Q8TE99 (ACPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acid phosphatase-like protein 2
EC=3.1.3.2

Gene names

Name:	ACPL2
ORF Names:	UNQ370/PRO706

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TE99-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TE99-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MLFRNRFLLLLALAALLAFVSLSLQFF → MEHSVCPSSAV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 480	457	Acid phosphatase-like protein 2		PRO_0000314924
Sites
	Active site	97	1	Nucleophile By similarity
	Active site	379	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	305	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 27	27	MLFRN…SLQFF → MEHSVCPSSAV in isoform 2.		VSP_030432

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: C1A8BEC2B68ECA62	FASTA	480	55,240
	10 20 30 40 50 60 MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD PVTEPPVTDP 70 80 90 100 110 120 VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR YPLYVIPKTK RPEIDCTLVA 130 140 150 160 170 180 NRKPYHPKLE AFISHMSKGS GASFESPLNS LPLYPNHPLC EMGELTQTGV VQHLQNGQLL 190 200 210 220 230 240 RDIYLKKHKL LPNDWSADQL YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF 250 260 270 280 290 300 CSGSCYCPVR NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC 310 320 330 340 350 360 HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH PILNQTIGRM 370 380 390 400 410 420 QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA ARLIFELWQD REKPSEHSVR 430 440 450 460 470 480 ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE NLVRFVKRDM FVALGGSGTN YYDACHREGF
	Isoform 2 [UniParc]. Checksum: 334FF1A12565DADA	FASTA	464	53,257
	10 20 30 40 50 60 MEHSVCPSSA VHLIPVSTPK NGMSSKSRKR IMPDPVTEPP VTDPVYEALL YCNIPSVAER 70 80 90 100 110 120 SMEGHAPHHF KLVSVHVFIR HGDRYPLYVI PKTKRPEIDC TLVANRKPYH PKLEAFISHM 130 140 150 160 170 180 SKGSGASFES PLNSLPLYPN HPLCEMGELT QTGVVQHLQN GQLLRDIYLK KHKLLPNDWS 190 200 210 220 230 240 ADQLYLETTG KSRTLQSGLA LLYGFLPDFD WKKIYFRHQP SALFCSGSCY CPVRNQYLEK 250 260 270 280 290 300 EQRRQYLLRL KNSQLEKTYG EMAKIVDVPT KQLRAANPID SMLCHFCHNV SFPCTRNGCV 310 320 330 340 350 360 DMEHFKVIKT HQIEDERERR EKKLYFGYSL LGAHPILNQT IGRMQRATEG RKEELFALYS 370 380 390 400 410 420 AHDVTLSPVL SALGLSEARF PRFAARLIFE LWQDREKPSE HSVRILYNGV DVTFHTSFCQ 430 440 450 460 DHHKRSPKPM CPLENLVRFV KRDMFVALGG SGTNYYDACH REGF

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Hepatoma.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ovary and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358460 mRNA. Translation: AAQ88825.1. AK074331 mRNA. Translation: BAB85053.1. CH471052 Genomic DNA. Translation: EAW79007.1. CH471052 Genomic DNA. Translation: EAW79009.1. BC035834 mRNA. Translation: AAH35834.1. BC036701 mRNA. Translation: AAH36701.1.
IPI	IPI00152681. IPI00792585.
RefSeq	NP_001032249.1. NM_001037172.1. NP_689495.1. NM_152282.3.
UniGene	Hs.657887.
3D structure databases
HSSP	HSSP built from PDB template 1ND5 based on UniProtKB P15309.
ProteinModelPortal	Q8TE99.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000286353.
PTM databases
PhosphoSite	Q8TE99.
Polymorphism databases
DMDM	74730610.
Proteomic databases
PaxDb	Q8TE99.
PRIDE	Q8TE99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286353; ENSP00000286353; ENSG00000155893. ENST00000393007; ENSP00000376731; ENSG00000155893. ENST00000393010; ENSP00000376733; ENSG00000155893.
GeneID	92370.
KEGG	hsa:92370.
UCSC	uc003etu.3. human.
Organism-specific databases
CTD	92370.
GeneCards	GC03P140950.
HGNC	HGNC:26303. ACPL2.
HPA	HPA017243.
neXtProt	NX_Q8TE99.
PharmGKB	PA134964387.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321954.
HOGENOM	HOG000033787.
HOVERGEN	HBG106056.
InParanoid	Q8TE99.
OMA	CHNVSFP.
PhylomeDB	Q8TE99.
Gene expression databases
ArrayExpress	Q8TE99.
Bgee	Q8TE99.
CleanEx	HS_ACPL2.
Genevestigator	Q8TE99.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. False negative. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	92370.
NextBio	77736.

Entry information

Entry name

ACPL2_HUMAN

Accession

Primary (citable) accession number: Q8TE99
Secondary accession number(s): D3DNF5, Q49AJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.