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Protein

Putative methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei266S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei293S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei323S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei373NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • tRNA (cytosine-5-)-methyltransferase activity Source: GO_Central
  • tRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase NSUN6 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family member 6
Gene namesi
Name:NSUN6
Synonyms:NOPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000241058.3
HGNCiHGNC:23529 NSUN6
neXtProtiNX_Q8TEA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi221078
OpenTargetsiENSG00000241058
PharmGKBiPA134986220

Polymorphism and mutation databases

BioMutaiNSUN6
DMDMi74751440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002631141 – 469Putative methyltransferase NSUN6Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei419N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TEA1
MaxQBiQ8TEA1
PaxDbiQ8TEA1
PeptideAtlasiQ8TEA1
PRIDEiQ8TEA1

PTM databases

CarbonylDBiQ8TEA1
iPTMnetiQ8TEA1
PhosphoSitePlusiQ8TEA1

Expressioni

Gene expression databases

BgeeiENSG00000241058
CleanExiHS_NSUN6
ExpressionAtlasiQ8TEA1 baseline and differential
GenevisibleiQ8TEA1 HS

Organism-specific databases

HPAiHPA045902

Interactioni

Protein-protein interaction databases

BioGridi128682, 3 interactors
STRINGi9606.ENSP00000366519

Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 21Combined sources11
Helixi24 – 30Combined sources7
Helixi32 – 45Combined sources14
Beta strandi46 – 48Combined sources3
Beta strandi51 – 57Combined sources7
Turni59 – 61Combined sources3
Helixi64 – 78Combined sources15
Turni79 – 81Combined sources3
Beta strandi90 – 92Combined sources3
Beta strandi95 – 99Combined sources5
Beta strandi111 – 116Combined sources6
Helixi118 – 126Combined sources9
Helixi132 – 134Combined sources3
Beta strandi135 – 138Combined sources4
Beta strandi147 – 153Combined sources7
Beta strandi169 – 179Combined sources11
Helixi181 – 184Combined sources4
Beta strandi195 – 204Combined sources10
Beta strandi209 – 211Combined sources3
Turni213 – 215Combined sources3
Beta strandi216 – 218Combined sources3
Helixi221 – 230Combined sources10
Beta strandi237 – 240Combined sources4
Turni244 – 246Combined sources3
Helixi247 – 255Combined sources9
Turni256 – 258Combined sources3
Beta strandi260 – 267Combined sources8
Helixi269 – 281Combined sources13
Beta strandi286 – 291Combined sources6
Helixi294 – 296Combined sources3
Beta strandi310 – 312Combined sources3
Beta strandi317 – 323Combined sources7
Helixi341 – 345Combined sources5
Helixi347 – 361Combined sources15
Beta strandi362 – 373Combined sources12
Turni378 – 380Combined sources3
Helixi381 – 390Combined sources10
Beta strandi394 – 396Combined sources3
Beta strandi409 – 411Combined sources3
Helixi415 – 419Combined sources5
Beta strandi421 – 424Combined sources4
Beta strandi426 – 429Combined sources4
Helixi436 – 440Combined sources5
Helixi444 – 453Combined sources10
Beta strandi458 – 465Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WWQX-ray2.81A/B1-469[»]
5WWRX-ray3.10A/B1-469[»]
5WWSX-ray3.25A/B1-469[»]
5WWTX-ray3.20A/B1-469[»]
ProteinModelPortaliQ8TEA1
SMRiQ8TEA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 203PUAPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni242 – 248S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1122 Eukaryota
COG0144 LUCA
GeneTreeiENSGT00660000095341
HOGENOMiHOG000224258
HOVERGENiHBG060395
InParanoidiQ8TEA1
KOiK21971
OMAiQVAWALT
OrthoDBiEOG091G0IS6
PhylomeDBiQ8TEA1
TreeFamiTF324225

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR018314 Fmu/NOL1/Nop2p_CS
IPR001678 MeTrfase_RsmB/NOP2
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR023267 RCMT
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01189 Methyltr_RsmB-F, 1 hit
PRINTSiPR02008 RCMTFAMILY
SUPFAMiSSF53335 SSF53335, 2 hits
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS01153 NOL1_NOP2_SUN, 1 hit
PS50890 PUA, 1 hit
PS51686 SAM_MT_RSMB_NOP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TEA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP
60 70 80 90 100
SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV
110 120 130 140 150
IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV
160 170 180 190 200
YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE
210 220 230 240 250
PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT
260 270 280 290 300
HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
310 320 330 340 350
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL
360 370 380 390 400
QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE
410 420 430 440 450
PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL
460
ANKDSIGFFI AKFVKCKST
Length:469
Mass (Da):51,770
Last modified:June 1, 2002 - v1
Checksum:iEB6D383915547CF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074323 mRNA Translation: BAB85051.1
EF445003 Genomic DNA Translation: ACA06032.1
EF445003 Genomic DNA Translation: ACA06033.1
AL512641 Genomic DNA No translation available.
AL450384 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86191.1
BC035778 mRNA Translation: AAH35778.1
CCDSiCCDS7130.1
RefSeqiNP_872349.1, NM_182543.3
UniGeneiHs.396175
Hs.655091
Hs.731893

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058
GeneIDi221078
KEGGihsa:221078
UCSCiuc010qcp.2 human

Similar proteinsi

Entry informationi

Entry nameiNSUN6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEA1
Secondary accession number(s): B0YJ54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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