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Protein

Glucose-6-phosphate exchanger SLC37A2

Gene

SLC37A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.1 Publication

Enzyme regulationi

Inhibited by vanadate but not by chlorogenic acid.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: GO_Central
  • carbohydrate transport Source: UniProtKB-KW
  • glucose-6-phosphate transport Source: UniProtKB
  • phosphate ion transmembrane transport Source: UniProtKB
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Antiport, Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.4.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A21 Publication
Alternative name(s):
Solute carrier family 37 member 2Imported
Gene namesi
Name:SLC37A2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20644. SLC37A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence analysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917577.

Polymorphism and mutation databases

BioMutaiSLC37A2.
DMDMi160185473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Glucose-6-phosphate exchanger SLC37A2PRO_0000308322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TED4.
PRIDEiQ8TED4.

PTM databases

iPTMnetiQ8TED4.
PhosphoSiteiQ8TED4.

Expressioni

Tissue specificityi

Detected in intestine and pancreas. Lower expression is also detected in liver and kidney.1 Publication

Gene expression databases

BgeeiQ8TED4.
CleanExiHS_SLC37A2.
ExpressionAtlasiQ8TED4. baseline and differential.
GenevisibleiQ8TED4. HS.

Organism-specific databases

HPAiHPA014948.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311833.

Structurei

3D structure databases

ProteinModelPortaliQ8TED4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ8TED4.
KOiK13783.
OMAiWCNWPPF.
OrthoDBiEOG773XFZ.
PhylomeDBiQ8TED4.
TreeFamiTF314991.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TED4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSSLAPGVW FFRAFSRDSW FRGLILLLTF LIYACYHMSR KPISIVKSRL
60 70 80 90 100
HQNCSEQIKP INDTHSLNDT MWCSWAPFDK DNYKELLGGV DNAFLIAYAI
110 120 130 140 150
GMFISGVFGE RLPLRYYLSA GMLLSGLFTS LFGLGYFWNI HELWYFVVIQ
160 170 180 190 200
VCNGLVQTTG WPSVVTCVGN WFGKGKRGFI MGIWNSHTSV GNILGSLIAG
210 220 230 240 250
IWVNGQWGLS FIVPGIITAV MGVITFLFLI EHPEDVDCAP PQHHGEPAEN
260 270 280 290 300
QDNPEDPGNS PCSIRESGLE TVAKCSKGPC EEPAAISFFG ALRIPGVVEF
310 320 330 340 350
SLCLLFAKLV SYTFLYWLPL YIANVAHFSA KEAGDLSTLF DVGGIIGGIV
360 370 380 390 400
AGLVSDYTNG RATTCCVMLI LAAPMMFLYN YIGQDGIASS IVMLIICGGL
410 420 430 440 450
VNGPYALITT AVSADLGTHK SLKGNAKALS TVTAIIDGTG SIGAALGPLL
460 470 480 490 500
AGLISPTGWN NVFYMLISAD VLACLLLCRL VYKEILAWKV SLSRGSGYKE

I
Length:501
Mass (Da):54,436
Last modified:October 23, 2007 - v2
Checksum:i5B19560992231164
GO
Isoform 2 (identifier: Q8TED4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-501: YKEI → SSMVLTHQ

Show »
Length:505
Mass (Da):54,787
Checksum:i34853B4BC984C087
GO
Isoform 3 (identifier: Q8TED4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-385: GGIVAGLVSD...MFLYNYIGQD → DVPVQLHWPG...IRAHHHCCLC
     386-501: Missing.

