Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative E3 ubiquitin-protein ligase SH3RF2

Gene

SH3RF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.Curated2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 5342RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • phosphatase binding Source: UniProtKB
  • protein phosphatase 1 binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protein phosphatase inhibitor

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative E3 ubiquitin-protein ligase SH3RF2 (EC:6.3.2.-)
Alternative name(s):
Heart protein phosphatase 1-binding protein
Short name:
HEPP1
Protein phosphatase 1 regulatory subunit 39
RING finger protein 158
SH3 domain-containing RING finger protein 2
Gene namesi
Name:SH3RF2
Synonyms:PPP1R39, RNF158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26299. SH3RF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi643 – 6431V → G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-645. 1 Publication
Mutagenesisi645 – 6451F → G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-643. 1 Publication

Organism-specific databases

PharmGKBiPA134944983.

Polymorphism and mutation databases

BioMutaiSH3RF2.
DMDMi296452957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Putative E3 ubiquitin-protein ligase SH3RF2PRO_0000269512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei649 – 6491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TEC5.
MaxQBiQ8TEC5.
PaxDbiQ8TEC5.
PRIDEiQ8TEC5.
TopDownProteomicsiQ8TEC5-1. [Q8TEC5-1]

PTM databases

PhosphoSiteiQ8TEC5.

Expressioni

Tissue specificityi

Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.1 Publication

Gene expression databases

BgeeiQ8TEC5.
CleanExiHS_SH3RF2.
GenevisibleiQ8TEC5. HS.

Organism-specific databases

HPAiHPA035903.
HPA058119.

Interactioni

Subunit structurei

Interacts with FASLG and PPP1CA.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-2130111,EBI-744695
PPP1CAP621363EBI-2130111,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase 1 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127517. 33 interactions.
IntActiQ8TEC5. 6 interactions.
STRINGi9606.ENSP00000352028.

Structurei

3D structure databases

ProteinModelPortaliQ8TEC5.
SMRiQ8TEC5. Positions 5-78, 123-248, 381-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 18460SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini187 – 25266SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini380 – 44162SH3 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 6466Interaction with PPP1CA

Domaini

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

Sequence similaritiesi

Belongs to the SH3RF family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 3 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 5342RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000060125.
HOVERGENiHBG082418.
InParanoidiQ8TEC5.
KOiK12171.
OMAiNMFVALH.
OrthoDBiEOG7HMS0X.
PhylomeDBiQ8TEC5.
TreeFamiTF105571.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP
60 70 80 90 100
ECRTPVFSNI EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR
110 120 130 140 150
KSRTNPRRLQ ASPFRLVPNV RIHMDGVPRA KALCNYRGQN PGDLRFNKGD
160 170 180 190 200
IILLRRQLDE NWYQGEINGI SGNFPASSVE VIKQLPQPPP LCRALYNFDL
210 220 230 240 250
RGKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDKVG IFPILFVEPN
260 270 280 290 300
LTARHLLEKN KGRQSSRTKN LSLVSSSSRG NTSTLRRGPG SRRKVPGQFS
310 320 330 340 350
ITTALNTLNR MVHSPSGRHM VEISTPVLIS SSNPSVITQP MEKADVPSSC
360 370 380 390 400
VGQVSTYHPA PVSPGHSTAV VSLPGSQQHL SANMFVALHS YSAHGPDELD
410 420 430 440 450
LQKGEGVRVL GKCQDGWLRG VSLVTGRVGI FPNNYVIPIF RKTSSFPDSR
460 470 480 490 500
SPGLYTTWTL STSSVSSQGS ISEGDPRQSR PFKSVFVPTA IVNPVRSTAG
510 520 530 540 550
PGTLGQGSLR KGRSSMRKNG SLQRPLQSGI PTLVVGSLRR SPTMVLRPQQ
560 570 580 590 600
FQFYQPQGIP SSPSAVVVEM GSKPALTGEP ALTCISRGSE AWIHSAASSL
610 620 630 640 650
IMEDKEIPIK SEPLPKPPAS APPSILVKPE NSRNGIEKQV KTVRFQNYSP
660 670 680 690 700
PPTKHYTSHP TSGKPEQPAT LKASQPEAAS LGPEMTVLFA HRSGCHSGQQ
710 720
TDLRRKSALG KATTLVSTAS GTQTVFPSK
Length:729
Mass (Da):79,320
Last modified:May 18, 2010 - v3
Checksum:iF85CCC0188DA8477
GO
Isoform 2 (identifier: Q8TEC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-508: Missing.
     509-519: LRKGRSSMRKN → MRKSKWWQRD

Show »
Length:220
Mass (Da):23,799
Checksum:i299343322F39CAB2
GO
Isoform 3 (identifier: Q8TEC5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-543: Missing.

