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Protein

U3 small nucleolar RNA-associated protein 15 homolog

Gene

UTP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ8TED0.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15 homolog
Gene namesi
Name:UTP15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25758. UTP15.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • cytoplasm Source: LIFEdb
  • fibrillar center Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670631.

Polymorphism and mutation databases

DMDMi296452998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 518517U3 small nucleolar RNA-associated protein 15 homologPRO_0000051321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TED0.
MaxQBiQ8TED0.
PaxDbiQ8TED0.
PeptideAtlasiQ8TED0.
PRIDEiQ8TED0.

2D gel databases

SWISS-2DPAGEQ8TED0.

PTM databases

iPTMnetiQ8TED0.
PhosphoSiteiQ8TED0.

Expressioni

Gene expression databases

BgeeiENSG00000164338.
CleanExiHS_UTP15.
ExpressionAtlasiQ8TED0. baseline and differential.
GenevisibleiQ8TED0. HS.

Organism-specific databases

HPAiHPA044697.

Interactioni

Subunit structurei

Forms a complex with UTP4, NOL11, WDR43 and WDR75.1 Publication

Protein-protein interaction databases

BioGridi123907. 39 interactions.
IntActiQ8TED0. 9 interactions.
MINTiMINT-3045726.
STRINGi9606.ENSP00000296792.

Structurei

3D structure databases

ProteinModelPortaliQ8TED0.
SMRiQ8TED0. Positions 39-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 7540WD 1Add
BLAST
Repeati78 – 11740WD 2Add
BLAST
Repeati120 – 15940WD 3Add
BLAST
Repeati162 – 20241WD 4Add
BLAST
Repeati204 – 24239WD 5Add
BLAST
Repeati246 – 28540WD 6Add
BLAST
Repeati287 – 32640WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
HOVERGENiHBG080690.
InParanoidiQ8TED0.
KOiK14549.
PhylomeDBiQ8TED0.
TreeFamiTF319494.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TED0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP
60 70 80 90 100
PYNYAVTASS RIHIYGRYSQ EPIKTFSRFK DTAYCATFRQ DGRLLVAGSE
110 120 130 140 150
DGGVQLFDIS GRAPLRQFEG HTKAVHTVDF TADKYHVVSG ADDYTVKLWD
160 170 180 190 200
IPNSKEILTF KEHSDYVRCG CASKLNPDLF ITGSYDHTVK MFDARTSESV
210 220 230 240 250
LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT
260 270 280 290 300
VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE
310 320 330 340 350
DETIVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD
360 370 380 390 400
ILINRPAKKH LELYDRDLKH FRISKALDRV LDPTCTIKTP EITVSIIKEL
410 420 430 440 450
NRRGVLANAL AGRDEKEISH VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL
460 470 480 490 500
PVIGQSPVVD KKFLLLQGLV EKEIDYQREL LETLGMMDML FATMRRKEGT
510
SVLEHTSDGF PENKKIES
Length:518
Mass (Da):58,415
Last modified:May 18, 2010 - v3
Checksum:iCB1994E968981BD0
GO
Isoform 2 (identifier: Q8TED0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):36,982
Checksum:i42757D0D8C81BA0F
GO
Isoform 3 (identifier: Q8TED0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-49: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):56,356
Checksum:iB6285C9EA48635D5
GO

Sequence cautioni

The sequence BAB14271 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB85020 differs from that shown. Reason: Frameshift at position 489. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301F → S in BAB85020 (PubMed:14702039).Curated
Sequence conflicti313 – 3131L → P in CAG33576 (Ref. 4) Curated
Sequence conflicti382 – 3821D → G in BAB14271 (PubMed:14702039).Curated
Sequence conflicti399 – 3991E → G in BAB85020 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281Y → H.
Corresponds to variant rs16870608 [ dbSNP | Ensembl ].
VAR_057621
Natural varianti332 – 3321R → S.
Corresponds to variant rs35313343 [ dbSNP | Ensembl ].
VAR_057622
Natural varianti483 – 4831T → P.
Corresponds to variant rs35898225 [ dbSNP | Ensembl ].
VAR_057623

