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Protein

DDB1- and CUL4-associated factor 11

Gene

DCAF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664. Neddylation.
SignaLinkiQ8TEB1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 11
Alternative name(s):
WD repeat-containing protein 23
Gene namesi
Name:DCAF11
Synonyms:WDR23
ORF Names:GL014, PRO2389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100897.17.
HGNCiHGNC:20258. DCAF11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100897.
PharmGKBiPA165478701.

Polymorphism and mutation databases

BioMutaiDCAF11.
DMDMi37538034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513711 – 546DDB1- and CUL4-associated factor 11Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineBy similarity1
Isoform 2 (identifier: Q8TEB1-2)
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TEB1.
MaxQBiQ8TEB1.
PaxDbiQ8TEB1.
PeptideAtlasiQ8TEB1.
PRIDEiQ8TEB1.

PTM databases

iPTMnetiQ8TEB1.
PhosphoSitePlusiQ8TEB1.

Expressioni

Gene expression databases

BgeeiENSG00000100897.
CleanExiHS_WDR23.
ExpressionAtlasiQ8TEB1. baseline and differential.
GenevisibleiQ8TEB1. HS.

Organism-specific databases

HPAiHPA003583.
HPA031157.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
vifP125043EBI-2213388,EBI-779991From Human immunodeficiency virus type 1 group M subtype B (isolate NY5).

Protein-protein interaction databases

BioGridi123251. 54 interactors.
IntActiQ8TEB1. 15 interactors.
STRINGi9606.ENSP00000415556.

Structurei

3D structure databases

ProteinModelPortaliQ8TEB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati170 – 210WD 1Add BLAST41
Repeati216 – 258WD 2Add BLAST43
Repeati263 – 302WD 3Add BLAST40
Repeati305 – 345WD 4Add BLAST41
Repeati353 – 392WD 5Add BLAST40
Repeati435 – 480WD 6Add BLAST46
Repeati481 – 520WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ14. Eukaryota.
ENOG410XP4W. LUCA.
GeneTreeiENSGT00720000108873.
HOVERGENiHBG055176.
InParanoidiQ8TEB1.
KOiK11801.
OMAiHFLYSSW.
OrthoDBiEOG091G07OQ.
PhylomeDBiQ8TEB1.
TreeFamiTF314126.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR017399. DCAF11/LEC14B.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 3 hits.
PIRSFiPIRSF038135. WD_repeat_p23. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL
60 70 80 90 100
RRGQVRLVQG GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD
110 120 130 140 150
TRELEFNEIK TQVELATGQL GLRRAAQKHS FPRMLHQRER GLCHRGSFSL
160 170 180 190 200
GEQSRVISHF LPNDLGFTDS YSQKAFCGIY SKDGQIFMSA CQDQTIRLYD
210 220 230 240 250
CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD YIHICNIYGE
260 270 280 290 300
GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
310 320 330 340 350
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA
360 370 380 390 400
LAGHQDGITF IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA
410 420 430 440 450
TQQNWDYRWQ QVPKKAWRKL KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS
460 470 480 490 500
TGQQFIYSGC STGKVVVYDL LSGHIVKKLT NHKACVRDVS WHPFEEKIVS
510 520 530 540
SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST PFSSPQ
Length:546
Mass (Da):61,670
Last modified:June 1, 2002 - v1
Checksum:i274A98A59059815D
GO
Isoform 2 (identifier: Q8TEB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-70: Missing.

Show »
Length:520
Mass (Da):58,846
Checksum:iA6F446919DDF61B0
GO
Isoform 3 (identifier: Q8TEB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: MGSRNSSSAG...LGEQSRVISH → MTELGMVVLG...STAFLECCTS

Show »
Length:446
Mass (Da):50,675
Checksum:iF2FE011CF8774B70
GO

Sequence cautioni

Q8TEB1: The sequence AAG35498 differs from that shown. Reason: Erroneous initiation.Curated
Q8TEB1: The sequence AAG44727 differs from that shown. Reason: Frameshift at positions 514, 516, 519 and 535.Curated
Q8TEB1: The sequence BAB15698 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125A → P (Ref. 7) Curated1
Sequence conflicti222L → S in AAG35498 (Ref. 7) Curated1
Sequence conflicti331I → KS in AAH08858 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020121207R → H3 PublicationsCorresponds to variant dbSNP:rs3825584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0084231 – 159MGSRN…RVISH → MTELGMVVLGIDTTHLWMLP LTPGSWNSMRSRHKWNWPQG SWGLGGPPRSTAFLECCTS in isoform 3. 1 PublicationAdd BLAST159
Alternative sequenceiVSP_00842445 – 70Missing in isoform 2. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267858 mRNA. Translation: AAG44727.1. Frameshift.
AK027223 mRNA. Translation: BAB15698.1. Different initiation.
AK057636 mRNA. Translation: BAG51945.1.
AK074296 mRNA. Translation: BAB85041.1.
BX161405 mRNA. Translation: CAD61885.1.
BX247970 mRNA. Translation: CAD62308.1.
AL136295 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66110.1.
CH471078 Genomic DNA. Translation: EAW66111.1.
CH471078 Genomic DNA. Translation: EAW66112.1.
CH471078 Genomic DNA. Translation: EAW66113.1.
CH471078 Genomic DNA. Translation: EAW66114.1.
BC008858 mRNA. Translation: AAH08858.2.
BC067132 mRNA. Translation: AAH67132.1.
AF130070 mRNA. Translation: AAG35498.1. Different initiation.
AL833831 mRNA. Translation: CAD38691.1.
CCDSiCCDS41929.1. [Q8TEB1-2]
CCDS9610.1. [Q8TEB1-1]
RefSeqiNP_001156956.1. NM_001163484.1. [Q8TEB1-1]
NP_079506.3. NM_025230.4. [Q8TEB1-1]
NP_852002.1. NM_181357.2. [Q8TEB1-2]
UniGeneiHs.525251.

Genome annotation databases

EnsembliENST00000396936; ENSP00000380142; ENSG00000100897. [Q8TEB1-3]
ENST00000396941; ENSP00000380146; ENSG00000100897. [Q8TEB1-2]
ENST00000446197; ENSP00000415556; ENSG00000100897. [Q8TEB1-1]
ENST00000559115; ENSP00000452898; ENSG00000100897. [Q8TEB1-1]
GeneIDi80344.
KEGGihsa:80344.
UCSCiuc001wlv.4. human. [Q8TEB1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCA11_HUMAN
AccessioniPrimary (citable) accession number: Q8TEB1
Secondary accession number(s): B3KQ83
, D3DS56, Q5D039, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways