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Protein

ATP-dependent RNA helicase DQX1

Gene

DQX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 77ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DQX1 (EC:3.6.4.12)
Alternative name(s):
DEAQ box polypeptide 1
Gene namesi
Name:DQX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20410. DQX1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi165545.
OpenTargetsiENSG00000144045.
PharmGKBiPA134916600.

Polymorphism and mutation databases

BioMutaiDQX1.
DMDMi145558898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843771 – 717ATP-dependent RNA helicase DQX1Add BLAST717

Proteomic databases

MaxQBiQ8TE96.
PaxDbiQ8TE96.
PeptideAtlasiQ8TE96.
PRIDEiQ8TE96.

PTM databases

iPTMnetiQ8TE96.
PhosphoSitePlusiQ8TE96.

Expressioni

Gene expression databases

BgeeiENSG00000144045.
CleanExiHS_DQX1.
ExpressionAtlasiQ8TE96. baseline and differential.
GenevisibleiQ8TE96. HS.

Organism-specific databases

HPAiHPA039158.

Interactioni

Protein-protein interaction databases

BioGridi127915. 16 interactors.
IntActiQ8TE96. 1 interactor.
MINTiMINT-6941492.
STRINGi9606.ENSP00000377523.

Structurei

3D structure databases

ProteinModelPortaliQ8TE96.
SMRiQ8TE96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 225Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini248 – 447Helicase C-terminalPROSITE-ProRule annotationAdd BLAST200

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi170 – 173DEAQ box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 203Poly-Val4

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00880000137867.
HOGENOMiHOG000175261.
HOVERGENiHBG039428.
InParanoidiQ8TE96.
KOiK14433.
OMAiKLRAFWG.
OrthoDBiEOG091G025L.
PhylomeDBiQ8TE96.
TreeFamiTF105735.

Family and domain databases

InterProiView protein in InterPro
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF04408. HA2. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQPLRLAE EYGPSPGESE LAVNPFDGLP FSSRYYELLK QRQALPIWAA
60 70 80 90 100
RFTFLEQLES NPTGVVLVSG EPGSGKSTQI PQWCAEFALA RGFQKGQVTV
110 120 130 140 150
TQPYPLAARS LALRVADEMD LTLGHEVGYS IPQEDCTGPN TLLRFCWDRL
160 170 180 190 200
LLQEVASTRG TGAWGVLVLD EAQERSVASD SLQGLLQDAR LEKLPGDLRV
210 220 230 240 250
VVVTDPALEP KLRAFWGNPP IVHIPREPGE RPSPIYWDTI PPDRVEAACQ
260 270 280 290 300
AVLELCRKEL PGDVLVFLPS EEEISLCCES LSREVESLLL QGLPPRVLPL
310 320 330 340 350
HPDCGRAVQA VYEDMDARKV VVTHWLADFS FSLPSIQHVI DSGLELRSVY
360 370 380 390 400
NPRIRAEFQV LRPISKCQAE ARRLRARGFP PGSCLCLYPK SFLELEAPPL
410 420 430 440 450
PQPRVCEENL SSLVLLLKRR QIAEPGECHF LDQPAPEALM QALEDLDYLA
460 470 480 490 500
ALDDDGDLSD LGVILSEFPL APELAKALLA SCEFDCVDEM LTLAAMLTAA
510 520 530 540 550
PGFTRPPLSA EEAALRRALE HTDGDHSSLI QVYEAFIQSG ADEAWCQARG
560 570 580 590 600
LNWAALCQAH KLRGELLELM QRIELPLSLP AFGSEQNRRD LQKALVSGYF
610 620 630 640 650
LKVARDTDGT GNYLLLTHKH VAQLSSYCCY RSRRAPARPP PWVLYHNFTI
660 670 680 690 700
SKDNCLSIVS EIQPQMLVEL APPYFLSNLP PSESRDLLNQ LREGMADSTA
710
GSKSSSAQEF RDPCVLQ
Length:717
Mass (Da):79,476
Last modified:April 17, 2007 - v2
Checksum:iE7EF8090243F0CAB
GO
Isoform 2 (identifier: Q8TE96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:599
Mass (Da):66,536
Checksum:iF7C7F82010F41342
GO
Isoform 3 (identifier: Q8TE96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-357: YNPRIRAE → SEREIAVG
     358-717: Missing.

Show »
Length:357
Mass (Da):39,414
Checksum:i6C625B3A11F04C56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61N → S in AK092420 (PubMed:14702039).Curated1
Sequence conflicti125H → R in AK092420 (PubMed:14702039).Curated1
Sequence conflicti129Y → S in BAB85056 (PubMed:14702039).Curated1
Sequence conflicti598G → E in BAB85056 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244701 – 118Missing in isoform 2. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_024471350 – 357YNPRIRAE → SEREIAVG in isoform 3. 1 Publication8
Alternative sequenceiVSP_024472358 – 717Missing in isoform 3. 1 PublicationAdd BLAST360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074337 mRNA. Translation: BAB85056.1.
AK092420 mRNA. No translation available.
AC005041 Genomic DNA. No translation available.
BC075018 mRNA. Translation: AAH75018.1.
CCDSiCCDS1949.2. [Q8TE96-1]
RefSeqiNP_598376.2. NM_133637.2. [Q8TE96-1]
XP_011530946.1. XM_011532644.1. [Q8TE96-2]
UniGeneiHs.191705.

Genome annotation databases

EnsembliENST00000393951; ENSP00000377523; ENSG00000144045. [Q8TE96-1]
ENST00000404568; ENSP00000384621; ENSG00000144045. [Q8TE96-1]
GeneIDi165545.
KEGGihsa:165545.
UCSCiuc010yrw.3. human. [Q8TE96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDQX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TE96
Secondary accession number(s): Q6B017, Q8NAM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: August 30, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM