Q8TEA7 (TBCK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TBC domain-containing protein kinase-like protein

Gene names

Name:	TBCK
Synonyms:	TBCKL
ORF Names:	HSPC302

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	893 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Contains 1 protein kinase domain. Contains 1 Rab-GAP TBC domain. Contains 1 rhodanese domain.
Sequence caution	The sequence AAF28980.1 differs from that shown. Reason: Frameshift at positions 507, 516, 660, 665 and 672. The sequence BAC05244.1 differs from that shown. Reason: intron retention.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of Rab GTPase activity Inferred from electronic annotation. Source: GOC
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro Rab GTPase activator activity Inferred from electronic annotation. Source: InterPro transferase activity, transferring phosphorus-containing groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: Q8TEA7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.5 (identifier: Q8TEA7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     161-199: Missing.

Note: No experimental confirmation available.

Isoform 3 Ref.5 (identifier: Q8TEA7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     89-152: SCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIG → R

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 893	893	TBC domain-containing protein kinase-like protein		PRO_0000273278
Regions
	Domain	1 – 273	273	Protein kinase
	Domain	466 – 651	186	Rab-GAP TBC
	Domain	790 – 889	100	Rhodanese
Natural variations
	Alternative sequence	89 – 152	64	SCSTV…DFPIG → R in isoform 3. Ref.5		VSP_052274
	Alternative sequence	161 – 199	39	Missing in isoform 2. Ref.5		VSP_052275
	Natural variant	66	1	R → L. Ref.8		VAR_041380
	Natural variant	151	1	I → M. Ref.8		VAR_041381
	Natural variant	265	1	D → N. Ref.8		VAR_041382
	Natural variant	266	1	Q → E. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs3775091 [ dbSNP | Ensembl ].		VAR_030123
	Natural variant	425	1	T → M. Ref.8		VAR_041383
	Natural variant	471	1	M → I. Ref.8		VAR_041384
	Natural variant	489	1	K → N. Ref.8 Corresponds to variant rs2305685 [ dbSNP | Ensembl ].		VAR_030124
	Natural variant	503	1	R → I in a colorectal adenocarcinoma sample; somatic mutation. Ref.8		VAR_041385
	Natural variant	692	1	R → C. Ref.8		VAR_041386
	Natural variant	806	1	I → V in a head & Neck squamous cell carcinoma sample; somatic mutation. Ref.8		VAR_041387
Experimental info
	Sequence conflict	601	1	I → N in AAF28980. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 4. Checksum: 7B5A11E37A49D03B	FASTA	893	100,679
	10 20 30 40 50 60 MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 70 80 90 100 110 120 RGKHERLVVV AEHCERSLED LLRERKPVSC STVLCIAFEV LQGLQYMNKH GIVHRALSPH 130 140 150 160 170 180 NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHMPSKKPLP 190 200 210 220 230 240 SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTLIVLA EEHGCLDIIK 250 260 270 280 290 300 ELPETVIDLL NKCLTFHPSK RPTPDQLMKD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 310 320 330 340 350 360 LPEDISQLCK DINNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 370 380 390 400 410 420 EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 430 440 450 460 470 480 SAAATLPLII REKDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 490 500 510 520 530 540 GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 550 560 570 580 590 600 DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 610 620 630 640 650 660 IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 670 680 690 700 710 720 AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPS 730 740 750 760 770 780 SDSSGGRSSA PYFSAECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 790 800 810 820 830 840 KTPSKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPYTAMLQNF 850 860 870 880 890 KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTIPS PQI
	Isoform 2 [UniParc]. Checksum: DBF6940FE6D8D60C	FASTA	854	96,443
	10 20 30 40 50 60 MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 70 80 90 100 110 120 RGKHERLVVV AEHCERSLED LLRERKPVSC STVLCIAFEV LQGLQYMNKH GIVHRALSPH 130 140 150 160 170 180 NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE GRKLFQSLDI SERLKFLLTL 190 200 210 220 230 240 DCVDDTLIVL AEEHGCLDII KELPETVIDL LNKCLTFHPS KRPTPDQLMK DKVFSEVSPL 250 260 270 280 290 300 YTPFTKPASL FSSSLRCADL TLPEDISQLC KDINNDYLAE RSIEEVYYLW CLAGGDLEKE 310 320 330 340 350 360 LVNKEIIRSK PPICTLPNFL FEDGESFGQG RDRSSLLDDT TVTLSLCQLR NRLKDVGGEA 370 380 390 400 410 420 FYPLLEDDQS NLPHSNSNNE LSAAATLPLI IREKDTEYQL NRIILFDRLL KAYPYKKNQI 430 440 450 460 470 480 WKEARVDIPP LMRGLTWAAL LGVEGAIHAK YDAIDKDTPI PTDRQIEVDI PRCHQYDELL 490 500 510 520 530 540 SSPEGHAKFR RVLKAWVVSH PDLVYWQGLD SLCAPFLYLN FNNEALAYAC MSAFIPKYLY 550 560 570 580 590 600 NFFLKDNSHV IQEYLTVFSQ MIAFHDPELS NHLNEIGFIP DLYAIPWFLT MFTHVFPLHK 610 620 630 640 650 660 IFHLWDTLLL GNSSFPFCIG VAILQQLRDR LLANGFNECI LLFSDLPEID IERCVRESIN 670 680 690 700 710 720 LFCWTPKSAT YRQHAQPPKP SSDSSGGRSS APYFSAECPD PPKTDLSRES IPLNDLKSEV 730 740 750 760 770 780 SPRISAEDLI DLCELTVTGH FKTPSKKTKS SKPKLLVVDI RNSEDFIRGH ISGSINIPFS 790 800 810 820 830 840 AAFTAEGELT QGPYTAMLQN FKGKVIVIVG HVAKHTAEFA AHLVKMKYPR ICILDGGINK 850 IKPTGLLTIP SPQI
	Isoform 3 [UniParc]. Checksum: 010755C970CC33F1	FASTA	830	93,725
	10 20 30 40 50 60 MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 70 80 90 100 110 120 RGKHERLVVV AEHCERSLED LLRERKPVRY PSYLAPEVIA QGIFKTTDHM PSKKPLPSGP 130 140 150 160 170 180 KSDVWSLGII LFELCVGRKL FQSLDISERL KFLLTLDCVD DTLIVLAEEH GCLDIIKELP 190 200 210 220 230 240 ETVIDLLNKC LTFHPSKRPT PDQLMKDKVF SEVSPLYTPF TKPASLFSSS LRCADLTLPE 250 260 270 280 290 300 DISQLCKDIN NDYLAERSIE EVYYLWCLAG GDLEKELVNK EIIRSKPPIC TLPNFLFEDG 310 320 330 340 350 360 ESFGQGRDRS SLLDDTTVTL SLCQLRNRLK DVGGEAFYPL LEDDQSNLPH SNSNNELSAA 370 380 390 400 410 420 ATLPLIIREK DTEYQLNRII LFDRLLKAYP YKKNQIWKEA RVDIPPLMRG LTWAALLGVE 430 440 450 460 470 480 GAIHAKYDAI DKDTPIPTDR QIEVDIPRCH QYDELLSSPE GHAKFRRVLK AWVVSHPDLV 490 500 510 520 530 540 YWQGLDSLCA PFLYLNFNNE ALAYACMSAF IPKYLYNFFL KDNSHVIQEY LTVFSQMIAF 550 560 570 580 590 600 HDPELSNHLN EIGFIPDLYA IPWFLTMFTH VFPLHKIFHL WDTLLLGNSS FPFCIGVAIL 610 620 630 640 650 660 QQLRDRLLAN GFNECILLFS DLPEIDIERC VRESINLFCW TPKSATYRQH AQPPKPSSDS 670 680 690 700 710 720 SGGRSSAPYF SAECPDPPKT DLSRESIPLN DLKSEVSPRI SAEDLIDLCE LTVTGHFKTP 730 740 750 760 770 780 SKKTKSSKPK LLVVDIRNSE DFIRGHISGS INIPFSAAFT AEGELTQGPY TAMLQNFKGK 790 800 810 820 830 VIVIVGHVAK HTAEFAAHLV KMKYPRICIL DGGINKIKPT GLLTIPSPQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity." Ishibashi K., Kanno E., Itoh T., Fukuda M. Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-266. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-893 (ISOFORMS 1/2/3), VARIANT GLU-266. Tissue: Hepatoma and Trachea.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-266.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 608-893 (ISOFORMS 1/2/3). Tissue: Lymph, Placenta and Prostate.
