Q8TEA8 (DTD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-tyrosyl-tRNA(Tyr) deacylase 1
EC=3.1.-.-

Alternative name(s):
Histidyl-tRNA synthase-related

Gene names

Name:	DTD1
Synonyms:	C20orf88, HARS2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine Potential.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. Ref.1
Sequence similarities	Belongs to the DTD family.
Sequence caution	The sequence BAB85044.1 differs from that shown. Reason: Presence of Alu-repeat DNA.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-amino acid catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular_function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 209

209

D-tyrosyl-tRNA(Tyr) deacylase 1

PRO_0000164626

Sites

Active site

81

1

Nucleophile By similarity

Amino acid modifications

Modified residue

196

1

Phosphoserine By similarity

Modified residue

197

1

Phosphoserine Ref.7 Ref.8 Ref.11

Modified residue

205

1

Phosphoserine Ref.7 Ref.8

Experimental info

Sequence conflict

94

1

H → N in AAH45167. Ref.5

Sequence conflict

134

1

H → R in AAL57046. Ref.1

Secondary structure

1

.

.

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209

Helix Strand Turn

Details...

Beta strand

2 – 15

14

Beta strand

18 – 32

15

Helix

39 – 51

13

Helix

67 – 70

4

Beta strand

73 – 78

6

Helix

80 – 82

3

Beta strand

87 – 90

4

Helix

99 – 116

18

Helix

119 – 121

3

Beta strand

122 – 124

3

Beta strand

131 – 146

16

Sequences

	Sequence		Length	Mass (Da)
	Q8TEA8 [UniParc]. Last modified March 28, 2003. Version 2. Checksum: F006ED14974ACC92	FASTA	209	23,424
	10 20 30 40 50 60 MKAVVQRVTR ASVTVGGEQI SAIGRGICVL LGISLEDTQK ELEHMVRKIL NLRVFEDESG 70 80 90 100 110 120 KHWSKSVMDK QYEILCVSQF TLQCVLKGNK PDFHLAMPTE QAEGFYNSFL EQLRKTYRPE 130 140 150 160 170 180 LIKDGKFGAY MQVHIQNDGP VTIELESPAP GTATSDPKQL SKLEKQQQRK EKTRAKGPSE 190 200 SSKERNTPRK EDRSASSGAE GDVSSEREP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and identification of a novel cDNA which may be associated with FKBP25." Meng X.X., Chen J.J., Yang Q.Q., Wang S., Chao Y., Ying K., Xie Y., Mao Y. Biochem. Genet. 40:303-310(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Hepatoma.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin.
[6]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND SER-205, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND SER-205, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF332356 mRNA. Translation: AAL57046.1.
AK074304 mRNA. Translation: BAB85044.1. Sequence problems.
AK291440 mRNA. Translation: BAF84129.1.
AL121900, AL121780 Genomic DNA. Translation: CAH73147.1.
AL121780, AL121900 Genomic DNA. Translation: CAI15669.1.
CH471133 Genomic DNA. Translation: EAX10227.1.
BC000599 mRNA. No translation available.
CH471133 Genomic DNA. Translation: EAX10228.1.
BC045167 mRNA. Translation: AAH45167.1.
BC100923 mRNA. Translation: AAI00924.1.
BC100924 mRNA. Translation: AAI00925.1.
BC100925 mRNA. Translation: AAI00926.1.

IPI

IPI00152692.

RefSeq

NP_543010.3. NM_080820.4.

UniGene

Hs.659442.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OKV	X-ray	2.00	A/B/C/D	1-209	[»]

ProteinModelPortal

Q8TEA8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8TEA8. 1 interaction.

STRING

9606.ENSP00000366672.

PTM databases

PhosphoSite

Q8TEA8.

Polymorphism databases

DMDM

29427856.

Proteomic databases

PaxDb

Q8TEA8.

PeptideAtlas

Q8TEA8.

PRIDE

Q8TEA8.

Protocols and materials databases

DNASU

92675.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000377452; ENSP00000366672; ENSG00000125821.

GeneID

92675.

KEGG

hsa:92675.

UCSC

uc002wrf.4. human.

Organism-specific databases

CTD

92675.

GeneCards

GC20P018568.

HGNC

HGNC:16219. DTD1.

HPA

HPA040981.

MIM

610996. gene.

neXtProt

NX_Q8TEA8.

PharmGKB

PA162384107.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1490.

HOVERGEN

HBG039436.

InParanoid

Q8TEA8.

KO

K07560.

OMA

DGPVTIW.

OrthoDB

EOG48WC2Z.

PhylomeDB

Q8TEA8.

Gene expression databases

Bgee

Q8TEA8.

CleanEx

HS_DTD1.
HS_HARS2.

Genevestigator

Q8TEA8.

GermOnline

ENSG00000125821. Homo sapiens.

Family and domain databases

Gene3D

3.50.80.10. 1 hit.

InterPro

IPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view]

PANTHER

PTHR10472. PTHR10472. 1 hit.

Pfam

PF02580. Tyr_Deacylase. 1 hit.
[Graphical view]

SUPFAM

SSF69500. DTyrtRNA_deacyls. 1 hit.

TIGRFAMs

TIGR00256. TIGR00256. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

DTD1. human.

EvolutionaryTrace

Q8TEA8.

GenomeRNAi

92675.

NextBio

77831.

SOURCE

Search...

Entry information

Entry name

DTD1_HUMAN

Accession

Primary (citable) accession number: Q8TEA8
Secondary accession number(s): A8K5X5 , D3DW37, Q496D1, Q5W184, Q8WXU8, Q9BW67, Q9H464, Q9H474

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 28, 2003
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.