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Q8TEE9 (SAP25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase complex subunit SAP25
Alternative name(s):
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25
Gene names
Name:SAP25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex By similarity.

Subunit structure

May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 By similarity. Ref.3

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Shuttles between the nucleus and the cytoplasm By similarity.

Sequence caution

The sequence BAB85001.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Histone deacetylase complex subunit SAP25
PRO_0000350873

Sequences

Sequence LengthMass (Da)Tools
Q8TEE9 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: F0ADC8A992B40BE2

FASTA19920,873
        10         20         30         40         50         60 
MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG RGLRPVAPAT 

        70         80         90        100        110        120 
GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS KAPQQMMGSL KLLPPPPIMS 

       130        140        150        160        170        180 
ARVLPRPSPS RGPSTAWLSG PELIALTGLL QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP 

       190 
SSSQGADLSL PQTPDTHCP 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Leukocyte.
[3]"Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex."
Shiio Y., Rose D.W., Aur R., Donohoe S., Aebersold R., Eisenman R.N.
Mol. Cell. Biol. 26:1386-1397(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SIN3A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074175 mRNA. Translation: BAB85001.1. Sequence problems.
BC046135 mRNA. No translation available.
CCDSCCDS55137.1.
RefSeqNP_001162153.1. NM_001168682.1.
UniGeneHs.633863.

3D structure databases

ProteinModelPortalQ8TEE9.
SMRQ8TEE9. Positions 134-186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid941018. 30 interactions.
IntActQ8TEE9. 3 interactions.
MINTMINT-1406893.
STRING9606.ENSP00000340429.

Polymorphism databases

DMDM206558307.

Proteomic databases

PaxDbQ8TEE9.
PRIDEQ8TEE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000538735; ENSP00000442339; ENSG00000205307.
GeneID100316904.
KEGGhsa:100316904.
UCSCuc003uvh.3. human.

Organism-specific databases

CTD100316904.
GeneCardsGC07M100171.
HGNCHGNC:41908. SAP25.
HPAHPA062610.
neXtProtNX_Q8TEE9.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149106.
HOGENOMHOG000154253.
HOVERGENHBG108457.
InParanoidQ8TEE9.
OMAGPRLVWG.
OrthoDBEOG7N37DQ.
PhylomeDBQ8TEE9.
TreeFamTF350622.

Gene expression databases

GenevestigatorQ8TEE9.

Family and domain databases

InterProIPR029163. SAP25.
[Graphical view]
PfamPF15476. SAP25. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio34051142.
PROQ8TEE9.

Entry information

Entry nameSAP25_HUMAN
AccessionPrimary (citable) accession number: Q8TEE9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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