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Q8TEA1

- NSUN6_HUMAN

UniProt

Q8TEA1 - NSUN6_HUMAN

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Protein
Putative methyltransferase NSUN6
Gene
NSUN6, NOPD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May have S-adenosyl-L-methionine-dependent methyl-transferase activity Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei266 – 2661S-adenosyl-L-methionine By similarity
Binding sitei293 – 2931S-adenosyl-L-methionine By similarity
Binding sitei323 – 3231S-adenosyl-L-methionine By similarity
Active sitei373 – 3731Nucleophile By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. methyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase NSUN6 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family member 6
Gene namesi
Name:NSUN6
Synonyms:NOPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23529. NSUN6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Putative methyltransferase NSUN6
PRO_0000263114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8TEA1.
PaxDbiQ8TEA1.
PeptideAtlasiQ8TEA1.
PRIDEiQ8TEA1.

PTM databases

PhosphoSiteiQ8TEA1.

Expressioni

Gene expression databases

BgeeiQ8TEA1.
CleanExiHS_NSUN6.
GenevestigatoriQ8TEA1.

Organism-specific databases

HPAiHPA045902.

Interactioni

Protein-protein interaction databases

BioGridi128682. 1 interaction.
STRINGi9606.ENSP00000366519.

Structurei

3D structure databases

ProteinModelPortaliQ8TEA1.
SMRiQ8TEA1. Positions 205-426.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 20393PUA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 2487S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Contains 1 PUA domain.

Phylogenomic databases

eggNOGiCOG0144.
HOGENOMiHOG000224258.
HOVERGENiHBG060395.
InParanoidiQ8TEA1.
OMAiPRYLFLQ.
OrthoDBiEOG7B8S4B.
PhylomeDBiQ8TEA1.
TreeFamiTF324225.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR001678. Fmu/NOL1/Nop2p.
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF88697. SSF88697. 1 hit.
PROSITEiPS01153. NOL1_NOP2_SUN. 1 hit.
PS50890. PUA. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEA1-1 [UniParc]FASTAAdd to Basket

« Hide

MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP    50
SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV 100
IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV 150
YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE 200
PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT 250
HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL 300
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL 350
QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE 400
PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL 450
ANKDSIGFFI AKFVKCKST 469
Length:469
Mass (Da):51,770
Last modified:June 1, 2002 - v1
Checksum:iEB6D383915547CF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074323 mRNA. Translation: BAB85051.1.
EF445003 Genomic DNA. Translation: ACA06032.1.
EF445003 Genomic DNA. Translation: ACA06033.1.
AL512641, AL450384 Genomic DNA. Translation: CAH70493.1.
AL450384, AL512641 Genomic DNA. Translation: CAH73205.1.
CH471072 Genomic DNA. Translation: EAW86191.1.
BC035778 mRNA. Translation: AAH35778.1.
CCDSiCCDS7130.1.
RefSeqiNP_872349.1. NM_182543.2.
UniGeneiHs.396175.

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058.
GeneIDi221078.
KEGGihsa:221078.
UCSCiuc010qcp.1. human.

Polymorphism databases

DMDMi74751440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074323 mRNA. Translation: BAB85051.1 .
EF445003 Genomic DNA. Translation: ACA06032.1 .
EF445003 Genomic DNA. Translation: ACA06033.1 .
AL512641 , AL450384 Genomic DNA. Translation: CAH70493.1 .
AL450384 , AL512641 Genomic DNA. Translation: CAH73205.1 .
CH471072 Genomic DNA. Translation: EAW86191.1 .
BC035778 mRNA. Translation: AAH35778.1 .
CCDSi CCDS7130.1.
RefSeqi NP_872349.1. NM_182543.2.
UniGenei Hs.396175.

3D structure databases

ProteinModelPortali Q8TEA1.
SMRi Q8TEA1. Positions 205-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128682. 1 interaction.
STRINGi 9606.ENSP00000366519.

PTM databases

PhosphoSitei Q8TEA1.

Polymorphism databases

DMDMi 74751440.

Proteomic databases

MaxQBi Q8TEA1.
PaxDbi Q8TEA1.
PeptideAtlasi Q8TEA1.
PRIDEi Q8TEA1.

Protocols and materials databases

DNASUi 221078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377304 ; ENSP00000366519 ; ENSG00000241058 .
GeneIDi 221078.
KEGGi hsa:221078.
UCSCi uc010qcp.1. human.

Organism-specific databases

CTDi 221078.
GeneCardsi GC10M018874.
HGNCi HGNC:23529. NSUN6.
HPAi HPA045902.
neXtProti NX_Q8TEA1.
PharmGKBi PA134986220.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0144.
HOGENOMi HOG000224258.
HOVERGENi HBG060395.
InParanoidi Q8TEA1.
OMAi PRYLFLQ.
OrthoDBi EOG7B8S4B.
PhylomeDBi Q8TEA1.
TreeFami TF324225.

Miscellaneous databases

GenomeRNAii 221078.
NextBioi 91183.
PROi Q8TEA1.

Gene expression databases

Bgeei Q8TEA1.
CleanExi HS_NSUN6.
Genevestigatori Q8TEA1.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.50.150. 2 hits.
InterProi IPR001678. Fmu/NOL1/Nop2p.
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view ]
PRINTSi PR02008. RCMTFAMILY.
SUPFAMi SSF53335. SSF53335. 2 hits.
SSF88697. SSF88697. 1 hit.
PROSITEi PS01153. NOL1_NOP2_SUN. 1 hit.
PS50890. PUA. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNSUN6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEA1
Secondary accession number(s): B0YJ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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