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Q8TEL6

- TP4AP_HUMAN

UniProt

Q8TEL6 - TP4AP_HUMAN

Protein

Short transient receptor potential channel 4-associated protein

Gene

TRPC4AP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (15 Nov 2002)
      Previous versions | rss
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    Functioni

    Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. calcium ion transmembrane transport Source: Reactome
    2. ion transmembrane transport Source: Reactome
    3. protein ubiquitination Source: UniProtKB
    4. transmembrane transport Source: Reactome
    5. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 4-associated protein
    Short name:
    Trp4-associated protein
    Short name:
    Trpc4-associated protein
    Alternative name(s):
    Protein TAP1
    TNF-receptor ubiquitous scaffolding/signaling protein
    Short name:
    Protein TRUSS
    Gene namesi
    Name:TRPC4AP
    Synonyms:C20orf188, TRRP4AP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16181. TRPC4AP.

    Subcellular locationi

    GO - Cellular componenti

    1. Cul4A-RING E3 ubiquitin ligase complex Source: UniProtKB
    2. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 797796Short transient receptor potential channel 4-associated proteinPRO_0000072641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8TEL6.
    PaxDbiQ8TEL6.
    PRIDEiQ8TEL6.

    PTM databases

    PhosphoSiteiQ8TEL6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TEL6.
    BgeeiQ8TEL6.
    CleanExiHS_TRPC4AP.
    GenevestigatoriQ8TEL6.

    Organism-specific databases

    HPAiHPA051197.

    Interactioni

    Subunit structurei

    Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 By similarity. Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts with MYC.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CAP621362EBI-2559060,EBI-357253

    Protein-protein interaction databases

    BioGridi117569. 21 interactions.
    DIPiDIP-42719N.
    IntActiQ8TEL6. 5 interactions.
    MINTiMINT-2844857.
    STRINGi9606.ENSP00000252015.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 400399Interaction with TNFRSF1ABy similarityAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG42180.
    HOGENOMiHOG000231794.
    HOVERGENiHBG059886.
    InParanoidiQ8TEL6.
    KOiK11796.
    OMAiHYLNKDK.
    OrthoDBiEOG7P02H9.
    PhylomeDBiQ8TEL6.
    TreeFamiTF329145.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR022162. DUF3689.
    [Graphical view]
    PfamiPF12463. DUF3689. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TEL6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG    50
    LVRAVQFTET FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKE 100
    ISPLLSMEAM AFVTEERKLT QETTYPNTYI FDLFGGVDLL VEILMRPTIS 150
    IRGQKLKISD EMSKDCLSIL YNTCVCTEGV TKRLAEKNDF VIFLFTLMTS 200
    KKTFLQTATL IEDILGVKKE MIRLDEVPNL SSLVSNFDQQ QLANFCRILA 250
    VTISEMDTGN DDKHTLLAKN AQQKKSLSLG PSAAEINQAA LLSIPGFVER 300
    LCKLATRKVS ESTGTASFLQ ELEEWYTWLD NALVLDALMR VANEESEHNQ 350
    ASIVFPPPGA SEENGLPHTS ARTQLPQSMK IMHEIMYKLE VLYVLCVLLM 400
    GRQRNQVHRM IAEFKLIPGL NNLFDKLIWR KHSASALVLH GHNQNCDCSP 450
    DITLKIQFLR LLQSFSDHHE NKYLLLNNQE LNELSAISLK ANIPEVEAVL 500
    NTDRSLVCDG KRGLLTRLLQ VMKKEPAESS FRFWQARAVE SFLRGTTSYA 550
    DQMFLLKRGL LEHILYCIVD SECKSRDVLQ SYFDLLGELM KFNVDAFKRF 600
    NKYINTDAKF QVFLKQINSS LVDSNMLVRC VTLSLDRFEN QVDMKVAEVL 650
    SECRLLAYIS QVPTQMSFLF RLINIIHVQT LTQENVSCLN TSLVILMLAR 700
    RKERLPLYLR LLQRMEHSKK YPGFLLNNFH NLLRFWQQHY LHKDKDSTCL 750
    ENSSCISFSY WKETVSILLN PDRQSPSALV SYIEEPYMDI DRDFTEE 797
    Length:797
    Mass (Da):90,852
    Last modified:November 15, 2002 - v2
    Checksum:i999A8CA3B0D2CEEE
    GO
    Isoform 2 (identifier: Q8TEL6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         533-797: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:532
    Mass (Da):59,547
    Checksum:iD9E123C910E93950
    GO
    Isoform 3 (identifier: Q8TEL6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-358: Missing.

