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Protein

ATP-dependent RNA helicase DQX1

Gene

DQX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DQX1 (EC:3.6.4.12)
Alternative name(s):
DEAQ box polypeptide 1
Gene namesi
Name:DQX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20410. DQX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916600.

Polymorphism and mutation databases

BioMutaiDQX1.
DMDMi145558898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717ATP-dependent RNA helicase DQX1PRO_0000284377Add
BLAST

Proteomic databases

MaxQBiQ8TE96.
PaxDbiQ8TE96.
PRIDEiQ8TE96.

PTM databases

iPTMnetiQ8TE96.
PhosphoSiteiQ8TE96.

Expressioni

Gene expression databases

BgeeiQ8TE96.
CleanExiHS_DQX1.
ExpressionAtlasiQ8TE96. baseline and differential.
GenevisibleiQ8TE96. HS.

Organism-specific databases

HPAiHPA039158.

Interactioni

Protein-protein interaction databases

BioGridi127915. 14 interactions.
IntActiQ8TE96. 1 interaction.
MINTiMINT-6941492.
STRINGi9606.ENSP00000377523.

Structurei

3D structure databases

ProteinModelPortaliQ8TE96.
SMRiQ8TE96. Positions 23-693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 225169Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini248 – 447200Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi170 – 1734DEAQ box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 2034Poly-Val

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00770000120558.
HOGENOMiHOG000175261.
HOVERGENiHBG039428.
InParanoidiQ8TE96.
KOiK14433.
OMAiKLRAFWG.
OrthoDBiEOG715Q3J.
PhylomeDBiQ8TE96.
TreeFamiTF105735.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04408. HA2. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQPLRLAE EYGPSPGESE LAVNPFDGLP FSSRYYELLK QRQALPIWAA
60 70 80 90 100
RFTFLEQLES NPTGVVLVSG EPGSGKSTQI PQWCAEFALA RGFQKGQVTV
110 120 130 140 150
TQPYPLAARS LALRVADEMD LTLGHEVGYS IPQEDCTGPN TLLRFCWDRL
160 170 180 190 200
LLQEVASTRG TGAWGVLVLD EAQERSVASD SLQGLLQDAR LEKLPGDLRV
210 220 230 240 250
VVVTDPALEP KLRAFWGNPP IVHIPREPGE RPSPIYWDTI PPDRVEAACQ
260 270 280 290 300
AVLELCRKEL PGDVLVFLPS EEEISLCCES LSREVESLLL QGLPPRVLPL
310 320 330 340 350
HPDCGRAVQA VYEDMDARKV VVTHWLADFS FSLPSIQHVI DSGLELRSVY
360 370 380 390 400
NPRIRAEFQV LRPISKCQAE ARRLRARGFP PGSCLCLYPK SFLELEAPPL
410 420 430 440 450
PQPRVCEENL SSLVLLLKRR QIAEPGECHF LDQPAPEALM QALEDLDYLA
460 470 480 490 500
ALDDDGDLSD LGVILSEFPL APELAKALLA SCEFDCVDEM LTLAAMLTAA
510 520 530 540 550
PGFTRPPLSA EEAALRRALE HTDGDHSSLI QVYEAFIQSG ADEAWCQARG
560 570 580 590 600
LNWAALCQAH KLRGELLELM QRIELPLSLP AFGSEQNRRD LQKALVSGYF
610 620 630 640 650
LKVARDTDGT GNYLLLTHKH VAQLSSYCCY RSRRAPARPP PWVLYHNFTI
660 670 680 690 700
SKDNCLSIVS EIQPQMLVEL APPYFLSNLP PSESRDLLNQ LREGMADSTA
710
GSKSSSAQEF RDPCVLQ
Length:717
Mass (Da):79,476
Last modified:April 17, 2007 - v2
Checksum:iE7EF8090243F0CAB
GO
Isoform 2 (identifier: Q8TE96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:599
Mass (Da):66,536
Checksum:iF7C7F82010F41342
GO
Isoform 3 (identifier: Q8TE96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-357: YNPRIRAE → SEREIAVG
     358-717: Missing.

