Q8TEE9 (SAP25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase complex subunit SAP25

Alternative name(s):
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25

Gene names

Name:

SAP25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex By similarity.
Subunit structure	May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 By similarity. Ref.3
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Shuttles between the nucleus and the cytoplasm By similarity.
Sequence caution	The sequence BAB85001.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Histone deacetylase complex subunit SAP25		PRO_0000350873

Sequences

	Sequence		Length	Mass (Da)
	Q8TEE9 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: F0ADC8A992B40BE2	FASTA	199	20,873
	10 20 30 40 50 60 MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG RGLRPVAPAT 70 80 90 100 110 120 GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS KAPQQMMGSL KLLPPPPIMS 130 140 150 160 170 180 ARVLPRPSPS RGPSTAWLSG PELIALTGLL QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP 190 SSSQGADLSL PQTPDTHCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Leukocyte.
[3]	"Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex." Shiio Y., Rose D.W., Aur R., Donohoe S., Aebersold R., Eisenman R.N. Mol. Cell. Biol. 26:1386-1397(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SIN3A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074175 mRNA. Translation: BAB85001.1. Sequence problems. BC046135 mRNA. No translation available.
IPI	IPI00291704.
RefSeq	NP_001162153.1. NM_001168682.1.
UniGene	Hs.633863.
3D structure databases
ProteinModelPortal	Q8TEE9.
SMR	Q8TEE9. Positions 134-186.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TEE9. 2 interactions.
MINT	MINT-1406893.
STRING	9606.ENSP00000340429.
Proteomic databases
PaxDb	Q8TEE9.
PRIDE	Q8TEE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000538735; ENSP00000442339; ENSG00000205307.
GeneID	100316904.
KEGG	hsa:100316904.
UCSC	uc003uvh.3. human.
Organism-specific databases
CTD	100316904.
GeneCards	GC07M100171.
HGNC	HGNC:41908. SAP25.
neXtProt	NX_Q8TEE9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149106.
HOGENOM	HOG000154253.
HOVERGEN	HBG108457.
InParanoid	Q8TEE9.
OMA	VWGPSCA.
OrthoDB	EOG4Z0B6R.
Gene expression databases
Genevestigator	Q8TEE9.
Family and domain databases
ProtoNet	Search...
Other
NextBio	34051142.

Entry information

Entry name

SAP25_HUMAN

Accession

Primary (citable) accession number: Q8TEE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.