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Protein

U3 small nucleolar RNA-associated protein 15 homolog

Gene

UTP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • positive regulation of rRNA processing Source: UniProtKB
  • positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
  • rRNA processing Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ8TED0.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15 homolog
Gene namesi
Name:UTP15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164338.9.
HGNCiHGNC:25758. UTP15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164338.
PharmGKBiPA142670631.

Polymorphism and mutation databases

DMDMi296452998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000513212 – 518U3 small nucleolar RNA-associated protein 15 homologAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8TED0.
MaxQBiQ8TED0.
PaxDbiQ8TED0.
PeptideAtlasiQ8TED0.
PRIDEiQ8TED0.

2D gel databases

SWISS-2DPAGEiQ8TED0.

PTM databases

iPTMnetiQ8TED0.
PhosphoSitePlusiQ8TED0.

Expressioni

Gene expression databases

BgeeiENSG00000164338.
CleanExiHS_UTP15.
ExpressionAtlasiQ8TED0. baseline and differential.
GenevisibleiQ8TED0. HS.

Organism-specific databases

HPAiHPA044697.

Interactioni

Subunit structurei

Interacts directly with UTP4 and WDR43 (PubMed:24219289). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).2 Publications1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP4Q969X62EBI-1048301,EBI-2602591

Protein-protein interaction databases

BioGridi123907. 42 interactors.
IntActiQ8TED0. 12 interactors.
MINTiMINT-3045726.
STRINGi9606.ENSP00000296792.

Structurei

3D structure databases

ProteinModelPortaliQ8TED0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati78 – 117WD 2Add BLAST40
Repeati120 – 159WD 3Add BLAST40
Repeati162 – 202WD 4Add BLAST41
Repeati204 – 242WD 5Add BLAST39
Repeati246 – 285WD 6Add BLAST40
Repeati287 – 326WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
HOVERGENiHBG080690.
InParanoidiQ8TED0.
KOiK14549.
PhylomeDBiQ8TED0.
TreeFamiTF319494.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF09384. UTP15_C. 1 hit.
PF00400. WD40. 4 hits.
SMARTiView protein in SMART
SM00320. WD40. 6 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TED0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP
60 70 80 90 100
PYNYAVTASS RIHIYGRYSQ EPIKTFSRFK DTAYCATFRQ DGRLLVAGSE
110 120 130 140 150
DGGVQLFDIS GRAPLRQFEG HTKAVHTVDF TADKYHVVSG ADDYTVKLWD
160 170 180 190 200
IPNSKEILTF KEHSDYVRCG CASKLNPDLF ITGSYDHTVK MFDARTSESV
210 220 230 240 250
LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT
260 270 280 290 300
VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE
310 320 330 340 350
DETIVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD
360 370 380 390 400
ILINRPAKKH LELYDRDLKH FRISKALDRV LDPTCTIKTP EITVSIIKEL
410 420 430 440 450
NRRGVLANAL AGRDEKEISH VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL
460 470 480 490 500
PVIGQSPVVD KKFLLLQGLV EKEIDYQREL LETLGMMDML FATMRRKEGT
510
SVLEHTSDGF PENKKIES
Length:518
Mass (Da):58,415
Last modified:May 18, 2010 - v3
Checksum:iCB1994E968981BD0
GO
Isoform 2 (identifier: Q8TED0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):36,982
Checksum:i42757D0D8C81BA0F
GO
Isoform 3 (identifier: Q8TED0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-49: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):56,356
Checksum:iB6285C9EA48635D5
GO

Sequence cautioni

The sequence BAB14271 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85020 differs from that shown. Reason: Frameshift at position 489.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130F → S in BAB85020 (PubMed:14702039).Curated1
Sequence conflicti313L → P in CAG33576 (Ref. 4) Curated1
Sequence conflicti382D → G in BAB14271 (PubMed:14702039).Curated1
Sequence conflicti399E → G in BAB85020 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057621228Y → H. Corresponds to variant dbSNP:rs16870608Ensembl.1
Natural variantiVAR_057622332R → S. Corresponds to variant dbSNP:rs35313343Ensembl.1
Natural variantiVAR_057623483T → P. Corresponds to variant dbSNP:rs35898225Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552551 – 190Missing in isoform 2. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_05525631 – 49Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022849 mRNA. Translation: BAB14271.1. Different initiation.
AK074217 mRNA. Translation: BAB85020.1. Frameshift.
AK300525 mRNA. Translation: BAG62237.1.
AK302021 mRNA. Translation: BAG63420.1.
AC010279 Genomic DNA. No translation available.
BC013064 mRNA. Translation: AAH13064.1.
CR457295 mRNA. Translation: CAG33576.1.
CCDSiCCDS34186.1. [Q8TED0-1]
CCDS68893.1. [Q8TED0-3]
CCDS68894.1. [Q8TED0-2]
RefSeqiNP_001271359.1. NM_001284430.1. [Q8TED0-3]
NP_001271360.1. NM_001284431.1. [Q8TED0-2]
NP_115551.2. NM_032175.3. [Q8TED0-1]
XP_011541982.1. XM_011543680.2. [Q8TED0-1]
UniGeneiHs.406703.

Genome annotation databases

EnsembliENST00000296792; ENSP00000296792; ENSG00000164338. [Q8TED0-1]
ENST00000508491; ENSP00000424609; ENSG00000164338. [Q8TED0-3]
ENST00000543251; ENSP00000440796; ENSG00000164338. [Q8TED0-2]
GeneIDi84135.
KEGGihsa:84135.
UCSCiuc003kcw.3. human. [Q8TED0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUTP15_HUMAN
AccessioniPrimary (citable) accession number: Q8TED0
Secondary accession number(s): B4DU75
, B4DXK8, Q6IA60, Q96E08, Q9H9F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 18, 2010
Last modified: November 22, 2017
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot