALTSVVD QDGGVHILQV PVWNQQEVEI 450
HIPITLYPSI LTFPWQPKTG AYQYTIRAHG GSGNFSWSSS SHLVATVTVK 500
GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF APCQVEARVG 550
QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 600
GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS 650
VALVTLGSSK EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS 700
RNYQQHWILV TCQALGEQVI ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS 750
RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS SHRNPRLDLA AYDQEGRRFD 800
NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA 850
SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 900
EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL 950
PGSSTIMIHD LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR 1000
VLDLHKKPFL AKYFPFMDLK LRAASPIITL VALDEALDNY TITFLIRGVA 1050
IGQTSLTASV TNKAGQRINS APQQIEVFPP FRLMPRKVTL LIGATMQVTS 1100
EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG LVQAVDAETG 1150
KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS 1200
FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR 1250
TGLRVVVKAV DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM 1300
SPNSYIKLQT NRDGAASLSY RVLDGPEKVP VVHVDEKGFL ASGSMIGTST 1350
IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS MSPVLHTQNK EALVAVPLGM 1400
TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT NNTCVVRTVS 1450
VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS 1500
LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV 1550
VSVPQRIMAR HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI 1600
QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL 1650
TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSPG LFADQAEILL 1700
SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG WPSFITYTVG 1750
VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF 1800
QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG 1850
HSPHYFAASS PTSPNALPPA RKASPPSGLW SPAYASH 1887
Length:1,887
Mass (Da):205,111
Last modified:October 17, 2006 - v3
Checksum:i70B5C35E685C8DF8
GO
Isoform 2 (identifier: Q8TEM1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Show »
Length:967
Mass (Da):105,810
Checksum:i56A41738E2C8DEF1
GO

Sequence cautioni

The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti297 – 2971A → T.
Corresponds to variant rs7628051 [ dbSNP | Ensembl ].
VAR_028147
Natural varianti608 – 6081I → V.
Corresponds to variant rs3732671 [ dbSNP | Ensembl ].
VAR_028148
Natural varianti755 – 7551A → V.
Corresponds to variant rs6795271 [ dbSNP | Ensembl ].
VAR_028149
Natural varianti786 – 7861R → L Polymorphism confirmed at protein level. 2 Publications
Corresponds to variant rs2280084 [ dbSNP | Ensembl ].
VAR_026474
Natural varianti821 – 8211P → A.
Corresponds to variant rs2280085 [ dbSNP | Ensembl ].
VAR_028150
Natural varianti944 – 9441A → P.
Corresponds to variant rs433032 [ dbSNP | Ensembl ].
VAR_028151
Natural varianti1096 – 10961M → I.
Corresponds to variant rs2271505 [ dbSNP | Ensembl ].
VAR_028152
Natural varianti1430 – 14301D → E.
Corresponds to variant rs13081937 [ dbSNP | Ensembl ].
VAR_028153
Natural varianti1752 – 17521L → S.3 Publications
Corresponds to variant rs354479 [ dbSNP | Ensembl ].
VAR_026475
Natural varianti1787 – 17871V → M.3 Publications
Corresponds to variant rs354478 [ dbSNP | Ensembl ].
VAR_026476

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei947 – 96721HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2.
VSP_018567Add
BLAST
Alternative sequencei968 – 1887920Missing in isoform 2.
VSP_018568Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1512 – 15121A → T in BAC11688. 1 Publication
Sequence conflicti1761 – 17611P → S in BAC11688. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1.
AK026042 mRNA. Translation: BAB15332.1. Different initiation.
AK074101 mRNA. Translation: BAB84927.1.
AB020713 mRNA. Translation: BAA74929.1.
AK075545 mRNA. Translation: BAC11688.1. Different initiation.
AL117527 mRNA. Translation: CAB55979.2.
CCDSiCCDS33704.1. [Q8TEM1-1]
PIRiT17289.
RefSeqiNP_079199.2. NM_024923.3. [Q8TEM1-1]
UniGeneiHs.475525.

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182. [Q8TEM1-1]
GeneIDi23225.
KEGGihsa:23225.
UCSCiuc003bxv.1. human. [Q8TEM1-1]
uc003bxx.3. human. [Q8TEM1-2]

Polymorphism databases

DMDMi116242720.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC027124 Genomic DNA. No translation available.
AC069246 Genomic DNA. No translation available.
BC067089 mRNA. Translation: AAH67089.1 .
AK026042 mRNA. Translation: BAB15332.1 . Different initiation.
AK074101 mRNA. Translation: BAB84927.1 .
AB020713 mRNA. Translation: BAA74929.1 .
AK075545 mRNA. Translation: BAC11688.1 . Different initiation.
AL117527 mRNA. Translation: CAB55979.2 .
CCDSi CCDS33704.1. [Q8TEM1-1 ]
PIRi T17289.
RefSeqi NP_079199.2. NM_024923.3. [Q8TEM1-1 ]
UniGenei Hs.475525.

3D structure databases

ProteinModelPortali Q8TEM1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116831. 16 interactions.
IntActi Q8TEM1. 11 interactions.
MINTi MINT-4535557.
STRINGi 9606.ENSP00000254508.

PTM databases

PhosphoSitei Q8TEM1.

Polymorphism databases

DMDMi 116242720.

Proteomic databases

MaxQBi Q8TEM1.
PaxDbi Q8TEM1.
PRIDEi Q8TEM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254508 ; ENSP00000254508 ; ENSG00000132182 . [Q8TEM1-1 ]
GeneIDi 23225.
KEGGi hsa:23225.
UCSCi uc003bxv.1. human. [Q8TEM1-1 ]
uc003bxx.3. human. [Q8TEM1-2 ]

Organism-specific databases

CTDi 23225.
GeneCardsi GC03M013420.
H-InvDB HIX0003074.
HIX0018493.
HIX0024491.
HGNCi HGNC:30052. NUP210.
MIMi 607703. gene.
neXtProti NX_Q8TEM1.
PharmGKBi PA128394614.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315446.
HOGENOMi HOG000115312.
HOVERGENi HBG082098.
InParanoidi Q8TEM1.
KOi K14314.
OMAi PVWNQQE.
OrthoDBi EOG7PS1DJ.
PhylomeDBi Q8TEM1.
TreeFami TF313331.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

ChiTaRSi NUP210. human.
GenomeRNAii 23225.
NextBioi 44833.
PROi Q8TEM1.
SOURCEi Search...

Gene expression databases

Bgeei Q8TEM1.
CleanExi HS_NUP210.
Genevestigatori Q8TEM1.

Family and domain databases

InterProi IPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view ]
Pfami PF02368. Big_2. 1 hit.
[Graphical view ]
SMARTi SM00635. BID_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49373. SSF49373. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1887 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1887 (ISOFORM 2), VARIANT LEU-786.
    Tissue: Brain and Spleen.
  4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787, TISSUE SPECIFICITY.
    Tissue: Brain.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1405-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
    Tissue: Ovary tumor.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1460-1887 (ISOFORM 1), VARIANTS SER-1752 AND MET-1787.
    Tissue: Testis.
  7. "The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore."
    Courvalin J.-C., Lassoued K., Bartnik E., Blobel G., Wozniak R.W.
    J. Clin. Invest. 86:279-285(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma.
  8. "Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans."
    Cohen M., Feinstein N., Wilson K.L., Gruenbaum Y.
    Mol. Biol. Cell 14:4230-4237(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1881 AND SER-1886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441.
    Tissue: Liver.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874 AND SER-1881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
    Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
    J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-786, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPO210_HUMAN
AccessioniPrimary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56
, O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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