    Show »
    Length:789
    Mass (Da):90,043
    Checksum:i8FF952722B28B257
    GO

    Sequence cautioni

    The sequence BAB84932.1 differs from that shown. Reason: Frameshift at position 43.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei351 – 3588Missing in isoform 3. 1 PublicationVSP_054231
    Alternative sequencei533 – 797265Missing in isoform 2. 1 PublicationVSP_003982Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074106 mRNA. Translation: BAB84932.1. Frameshift.
    AB590540 mRNA. Translation: BAJ20695.1.
    AL132825 Genomic DNA. Translation: CAC14946.1.
    CH471077 Genomic DNA. Translation: EAW76233.1.
    CH471077 Genomic DNA. Translation: EAW76235.1.
    CH471077 Genomic DNA. Translation: EAW76229.1.
    CH471077 Genomic DNA. Translation: EAW76234.1.
    BC001323 mRNA. Translation: AAH01323.1.
    BC008836 mRNA. Translation: AAH08836.2.
    BC013144 mRNA. Translation: AAH13144.1.
    AL117480 mRNA. Translation: CAB55953.1.
    CCDSiCCDS13246.1. [Q8TEL6-1]
    CCDS46591.1. [Q8TEL6-3]
    PIRiT17263.
    RefSeqiNP_056453.1. NM_015638.2. [Q8TEL6-1]
    NP_955400.1. NM_199368.1. [Q8TEL6-3]
    UniGeneiHs.168073.

    Genome annotation databases

    EnsembliENST00000252015; ENSP00000252015; ENSG00000100991. [Q8TEL6-1]
    ENST00000451813; ENSP00000400614; ENSG00000100991. [Q8TEL6-3]
    GeneIDi26133.
    KEGGihsa:26133.
    UCSCiuc002xbk.3. human. [Q8TEL6-1]
    uc002xbl.3. human.

    Polymorphism databases

    DMDMi25091357.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074106 mRNA. Translation: BAB84932.1 . Frameshift.
    AB590540 mRNA. Translation: BAJ20695.1 .
    AL132825 Genomic DNA. Translation: CAC14946.1 .
    CH471077 Genomic DNA. Translation: EAW76233.1 .
    CH471077 Genomic DNA. Translation: EAW76235.1 .
    CH471077 Genomic DNA. Translation: EAW76229.1 .
    CH471077 Genomic DNA. Translation: EAW76234.1 .
    BC001323 mRNA. Translation: AAH01323.1 .
    BC008836 mRNA. Translation: AAH08836.2 .
    BC013144 mRNA. Translation: AAH13144.1 .
    AL117480 mRNA. Translation: CAB55953.1 .
    CCDSi CCDS13246.1. [Q8TEL6-1 ]
    CCDS46591.1. [Q8TEL6-3 ]
    PIRi T17263.
    RefSeqi NP_056453.1. NM_015638.2. [Q8TEL6-1 ]
    NP_955400.1. NM_199368.1. [Q8TEL6-3 ]
    UniGenei Hs.168073.

    3D structure databases

    ProteinModelPortali Q8TEL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117569. 21 interactions.
    DIPi DIP-42719N.
    IntActi Q8TEL6. 5 interactions.
    MINTi MINT-2844857.
    STRINGi 9606.ENSP00000252015.

    PTM databases

    PhosphoSitei Q8TEL6.

    Polymorphism databases

    DMDMi 25091357.

    Proteomic databases

    MaxQBi Q8TEL6.
    PaxDbi Q8TEL6.
    PRIDEi Q8TEL6.

    Protocols and materials databases

    DNASUi 26133.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252015 ; ENSP00000252015 ; ENSG00000100991 . [Q8TEL6-1 ]
    ENST00000451813 ; ENSP00000400614 ; ENSG00000100991 . [Q8TEL6-3 ]
    GeneIDi 26133.
    KEGGi hsa:26133.
    UCSCi uc002xbk.3. human. [Q8TEL6-1 ]
    uc002xbl.3. human.

    Organism-specific databases

    CTDi 26133.
    GeneCardsi GC20M033590.
    HGNCi HGNC:16181. TRPC4AP.
    HPAi HPA051197.
    MIMi 608430. gene.
    neXtProti NX_Q8TEL6.
    PharmGKBi PA25730.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42180.
    HOGENOMi HOG000231794.
    HOVERGENi HBG059886.
    InParanoidi Q8TEL6.
    KOi K11796.
    OMAi HYLNKDK.
    OrthoDBi EOG7P02H9.
    PhylomeDBi Q8TEL6.
    TreeFami TF329145.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    ChiTaRSi TRPC4AP. human.
    GeneWikii TRPC4AP.
    GenomeRNAii 26133.
    NextBioi 48157.
    PROi Q8TEL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TEL6.
    Bgeei Q8TEL6.
    CleanExi HS_TRPC4AP.
    Genevestigatori Q8TEL6.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR022162. DUF3689.
    [Graphical view ]
    Pfami PF12463. DUF3689. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Muscle and Prostate.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-797 (ISOFORM 1).
      Tissue: Mammary cancer.
    6. "Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells."
      Choi S.H., Wright J.B., Gerber S.A., Cole M.D.
      Genes Dev. 24:1236-1241(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A DCX (DDB1-CUL4-X-BOX) E3 UBIQUITIN-PROTEIN LIGASE COMPLEX, INTERACTION WITH MYC.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTP4AP_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEL6
    Secondary accession number(s): E1P5Q0
    , E1P5Q1, Q96H82, Q9BVB8, Q9H429, Q9UFS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3