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Protein

Probable glutathione peroxidase 8

Gene

GPX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:GPX8
ORF Names:UNQ847/PRO1785
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:33100. GPX8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 4023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720300.

Chemistry

DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiGPX8.
DMDMi269849565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable glutathione peroxidase 8PRO_0000317756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TED1.
MaxQBiQ8TED1.
PaxDbiQ8TED1.
PRIDEiQ8TED1.

PTM databases

iPTMnetiQ8TED1.
PhosphoSiteiQ8TED1.
SwissPalmiQ8TED1.

Expressioni

Gene expression databases

BgeeiQ8TED1.
CleanExiHS_GPX8.
ExpressionAtlasiQ8TED1. baseline and differential.
GenevisibleiQ8TED1. HS.

Organism-specific databases

HPAiHPA036720.
HPA036721.

Interactioni

Protein-protein interaction databases

BioGridi138926. 5 interactions.
STRINGi9606.ENSP00000423822.

Structurei

Secondary structure

1
209
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 493Combined sources
Beta strandi51 – 544Combined sources
Beta strandi59 – 613Combined sources
Helixi62 – 654Combined sources
Beta strandi68 – 758Combined sources
Beta strandi77 – 793Combined sources
Helixi82 – 9615Combined sources
Turni97 – 993Combined sources
Beta strandi100 – 1078Combined sources
Helixi119 – 13012Combined sources
Helixi149 – 15810Combined sources
Beta strandi168 – 1714Combined sources
Beta strandi177 – 1815Combined sources
Helixi187 – 1893Combined sources
Helixi191 – 20717Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CYNX-ray2.00A/B/C44-209[»]
3KIJX-ray1.80A/B/C38-209[»]
ProteinModelPortaliQ8TED1.
SMRiQ8TED1. Positions 39-209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TED1.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ8TED1.
KOiK00432.
OMAiAYPLKCS.
OrthoDBiEOG757CZF.
PhylomeDBiQ8TED1.
TreeFamiTF331942.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TED1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLAAYPLK CSGPRAKVFA VLLSIVLCTV TLFLLQLKFL KPKINSFYAF
60 70 80 90 100
EVKDAKGRTV SLEKYKGKVS LVVNVASDCQ LTDRNYLGLK ELHKEFGPSH
110 120 130 140 150
FSVLAFPCNQ FGESEPRPSK EVESFARKNY GVTFPIFHKI KILGSEGEPA
160 170 180 190 200
FRFLVDSSKK EPRWNFWKYL VNPEGQVVKF WKPEEPIEVI RPDIAALVRQ

VIIKKKEDL
Length:209
Mass (Da):23,881
Last modified:November 24, 2009 - v2
Checksum:i82DACC1A85FDF6D7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821K → R.4 Publications
Corresponds to variant rs381852 [ dbSNP | Ensembl ].
VAR_060456

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358715 mRNA. Translation: AAQ89077.1.
AK074216 mRNA. Translation: BAB85019.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54908.1.
BC029424 mRNA. Translation: AAH29424.1.
CCDSiCCDS34156.1.
RefSeqiNP_001008398.2. NM_001008397.3.
NP_001293126.1. NM_001306197.1.
NP_001293127.1. NM_001306198.1.
NP_001293130.1. NM_001306201.1.
UniGeneiHs.289044.

Genome annotation databases

EnsembliENST00000503787; ENSP00000423822; ENSG00000164294.
GeneIDi493869.
KEGGihsa:493869.
UCSCiuc003jpq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358715 mRNA. Translation: AAQ89077.1.
AK074216 mRNA. Translation: BAB85019.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54908.1.
BC029424 mRNA. Translation: AAH29424.1.
CCDSiCCDS34156.1.
RefSeqiNP_001008398.2. NM_001008397.3.
NP_001293126.1. NM_001306197.1.
NP_001293127.1. NM_001306198.1.
NP_001293130.1. NM_001306201.1.
UniGeneiHs.289044.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CYNX-ray2.00A/B/C44-209[»]
3KIJX-ray1.80A/B/C38-209[»]
ProteinModelPortaliQ8TED1.
SMRiQ8TED1. Positions 39-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138926. 5 interactions.
STRINGi9606.ENSP00000423822.

Chemistry

DrugBankiDB00143. Glutathione.

PTM databases

iPTMnetiQ8TED1.
PhosphoSiteiQ8TED1.
SwissPalmiQ8TED1.

Polymorphism and mutation databases

BioMutaiGPX8.
DMDMi269849565.

Proteomic databases

EPDiQ8TED1.
MaxQBiQ8TED1.
PaxDbiQ8TED1.
PRIDEiQ8TED1.

Protocols and materials databases

DNASUi493869.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503787; ENSP00000423822; ENSG00000164294.
GeneIDi493869.
KEGGihsa:493869.
UCSCiuc003jpq.3. human.

Organism-specific databases

CTDi493869.
GeneCardsiGPX8.
HGNCiHGNC:33100. GPX8.
HPAiHPA036720.
HPA036721.
neXtProtiNX_Q8TED1.
PharmGKBiPA164720300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ8TED1.
KOiK00432.
OMAiAYPLKCS.
OrthoDBiEOG757CZF.
PhylomeDBiQ8TED1.
TreeFamiTF331942.

Enzyme and pathway databases

BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

EvolutionaryTraceiQ8TED1.
GeneWikiiGPX8.
GenomeRNAii493869.
NextBioi111787.
PROiQ8TED1.

Gene expression databases

BgeeiQ8TED1.
CleanExiHS_GPX8.
ExpressionAtlasiQ8TED1. baseline and differential.
GenevisibleiQ8TED1. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-182.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-182.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-182.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-182.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "The structure of human GPX8."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 44-209.

Entry informationi

Entry nameiGPX8_HUMAN
AccessioniPrimary (citable) accession number: Q8TED1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.