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Protein

Nuclear pore membrane glycoprotein 210

Gene

NUP210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.1 Publication

Miscellaneous

Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210
Short name:
Nuclear pore protein gp210
Alternative name(s):
Nuclear envelope pore membrane protein POM 210
Short name:
POM210
Nucleoporin Nup210
Pore membrane protein of 210 kDa
Gene namesi
Name:NUP210
Synonyms:KIAA0906
ORF Names:PSEC0245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000132182.11
HGNCiHGNC:30052 NUP210
MIMi607703 gene
neXtProtiNX_Q8TEM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1808LumenalCuratedAdd BLAST1782
Transmembranei1809 – 1829HelicalSequence analysisAdd BLAST21
Topological domaini1830 – 1887CytoplasmicCuratedAdd BLAST58

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23225
OpenTargetsiENSG00000132182
PharmGKBiPA128394614

Polymorphism and mutation databases

BioMutaiNUP210
DMDMi116242720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000023604627 – 1887Nuclear pore membrane glycoprotein 210Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi926N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1441N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei1844PhosphothreonineCombined sources1
Modified residuei1874PhosphoserineCombined sources1
Modified residuei1877PhosphoserineCombined sources1
Modified residuei1881PhosphoserineCombined sources1
Modified residuei1886PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).By similarity
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8TEM1
MaxQBiQ8TEM1
PaxDbiQ8TEM1
PeptideAtlasiQ8TEM1
PRIDEiQ8TEM1
ProteomicsDBi74472
74473 [Q8TEM1-2]

PTM databases

iPTMnetiQ8TEM1
PhosphoSitePlusiQ8TEM1

Expressioni

Tissue specificityi

Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000132182
CleanExiHS_NUP210
GenevisibleiQ8TEM1 HS

Organism-specific databases

HPAiHPA066888

Interactioni

Subunit structurei

Forms dimers and possibly higher-order oligomers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116831, 39 interactors
IntActiQ8TEM1, 23 interactors
STRINGi9606.ENSP00000254508

Structurei

3D structure databases

ProteinModelPortaliQ8TEM1
SMRiQ8TEM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi486 – 491Poly-Ser6

Sequence similaritiesi

Belongs to the NUP210 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1833 Eukaryota
ENOG410XNNU LUCA
GeneTreeiENSGT00390000009491
HOGENOMiHOG000115312
HOVERGENiHBG082098
InParanoidiQ8TEM1
KOiK14314
OMAiHFGEMKV
OrthoDBiEOG091G006N
PhylomeDBiQ8TEM1
TreeFamiTF313331

