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Protein

Histone deacetylase complex subunit SAP25

Gene

SAP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP25
Alternative name(s):
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25
Gene namesi
Name:SAP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:41908. SAP25.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSAP25.
DMDMi206558307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Histone deacetylase complex subunit SAP25PRO_0000350873Add
BLAST

Proteomic databases

PaxDbiQ8TEE9.
PRIDEiQ8TEE9.

Expressioni

Gene expression databases

ExpressionAtlasiQ8TEE9. baseline.
GenevisibleiQ8TEE9. HS.

Organism-specific databases

HPAiHPA062610.

Interactioni

Subunit structurei

May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi941018. 30 interactions.
IntActiQ8TEE9. 3 interactions.
MINTiMINT-1406893.
STRINGi9606.ENSP00000442339.

Structurei

3D structure databases

ProteinModelPortaliQ8TEE9.
SMRiQ8TEE9. Positions 134-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG149106.
GeneTreeiENSGT00390000007899.
HOGENOMiHOG000154253.
HOVERGENiHBG108457.
InParanoidiQ8TEE9.
KOiK19193.
OMAiGPRLVWG.
OrthoDBiEOG7N37DQ.
PhylomeDBiQ8TEE9.
TreeFamiTF350622.

Family and domain databases

InterProiIPR029163. SAP25.
[Graphical view]
PfamiPF15476. SAP25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG
60 70 80 90 100
RGLRPVAPAT GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS
110 120 130 140 150
KAPQQMMGSL KLLPPPPIMS ARVLPRPSPS RGPSTAWLSG PELIALTGLL
160 170 180 190
QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP SSSQGADLSL PQTPDTHCP
Length:199
Mass (Da):20,873
Last modified:September 23, 2008 - v2
Checksum:iF0ADC8A992B40BE2
GO

Sequence cautioni

The sequence BAB85001.1 differs from that shown.Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074175 mRNA. Translation: BAB85001.1. Sequence problems.
BC046135 mRNA. No translation available.
CCDSiCCDS55137.1.
RefSeqiNP_001162153.1. NM_001168682.1.
UniGeneiHs.633863.

Genome annotation databases

EnsembliENST00000538735; ENSP00000442339; ENSG00000205307.
ENST00000614631; ENSP00000481351; ENSG00000205307.
GeneIDi100316904.
KEGGihsa:100316904.
UCSCiuc003uvh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074175 mRNA. Translation: BAB85001.1. Sequence problems.
BC046135 mRNA. No translation available.
CCDSiCCDS55137.1.
RefSeqiNP_001162153.1. NM_001168682.1.
UniGeneiHs.633863.

3D structure databases

ProteinModelPortaliQ8TEE9.
SMRiQ8TEE9. Positions 134-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi941018. 30 interactions.
IntActiQ8TEE9. 3 interactions.
MINTiMINT-1406893.
STRINGi9606.ENSP00000442339.

Polymorphism and mutation databases

BioMutaiSAP25.
DMDMi206558307.

Proteomic databases

PaxDbiQ8TEE9.
PRIDEiQ8TEE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000538735; ENSP00000442339; ENSG00000205307.
ENST00000614631; ENSP00000481351; ENSG00000205307.
GeneIDi100316904.
KEGGihsa:100316904.
UCSCiuc003uvh.3. human.

Organism-specific databases

CTDi100316904.
GeneCardsiGC07M100171.
HGNCiHGNC:41908. SAP25.
HPAiHPA062610.
neXtProtiNX_Q8TEE9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149106.
GeneTreeiENSGT00390000007899.
HOGENOMiHOG000154253.
HOVERGENiHBG108457.
InParanoidiQ8TEE9.
KOiK19193.
OMAiGPRLVWG.
OrthoDBiEOG7N37DQ.
PhylomeDBiQ8TEE9.
TreeFamiTF350622.

Miscellaneous databases

NextBioi34051142.
PROiQ8TEE9.

Gene expression databases

ExpressionAtlasiQ8TEE9. baseline.
GenevisibleiQ8TEE9. HS.

Family and domain databases

InterProiIPR029163. SAP25.
[Graphical view]
PfamiPF15476. SAP25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Leukocyte.
  3. "Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex."
    Shiio Y., Rose D.W., Aur R., Donohoe S., Aebersold R., Eisenman R.N.
    Mol. Cell. Biol. 26:1386-1397(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIN3A.

Entry informationi

Entry nameiSAP25_HUMAN
AccessioniPrimary (citable) accession number: Q8TEE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.