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Protein

SH3 domain and tetratricopeptide repeat-containing protein 1

Gene

SH3TC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain and tetratricopeptide repeat-containing protein 1
Gene namesi
Name:SH3TC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26009. SH3TC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394666.

Polymorphism and mutation databases

BioMutaiSH3TC1.
DMDMi313104192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13361336SH3 domain and tetratricopeptide repeat-containing protein 1PRO_0000106355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei1248 – 12481PhosphotyrosineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TE82.
MaxQBiQ8TE82.
PaxDbiQ8TE82.
PRIDEiQ8TE82.
TopDownProteomicsiQ8TE82.

PTM databases

iPTMnetiQ8TE82.
PhosphoSiteiQ8TE82.
SwissPalmiQ8TE82.

Expressioni

Gene expression databases

BgeeiQ8TE82.
CleanExiHS_SH3TC1.
ExpressionAtlasiQ8TE82. baseline and differential.

Organism-specific databases

HPAiHPA038132.
HPA056807.

Interactioni

Protein-protein interaction databases

BioGridi119952. 1 interaction.
IntActiQ8TE82. 1 interaction.
STRINGi9606.ENSP00000245105.

Structurei

3D structure databases

ProteinModelPortaliQ8TE82.
SMRiQ8TE82. Positions 309-365, 943-1225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini305 – 36864SH3PROSITE-ProRule annotationAdd
BLAST
Repeati560 – 59334TPR 1Add
BLAST
Repeati601 – 63434TPR 2Add
BLAST
Repeati665 – 69834TPR 3Add
BLAST
Repeati786 – 81934TPR 4Add
BLAST
Repeati863 – 89634TPR 5Add
BLAST
Repeati946 – 97934TPR 6Add
BLAST
Repeati1027 – 106337TPR 7Add
BLAST
Repeati1192 – 122534TPR 8Add
BLAST
Repeati1277 – 131135TPR 9Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 9 TPR repeats.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFSQ. Eukaryota.
ENOG410Y8HX. LUCA.
GeneTreeiENSGT00530000063812.
HOGENOMiHOG000121783.
HOVERGENiHBG108451.
InParanoidiQ8TE82.
OMAiIYNEYQL.
OrthoDBiEOG76T9QF.
PhylomeDBiQ8TE82.
TreeFamiTF333167.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR001452. SH3_domain.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TE82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLPAVTTE EPTPMGRGPV GPSGGGSTRD QVRTVVMRPS VSWEKAGPEE
60 70 80 90 100
AKAPVRGDEA PPARVAGPAA GTPPCQMGVY PTDLTLQLLA VRRKSRLRDP
110 120 130 140 150
GLQQTLRGQL RLLENDSREM ARVLGELSAR LLSIHSDQDR IVVTFKTFEE
160 170 180 190 200
IWKFSTYHAL GFTHHCLANL LMDQAFWLLL PSEEEETAIQ VHVDENALRL
210 220 230 240 250
THESLLIQEG PFFVLCPDHH VRVMTGPRDA GNGPQALRQA SGAPQGEAAP
260 270 280 290 300
ETDSSPPSPS VSSEEVAVAA APEPLIPFHQ WALRIPQDPI DDAMGGPVMP
310 320 330 340 350
GNPLMAVGLA SALADFQGSG PEEMTFRGGD LIEILGAQVP SLPWCVGRHA
360 370 380 390 400
ASGRVGFVRS SLISMQGPVS ELESAIFLNE EEKSFFSEGC FSEEDARQLL
410 420 430 440 450
RRMSGTDVCS VYSLDSVEEA ETEQPQEKEI PPPCLSLEPQ ETLQKVKNVL
460 470 480 490 500
EQCKTCPGCP QEPASWGLCA ASSDVSLQDP EEPSFCLEAE DDWEDPEALS
510 520 530 540 550
SLLLFLNAPG YKASFRGLYD VALPWLSSVF RSFSDEEELT GRLAQARGAA
560 570 580 590 600
KKAGLLMALA RLCFLLGRLC SRRLKLSQAR VYFEEALGAL EGSFGDLFLV
610 620 630 640 650
VAVYANLASI YRKQKNREKC AQVVPKAMAL LLGTPDHICS TEAEGELLQL
660 670 680 690 700
ALRRAVGGQS LQAEARACFL LARHHVHLKQ PEEALPFLER LLLLHRDSGA
710 720 730 740 750
PEAAWLSDCY LLLADIYSRK CLPHLVLSCV KVASLRTRGS LAGSLRSVNL
760 770 780 790 800
VLQNAPQPHS LPAQTSHYLR QALASLTPGT GQALRGPLYT SLAQLYSHHG
810 820 830 840 850
CHGPAITFMT QAVEASAIAG VRAIVDHLVA LAWLHVLHGQ SPVALDILQS
860 870 880 890 900
VRDAVVASED QEGVIANMVA VALKRTGRTR QAAESYYRAL RVARDLGQQR
910 920 930 940 950
NQAVGLANFG ALCLHAGASR LAQHYLLEAV RLFSRLPLGE CGRDFTHVLL
960 970 980 990 1000
QLGHLCTRQG PAQQGKGYYE WALLVAVEMG HVESQLRAVQ RLCHFYSAVM
1010 1020 1030 1040 1050
PSEAQCVIYH ELQLSLACKV ADKVLEGQLL ETISQLYLSL GTERAYKSAL
1060 1070 1080 1090 1100
DYTKRSLGIF IDLQKKEKEA HAWLQAGKIY YILRQSELVD LYIQVAQNVA
1110 1120 1130 1140 1150
LYTGDPNLGL ELFEAAGDIF FDGAWEREKA VSFYRDRALP LAVTTGNRKA
1160 1170 1180 1190 1200
ELRLCNKLVA LLATLEEPQE GLEFAHMALA LSITLGDRLN ERVAYHRLAA
1210 1220 1230 1240 1250
LQHRLGHGEL AEHFYLKALS LCNSPLEFDE ETLYYVKVYL VLGDIIFYDL
1260 1270 1280 1290 1300
KDPFDAAGYY QLALAAAVDL GNKKAQLKIY TRLATIYHNF LLDREKSLFF
1310 1320 1330
YQKARTFATE LNVRRVNLPP LPLCGWAPWL APSHPR
Length:1,336
Mass (Da):146,961
Last modified:November 30, 2010 - v3
Checksum:i0653B347D6B2500A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1016 – 10161L → P in BAB85071 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti291 – 2911D → N.
Corresponds to variant rs1281138 [ dbSNP | Ensembl ].
VAR_034127
Natural varianti437 – 4371L → P.1 Publication
Corresponds to variant rs1281145 [ dbSNP | Ensembl ].
VAR_034128
Natural varianti719 – 7191R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035866
Natural varianti785 – 7851R → C.
Corresponds to variant rs1281149 [ dbSNP | Ensembl ].
VAR_021934
Natural varianti1130 – 11301A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035867

