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Q8TEE9

- SAP25_HUMAN

UniProt

Q8TEE9 - SAP25_HUMAN

Protein

Histone deacetylase complex subunit SAP25

Gene

SAP25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.By similarity

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase complex subunit SAP25
    Alternative name(s):
    25 kDa Sin3-associated polypeptide
    Sin3 corepressor complex subunit SAP25
    Gene namesi
    Name:SAP25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:41908. SAP25.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Shuttles between the nucleus and the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Histone deacetylase complex subunit SAP25PRO_0000350873Add
    BLAST

    Proteomic databases

    PaxDbiQ8TEE9.
    PRIDEiQ8TEE9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8TEE9.

    Organism-specific databases

    HPAiHPA062610.

    Interactioni

    Subunit structurei

    May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi941018. 30 interactions.
    IntActiQ8TEE9. 3 interactions.
    MINTiMINT-1406893.
    STRINGi9606.ENSP00000340429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEE9.
    SMRiQ8TEE9. Positions 134-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG149106.
    HOGENOMiHOG000154253.
    HOVERGENiHBG108457.
    InParanoidiQ8TEE9.
    OMAiGPRLVWG.
    OrthoDBiEOG7N37DQ.
    PhylomeDBiQ8TEE9.
    TreeFamiTF350622.

    Family and domain databases

    InterProiIPR029163. SAP25.
    [Graphical view]
    PfamiPF15476. SAP25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TEE9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG    50
    RGLRPVAPAT GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS 100
    KAPQQMMGSL KLLPPPPIMS ARVLPRPSPS RGPSTAWLSG PELIALTGLL 150
    QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP SSSQGADLSL PQTPDTHCP 199
    Length:199
    Mass (Da):20,873
    Last modified:September 23, 2008 - v2
    Checksum:iF0ADC8A992B40BE2
    GO

    Sequence cautioni

    The sequence BAB85001.1 differs from that shown. Reason: Intron retention.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074175 mRNA. Translation: BAB85001.1. Sequence problems.
    BC046135 mRNA. No translation available.
    CCDSiCCDS55137.1.
    RefSeqiNP_001162153.1. NM_001168682.1.
    UniGeneiHs.633863.

    Genome annotation databases

    EnsembliENST00000538735; ENSP00000442339; ENSG00000205307.
    GeneIDi100316904.
    KEGGihsa:100316904.
    UCSCiuc003uvh.3. human.

    Polymorphism databases

    DMDMi206558307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074175 mRNA. Translation: BAB85001.1 . Sequence problems.
    BC046135 mRNA. No translation available.
    CCDSi CCDS55137.1.
    RefSeqi NP_001162153.1. NM_001168682.1.
    UniGenei Hs.633863.

    3D structure databases

    ProteinModelPortali Q8TEE9.
    SMRi Q8TEE9. Positions 134-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 941018. 30 interactions.
    IntActi Q8TEE9. 3 interactions.
    MINTi MINT-1406893.
    STRINGi 9606.ENSP00000340429.

    Polymorphism databases

    DMDMi 206558307.

    Proteomic databases

    PaxDbi Q8TEE9.
    PRIDEi Q8TEE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000538735 ; ENSP00000442339 ; ENSG00000205307 .
    GeneIDi 100316904.
    KEGGi hsa:100316904.
    UCSCi uc003uvh.3. human.

    Organism-specific databases

    CTDi 100316904.
    GeneCardsi GC07M100171.
    HGNCi HGNC:41908. SAP25.
    HPAi HPA062610.
    neXtProti NX_Q8TEE9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149106.
    HOGENOMi HOG000154253.
    HOVERGENi HBG108457.
    InParanoidi Q8TEE9.
    OMAi GPRLVWG.
    OrthoDBi EOG7N37DQ.
    PhylomeDBi Q8TEE9.
    TreeFami TF350622.

    Miscellaneous databases

    NextBioi 34051142.
    PROi Q8TEE9.

    Gene expression databases

    Genevestigatori Q8TEE9.

    Family and domain databases

    InterProi IPR029163. SAP25.
    [Graphical view ]
    Pfami PF15476. SAP25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Leukocyte.
    3. "Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex."
      Shiio Y., Rose D.W., Aur R., Donohoe S., Aebersold R., Eisenman R.N.
      Mol. Cell. Biol. 26:1386-1397(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIN3A.

    Entry informationi

    Entry nameiSAP25_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM

    External Data

    Dasty 3