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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

DOT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186S-adenosyl-L-methionine1

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • histone-lysine N-methyltransferase activity Source: UniProtKB
  • histone methyltransferase activity Source: MGI
  • histone methyltransferase activity (H3-K79 specific) Source: GO_Central
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • chromatin silencing at telomere Source: GO_Central
  • DNA damage checkpoint Source: GO_Central
  • DNA repair Source: GO_Central
  • histone H3-K79 methylation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell cycle Source: InterPro
  • regulation of JAK-STAT cascade Source: UniProtKB
  • regulation of transcription regulatory region DNA binding Source: UniProtKB
  • telomere organization Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciZFISH:HS02643-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.
SIGNORiQ8TEK3.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC:2.1.1.43)
Alternative name(s):
DOT1-like protein
Histone H3-K79 methyltransferase
Short name:
H3-K79-HMTase
Lysine N-methyltransferase 4
Gene namesi
Name:DOT1L
Synonyms:KIAA1814, KMT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24948. DOT1L.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi163 – 165GSG → RCR: Abolishes methyltransferase activity. 1 Publication3
Mutagenesisi241N → A or D: Loss of activity. 1 Publication1
Mutagenesisi312Y → A: Loss of activity. 1 Publication1
Mutagenesisi312Y → F: No effect. 1 Publication1

Organism-specific databases

DisGeNETi84444.
OpenTargetsiENSG00000104885.
PharmGKBiPA134993717.

Chemistry databases

ChEMBLiCHEMBL1795117.
GuidetoPHARMACOLOGYi2650.

Polymorphism and mutation databases

BioMutaiDOT1L.
DMDMi25090171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860891 – 1739Histone-lysine N-methyltransferase, H3 lysine-79 specificAdd BLAST1739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei297PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei480PhosphothreonineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei900PhosphothreonineCombined sources1
Modified residuei902PhosphoserineCombined sources1
Modified residuei984PhosphothreonineCombined sources1
Modified residuei997PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1009PhosphoserineCombined sources1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1213PhosphoserineCombined sources1
Modified residuei1246PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TEK3.
MaxQBiQ8TEK3.
PaxDbiQ8TEK3.
PeptideAtlasiQ8TEK3.
PRIDEiQ8TEK3.

PTM databases

iPTMnetiQ8TEK3.
PhosphoSitePlusiQ8TEK3.

Expressioni

Gene expression databases

BgeeiENSG00000104885.
CleanExiHS_DOT1L.
ExpressionAtlasiQ8TEK3. baseline and differential.
GenevisibleiQ8TEK3. HS.

Organism-specific databases

HPAiHPA011875.

Interactioni

Subunit structurei

Interacts with MLLT10.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MLLT1Q031116EBI-2619253,EBI-1384215
MLLT3P425684EBI-2619253,EBI-716132

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124082. 44 interactors.
DIPiDIP-56410N.
IntActiQ8TEK3. 25 interactors.
MINTiMINT-6611327.
STRINGi9606.ENSP00000381657.

Chemistry databases

BindingDBiQ8TEK3.

