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Protein

Putative methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei266S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei293S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei323S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei373NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • tRNA (cytosine-5-)-methyltransferase activity Source: GO_Central
  • tRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase NSUN6 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family member 6
Gene namesi
Name:NSUN6
Synonyms:NOPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000241058.3.
HGNCiHGNC:23529. NSUN6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi221078.
OpenTargetsiENSG00000241058.
PharmGKBiPA134986220.

Polymorphism and mutation databases

BioMutaiNSUN6.
DMDMi74751440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002631141 – 469Putative methyltransferase NSUN6Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei419N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TEA1.
MaxQBiQ8TEA1.
PaxDbiQ8TEA1.
PeptideAtlasiQ8TEA1.
PRIDEiQ8TEA1.

PTM databases

iPTMnetiQ8TEA1.
PhosphoSitePlusiQ8TEA1.

Expressioni

Gene expression databases

BgeeiENSG00000241058.
CleanExiHS_NSUN6.
ExpressionAtlasiQ8TEA1. baseline and differential.
GenevisibleiQ8TEA1. HS.

Organism-specific databases

HPAiHPA045902.

Interactioni

Protein-protein interaction databases

BioGridi128682. 3 interactors.
STRINGi9606.ENSP00000366519.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WWQX-ray2.81A/B1-469[»]
5WWRX-ray3.10A/B1-469[»]
5WWSX-ray3.25A/B1-469[»]
5WWTX-ray3.20A/B1-469[»]
ProteinModelPortaliQ8TEA1.
SMRiQ8TEA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 203PUAPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni242 – 248S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1122. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000224258.
HOVERGENiHBG060395.
InParanoidiQ8TEA1.
KOiK21971.
OMAiQVAWALT.
OrthoDBiEOG091G0IS6.
PhylomeDBiQ8TEA1.
TreeFamiTF324225.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR036974. PUA_sf.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS50890. PUA. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TEA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP
60 70 80 90 100
SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV
110 120 130 140 150
IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV
160 170 180 190 200
YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE
210 220 230 240 250
PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT
260 270 280 290 300
HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
310 320 330 340 350
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL
360 370 380 390 400
QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE
410 420 430 440 450
PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL
460
ANKDSIGFFI AKFVKCKST
Length:469
Mass (Da):51,770
Last modified:June 1, 2002 - v1
Checksum:iEB6D383915547CF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074323 mRNA. Translation: BAB85051.1.
EF445003 Genomic DNA. Translation: ACA06032.1.
EF445003 Genomic DNA. Translation: ACA06033.1.
AL512641, AL450384 Genomic DNA. Translation: CAH70493.1.
AL450384, AL512641 Genomic DNA. Translation: CAH73205.1.
CH471072 Genomic DNA. Translation: EAW86191.1.
BC035778 mRNA. Translation: AAH35778.1.
CCDSiCCDS7130.1.
RefSeqiNP_872349.1. NM_182543.3.
UniGeneiHs.396175.
Hs.655091.
Hs.731893.

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058.
GeneIDi221078.
KEGGihsa:221078.
UCSCiuc010qcp.2. human.

Similar proteinsi

Entry informationi

Entry nameiNSUN6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEA1
Secondary accession number(s): B0YJ54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families