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Protein

DDB1- and CUL4-associated factor 11

Gene

DCAF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ8TEB1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 11
Alternative name(s):
WD repeat-containing protein 23
Gene namesi
Name:DCAF11
Synonyms:WDR23
ORF Names:GL014, PRO2389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20258. DCAF11.

Subcellular locationi

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478701.

Polymorphism and mutation databases

BioMutaiDCAF11.
DMDMi37538034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546DDB1- and CUL4-associated factor 11PRO_0000051371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineBy similarity
Isoform 2 (identifier: Q8TEB1-2)
Modified residuei49 – 491PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TEB1.
MaxQBiQ8TEB1.
PaxDbiQ8TEB1.
PRIDEiQ8TEB1.

PTM databases

iPTMnetiQ8TEB1.
PhosphoSiteiQ8TEB1.

Expressioni

Gene expression databases

BgeeiQ8TEB1.
CleanExiHS_WDR23.
ExpressionAtlasiQ8TEB1. baseline and differential.
GenevisibleiQ8TEB1. HS.

Organism-specific databases

HPAiHPA003583.
HPA031157.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
vifP125043EBI-2213388,EBI-779991From a different organism.

Protein-protein interaction databases

BioGridi123251. 43 interactions.
IntActiQ8TEB1. 13 interactions.
STRINGi9606.ENSP00000415556.

Structurei

3D structure databases

ProteinModelPortaliQ8TEB1.
SMRiQ8TEB1. Positions 180-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati170 – 21041WD 1Add
BLAST
Repeati216 – 25843WD 2Add
BLAST
Repeati263 – 30240WD 3Add
BLAST
Repeati305 – 34541WD 4Add
BLAST
Repeati353 – 39240WD 5Add
BLAST
Repeati435 – 48046WD 6Add
BLAST
Repeati481 – 52040WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ14. Eukaryota.
ENOG410XP4W. LUCA.
GeneTreeiENSGT00720000108873.
HOVERGENiHBG055176.
InParanoidiQ8TEB1.
KOiK11801.
OMAiQDDMPES.
OrthoDBiEOG7NSB2H.
PhylomeDBiQ8TEB1.
TreeFamiTF314126.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017399. DCAF11/LEC14B.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PIRSFiPIRSF038135. WD_repeat_p23. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TEB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL
60 70 80 90 100
RRGQVRLVQG GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD
110 120 130 140 150
TRELEFNEIK TQVELATGQL GLRRAAQKHS FPRMLHQRER GLCHRGSFSL
160 170 180 190 200
GEQSRVISHF LPNDLGFTDS YSQKAFCGIY SKDGQIFMSA CQDQTIRLYD
210 220 230 240 250
CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD YIHICNIYGE
260 270 280 290 300
GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
310 320 330 340 350
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA
360 370 380 390 400
LAGHQDGITF IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA
410 420 430 440 450
TQQNWDYRWQ QVPKKAWRKL KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS
460 470 480 490 500
TGQQFIYSGC STGKVVVYDL LSGHIVKKLT NHKACVRDVS WHPFEEKIVS
510 520 530 540
SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST PFSSPQ
Length:546
Mass (Da):61,670
Last modified:June 1, 2002 - v1
Checksum:i274A98A59059815D
GO
Isoform 2 (identifier: Q8TEB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-70: Missing.

Show »
Length:520
Mass (Da):58,846
Checksum:iA6F446919DDF61B0
GO
Isoform 3 (identifier: Q8TEB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: MGSRNSSSAG...LGEQSRVISH → MTELGMVVLG...STAFLECCTS

Show »
Length:446
Mass (Da):50,675
Checksum:iF2FE011CF8774B70
GO

Sequence cautioni

The sequence AAG35498.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAG44727.1 differs from that shown. Reason: Frameshift at positions 514, 516, 519 and 535. Curated
The sequence BAB15698.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251A → P (Ref. 7) Curated
Sequence conflicti222 – 2221L → S in AAG35498 (Ref. 7) Curated
Sequence conflicti331 – 3311I → KS in AAH08858 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti207 – 2071R → H.3 Publications
Corresponds to variant rs3825584 [ dbSNP | Ensembl ].
VAR_020121

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 159159MGSRN…RVISH → MTELGMVVLGIDTTHLWMLP LTPGSWNSMRSRHKWNWPQG SWGLGGPPRSTAFLECCTS in isoform 3. 1 PublicationVSP_008423Add
BLAST
Alternative sequencei45 – 7026Missing in isoform 2. 2 PublicationsVSP_008424Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267858 mRNA. Translation: AAG44727.1. Frameshift.
AK027223 mRNA. Translation: BAB15698.1. Different initiation.
AK057636 mRNA. Translation: BAG51945.1.
AK074296 mRNA. Translation: BAB85041.1.
BX161405 mRNA. Translation: CAD61885.1.
BX247970 mRNA. Translation: CAD62308.1.
AL136295 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66110.1.
CH471078 Genomic DNA. Translation: EAW66111.1.
CH471078 Genomic DNA. Translation: EAW66112.1.
CH471078 Genomic DNA. Translation: EAW66113.1.
CH471078 Genomic DNA. Translation: EAW66114.1.
BC008858 mRNA. Translation: AAH08858.2.
BC067132 mRNA. Translation: AAH67132.1.
AF130070 mRNA. Translation: AAG35498.1. Different initiation.
AL833831 mRNA. Translation: CAD38691.1.
CCDSiCCDS41929.1. [Q8TEB1-2]
CCDS9610.1. [Q8TEB1-1]
RefSeqiNP_001156956.1. NM_001163484.1. [Q8TEB1-1]
NP_079506.3. NM_025230.4. [Q8TEB1-1]
NP_852002.1. NM_181357.2. [Q8TEB1-2]
UniGeneiHs.525251.

