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Protein

Short transient receptor potential channel 4-associated protein

Gene

TRPC4AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • calcium channel activity Source: Reactome
  • phosphatase binding Source: UniProtKB

GO - Biological processi

  • calcium ion transmembrane transport Source: Reactome
  • hair follicle maturation Source: Ensembl
  • protein ubiquitination Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 4-associated protein
Short name:
Trp4-associated protein
Short name:
Trpc4-associated protein
Alternative name(s):
Protein TAP1
TNF-receptor ubiquitous scaffolding/signaling protein
Short name:
Protein TRUSS
Gene namesi
Name:TRPC4AP
Synonyms:C20orf188, TRRP4AP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000100991.11
HGNCiHGNC:16181 TRPC4AP
MIMi608430 gene
neXtProtiNX_Q8TEL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi26133
OpenTargetsiENSG00000100991
PharmGKBiPA25730

Polymorphism and mutation databases

BioMutaiTRPC4AP
DMDMi25091357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000726412 – 797Short transient receptor potential channel 4-associated proteinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TEL6
MaxQBiQ8TEL6
PaxDbiQ8TEL6
PeptideAtlasiQ8TEL6
PRIDEiQ8TEL6

PTM databases

iPTMnetiQ8TEL6
PhosphoSitePlusiQ8TEL6

Expressioni

Gene expression databases

BgeeiENSG00000100991
CleanExiHS_TRPC4AP
GenevisibleiQ8TEL6 HS

Organism-specific databases

HPAiHPA051197
HPA065061

Interactioni

Subunit structurei

Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1. Interacts with MYC.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-2559060,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117569, 55 interactors
DIPiDIP-42719N
IntActiQ8TEL6, 14 interactors
MINTiQ8TEL6
STRINGi9606.ENSP00000252015

Structurei

3D structure databases

ProteinModelPortaliQ8TEL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 400Interaction with TNFRSF1ABy similarityAdd BLAST399

Phylogenomic databases

eggNOGiENOG410IH9D Eukaryota
ENOG410ZAXR LUCA
GeneTreeiENSGT00390000018330
HOGENOMiHOG000231794
HOVERGENiHBG059886
InParanoidiQ8TEL6
KOiK11796
OMAiILNNFHS
OrthoDBiEOG091G02AE
PhylomeDBiQ8TEL6
TreeFamiTF329145

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022162 TRPC4AP
PfamiView protein in Pfam
PF12463 DUF3689, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG
60 70 80 90 100
LVRAVQFTET FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKE
110 120 130 140 150
ISPLLSMEAM AFVTEERKLT QETTYPNTYI FDLFGGVDLL VEILMRPTIS
160 170 180 190 200
IRGQKLKISD EMSKDCLSIL YNTCVCTEGV TKRLAEKNDF VIFLFTLMTS
210 220 230 240 250
KKTFLQTATL IEDILGVKKE MIRLDEVPNL SSLVSNFDQQ QLANFCRILA
260 270 280 290 300
VTISEMDTGN DDKHTLLAKN AQQKKSLSLG PSAAEINQAA LLSIPGFVER
310 320 330 340 350
LCKLATRKVS ESTGTASFLQ ELEEWYTWLD NALVLDALMR VANEESEHNQ
360 370 380 390 400
ASIVFPPPGA SEENGLPHTS ARTQLPQSMK IMHEIMYKLE VLYVLCVLLM
410 420 430 440 450
GRQRNQVHRM IAEFKLIPGL NNLFDKLIWR KHSASALVLH GHNQNCDCSP
460 470 480 490 500
DITLKIQFLR LLQSFSDHHE NKYLLLNNQE LNELSAISLK ANIPEVEAVL
510 520 530 540 550
NTDRSLVCDG KRGLLTRLLQ VMKKEPAESS FRFWQARAVE SFLRGTTSYA
560 570 580 590 600
DQMFLLKRGL LEHILYCIVD SECKSRDVLQ SYFDLLGELM KFNVDAFKRF
610 620 630 640 650
NKYINTDAKF QVFLKQINSS LVDSNMLVRC VTLSLDRFEN QVDMKVAEVL
660 670 680 690 700
SECRLLAYIS QVPTQMSFLF RLINIIHVQT LTQENVSCLN TSLVILMLAR
710 720 730 740 750
RKERLPLYLR LLQRMEHSKK YPGFLLNNFH NLLRFWQQHY LHKDKDSTCL
760 770 780 790
ENSSCISFSY WKETVSILLN PDRQSPSALV SYIEEPYMDI DRDFTEE
Length:797
Mass (Da):90,852
Last modified:November 15, 2002 - v2
Checksum:i999A8CA3B0D2CEEE
GO
Isoform 2 (identifier: Q8TEL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-797: Missing.

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):59,547
Checksum:iD9E123C910E93950
GO
Isoform 3 (identifier: Q8TEL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-358: Missing.

Show »
Length:789
Mass (Da):90,043
Checksum:i8FF952722B28B257
GO

Sequence cautioni

The sequence BAB84932 differs from that shown. Reason: Frameshift at position 43.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054231351 – 358Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_003982533 – 797Missing in isoform 2. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074106 mRNA Translation: BAB84932.1 Frameshift.
AB590540 mRNA Translation: BAJ20695.1
AL132825 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76233.1
CH471077 Genomic DNA Translation: EAW76235.1
CH471077 Genomic DNA Translation: EAW76229.1
CH471077 Genomic DNA Translation: EAW76234.1
BC001323 mRNA Translation: AAH01323.1
BC008836 mRNA Translation: AAH08836.2
BC013144 mRNA Translation: AAH13144.1
AL117480 mRNA Translation: CAB55953.1
CCDSiCCDS13246.1 [Q8TEL6-1]
CCDS46591.1 [Q8TEL6-3]
PIRiT17263
RefSeqiNP_056453.1, NM_015638.2 [Q8TEL6-1]
NP_955400.1, NM_199368.1 [Q8TEL6-3]
UniGeneiHs.168073

Genome annotation databases

EnsembliENST00000252015; ENSP00000252015; ENSG00000100991 [Q8TEL6-1]
ENST00000451813; ENSP00000400614; ENSG00000100991 [Q8TEL6-3]
GeneIDi26133
KEGGihsa:26133
UCSCiuc002xbk.4 human [Q8TEL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTP4AP_HUMAN
AccessioniPrimary (citable) accession number: Q8TEL6
Secondary accession number(s): E1P5Q0
, E1P5Q1, Q96H82, Q9BVB8, Q9H429, Q9UFS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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