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Q8TEA1

- NSUN6_HUMAN

UniProt

Q8TEA1 - NSUN6_HUMAN

Protein

Putative methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May have S-adenosyl-L-methionine-dependent methyl-transferase activity.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei266 – 2661S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei293 – 2931S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei323 – 3231S-adenosyl-L-methioninePROSITE-ProRule annotation
    Active sitei373 – 3731NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative methyltransferase NSUN6 (EC:2.1.1.-)
    Alternative name(s):
    NOL1/NOP2/Sun and PUA domain-containing protein 1
    NOL1/NOP2/Sun domain family member 6
    Gene namesi
    Name:NSUN6
    Synonyms:NOPD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23529. NSUN6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134986220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Putative methyltransferase NSUN6PRO_0000263114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei419 – 4191N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8TEA1.
    PaxDbiQ8TEA1.
    PeptideAtlasiQ8TEA1.
    PRIDEiQ8TEA1.

    PTM databases

    PhosphoSiteiQ8TEA1.

    Expressioni

    Gene expression databases

    BgeeiQ8TEA1.
    CleanExiHS_NSUN6.
    GenevestigatoriQ8TEA1.

    Organism-specific databases

    HPAiHPA045902.

    Interactioni

    Protein-protein interaction databases

    BioGridi128682. 2 interactions.
    STRINGi9606.ENSP00000366519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TEA1.
    SMRiQ8TEA1. Positions 205-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 20393PUAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 2487S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation
    Contains 1 PUA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0144.
    HOGENOMiHOG000224258.
    HOVERGENiHBG060395.
    InParanoidiQ8TEA1.
    OMAiPRYLFLQ.
    OrthoDBiEOG7B8S4B.
    PhylomeDBiQ8TEA1.
    TreeFamiTF324225.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR001678. Fmu/NOL1/Nop2p.
    IPR018314. Fmu/NOL1/Nop2p_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR023267. RCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
    [Graphical view]
    PRINTSiPR02008. RCMTFAMILY.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    SSF88697. SSF88697. 1 hit.
    PROSITEiPS01153. NOL1_NOP2_SUN. 1 hit.
    PS50890. PUA. 1 hit.
    PS51686. SAM_MT_RSMB_NOP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TEA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP    50
    SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV 100
    IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV 150
    YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE 200
    PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT 250
    HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL 300
    DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL 350
    QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE 400
    PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL 450
    ANKDSIGFFI AKFVKCKST 469
    Length:469
    Mass (Da):51,770
    Last modified:June 1, 2002 - v1
    Checksum:iEB6D383915547CF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074323 mRNA. Translation: BAB85051.1.
    EF445003 Genomic DNA. Translation: ACA06032.1.
    EF445003 Genomic DNA. Translation: ACA06033.1.
    AL512641, AL450384 Genomic DNA. Translation: CAH70493.1.
    AL450384, AL512641 Genomic DNA. Translation: CAH73205.1.
    CH471072 Genomic DNA. Translation: EAW86191.1.
    BC035778 mRNA. Translation: AAH35778.1.
    CCDSiCCDS7130.1.
    RefSeqiNP_872349.1. NM_182543.2.
    UniGeneiHs.396175.

    Genome annotation databases

    EnsembliENST00000377304; ENSP00000366519; ENSG00000241058.
    GeneIDi221078.
    KEGGihsa:221078.
    UCSCiuc010qcp.1. human.

    Polymorphism databases

    DMDMi74751440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074323 mRNA. Translation: BAB85051.1 .
    EF445003 Genomic DNA. Translation: ACA06032.1 .
    EF445003 Genomic DNA. Translation: ACA06033.1 .
    AL512641 , AL450384 Genomic DNA. Translation: CAH70493.1 .
    AL450384 , AL512641 Genomic DNA. Translation: CAH73205.1 .
    CH471072 Genomic DNA. Translation: EAW86191.1 .
    BC035778 mRNA. Translation: AAH35778.1 .
    CCDSi CCDS7130.1.
    RefSeqi NP_872349.1. NM_182543.2.
    UniGenei Hs.396175.

    3D structure databases

    ProteinModelPortali Q8TEA1.
    SMRi Q8TEA1. Positions 205-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128682. 2 interactions.
    STRINGi 9606.ENSP00000366519.

    PTM databases

    PhosphoSitei Q8TEA1.

    Polymorphism databases

    DMDMi 74751440.

    Proteomic databases

    MaxQBi Q8TEA1.
    PaxDbi Q8TEA1.
    PeptideAtlasi Q8TEA1.
    PRIDEi Q8TEA1.

    Protocols and materials databases

    DNASUi 221078.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377304 ; ENSP00000366519 ; ENSG00000241058 .
    GeneIDi 221078.
    KEGGi hsa:221078.
    UCSCi uc010qcp.1. human.

    Organism-specific databases

    CTDi 221078.
    GeneCardsi GC10M018874.
    HGNCi HGNC:23529. NSUN6.
    HPAi HPA045902.
    neXtProti NX_Q8TEA1.
    PharmGKBi PA134986220.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0144.
    HOGENOMi HOG000224258.
    HOVERGENi HBG060395.
    InParanoidi Q8TEA1.
    OMAi PRYLFLQ.
    OrthoDBi EOG7B8S4B.
    PhylomeDBi Q8TEA1.
    TreeFami TF324225.

    Miscellaneous databases

    GenomeRNAii 221078.
    NextBioi 91183.
    PROi Q8TEA1.

    Gene expression databases

    Bgeei Q8TEA1.
    CleanExi HS_NSUN6.
    Genevestigatori Q8TEA1.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR001678. Fmu/NOL1/Nop2p.
    IPR018314. Fmu/NOL1/Nop2p_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR023267. RCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01189. Nol1_Nop2_Fmu. 1 hit.
    [Graphical view ]
    PRINTSi PR02008. RCMTFAMILY.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    SSF88697. SSF88697. 1 hit.
    PROSITEi PS01153. NOL1_NOP2_SUN. 1 hit.
    PS50890. PUA. 1 hit.
    PS51686. SAM_MT_RSMB_NOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNSUN6_HUMAN
    AccessioniPrimary (citable) accession number: Q8TEA1
    Secondary accession number(s): B0YJ54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3