Q8TEB1 (DCA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DDB1- and CUL4-associated factor 11

Alternative name(s):
WD repeat-containing protein 23

Gene names

Name:	DCAF11
Synonyms:	WDR23
ORF Names:	GL014, PRO2389

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Ref.9
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with DDB1 and CUL4A. Ref.9
Sequence similarities	Contains 7 WD repeats.
Sequence caution	The sequence AAG35498.1 differs from that shown. Reason: Erroneous initiation. The sequence AAG44727.1 differs from that shown. Reason: Frameshift at positions 514, 516, 519 and 535. The sequence BAB15698.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein ubiquitination Inferred by curator Ref.9. Source: UniProtKB
Cellular component	CUL4 RING ubiquitin ligase complex Inferred from direct assay Ref.9. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TEB1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TEB1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     45-70: Missing.

Isoform 3 (identifier: Q8TEB1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: MGSRNSSSAG...LGEQSRVISH → MTELGMVVLG...STAFLECCTS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	DDB1- and CUL4-associated factor 11		PRO_0000051371
Regions
	Repeat	170 – 210	41	WD 1
	Repeat	216 – 258	43	WD 2
	Repeat	263 – 302	40	WD 3
	Repeat	305 – 345	41	WD 4
	Repeat	353 – 392	40	WD 5
	Repeat	435 – 480	46	WD 6
	Repeat	481 – 520	40	WD 7
Amino acid modifications
	Modified residue	75	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 159	159	MGSRN…RVISH → MTELGMVVLGIDTTHLWMLP LTPGSWNSMRSRHKWNWPQG SWGLGGPPRSTAFLECCTS in isoform 3.		VSP_008423
	Alternative sequence	45 – 70	26	Missing in isoform 2.		VSP_008424
	Natural variant	207	1	R → H. Ref.1 Ref.6 Ref.7 Corresponds to variant rs3825584 [ dbSNP | Ensembl ].		VAR_020121
Experimental info
	Sequence conflict	125	1	A → P Ref.7
	Sequence conflict	222	1	L → S in AAG35498. Ref.7
	Sequence conflict	331	1	I → KS in AAH08858. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 274A98A59059815D	FASTA	546	61,670
	10 20 30 40 50 60 MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG 70 80 90 100 110 120 GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL 130 140 150 160 170 180 GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY 190 200 210 220 230 240 SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD 250 260 270 280 290 300 YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT 310 320 330 340 350 360 LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF 370 380 390 400 410 420 IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL 430 440 450 460 470 480 KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT 490 500 510 520 530 540 NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST PFSSPQ
	Isoform 2 [UniParc]. Checksum: A6F446919DDF61B0	FASTA	520	58,846
	10 20 30 40 50 60 MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQALLDSE EENDRAWDGR 70 80 90 100 110 120 LGDRYNPPVD ATPDTRELEF NEIKTQVELA TGQLGLRRAA QKHSFPRMLH QRERGLCHRG 130 140 150 160 170 180 SFSLGEQSRV ISHFLPNDLG FTDSYSQKAF CGIYSKDGQI FMSACQDQTI RLYDCRYGRF 190 200 210 220 230 240 RKFKSIKARD VGWSVLDVAF TPDGNHFLYS SWSDYIHICN IYGEGDTHTA LDLRPDERRF 250 260 270 280 290 300 AVFSIAVSSD GREVLGGAND GCLYVFDREQ NRRTLQIESH EDDVNAVAFA DISSQILFSG 310 320 330 340 350 360 GDDAICKVWD RRTMREDDPK PVGALAGHQD GITFIDSKGD ARYLISNSKD QTIKLWDIRR 370 380 390 400 410 420 FSSREGMEAS RQAATQQNWD YRWQQVPKKA WRKLKLPGDS SLMTYRGHGV LHTLIRCRFS 430 440 450 460 470 480 PIHSTGQQFI YSGCSTGKVV VYDLLSGHIV KKLTNHKACV RDVSWHPFEE KIVSSSWDGN 490 500 510 520 LRLWQYRQAE YFQDDMPESE ECASAPAPVP QSSTPFSSPQ
	Isoform 3 [UniParc]. Checksum: F2FE011CF8774B70	FASTA	446	50,675