Structurei

Secondary structure

11739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi18 – 23Combined sources6
Beta strandi26 – 28Combined sources3
Helixi33 – 47Combined sources15
Helixi49 – 54Combined sources6
Helixi57 – 62Combined sources6
Helixi68 – 90Combined sources23
Beta strandi91 – 93Combined sources3
Beta strandi98 – 100Combined sources3
Helixi104 – 118Combined sources15
Helixi122 – 124Combined sources3
Helixi126 – 128Combined sources3
Beta strandi129 – 131Combined sources3
Helixi133 – 138Combined sources6
Helixi140 – 151Combined sources12
Beta strandi158 – 163Combined sources6
Helixi168 – 176Combined sources9
Beta strandi180 – 186Combined sources7
Helixi189 – 209Combined sources21
Beta strandi215 – 220Combined sources6
Helixi226 – 233Combined sources8
Beta strandi236 – 240Combined sources5
Turni243 – 245Combined sources3
Helixi247 – 257Combined sources11
Beta strandi265 – 270Combined sources6
Beta strandi281 – 283Combined sources3
Helixi287 – 289Combined sources3
Beta strandi290 – 295Combined sources6
Turni298 – 300Combined sources3
Beta strandi307 – 309Combined sources3
Beta strandi313 – 317Combined sources5
Helixi320 – 330Combined sources11
Helixi332 – 342Combined sources11
Beta strandi880 – 882Combined sources3
Turni885 – 887Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NW3X-ray2.50A1-416[»]
2MV7NMR-B877-900[»]
3QOWX-ray2.10A1-416[»]
3QOXX-ray2.30A1-416[»]
3SR4X-ray2.50A1-351[»]
3SX0X-ray2.28A1-420[»]
3UWPX-ray2.05A1-420[»]
4EK9X-ray2.50A1-416[»]
4EKGX-ray2.80A1-416[»]
4EKIX-ray2.85A1-416[»]
4EQZX-ray2.15A1-420[»]
4ER0X-ray2.50A1-420[»]
4ER3X-ray2.40A1-351[»]
4ER5X-ray2.57A1-412[»]
4ER6X-ray2.30A1-412[»]
4ER7X-ray2.20A1-420[»]
4HRAX-ray3.15A1-416[»]
4WVLX-ray2.41A1-347[»]
5DRTX-ray2.69A/B2-333[»]
5DRYX-ray2.41A/B2-333[»]
5DSXX-ray2.41A/B2-332[»]
5DT2X-ray2.30A/B2-332[»]
5DTMX-ray2.20A/B2-332[»]
5DTQX-ray2.61A/B2-332[»]
5DTRX-ray2.34A/B2-332[»]
5JUWX-ray2.28A1-420[»]
ProteinModelPortaliQ8TEK3.
SMRiQ8TEK3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TEK3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 330DOT1PROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 139S-adenosyl-L-methionine binding4
Regioni159 – 168S-adenosyl-L-methionine binding10
Regioni222 – 223S-adenosyl-L-methionine binding2
Regioni391 – 416Required for interaction with nucleosomes and DNA1 PublicationAdd BLAST26

