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Protein

SH3 domain-containing RING finger protein 3

Gene

SH3RF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9842RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing RING finger protein 3
Alternative name(s):
Plenty of SH3s 2
SH3 multiple domains protein 4
Gene namesi
Name:SH3RF3
Synonyms:POSH2, SH3MD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24699. SH3RF3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403291.

Polymorphism and mutation databases

BioMutaiSH3RF3.
DMDMi146325718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882SH3 domain-containing RING finger protein 3PRO_0000284883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei400 – 4001PhosphoserineCombined sources
Modified residuei797 – 7971PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TEJ3.
MaxQBiQ8TEJ3.
PaxDbiQ8TEJ3.
PRIDEiQ8TEJ3.

PTM databases

iPTMnetiQ8TEJ3.
PhosphoSiteiQ8TEJ3.

Expressioni

Gene expression databases

BgeeiQ8TEJ3.
CleanExiHS_SH3RF3.
GenevisibleiQ8TEJ3. HS.

Organism-specific databases

HPAiHPA044822.
HPA048444.

Interactioni

Subunit structurei

Interacts with PAK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAK2Q131772EBI-7975674,EBI-1045887
RAC1P630006EBI-7975674,EBI-413628

Protein-protein interaction databases

BioGridi131307. 6 interactions.
DIPiDIP-43763N.
IntActiQ8TEJ3. 6 interactions.
MINTiMINT-2791992.
STRINGi9606.ENSP00000309186.

Structurei

3D structure databases

ProteinModelPortaliQ8TEJ3.
SMRiQ8TEJ3. Positions 50-123, 197-323, 469-523, 828-880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 25360SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 31964SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini464 – 52562SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini823 – 88260SH3 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 345Poly-Arg
Compositional biasi151 – 1555Poly-Gly

Domaini

The third SH3 domain mediates interaction with PAK2.

Sequence similaritiesi

Belongs to the SH3RF family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 4 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9842RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000045564.
HOVERGENiHBG069552.
InParanoidiQ8TEJ3.
KOiK12171.
OMAiGKALYNY.
PhylomeDBiQ8TEJ3.
TreeFamiTF105571.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028511. POSH2.
IPR001452. SH3_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR10663:SF141. PTHR10663:SF141. 4 hits.
PfamiPF00018. SH3_1. 2 hits.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 4 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 4 hits.
PROSITEiPS50002. SH3. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGASWLCA SKAAAAAAQS EGDEDRPGER RRRRAAATAA GAGEDMDESS
60 70 80 90 100
LLDLLECSVC LERLDTTAKV LPCQHTFCRR CLESIVCSRH ELRCPECRIL
110 120 130 140 150
VGCGVDELPA NILLVRLLDG IRQRPRAGTS PGGSPPARPI PGQSAAPTLA
160 170 180 190 200
GGGGGAAGST PGSPVFLSAA AGSTAGSLRE LATSRTAPAA KNPCLLPYGK
210 220 230 240 250
ALYSYEGKEP GDLKFNKGDI IVLRRKVDEQ WYHGELHGTQ GFLPASYIQC
260 270 280 290 300
IQPLPHAPPQ GKALYDFEMK DKDQDKDCLT FTKDEILTVL RRVDENWAEG
310 320 330 340 350
MLGDKIGIFP LLYVELNDSA KQLIEMDKPC PAAASSCNAS LPSDSGAVAS
360 370 380 390 400
VAPSPTLSSS GAVSAFQRRV DGKKNTKKRH SFTALSVTHR SSQAASHRHS
410 420 430 440 450
MEISAPVLIS SSDPRAAARI GDLAHLSCAA PTQDVSSSAG STPTAVPRAA
460 470 480 490 500
SVSGEQGTPP KVQLPLNVYL ALYAYKPQKS DELELHKGEM YRVLEKCQDG
510 520 530 540 550
WFKGASLRTG VSGVFPGNYV TPVSRVPAGG AGPPRNNVVG GSPLAKGITT
560 570 580 590 600
TMHPGSGSLS SLATATRPAL PITTPQAHAQ HPTASPPTGS CLRHSAQPTA
610 620 630 640 650
SQARSTISTA AHSAAQAQDR PTATVSPLRT QNSPSRLPAT SLRPHSVVSP
660 670 680 690 700
QHSHQPPVQM CPRPAIPLTS AASAITPPNV SAANLNGEAG GGPIGVLSTS
710 720 730 740 750
SPTNTGCKLD EKKSEKKEKK SGLLKLLAGA STKKKSRSPP SVSPTHDPQV
760 770 780 790 800
AVDALLQGAV GPEVSSLSIH GRAGSCPIES EMQGAMGMEP LHRKAGSLDL
810 820 830 840 850
NFTSPSRQAP LSMAAIRPEP KLLPRERYRV VVSYPPQSEA EIELKEGDIV
860 870 880
FVHKKREDGW YKGTLQRNGR TGLFPGSFVE SF
Length:882
Mass (Da):92,776
Last modified:May 1, 2007 - v2
Checksum:i07DF961AF2C80A08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010906 Genomic DNA. No translation available.
AC140485 Genomic DNA. No translation available.
AC139850 Genomic DNA. No translation available.
AC109344 Genomic DNA. No translation available.
DQ307286 mRNA. Translation: ABC25188.1.
AK074131 mRNA. Translation: BAB84957.1.
AL831825 mRNA. Translation: CAD38539.1.
CCDSiCCDS74557.1.
RefSeqiNP_001092759.1. NM_001099289.2.
UniGeneiHs.171244.
Hs.535157.
Hs.712087.