Family and domain databases

InterProiView protein in InterPro
IPR003343 Big_2
IPR008964 Invasin/intimin_cell_adhesion
PfamiView protein in Pfam
PF02368 Big_2, 1 hit
SMARTiView protein in SMART
SM00635 BID_2, 1 hit
SUPFAMiSSF49373 SSF49373, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS
60 70 80 90 100
EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED
110 120 130 140 150
ITTGQVLRCD AIVDLIHDIQ IVSTTRELYL EDSPLELKIQ ALDSEGNTFS
160 170 180 190 200
TLAGLVFEWT IVKDSEADRF SDSHNALRIL TFLESTYIPP SYISEMEKAA
210 220 230 240 250
KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL ENILLNPAYD
260 270 280 290 300
VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV
310 320 330 340 350
AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF
360 370 380 390 400
TVHPGDRWVL ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL
410 420 430 440 450
SSSQNGSYHR IRALKRGQTA IDAALTSVVD QDGGVHILQV PVWNQQEVEI
460 470 480 490 500
HIPITLYPSI LTFPWQPKTG AYQYTIRAHG GSGNFSWSSS SHLVATVTVK
510 520 530 540 550
GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF APCQVEARVG
560 570 580 590 600
QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP
610 620 630 640 650
GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS
660 670 680 690 700
VALVTLGSSK EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS
710 720 730 740 750
RNYQQHWILV TCQALGEQVI ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS
760 770 780 790 800
RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS SHRNPRLDLA AYDQEGRRFD
810 820 830 840 850
NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA
860 870 880 890 900
SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE
910 920 930 940 950
EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL
960 970 980 990 1000
PGSSTIMIHD LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR
1010 1020 1030 1040 1050
VLDLHKKPFL AKYFPFMDLK LRAASPIITL VALDEALDNY TITFLIRGVA
1060 1070 1080 1090 1100
IGQTSLTASV TNKAGQRINS APQQIEVFPP FRLMPRKVTL LIGATMQVTS
1110 1120 1130 1140 1150
EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG LVQAVDAETG
1160 1170 1180 1190 1200
KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS
1210 1220 1230 1240 1250
FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR
1260 1270 1280 1290 1300
TGLRVVVKAV DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM
1310 1320 1330 1340 1350
SPNSYIKLQT NRDGAASLSY RVLDGPEKVP VVHVDEKGFL ASGSMIGTST
1360 1370 1380 1390 1400
IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS MSPVLHTQNK EALVAVPLGM
1410 1420 1430 1440 1450
TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT NNTCVVRTVS
1460 1470 1480 1490 1500
VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS
1510 1520 1530 1540 1550
LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV
1560 1570 1580 1590 1600
VSVPQRIMAR HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI
1610 1620 1630 1640 1650
QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL
1660 1670 1680 1690 1700
TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSPG LFADQAEILL
1710 1720 1730 1740 1750
SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG WPSFITYTVG
1760 1770 1780 1790 1800
VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF
1810 1820 1830 1840 1850
QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG
1860 1870 1880
HSPHYFAASS PTSPNALPPA RKASPPSGLW SPAYASH
Length:1,887
Mass (Da):205,111
Last modified:October 17, 2006 - v3
Checksum:i70B5C35E685C8DF8
GO
Isoform 2 (identifier: Q8TEM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     947-967: HPLLPGSSTIMIHDLCLVFPA → SLGHRSPLLVFIPYLGCCVVN
     968-1887: Missing.

Show »
Length:967
Mass (Da):105,810
Checksum:i56A41738E2C8DEF1
GO

Sequence cautioni

The sequence BAB15332 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11688 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1512A → T in BAC11688 (PubMed:16303743).Curated1
Sequence conflicti1761P → S in BAC11688 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028147297A → T. Corresponds to variant dbSNP:rs7628051Ensembl.1
Natural variantiVAR_028148608I → V. Corresponds to variant dbSNP:rs3732671Ensembl.1
Natural variantiVAR_028149755A → V. Corresponds to variant dbSNP:rs6795271Ensembl.1
Natural variantiVAR_026474786R → L Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs2280084Ensembl.1
Natural variantiVAR_028150821P → A. Corresponds to variant dbSNP:rs2280085Ensembl.1
Natural variantiVAR_028151944A → P. Corresponds to variant dbSNP:rs433032Ensembl.1
Natural variantiVAR_0281521096M → I. Corresponds to variant dbSNP:rs2271505Ensembl.1
Natural variantiVAR_0281531430D → E. Corresponds to variant dbSNP:rs13081937Ensembl.1
Natural variantiVAR_0264751752L → S3 PublicationsCorresponds to variant dbSNP:rs354479Ensembl.1
Natural variantiVAR_0264761787V → M3 PublicationsCorresponds to variant dbSNP:rs354478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018567947 – 967HPLLP…LVFPA → SLGHRSPLLVFIPYLGCCVV N in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_018568968 – 1887Missing in isoform 2. 2 PublicationsAdd BLAST920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027124 Genomic DNA No translation available.
AC069246 Genomic DNA No translation available.
BC067089 mRNA Translation: AAH67089.1
AK026042 mRNA Translation: BAB15332.1 Different initiation.
AK074101 mRNA Translation: BAB84927.1
AB020713 mRNA Translation: BAA74929.1
AK075545 mRNA Translation: BAC11688.1 Different initiation.
AL117527 mRNA Translation: CAB55979.2
CCDSiCCDS33704.1 [Q8TEM1-1]
PIRiT17289
RefSeqiNP_079199.2, NM_024923.3 [Q8TEM1-1]
UniGeneiHs.475525

Genome annotation databases

EnsembliENST00000254508; ENSP00000254508; ENSG00000132182 [Q8TEM1-1]
GeneIDi23225
KEGGihsa:23225
UCSCiuc003bxv.3 human [Q8TEM1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPO210_HUMAN
AccessioniPrimary (citable) accession number: Q8TEM1
Secondary accession number(s): A6NN56
, O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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