Show »
Length:357
Mass (Da):39,414
Checksum:i6C625B3A11F04C56
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611N → S in AK092420 (PubMed:14702039).Curated
Sequence conflicti125 – 1251H → R in AK092420 (PubMed:14702039).Curated
Sequence conflicti129 – 1291Y → S in BAB85056 (PubMed:14702039).Curated
Sequence conflicti598 – 5981G → E in BAB85056 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 118118Missing in isoform 2. 2 PublicationsVSP_024470Add
BLAST
Alternative sequencei350 – 3578YNPRIRAE → SEREIAVG in isoform 3. 1 PublicationVSP_024471
Alternative sequencei358 – 717360Missing in isoform 3. 1 PublicationVSP_024472Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074337 mRNA. Translation: BAB85056.1.
AK092420 mRNA. No translation available.
AC005041 Genomic DNA. No translation available.
BC075018 mRNA. Translation: AAH75018.1.
CCDSiCCDS1949.2. [Q8TE96-1]
RefSeqiNP_598376.2. NM_133637.2. [Q8TE96-1]
XP_011530946.1. XM_011532644.1. [Q8TE96-2]
UniGeneiHs.191705.

Genome annotation databases

EnsembliENST00000393951; ENSP00000377523; ENSG00000144045. [Q8TE96-1]
ENST00000404568; ENSP00000384621; ENSG00000144045. [Q8TE96-1]
GeneIDi165545.
KEGGihsa:165545.
UCSCiuc010yrw.3. human. [Q8TE96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074337 mRNA. Translation: BAB85056.1.
AK092420 mRNA. No translation available.
AC005041 Genomic DNA. No translation available.
BC075018 mRNA. Translation: AAH75018.1.
CCDSiCCDS1949.2. [Q8TE96-1]
RefSeqiNP_598376.2. NM_133637.2. [Q8TE96-1]
XP_011530946.1. XM_011532644.1. [Q8TE96-2]
UniGeneiHs.191705.

3D structure databases

ProteinModelPortaliQ8TE96.
SMRiQ8TE96. Positions 23-693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127915. 14 interactions.
IntActiQ8TE96. 1 interaction.
MINTiMINT-6941492.
STRINGi9606.ENSP00000377523.

PTM databases

iPTMnetiQ8TE96.
PhosphoSiteiQ8TE96.

Polymorphism and mutation databases

BioMutaiDQX1.
DMDMi145558898.

Proteomic databases

MaxQBiQ8TE96.
PaxDbiQ8TE96.
PRIDEiQ8TE96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393951; ENSP00000377523; ENSG00000144045. [Q8TE96-1]
ENST00000404568; ENSP00000384621; ENSG00000144045. [Q8TE96-1]
GeneIDi165545.
KEGGihsa:165545.
UCSCiuc010yrw.3. human. [Q8TE96-1]

Organism-specific databases

CTDi165545.
GeneCardsiDQX1.
H-InvDBHIX0200286.
HGNCiHGNC:20410. DQX1.
HPAiHPA039158.
neXtProtiNX_Q8TE96.
PharmGKBiPA134916600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00770000120558.
HOGENOMiHOG000175261.
HOVERGENiHBG039428.
InParanoidiQ8TE96.
KOiK14433.
OMAiKLRAFWG.
OrthoDBiEOG715Q3J.
PhylomeDBiQ8TE96.
TreeFamiTF105735.

Miscellaneous databases

GenomeRNAii165545.
PROiQ8TE96.

Gene expression databases

BgeeiQ8TE96.
CleanExiHS_DQX1.
ExpressionAtlasiQ8TE96. baseline and differential.
GenevisibleiQ8TE96. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04408. HA2. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes."
    Ji W., Chen F., Do T., Do A., Roe B.A., Meisler M.H.
    Mamm. Genome 12:456-461(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiDQX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TE96
Secondary accession number(s): Q6B017, Q8NAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.