Genome annotation databases

EnsembliENST00000309415; ENSP00000309186; ENSG00000172985.
GeneIDi344558.
KEGGihsa:344558.
UCSCiuc010ywt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010906 Genomic DNA. No translation available.
AC140485 Genomic DNA. No translation available.
AC139850 Genomic DNA. No translation available.
AC109344 Genomic DNA. No translation available.
DQ307286 mRNA. Translation: ABC25188.1.
AK074131 mRNA. Translation: BAB84957.1.
AL831825 mRNA. Translation: CAD38539.1.
CCDSiCCDS74557.1.
RefSeqiNP_001092759.1. NM_001099289.2.
UniGeneiHs.171244.
Hs.535157.
Hs.712087.

3D structure databases

ProteinModelPortaliQ8TEJ3.
SMRiQ8TEJ3. Positions 50-123, 197-323, 469-523, 828-880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131307. 6 interactions.
DIPiDIP-43763N.
IntActiQ8TEJ3. 6 interactions.
MINTiMINT-2791992.
STRINGi9606.ENSP00000309186.

PTM databases

iPTMnetiQ8TEJ3.
PhosphoSiteiQ8TEJ3.

Polymorphism and mutation databases

BioMutaiSH3RF3.
DMDMi146325718.

Proteomic databases

EPDiQ8TEJ3.
MaxQBiQ8TEJ3.
PaxDbiQ8TEJ3.
PRIDEiQ8TEJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309415; ENSP00000309186; ENSG00000172985.
GeneIDi344558.
KEGGihsa:344558.
UCSCiuc010ywt.2. human.

Organism-specific databases

CTDi344558.
GeneCardsiSH3RF3.
H-InvDBHIX0023401.
HGNCiHGNC:24699. SH3RF3.
HPAiHPA044822.
HPA048444.
neXtProtiNX_Q8TEJ3.
PharmGKBiPA162403291.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000045564.
HOVERGENiHBG069552.
InParanoidiQ8TEJ3.
KOiK12171.
OMAiGKALYNY.
PhylomeDBiQ8TEJ3.
TreeFamiTF105571.

Miscellaneous databases

ChiTaRSiSH3RF3. human.
GenomeRNAii344558.
NextBioi98704.
PROiQ8TEJ3.

Gene expression databases

BgeeiQ8TEJ3.
CleanExiHS_SH3RF3.
GenevisibleiQ8TEJ3. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028511. POSH2.
IPR001452. SH3_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR10663:SF141. PTHR10663:SF141. 4 hits.
PfamiPF00018. SH3_1. 2 hits.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 4 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 4 hits.
PROSITEiPS50002. SH3. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome."
    Kaerkkaeinen S., Hiipakka M., Wang J.-H., Kleino I., Vaehae-Jaakkola M., Renkema G.H., Liss M., Wagner R., Saksela K.
    EMBO Rep. 7:186-191(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-314, INTERACTION WITH PAK2.
  3. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-882.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 672-882.
    Tissue: Brain.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400 AND SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSH3R3_HUMAN
AccessioniPrimary (citable) accession number: Q8TEJ3
Secondary accession number(s): A0SDZ7, A8MPR1, Q8NDU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.