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Protein

Putative methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei266 – 2661S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei293 – 2931S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei323 – 3231S-adenosyl-L-methioninePROSITE-ProRule annotation
Active sitei373 – 3731NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase NSUN6 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family member 6
Gene namesi
Name:NSUN6
Synonyms:NOPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23529. NSUN6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Putative methyltransferase NSUN6PRO_0000263114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8TEA1.
PaxDbiQ8TEA1.
PeptideAtlasiQ8TEA1.
PRIDEiQ8TEA1.

PTM databases

PhosphoSiteiQ8TEA1.

Expressioni

Gene expression databases

BgeeiQ8TEA1.
CleanExiHS_NSUN6.
GenevestigatoriQ8TEA1.

Organism-specific databases

HPAiHPA045902.

Interactioni

Protein-protein interaction databases

BioGridi128682. 2 interactions.
STRINGi9606.ENSP00000366519.

Structurei

3D structure databases

ProteinModelPortaliQ8TEA1.
SMRiQ8TEA1. Positions 205-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 20393PUAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 2487S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation
Contains 1 PUA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0144.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000224258.
HOVERGENiHBG060395.
InParanoidiQ8TEA1.
OMAiLGQRPNM.
OrthoDBiEOG7B8S4B.
PhylomeDBiQ8TEA1.
TreeFamiTF324225.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF88697. SSF88697. 1 hit.
PROSITEiPS01153. NOL1_NOP2_SUN. 1 hit.
PS50890. PUA. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TEA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP
60 70 80 90 100
SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV
110 120 130 140 150
IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV
160 170 180 190 200
YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE
210 220 230 240 250
PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT
260 270 280 290 300
HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
310 320 330 340 350
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL
360 370 380 390 400
QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE
410 420 430 440 450
PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL
460
ANKDSIGFFI AKFVKCKST
Length:469
Mass (Da):51,770
Last modified:June 1, 2002 - v1
Checksum:iEB6D383915547CF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074323 mRNA. Translation: BAB85051.1.
EF445003 Genomic DNA. Translation: ACA06032.1.
EF445003 Genomic DNA. Translation: ACA06033.1.
AL512641, AL450384 Genomic DNA. Translation: CAH70493.1.
AL450384, AL512641 Genomic DNA. Translation: CAH73205.1.
CH471072 Genomic DNA. Translation: EAW86191.1.
BC035778 mRNA. Translation: AAH35778.1.
CCDSiCCDS7130.1.
RefSeqiNP_872349.1. NM_182543.3.
UniGeneiHs.396175.
Hs.655091.
Hs.731893.

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058.
GeneIDi221078.
KEGGihsa:221078.
UCSCiuc010qcp.1. human.

Polymorphism databases

DMDMi74751440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074323 mRNA. Translation: BAB85051.1.
EF445003 Genomic DNA. Translation: ACA06032.1.
EF445003 Genomic DNA. Translation: ACA06033.1.
AL512641, AL450384 Genomic DNA. Translation: CAH70493.1.
AL450384, AL512641 Genomic DNA. Translation: CAH73205.1.
CH471072 Genomic DNA. Translation: EAW86191.1.
BC035778 mRNA. Translation: AAH35778.1.
CCDSiCCDS7130.1.
RefSeqiNP_872349.1. NM_182543.3.
UniGeneiHs.396175.
Hs.655091.
Hs.731893.

3D structure databases

ProteinModelPortaliQ8TEA1.
SMRiQ8TEA1. Positions 205-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128682. 2 interactions.
STRINGi9606.ENSP00000366519.

PTM databases

PhosphoSiteiQ8TEA1.

Polymorphism databases

DMDMi74751440.

Proteomic databases

MaxQBiQ8TEA1.
PaxDbiQ8TEA1.
PeptideAtlasiQ8TEA1.
PRIDEiQ8TEA1.

Protocols and materials databases

DNASUi221078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058.
GeneIDi221078.
KEGGihsa:221078.
UCSCiuc010qcp.1. human.

Organism-specific databases

CTDi221078.
GeneCardsiGC10M018874.
HGNCiHGNC:23529. NSUN6.
HPAiHPA045902.
neXtProtiNX_Q8TEA1.
PharmGKBiPA134986220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0144.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000224258.
HOVERGENiHBG060395.
InParanoidiQ8TEA1.
OMAiLGQRPNM.
OrthoDBiEOG7B8S4B.
PhylomeDBiQ8TEA1.
TreeFamiTF324225.

Miscellaneous databases

GenomeRNAii221078.
NextBioi91183.
PROiQ8TEA1.

Gene expression databases

BgeeiQ8TEA1.
CleanExiHS_NSUN6.
GenevestigatoriQ8TEA1.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF88697. SSF88697. 1 hit.
PROSITEiPS01153. NOL1_NOP2_SUN. 1 hit.
PS50890. PUA. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNSUN6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEA1
Secondary accession number(s): B0YJ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.