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Q8TE99

- ACPL2_HUMAN

UniProt

Q8TE99 - ACPL2_HUMAN

Protein

Acid phosphatase-like protein 2

Gene

ACPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971NucleophileBy similarity
    Active sitei379 – 3791Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase-like protein 2 (EC:3.1.3.2)
    Gene namesi
    Name:ACPL2
    ORF Names:UNQ370/PRO706
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:26303. ACPL2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134964387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 480457Acid phosphatase-like protein 2PRO_0000314924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8TE99.
    PRIDEiQ8TE99.

    PTM databases

    PhosphoSiteiQ8TE99.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TE99.
    BgeeiQ8TE99.
    CleanExiHS_ACPL2.
    GenevestigatoriQ8TE99.

    Organism-specific databases

    HPAiHPA017243.

    Interactioni

    Protein-protein interaction databases

    BioGridi124942. 1 interaction.
    STRINGi9606.ENSP00000286353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE99.
    SMRiQ8TE99. Positions 86-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG321954.
    HOGENOMiHOG000033787.
    HOVERGENiHBG106056.
    InParanoidiQ8TE99.
    OMAiCHNVSFP.
    PhylomeDBiQ8TE99.
    TreeFamiTF318821.

    Family and domain databases

    Gene3Di3.40.50.1240. 2 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE99-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD    50
    PVTEPPVTDP VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR 100
    YPLYVIPKTK RPEIDCTLVA NRKPYHPKLE AFISHMSKGS GASFESPLNS 150
    LPLYPNHPLC EMGELTQTGV VQHLQNGQLL RDIYLKKHKL LPNDWSADQL 200
    YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF CSGSCYCPVR 250
    NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC 300
    HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH 350
    PILNQTIGRM QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA 400
    ARLIFELWQD REKPSEHSVR ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE 450
    NLVRFVKRDM FVALGGSGTN YYDACHREGF 480
    Length:480
    Mass (Da):55,240
    Last modified:June 1, 2002 - v1
    Checksum:iC1A8BEC2B68ECA62
    GO
    Isoform 2 (identifier: Q8TE99-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MLFRNRFLLLLALAALLAFVSLSLQFF → MEHSVCPSSAV

    Note: No experimental confirmation available.

    Show »
    Length:464
    Mass (Da):53,257
    Checksum:i334FF1A12565DADA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727MLFRN…SLQFF → MEHSVCPSSAV in isoform 2. 1 PublicationVSP_030432Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358460 mRNA. Translation: AAQ88825.1.
    AK074331 mRNA. Translation: BAB85053.1.
    CH471052 Genomic DNA. Translation: EAW79007.1.
    CH471052 Genomic DNA. Translation: EAW79009.1.
    BC035834 mRNA. Translation: AAH35834.1.
    BC036701 mRNA. Translation: AAH36701.1.
    CCDSiCCDS3116.1. [Q8TE99-1]
    RefSeqiNP_001032249.1. NM_001037172.2. [Q8TE99-1]
    NP_001269657.1. NM_001282728.1.
    NP_689495.1. NM_152282.4. [Q8TE99-1]
    UniGeneiHs.657887.

    Genome annotation databases

    EnsembliENST00000286353; ENSP00000286353; ENSG00000155893. [Q8TE99-1]
    ENST00000393010; ENSP00000376733; ENSG00000155893. [Q8TE99-1]
    GeneIDi92370.
    KEGGihsa:92370.
    UCSCiuc003etu.3. human. [Q8TE99-1]

    Polymorphism databases

    DMDMi74730610.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358460 mRNA. Translation: AAQ88825.1 .
    AK074331 mRNA. Translation: BAB85053.1 .
    CH471052 Genomic DNA. Translation: EAW79007.1 .
    CH471052 Genomic DNA. Translation: EAW79009.1 .
    BC035834 mRNA. Translation: AAH35834.1 .
    BC036701 mRNA. Translation: AAH36701.1 .
    CCDSi CCDS3116.1. [Q8TE99-1 ]
    RefSeqi NP_001032249.1. NM_001037172.2. [Q8TE99-1 ]
    NP_001269657.1. NM_001282728.1.
    NP_689495.1. NM_152282.4. [Q8TE99-1 ]
    UniGenei Hs.657887.

    3D structure databases

    ProteinModelPortali Q8TE99.
    SMRi Q8TE99. Positions 86-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124942. 1 interaction.
    STRINGi 9606.ENSP00000286353.

    PTM databases

    PhosphoSitei Q8TE99.

    Polymorphism databases

    DMDMi 74730610.

    Proteomic databases

    PaxDbi Q8TE99.
    PRIDEi Q8TE99.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286353 ; ENSP00000286353 ; ENSG00000155893 . [Q8TE99-1 ]
    ENST00000393010 ; ENSP00000376733 ; ENSG00000155893 . [Q8TE99-1 ]
    GeneIDi 92370.
    KEGGi hsa:92370.
    UCSCi uc003etu.3. human. [Q8TE99-1 ]

    Organism-specific databases

    CTDi 92370.
    GeneCardsi GC03P140950.
    HGNCi HGNC:26303. ACPL2.
    HPAi HPA017243.
    neXtProti NX_Q8TE99.
    PharmGKBi PA134964387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321954.
    HOGENOMi HOG000033787.
    HOVERGENi HBG106056.
    InParanoidi Q8TE99.
    OMAi CHNVSFP.
    PhylomeDBi Q8TE99.
    TreeFami TF318821.

    Miscellaneous databases

    GenomeRNAii 92370.
    NextBioi 77736.
    PROi Q8TE99.

    Gene expression databases

    ArrayExpressi Q8TE99.
    Bgeei Q8TE99.
    CleanExi HS_ACPL2.
    Genevestigatori Q8TE99.

    Family and domain databases

    Gene3Di 3.40.50.1240. 2 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Ovary and Testis.

    Entry informationi

    Entry nameiACPL2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE99
    Secondary accession number(s): D3DNF5, Q49AJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3