Show »
Length:186
Mass (Da):19,895
Checksum:i1FCF3EE1BF6C9316
GO

Sequence cautioni

The sequence AAH31650.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB85025.1 differs from that shown. Reason: Erroneous termination at position 458. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481K → R in BAB85025 (PubMed:14702039).Curated
Sequence conflicti168 – 1681N → S in BAB85025 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161F → S.
Corresponds to variant rs34739859 [ dbSNP | Ensembl ].
VAR_052118
Natural varianti174 – 1741F → V.
Corresponds to variant rs34942619 [ dbSNP | Ensembl ].
VAR_052119
Natural varianti267 – 2671R → C.2 Publications
Corresponds to variant rs758037 [ dbSNP | Ensembl ].
VAR_029788
Natural varianti477 – 4771R → Q.
Corresponds to variant rs35165046 [ dbSNP | Ensembl ].
VAR_052120
Natural varianti592 – 5921W → R.2 Publications
Corresponds to variant rs2962525 [ dbSNP | Ensembl ].
VAR_029789
Natural varianti687 – 6871V → I.1 Publication
Corresponds to variant rs11435 [ dbSNP | Ensembl ].
VAR_029790
Natural varianti710 – 7101G → A.2 Publications
Corresponds to variant rs1056149 [ dbSNP | Ensembl ].
VAR_029791

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 543543Missing in isoform 3. 1 PublicationVSP_040662Add
BLAST
Alternative sequencei1 – 508508Missing in isoform 2. 2 PublicationsVSP_022058Add
BLAST
Alternative sequencei509 – 51911LRKGRSSMRKN → MRKSKWWQRD in isoform 2. 2 PublicationsVSP_022059Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058046 mRNA. Translation: BAB71639.1.
AK074234 mRNA. Translation: BAB85025.1. Different termination.
AK292576 mRNA. Translation: BAF85265.1.
AC005216 Genomic DNA. No translation available.
AC005351 Genomic DNA. No translation available.
AC011359 Genomic DNA. No translation available.
AC091887 Genomic DNA. No translation available.
BC031650 mRNA. Translation: AAH31650.2. Different initiation.
BC073914 mRNA. Translation: AAH73914.1.
BC125106 mRNA. Translation: AAI25107.1.
CCDSiCCDS4280.1. [Q8TEC5-1]
RefSeqiNP_689763.3. NM_152550.3.
XP_006714820.1. XM_006714757.1. [Q8TEC5-1]
XP_011535871.1. XM_011537569.1. [Q8TEC5-1]
UniGeneiHs.443728.

Genome annotation databases

EnsembliENST00000359120; ENSP00000352028; ENSG00000156463. [Q8TEC5-1]
ENST00000511217; ENSP00000424497; ENSG00000156463. [Q8TEC5-1]
GeneIDi153769.
KEGGihsa:153769.
UCSCiuc003lnt.4. human. [Q8TEC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058046 mRNA. Translation: BAB71639.1.
AK074234 mRNA. Translation: BAB85025.1. Different termination.
AK292576 mRNA. Translation: BAF85265.1.
AC005216 Genomic DNA. No translation available.
AC005351 Genomic DNA. No translation available.
AC011359 Genomic DNA. No translation available.
AC091887 Genomic DNA. No translation available.
BC031650 mRNA. Translation: AAH31650.2. Different initiation.
BC073914 mRNA. Translation: AAH73914.1.
BC125106 mRNA. Translation: AAI25107.1.
CCDSiCCDS4280.1. [Q8TEC5-1]
RefSeqiNP_689763.3. NM_152550.3.
XP_006714820.1. XM_006714757.1. [Q8TEC5-1]
XP_011535871.1. XM_011537569.1. [Q8TEC5-1]
UniGeneiHs.443728.

3D structure databases

ProteinModelPortaliQ8TEC5.
SMRiQ8TEC5. Positions 5-78, 123-248, 381-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127517. 33 interactions.
IntActiQ8TEC5. 6 interactions.
STRINGi9606.ENSP00000352028.

PTM databases

PhosphoSiteiQ8TEC5.

Polymorphism and mutation databases

BioMutaiSH3RF2.
DMDMi296452957.

Proteomic databases

EPDiQ8TEC5.
MaxQBiQ8TEC5.
PaxDbiQ8TEC5.
PRIDEiQ8TEC5.
TopDownProteomicsiQ8TEC5-1. [Q8TEC5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359120; ENSP00000352028; ENSG00000156463. [Q8TEC5-1]
ENST00000511217; ENSP00000424497; ENSG00000156463. [Q8TEC5-1]
GeneIDi153769.
KEGGihsa:153769.
UCSCiuc003lnt.4. human. [Q8TEC5-1]

Organism-specific databases

CTDi153769.
GeneCardsiSH3RF2.
HGNCiHGNC:26299. SH3RF2.
HPAiHPA035903.
HPA058119.
MIMi613377. gene.
neXtProtiNX_Q8TEC5.
PharmGKBiPA134944983.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000060125.
HOVERGENiHBG082418.
InParanoidiQ8TEC5.
KOiK12171.
OMAiNMFVALH.
OrthoDBiEOG7HMS0X.
PhylomeDBiQ8TEC5.
TreeFamiTF105571.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiSH3RF2. human.
GenomeRNAii153769.
NextBioi87187.
PROiQ8TEC5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TEC5.
CleanExiHS_SH3RF2.
GenevisibleiQ8TEC5. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1)."
    Chen C.Y., Lai N.S., Yang J.J., Huang H.L., Hung W.C., Li C., Lin T.H., Huang H.B.
    Biochem. Biophys. Res. Commun. 391:698-702(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH PPP1CA, TISSUE SPECIFICITY, MUTAGENESIS OF VAL-643 AND PHE-645.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS VARIANTS VARIANTS CYS-267; ARG-592; ILE-687 AND ALA-710.
    Tissue: Colon and Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS VARIANTS CYS-267; ARG-592 AND ALA-710.
    Tissue: Brain.
  5. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  6. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPP1CA.

Entry informationi

Entry nameiSH3R2_HUMAN
AccessioniPrimary (citable) accession number: Q8TEC5
Secondary accession number(s): A8K961
, Q08AM9, Q6GMR9, Q8N5S8, Q96LP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.