Genome annotation databases

EnsembliENST00000396936; ENSP00000380142; ENSG00000100897. [Q8TEB1-3]
ENST00000396941; ENSP00000380146; ENSG00000100897. [Q8TEB1-2]
ENST00000446197; ENSP00000415556; ENSG00000100897. [Q8TEB1-1]
ENST00000559115; ENSP00000452898; ENSG00000100897. [Q8TEB1-1]
GeneIDi80344.
KEGGihsa:80344.
UCSCiuc001wlv.4. human. [Q8TEB1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267858 mRNA. Translation: AAG44727.1. Frameshift.
AK027223 mRNA. Translation: BAB15698.1. Different initiation.
AK057636 mRNA. Translation: BAG51945.1.
AK074296 mRNA. Translation: BAB85041.1.
BX161405 mRNA. Translation: CAD61885.1.
BX247970 mRNA. Translation: CAD62308.1.
AL136295 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66110.1.
CH471078 Genomic DNA. Translation: EAW66111.1.
CH471078 Genomic DNA. Translation: EAW66112.1.
CH471078 Genomic DNA. Translation: EAW66113.1.
CH471078 Genomic DNA. Translation: EAW66114.1.
BC008858 mRNA. Translation: AAH08858.2.
BC067132 mRNA. Translation: AAH67132.1.
AF130070 mRNA. Translation: AAG35498.1. Different initiation.
AL833831 mRNA. Translation: CAD38691.1.
CCDSiCCDS41929.1. [Q8TEB1-2]
CCDS9610.1. [Q8TEB1-1]
RefSeqiNP_001156956.1. NM_001163484.1. [Q8TEB1-1]
NP_079506.3. NM_025230.4. [Q8TEB1-1]
NP_852002.1. NM_181357.2. [Q8TEB1-2]
UniGeneiHs.525251.

3D structure databases

ProteinModelPortaliQ8TEB1.
SMRiQ8TEB1. Positions 180-519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123251. 43 interactions.
IntActiQ8TEB1. 13 interactions.
STRINGi9606.ENSP00000415556.

PTM databases

iPTMnetiQ8TEB1.
PhosphoSiteiQ8TEB1.

Polymorphism and mutation databases

BioMutaiDCAF11.
DMDMi37538034.

Proteomic databases

EPDiQ8TEB1.
MaxQBiQ8TEB1.
PaxDbiQ8TEB1.
PRIDEiQ8TEB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396936; ENSP00000380142; ENSG00000100897. [Q8TEB1-3]
ENST00000396941; ENSP00000380146; ENSG00000100897. [Q8TEB1-2]
ENST00000446197; ENSP00000415556; ENSG00000100897. [Q8TEB1-1]
ENST00000559115; ENSP00000452898; ENSG00000100897. [Q8TEB1-1]
GeneIDi80344.
KEGGihsa:80344.
UCSCiuc001wlv.4. human. [Q8TEB1-1]

Organism-specific databases

CTDi80344.
GeneCardsiDCAF11.
HGNCiHGNC:20258. DCAF11.
HPAiHPA003583.
HPA031157.
MIMi613317. gene.
neXtProtiNX_Q8TEB1.
PharmGKBiPA165478701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ14. Eukaryota.
ENOG410XP4W. LUCA.
GeneTreeiENSGT00720000108873.
HOVERGENiHBG055176.
InParanoidiQ8TEB1.
KOiK11801.
OMAiQDDMPES.
OrthoDBiEOG7NSB2H.
PhylomeDBiQ8TEB1.
TreeFamiTF314126.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ8TEB1.

Miscellaneous databases

GenomeRNAii80344.
PROiQ8TEB1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TEB1.
CleanExiHS_WDR23.
ExpressionAtlasiQ8TEB1. baseline and differential.
GenevisibleiQ8TEB1. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017399. DCAF11/LEC14B.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PIRSFiPIRSF038135. WD_repeat_p23. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), VARIANT HIS-207.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hepatoma, Lung and Trachea.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Fetal brain and Neuroblastoma.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-207.
    Tissue: Brain and Eye.
  7. "Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-546, VARIANT HIS-207.
    Tissue: Fetal liver.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-546.
    Tissue: Testis.
  9. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."
    Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C.
    Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDB1 AND CUL4A, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."
    Angers S., Li T., Yi X., MacCoss M.J., Moon R.T., Zheng N.
    Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDCA11_HUMAN
AccessioniPrimary (citable) accession number: Q8TEB1
Secondary accession number(s): B3KQ83
, D3DS56, Q5D039, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.