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 190190Missing in isoform 2. 1 PublicationVSP_055255Add
BLAST
Alternative sequencei31 – 4919Missing in isoform 3. 1 PublicationVSP_055256Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022849 mRNA. Translation: BAB14271.1. Different initiation.
AK074217 mRNA. Translation: BAB85020.1. Frameshift.
AK300525 mRNA. Translation: BAG62237.1.
AK302021 mRNA. Translation: BAG63420.1.
AC010279 Genomic DNA. No translation available.
BC013064 mRNA. Translation: AAH13064.1.
CR457295 mRNA. Translation: CAG33576.1.
CCDSiCCDS34186.1. [Q8TED0-1]
CCDS68893.1. [Q8TED0-3]
CCDS68894.1. [Q8TED0-2]
RefSeqiNP_001271359.1. NM_001284430.1. [Q8TED0-3]
NP_001271360.1. NM_001284431.1. [Q8TED0-2]
NP_115551.2. NM_032175.3. [Q8TED0-1]
XP_011541982.1. XM_011543680.2. [Q8TED0-1]
UniGeneiHs.406703.

Genome annotation databases

EnsembliENST00000296792; ENSP00000296792; ENSG00000164338. [Q8TED0-1]
ENST00000508491; ENSP00000424609; ENSG00000164338. [Q8TED0-3]
ENST00000543251; ENSP00000440796; ENSG00000164338. [Q8TED0-2]
GeneIDi84135.
KEGGihsa:84135.
UCSCiuc003kcw.3. human. [Q8TED0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022849 mRNA. Translation: BAB14271.1. Different initiation.
AK074217 mRNA. Translation: BAB85020.1. Frameshift.
AK300525 mRNA. Translation: BAG62237.1.
AK302021 mRNA. Translation: BAG63420.1.
AC010279 Genomic DNA. No translation available.
BC013064 mRNA. Translation: AAH13064.1.
CR457295 mRNA. Translation: CAG33576.1.
CCDSiCCDS34186.1. [Q8TED0-1]
CCDS68893.1. [Q8TED0-3]
CCDS68894.1. [Q8TED0-2]
RefSeqiNP_001271359.1. NM_001284430.1. [Q8TED0-3]
NP_001271360.1. NM_001284431.1. [Q8TED0-2]
NP_115551.2. NM_032175.3. [Q8TED0-1]
XP_011541982.1. XM_011543680.2. [Q8TED0-1]
UniGeneiHs.406703.

3D structure databases

ProteinModelPortaliQ8TED0.
SMRiQ8TED0. Positions 39-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123907. 39 interactions.
IntActiQ8TED0. 9 interactions.
MINTiMINT-3045726.
STRINGi9606.ENSP00000296792.

PTM databases

iPTMnetiQ8TED0.
PhosphoSiteiQ8TED0.

Polymorphism and mutation databases

DMDMi296452998.

2D gel databases

SWISS-2DPAGEQ8TED0.

Proteomic databases

EPDiQ8TED0.
MaxQBiQ8TED0.
PaxDbiQ8TED0.
PeptideAtlasiQ8TED0.
PRIDEiQ8TED0.

Protocols and materials databases

DNASUi84135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296792; ENSP00000296792; ENSG00000164338. [Q8TED0-1]
ENST00000508491; ENSP00000424609; ENSG00000164338. [Q8TED0-3]
ENST00000543251; ENSP00000440796; ENSG00000164338. [Q8TED0-2]
GeneIDi84135.
KEGGihsa:84135.
UCSCiuc003kcw.3. human. [Q8TED0-1]

Organism-specific databases

CTDi84135.
GeneCardsiUTP15.
HGNCiHGNC:25758. UTP15.
HPAiHPA044697.
MIMi616194. gene.
neXtProtiNX_Q8TED0.
PharmGKBiPA142670631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
HOVERGENiHBG080690.
InParanoidiQ8TED0.
KOiK14549.
PhylomeDBiQ8TED0.
TreeFamiTF319494.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ8TED0.

Miscellaneous databases

ChiTaRSiUTP15. human.
GeneWikiiUTP15.
GenomeRNAii84135.
PROiQ8TED0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164338.
CleanExiHS_UTP15.
ExpressionAtlasiQ8TED0. baseline and differential.
GenevisibleiQ8TED0. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTP15_HUMAN
AccessioniPrimary (citable) accession number: Q8TED0
Secondary accession number(s): B4DU75
, B4DXK8, Q6IA60, Q96E08, Q9H9F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.