[6]	"Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-893 (ISOFORMS 1/2/3), VARIANT GLU-266. Tissue: Umbilical cord blood.
[7]	"The protein kinase complement of the human genome." Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[8]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-66; MET-151; ASN-265; MET-425; ILE-471; ASN-489; ILE-503; CYS-692 AND VAL-806.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB449876 mRNA. Translation: BAH16619.1. AK074305 mRNA. Translation: BAB85045.1. AK098157 mRNA. Translation: BAC05244.1. Sequence problems. AC093680 Genomic DNA. No translation available. AC107381 Genomic DNA. Translation: AAY40979.1. AC109361 Genomic DNA. No translation available. AC114734 Genomic DNA. Translation: AAY41041.1. AC125469 Genomic DNA. No translation available. AP001820 Genomic DNA. No translation available. CH471057 Genomic DNA. Translation: EAX06201.1. BC009208 mRNA. Translation: AAH09208.2. BC020853 mRNA. Translation: AAH20853.2. BC068496 mRNA. Translation: AAH68496.1. AF161420 mRNA. Translation: AAF28980.1. Frameshift.
IPI	IPI00062810. IPI00291665. IPI00791217.
RefSeq	NP_001156907.1. NM_001163435.1. NP_001156908.1. NM_001163436.1. NP_001156909.1. NM_001163437.1. NP_149106.2. NM_033115.3.
UniGene	Hs.292986.
3D structure databases
ProteinModelPortal	Q8TEA7.
ModBase	Search...
PTM databases
PhosphoSite	Q8TEA7.
Polymorphism databases
DMDM	269849737.
Proteomic databases
PaxDb	Q8TEA7.
PRIDE	Q8TEA7.
Protocols and materials databases
DNASU	93627.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273980; ENSP00000273980; ENSG00000145348. ENST00000361687; ENSP00000355338; ENSG00000145348. ENST00000394706; ENSP00000378196; ENSG00000145348. ENST00000394708; ENSP00000378198; ENSG00000145348. ENST00000432496; ENSP00000405847; ENSG00000145348.
GeneID	93627.
KEGG	hsa:93627.
UCSC	uc003hyb.2. human. uc003hyc.2. human. uc003hye.2. human.
Organism-specific databases
CTD	93627.
GeneCards	GC04M106967.
HGNC	HGNC:28261. TBCK.
HPA	HPA039951.
neXtProt	NX_Q8TEA7.
PharmGKB	PA165664603.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5210.
HOVERGEN	HBG055536.
InParanoid	Q8TEA7.
OMA	PRVCILD.
OrthoDB	EOG4NCMC1.
PhylomeDB	Q8TEA7.
Gene expression databases
ArrayExpress	Q8TEA7.
Bgee	Q8TEA7.
Genevestigator	Q8TEA7.
Family and domain databases
Gene3D	3.40.250.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR000195. Rab-GTPase-TBC_dom. IPR001763. Rhodanese-like_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00566. RabGAP-TBC. 1 hit. PF00581. Rhodanese. 1 hit. [Graphical view]
SMART	SM00450. RHOD. 1 hit. SM00164. TBC. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF47923. RabGAP_TBC. 2 hits. SSF52821. Rhodanese-like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50206. RHODANESE_3. 1 hit. PS50086. TBC_RABGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	93627.
NextBio	78173.

Entry information

Entry name

TBCK_HUMAN

Accession

Primary (citable) accession number: Q8TEA7
Secondary accession number(s): B9A6J1 , Q4W5B3, Q4W5E1, Q6NUP4, Q8N7M8, Q8WW57, Q96GV6, Q9P080

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 83 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.