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.PROSITE-ProRule annotation
Contains 1 DOT1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3924. Eukaryota.
ENOG410XSYC. LUCA.
GeneTreeiENSGT00390000013515.
HOGENOMiHOG000143530.
HOVERGENiHBG051393.
InParanoidiQ8TEK3.
KOiK11427.
OMAiNGLPYQS.
OrthoDBiEOG091G00FV.
PhylomeDBiQ8TEK3.
TreeFamiTF106393.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR021169. DOT1L/grappa.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q8TEK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRWVCEEIPD
60 70 80 90 100
LKLAMENYVL IDYDTKSFES MQRLCDKYNR AIDSIHQLWK GTTQPMKLNT
110 120 130 140 150
RPSTGLLRHI LQQVYNHSVT DPEKLNNYEP FSPEVYGETS FDLVAQMIDE
160 170 180 190 200
IKMTDDDLFV DLGSGVGQVV LQVAAATNCK HHYGVEKADI PAKYAETMDR
210 220 230 240 250
EFRKWMKWYG KKHAEYTLER GDFLSEEWRE RIANTSVIFV NNFAFGPEVD
260 270 280 290 300
HQLKERFANM KEGGRIVSSK PFAPLNFRIN SRNLSDIGTI MRVVELSPLK
310 320 330 340 350
GSVSWTGKPV SYYLHTIDRT ILENYFSSLK NPKLREEQEA ARRRQQRESK
360 370 380 390 400
SNAATPTKGP EGKVAGPADA PMDSGAEEEK AGAATVKKPS PSKARKKKLN
410 420 430 440 450
KKGRKMAGRK RGRPKKMNTA NPERKPKKNQ TALDALHAQT VSQTAASSPQ
460 470 480 490 500
DAYRSPHSPF YQLPPSVQRH SPNPLLVAPT PPALQKLLES FKIQYLQFLA
510 520 530 540 550
YTKTPQYKAS LQELLGQEKE KNAQLLGAAQ QLLSHCQAQK EEIRRLFQQK
560 570 580 590 600
LDELGVKALT YNDLIQAQKE ISAHNQQLRE QSEQLEQDNR ALRGQSLQLL
610 620 630 640 650
KARCEELQLD WATLSLEKLL KEKQALKSQI SEKQRHCLEL QISIVELEKS
660 670 680 690 700
QRQQELLQLK SCVPPDDALS LHLRGKGALG RELEPDASRL HLELDCTKFS
710 720 730 740 750
LPHLSSMSPE LSMNGQAAGY ELCGVLSRPS SKQNTPQYLA SPLDQEVVPC
760 770 780 790 800
TPSHVGRPRL EKLSGLAAPD YTRLSPAKIV LRRHLSQDHT VPGRPAASEL
810 820 830 840 850
HSRAEHTKEN GLPYQSPSVP GSMKLSPQDP RPLSPGALQL AGEKSSEKGL
860 870 880 890 900
RERAYGSSGE LITSLPISIP LSTVQPNKLP VSIPLASVVL PSRAERARST
910 920 930 940 950
PSPVLQPRDP SSTLEKQIGA NAHGAGSRSL ALAPAGFSYA GSVAISGALA
960 970 980 990 1000
GSPASLTPGA EPATLDESSS SGSLFATVGS RSSTPQHPLL LAQPRNSLPA
1010 1020 1030 1040 1050
SPAHQLSSSP RLGGAAQGPL PEASKGDLPS DSGFSDPESE AKRRIVFTIT
1060 1070 1080 1090 1100
TGAGSAKQSP SSKHSPLTAS ARGDCVPSHG QDSRRRGRRK RASAGTPSLS
1110 1120 1130 1140 1150
AGVSPKRRAL PSVAGLFTQP SGSPLNLNSM VSNINQPLEI TAISSPETSL
1160 1170 1180 1190 1200
KSSPVPYQDH DQPPVLKKER PLSQTNGAHY SPLTSDEEPG SEDEPSSARI
1210 1220 1230 1240 1250
ERKIATISLE SKSPPKTLEN GGGLAGRKPA PAGEPVNSSK WKSTFSPISD
1260 1270 1280 1290 1300
IGLAKSADSP LQASSALSQN SLFTFRPALE EPSADAKLAA HPRKGFPGSL
1310 1320 1330 1340 1350
SGADGLSPGT NPANGCTFGG GLAADLSLHS FSDGASLPHK GPEAAGLSSP
1360 1370 1380 1390 1400
LSFPSQRGKE GSDANPFLSK RQLDGLAGLK GEGSRGKEAG EGGLPLCGPT
1410 1420 1430 1440 1450
DKTPLLSGKA AKARDREVDL KNGHNLFISA AAVPPGSLLS GPGLAPAASS
1460 1470 1480 1490 1500
AGGAASSAQT HRSFLGPFPP GPQFALGPMS LQANLGSVAG SSVLQSLFSS
1510 1520 1530 1540 1550
VPAAAGLVHV SSAATRLTNS HAMGSFSGVA GGTVGGVVFN HAVPSASAHP
1560 1570 1580 1590 1600
FGARVGRGAA CGSATLGPSP LQAAASASAS SFQAPASVET RPPPPPPPPP
1610 1620 1630 1640 1650
PPLPPPAHLG RSPAGPPVLH APPPPNAALP PPPTLLASNP EPALLQSLAS
1660 1670 1680 1690 1700
LPPNQAFLPP TSAASLPPAN ASLSIKLTSL PHKGARPSFT VHHQPLPRLA
1710 1720 1730
LAQAAPGIPQ ASATGPSAVW VSLGMPPPYA AHLSGVKPR
Length:1,739
Mass (Da):184,853
Last modified:November 15, 2002 - v2
Checksum:iEBA575CE3C090CAC
GO
Isoform 1 (identifier: Q8TEK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1537-1537: V → N
     1538-1739: Missing.

Note: No experimental confirmation available.
Show »
Length:1,537
Mass (Da):164,856
Checksum:i9CEA12850DC4ACB1
GO

Sequence cautioni

The sequence AAC08316 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210G → E in BAB84946 (PubMed:12693554).Curated1
Sequence conflicti454 – 467RSPHS…LPPSV → TLRTPSGSPRRTKL (PubMed:11347906).CuratedAdd BLAST14
Sequence conflicti464P → L in BAB84946 (PubMed:12693554).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014287726L → M.Corresponds to variant rs880525dbSNPEnsembl.1
Natural variantiVAR_0142881386G → S.Corresponds to variant rs3815308dbSNPEnsembl.1
Natural variantiVAR_0142891418V → L.Corresponds to variant rs2302061dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022281537V → N in isoform 1. 1 Publication1
Alternative sequenceiVSP_0022291538 – 1739Missing in isoform 1. 1 PublicationAdd BLAST202

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509504 mRNA. Translation: AAM88322.1.
AC004490 Genomic DNA. Translation: AAC08316.1. Sequence problems.
AB058717 mRNA. Translation: BAB47443.1.
AK074120 mRNA. Translation: BAB84946.1.
CCDSiCCDS42460.1. [Q8TEK3-2]
RefSeqiNP_115871.1. NM_032482.2. [Q8TEK3-2]
UniGeneiHs.713641.