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074402 mRNA. Translation: BAB85071.1.
AC104650 Genomic DNA. Translation: AAY40932.1.
CCDSiCCDS3399.1.
RefSeqiNP_001305409.1. NM_001318480.1.
NP_061859.3. NM_018986.4.
XP_011511790.1. XM_011513488.1.
UniGeneiHs.479116.

Genome annotation databases

EnsembliENST00000245105; ENSP00000245105; ENSG00000125089.
GeneIDi54436.
KEGGihsa:54436.
UCSCiuc003gkv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074402 mRNA. Translation: BAB85071.1.
AC104650 Genomic DNA. Translation: AAY40932.1.
CCDSiCCDS3399.1.
RefSeqiNP_001305409.1. NM_001318480.1.
NP_061859.3. NM_018986.4.
XP_011511790.1. XM_011513488.1.
UniGeneiHs.479116.

3D structure databases

ProteinModelPortaliQ8TE82.
SMRiQ8TE82. Positions 309-365, 943-1225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119952. 1 interaction.
IntActiQ8TE82. 1 interaction.
STRINGi9606.ENSP00000245105.

PTM databases

iPTMnetiQ8TE82.
PhosphoSiteiQ8TE82.
SwissPalmiQ8TE82.

Polymorphism and mutation databases

BioMutaiSH3TC1.
DMDMi313104192.

Proteomic databases

EPDiQ8TE82.
MaxQBiQ8TE82.
PaxDbiQ8TE82.
PRIDEiQ8TE82.
TopDownProteomicsiQ8TE82.

Protocols and materials databases

DNASUi54436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245105; ENSP00000245105; ENSG00000125089.
GeneIDi54436.
KEGGihsa:54436.
UCSCiuc003gkv.5. human.

Organism-specific databases

CTDi54436.
GeneCardsiSH3TC1.
H-InvDBHIX0004083.
HIX0031603.
HGNCiHGNC:26009. SH3TC1.
HPAiHPA038132.
HPA056807.
neXtProtiNX_Q8TE82.
PharmGKBiPA128394666.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFSQ. Eukaryota.
ENOG410Y8HX. LUCA.
GeneTreeiENSGT00530000063812.
HOGENOMiHOG000121783.
HOVERGENiHBG108451.
InParanoidiQ8TE82.
OMAiIYNEYQL.
OrthoDBiEOG76T9QF.
PhylomeDBiQ8TE82.
TreeFamiTF333167.

Miscellaneous databases

ChiTaRSiSH3TC1. human.
GenomeRNAii54436.
NextBioi56650.
PROiQ8TE82.

Gene expression databases

BgeeiQ8TE82.
CleanExiHS_SH3TC1.
ExpressionAtlasiQ8TE82. baseline and differential.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR001452. SH3_domain.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-437.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-719 AND THR-1130.

Entry informationi

Entry nameiS3TC1_HUMAN
AccessioniPrimary (citable) accession number: Q8TE82
Secondary accession number(s): Q4W5G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 30, 2010
Last modified: May 11, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.