	10 20 30 40 50 60 MTELGMVVLG IDTTHLWMLP LTPGSWNSMR SRHKWNWPQG SWGLGGPPRS TAFLECCTSF 70 80 90 100 110 120 LPNDLGFTDS YSQKAFCGIY SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS 130 140 150 160 170 180 VLDVAFTPDG NHFLYSSWSD YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV 190 200 210 220 230 240 LGGANDGCLY VFDREQNRRT LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM 250 260 270 280 290 300 REDDPKPVGA LAGHQDGITF IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA 310 320 330 340 350 360 TQQNWDYRWQ QVPKKAWRKL KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC 370 380 390 400 410 420 STGKVVVYDL LSGHIVKKLT NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD 430 440 DMPESEECAS APAPVPQSST PFSSPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), VARIANT HIS-207. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Hepatoma, Lung and Trachea.
[3]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Fetal brain and Neuroblastoma.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-207. Tissue: Brain and Eye.
[7]	"Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-546, VARIANT HIS-207. Tissue: Fetal liver.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-546. Tissue: Testis.
[9]	"A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1." Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C. Mol. Cell 23:709-721(2006) [PubMed: 16949367] [Abstract] Cited for: FUNCTION, INTERACTION WITH DDB1 AND CUL4A, IDENTIFICATION BY MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF267858 mRNA. Translation: AAG44727.1. Frameshift. AK027223 mRNA. Translation: BAB15698.1. Different initiation. AK057636 mRNA. Translation: BAG51945.1. AK074296 mRNA. Translation: BAB85041.1. BX161405 mRNA. Translation: CAD61885.1. BX247970 mRNA. Translation: CAD62308.1. AL136295 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW66110.1. CH471078 Genomic DNA. Translation: EAW66111.1. CH471078 Genomic DNA. Translation: EAW66112.1. CH471078 Genomic DNA. Translation: EAW66113.1. CH471078 Genomic DNA. Translation: EAW66114.1. BC008858 mRNA. Translation: AAH08858.2. BC067132 mRNA. Translation: AAH67132.1. AF130070 mRNA. Translation: AAG35498.1. Different initiation. AL833831 mRNA. Translation: CAD38691.1.
IPI	IPI00178972. IPI00328589. IPI00328631.
RefSeq	NP_001156956.1. NM_001163484.1. NP_079506.3. NM_025230.4. NP_852002.1. NM_181357.2.
UniGene	Hs.525251.
3D structure databases
ProteinModelPortal	Q8TEB1.
SMR	Q8TEB1. Positions 169-521.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TEB1. 6 interactions.
STRING	Q8TEB1.
PTM databases
PhosphoSite	Q8TEB1.
Polymorphism databases
DMDM	37538034.
Proteomic databases
PRIDE	Q8TEB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326009; ENSP00000323680; ENSG00000100897.
GeneID	80344.
KEGG	hsa:80344.
UCSC	uc001wlv.1. human. uc001wlx.1. human. uc001wlz.1. human.
Organism-specific databases
CTD	80344.
GeneCards	GC14P024583.
H-InvDB	HIX0011553.
HGNC	HGNC:20258. DCAF11.
HPA	HPA031157.
MIM	613317. gene.
neXtProt	NX_Q8TEB1.
PharmGKB	PA134895487.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14539.
GeneTree	ENSGT00600000084531.
HOVERGEN	HBG055176.
InParanoid	Q8TEB1.
OMA	DVSWHPY.
OrthoDB	EOG44TP7K.
PhylomeDB	Q8TEB1.
Gene expression databases
ArrayExpress	Q8TEB1.
Bgee	Q8TEB1.
CleanEx	HS_WDR23.
Genevestigator	Q8TEB1.
GermOnline	ENSG00000100897. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. IPR017399. WD_repeat_p23. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K11801.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
PIRSF	PIRSF038135. WD_repeat_p23. 1 hit.
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	70930.
SOURCE	Search...

Entry information

Entry name

DCA11_HUMAN

Accession

Primary (citable) accession number: Q8TEB1
Secondary accession number(s): B3KQ83 , D3DS56, Q5D039, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.