Genome annotation databases

EnsembliENST00000398665; ENSP00000381657; ENSG00000104885. [Q8TEK3-2]
GeneIDi84444.
KEGGihsa:84444.
UCSCiuc002lvb.4. human. [Q8TEK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509504 mRNA. Translation: AAM88322.1.
AC004490 Genomic DNA. Translation: AAC08316.1. Sequence problems.
AB058717 mRNA. Translation: BAB47443.1.
AK074120 mRNA. Translation: BAB84946.1.
CCDSiCCDS42460.1. [Q8TEK3-2]
RefSeqiNP_115871.1. NM_032482.2. [Q8TEK3-2]
UniGeneiHs.713641.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NW3X-ray2.50A1-416[»]
2MV7NMR-B877-900[»]
3QOWX-ray2.10A1-416[»]
3QOXX-ray2.30A1-416[»]
3SR4X-ray2.50A1-351[»]
3SX0X-ray2.28A1-420[»]
3UWPX-ray2.05A1-420[»]
4EK9X-ray2.50A1-416[»]
4EKGX-ray2.80A1-416[»]
4EKIX-ray2.85A1-416[»]
4EQZX-ray2.15A1-420[»]
4ER0X-ray2.50A1-420[»]
4ER3X-ray2.40A1-351[»]
4ER5X-ray2.57A1-412[»]
4ER6X-ray2.30A1-412[»]
4ER7X-ray2.20A1-420[»]
4HRAX-ray3.15A1-416[»]
4WVLX-ray2.41A1-347[»]
5DRTX-ray2.69A/B2-333[»]
5DRYX-ray2.41A/B2-333[»]
5DSXX-ray2.41A/B2-332[»]
5DT2X-ray2.30A/B2-332[»]
5DTMX-ray2.20A/B2-332[»]
5DTQX-ray2.61A/B2-332[»]
5DTRX-ray2.34A/B2-332[»]
5JUWX-ray2.28A1-420[»]
ProteinModelPortaliQ8TEK3.
SMRiQ8TEK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124082. 44 interactors.
DIPiDIP-56410N.
IntActiQ8TEK3. 25 interactors.
MINTiMINT-6611327.
STRINGi9606.ENSP00000381657.

Chemistry databases

BindingDBiQ8TEK3.
ChEMBLiCHEMBL1795117.
GuidetoPHARMACOLOGYi2650.

PTM databases

iPTMnetiQ8TEK3.
PhosphoSitePlusiQ8TEK3.

Polymorphism and mutation databases

BioMutaiDOT1L.
DMDMi25090171.

Proteomic databases

EPDiQ8TEK3.
MaxQBiQ8TEK3.
PaxDbiQ8TEK3.
PeptideAtlasiQ8TEK3.
PRIDEiQ8TEK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398665; ENSP00000381657; ENSG00000104885. [Q8TEK3-2]
GeneIDi84444.
KEGGihsa:84444.
UCSCiuc002lvb.4. human. [Q8TEK3-1]

Organism-specific databases

CTDi84444.
DisGeNETi84444.
GeneCardsiDOT1L.
HGNCiHGNC:24948. DOT1L.
HPAiHPA011875.
MIMi607375. gene.
neXtProtiNX_Q8TEK3.
OpenTargetsiENSG00000104885.
PharmGKBiPA134993717.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3924. Eukaryota.
ENOG410XSYC. LUCA.
GeneTreeiENSGT00390000013515.
HOGENOMiHOG000143530.
HOVERGENiHBG051393.
InParanoidiQ8TEK3.
KOiK11427.
OMAiNGLPYQS.
OrthoDBiEOG091G00FV.
PhylomeDBiQ8TEK3.
TreeFamiTF106393.

Enzyme and pathway databases

BioCyciZFISH:HS02643-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.
SIGNORiQ8TEK3.

Miscellaneous databases

ChiTaRSiDOT1L. human.
EvolutionaryTraceiQ8TEK3.
GeneWikiiDOT1L.
GenomeRNAii84444.
PROiQ8TEK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104885.
CleanExiHS_DOT1L.
ExpressionAtlasiQ8TEK3. baseline and differential.
GenevisibleiQ8TEK3. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR021169. DOT1L/grappa.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOT1L_HUMAN
AccessioniPrimary (citable) accession number: Q8TEK3
Secondary accession number(s): O60379, Q96JL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.