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Q8TE99

- ACPL2_HUMAN

UniProt

Q8TE99 - ACPL2_HUMAN

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Protein

Acid phosphatase-like protein 2

Gene
ACPL2, UNQ370/PRO706
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Nucleophile By similarity
Active sitei379 – 3791Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase-like protein 2 (EC:3.1.3.2)
Gene namesi
Name:ACPL2
ORF Names:UNQ370/PRO706
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26303. ACPL2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 480457Acid phosphatase-like protein 2PRO_0000314924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TE99.
PRIDEiQ8TE99.

PTM databases

PhosphoSiteiQ8TE99.

Expressioni

Gene expression databases

ArrayExpressiQ8TE99.
BgeeiQ8TE99.
CleanExiHS_ACPL2.
GenevestigatoriQ8TE99.

Organism-specific databases

HPAiHPA017243.

Interactioni

Protein-protein interaction databases

BioGridi124942. 1 interaction.
STRINGi9606.ENSP00000286353.

Structurei

3D structure databases

ProteinModelPortaliQ8TE99.
SMRiQ8TE99. Positions 86-450.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG321954.
HOGENOMiHOG000033787.
HOVERGENiHBG106056.
InParanoidiQ8TE99.
OMAiCHNVSFP.
PhylomeDBiQ8TE99.
TreeFamiTF318821.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TE99-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD    50
PVTEPPVTDP VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR 100
YPLYVIPKTK RPEIDCTLVA NRKPYHPKLE AFISHMSKGS GASFESPLNS 150
LPLYPNHPLC EMGELTQTGV VQHLQNGQLL RDIYLKKHKL LPNDWSADQL 200
YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF CSGSCYCPVR 250
NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC 300
HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH 350
PILNQTIGRM QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA 400
ARLIFELWQD REKPSEHSVR ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE 450
NLVRFVKRDM FVALGGSGTN YYDACHREGF 480
Length:480
Mass (Da):55,240
Last modified:June 1, 2002 - v1
Checksum:iC1A8BEC2B68ECA62
GO
Isoform 2 (identifier: Q8TE99-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MLFRNRFLLLLALAALLAFVSLSLQFF → MEHSVCPSSAV

Note: No experimental confirmation available.

Show »
Length:464
Mass (Da):53,257
Checksum:i334FF1A12565DADA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MLFRN…SLQFF → MEHSVCPSSAV in isoform 2. VSP_030432Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358460 mRNA. Translation: AAQ88825.1.
AK074331 mRNA. Translation: BAB85053.1.
CH471052 Genomic DNA. Translation: EAW79007.1.
CH471052 Genomic DNA. Translation: EAW79009.1.
BC035834 mRNA. Translation: AAH35834.1.
BC036701 mRNA. Translation: AAH36701.1.
CCDSiCCDS3116.1. [Q8TE99-1]
RefSeqiNP_001032249.1. NM_001037172.2. [Q8TE99-1]
NP_001269657.1. NM_001282728.1.
NP_689495.1. NM_152282.4. [Q8TE99-1]
UniGeneiHs.657887.

Genome annotation databases

EnsembliENST00000286353; ENSP00000286353; ENSG00000155893. [Q8TE99-1]
ENST00000393007; ENSP00000376731; ENSG00000155893. [Q8TE99-2]
ENST00000393010; ENSP00000376733; ENSG00000155893. [Q8TE99-1]
GeneIDi92370.
KEGGihsa:92370.
UCSCiuc003etu.3. human. [Q8TE99-1]

Polymorphism databases

DMDMi74730610.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358460 mRNA. Translation: AAQ88825.1 .
AK074331 mRNA. Translation: BAB85053.1 .
CH471052 Genomic DNA. Translation: EAW79007.1 .
CH471052 Genomic DNA. Translation: EAW79009.1 .
BC035834 mRNA. Translation: AAH35834.1 .
BC036701 mRNA. Translation: AAH36701.1 .
CCDSi CCDS3116.1. [Q8TE99-1 ]
RefSeqi NP_001032249.1. NM_001037172.2. [Q8TE99-1 ]
NP_001269657.1. NM_001282728.1.
NP_689495.1. NM_152282.4. [Q8TE99-1 ]
UniGenei Hs.657887.

3D structure databases

ProteinModelPortali Q8TE99.
SMRi Q8TE99. Positions 86-450.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124942. 1 interaction.
STRINGi 9606.ENSP00000286353.

PTM databases

PhosphoSitei Q8TE99.

Polymorphism databases

DMDMi 74730610.

Proteomic databases

PaxDbi Q8TE99.
PRIDEi Q8TE99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286353 ; ENSP00000286353 ; ENSG00000155893 . [Q8TE99-1 ]
ENST00000393007 ; ENSP00000376731 ; ENSG00000155893 . [Q8TE99-2 ]
ENST00000393010 ; ENSP00000376733 ; ENSG00000155893 . [Q8TE99-1 ]
GeneIDi 92370.
KEGGi hsa:92370.
UCSCi uc003etu.3. human. [Q8TE99-1 ]

Organism-specific databases

CTDi 92370.
GeneCardsi GC03P140950.
HGNCi HGNC:26303. ACPL2.
HPAi HPA017243.
neXtProti NX_Q8TE99.
PharmGKBi PA134964387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321954.
HOGENOMi HOG000033787.
HOVERGENi HBG106056.
InParanoidi Q8TE99.
OMAi CHNVSFP.
PhylomeDBi Q8TE99.
TreeFami TF318821.

Miscellaneous databases

GenomeRNAii 92370.
NextBioi 77736.
PROi Q8TE99.

Gene expression databases

ArrayExpressi Q8TE99.
Bgeei Q8TE99.
CleanExi HS_ACPL2.
Genevestigatori Q8TE99.

Family and domain databases

Gene3Di 3.40.50.1240. 2 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary and Testis.

Entry informationi

Entry nameiACPL2_HUMAN
AccessioniPrimary (citable) accession number: Q8TE99
Secondary accession number(s): D3DNF5, Q49AJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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