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,925
Checksum:iD8F1AD92C7BB31BC
GO
Isoform 4 (identifier: Q8TED4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,154
Checksum:i38E366A8EE7BDFD6
GO

Sequence cautioni

The sequence BAB84926.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071W → R in BAB85016 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961I → V.
Corresponds to variant rs55752830 [ dbSNP | Ensembl ].
VAR_061803
Natural varianti268 – 2681G → S.
Corresponds to variant rs34485243 [ dbSNP | Ensembl ].
VAR_036794

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 375375Missing in isoform 4. 1 PublicationVSP_028960Add
BLAST
Alternative sequencei347 – 38539GGIVA…YIGQD → DVPVQLHWPGRDCQLHSDAD HLWGPGQWPIRAHHHCCLC in isoform 3. 1 PublicationVSP_028961Add
BLAST
Alternative sequencei386 – 501116Missing in isoform 3. 1 PublicationVSP_028962Add
BLAST
Alternative sequencei498 – 5014YKEI → SSMVLTHQ in isoform 2. 1 PublicationVSP_028963

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074100 mRNA. Translation: BAB84926.1. Different initiation.
AK074207 mRNA. Translation: BAB85016.1.
AK290314 mRNA. Translation: BAF83003.1.
CH471065 Genomic DNA. Translation: EAW67622.1.
BC051314 mRNA. Translation: AAH51314.1.
BC062990 mRNA. Translation: AAH62990.1.
CCDSiCCDS31714.1. [Q8TED4-2]
CCDS44757.1. [Q8TED4-1]
RefSeqiNP_001138762.1. NM_001145290.1. [Q8TED4-1]
NP_938018.1. NM_198277.2. [Q8TED4-2]
UniGeneiHs.352661.

Genome annotation databases

EnsembliENST00000308074; ENSP00000311833; ENSG00000134955. [Q8TED4-2]
ENST00000403796; ENSP00000384407; ENSG00000134955. [Q8TED4-1]
GeneIDi219855.
KEGGihsa:219855.
UCSCiuc001qbn.4. human. [Q8TED4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074100 mRNA. Translation: BAB84926.1. Different initiation.
AK074207 mRNA. Translation: BAB85016.1.
AK290314 mRNA. Translation: BAF83003.1.
CH471065 Genomic DNA. Translation: EAW67622.1.
BC051314 mRNA. Translation: AAH51314.1.
BC062990 mRNA. Translation: AAH62990.1.
CCDSiCCDS31714.1. [Q8TED4-2]
CCDS44757.1. [Q8TED4-1]
RefSeqiNP_001138762.1. NM_001145290.1. [Q8TED4-1]
NP_938018.1. NM_198277.2. [Q8TED4-2]
UniGeneiHs.352661.

3D structure databases

ProteinModelPortaliQ8TED4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311833.

Protein family/group databases

TCDBi2.A.1.4.8. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8TED4.
PhosphoSiteiQ8TED4.

Polymorphism and mutation databases

BioMutaiSLC37A2.
DMDMi160185473.

Proteomic databases

PaxDbiQ8TED4.
PRIDEiQ8TED4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308074; ENSP00000311833; ENSG00000134955. [Q8TED4-2]
ENST00000403796; ENSP00000384407; ENSG00000134955. [Q8TED4-1]
GeneIDi219855.
KEGGihsa:219855.
UCSCiuc001qbn.4. human. [Q8TED4-1]

Organism-specific databases

CTDi219855.
GeneCardsiSLC37A2.
HGNCiHGNC:20644. SLC37A2.
HPAiHPA014948.
neXtProtiNX_Q8TED4.
PharmGKBiPA134917577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ8TED4.
KOiK13783.
OMAiWCNWPPF.
OrthoDBiEOG773XFZ.
PhylomeDBiQ8TED4.
TreeFamiTF314991.

Miscellaneous databases

GenomeRNAii219855.
PROiQ8TED4.

Gene expression databases

BgeeiQ8TED4.
CleanExiHS_SLC37A2.
ExpressionAtlasiQ8TED4. baseline and differential.
GenevisibleiQ8TED4. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain and Pancreas.
  5. "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters."
    Pan C.J., Chen S.Y., Jun H.S., Lin S.R., Mansfield B.C., Chou J.Y.
    PLoS ONE 6:E23157-E23157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiG6PT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TED4
Secondary accession number(s): A8K2P9
, Q6P599, Q7Z7P8, Q8TEM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.