Q8TE76 (MORC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MORC family CW-type zinc finger protein 4

Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 2

Gene names

Name:	MORC4
Synonyms:	ZCWCC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	937 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Probable Ref.1.
Tissue specificity	Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas. Ref.1
Sequence similarities	Contains 1 CW-type zinc finger.
Sequence caution	The sequence BAB13859.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB71125.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
STAT3	P40763	2	EBI-3940432,EBI-518675

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TE76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TE76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Isoform 3 (identifier: Q8TE76-3)

The sequence of this isoform differs from the canonical sequence as follows:
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 937	937	MORC family CW-type zinc finger protein 4		PRO_0000096539
Regions
	Zinc finger	420 – 472	53	CW-type
	Coiled coil	762 – 876	115	Potential
Natural variations
	Alternative sequence	1 – 252	252	Missing in isoform 2.		VSP_045025
	Alternative sequence	875 – 937	63	VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3.		VSP_045026
	Natural variant	473	1	T → I. Ref.3 Corresponds to variant rs6622126 [ dbSNP | Ensembl ].		VAR_051197
	Natural variant	653	1	R → C. Corresponds to variant rs3827464 [ dbSNP | Ensembl ].		VAR_051198
Experimental info
	Sequence conflict	307	1	Y → H in BAB71125. Ref.3
	Sequence conflict	480	1	S → G in BAB13859. Ref.3
	Sequence conflict	519	1	G → E in ABL84747. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 7AABDA01596475D2	FASTA	937	106,348
	10 20 30 40 50 60 MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN 70 80 90 100 110 120 AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV 130 140 150 160 170 180 FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLECVQ AQAVIVPIVP FNQQNKKMII 190 200 210 220 230 240 TEDSLPSLEA ILNYSIFNRE NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY 250 260 270 280 290 300 DILVSDFDTE EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA 310 320 330 340 350 360 NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ VKPTRGEGVG 370 380 390 400 410 420 VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW KEKTSQDNFE TSTVARPIPK 430 440 450 460 470 480 VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS 490 500 510 520 530 540 KAKKQEQTVE EKKKMPMENE NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG 550 560 570 580 590 600 EESRSPSLQL KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE 610 620 630 640 650 660 APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK DQRQGSLLPE 670 680 690 700 710 720 ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG VRDSGAPIQL IPFNREELAE 730 740 750 760 770 780 RRKAVESWNP VPYSVASAAI PAAAIGEKAR GYEESEGHNT PKLKNQRELE ELKRTTEKLE 790 800 810 820 830 840 RVLAERNLFQ QKVEELEQER NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ 850 860 870 880 890 900 ILKAELERTK EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS 910 920 930 YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD
	Isoform 2 [UniParc]. Checksum: 828D6D1DAC45BA7F	FASTA	648	74,353
	10 20 30 40 50 60 MTGGVTSELP ETEYSLRAFC GILYMKPRMK IFLRQKKVTT QMIAKSLANV EYDTYKPTFT 70 80 90 100 110 120 NKQVRITFGF SCKNSNQFGI MMYHNNRLIK SFEKVGCQVK PTRGEGVGVI GVIECNFLKP 130 140 150 160 170 180 AYNKQDFEYT KEYRLTINAL AQKLNAYWKE KTSQDNFETS TVARPIPKVP DQTWVQCDEC 190 200 210 220 230 240 LKWRKLPGKI DPSMLPARWF CYYNSHPKYR RCSVPEEQEL TDEDLCLSKA KKQEQTVEEK 250 260 270 280 290 300 KKMPMENENH QVFSNPPKIL TVQEMAGLNN KTIGYEGIHS PSVLPSGGEE SRSPSLQLKP 310 320 330 340 350 360 LDSSVLQFSS KYKWILGEEP VEKRRRLQNE MTTPSLDYSM PAPYRRVEAP VAYPEGENSH 370 380 390 400 410 420 DKSSSERSTP PYLFPEYPEA SKNTGQNREV SILYPGAKDQ RQGSLLPEEL EDQMPRLVAE 430 440 450 460 470 480 ESNRGSTTIN KEEVNKGPFV AVVGVAKGVR DSGAPIQLIP FNREELAERR KAVESWNPVP 490 500 510 520 530 540 YSVASAAIPA AAIGEKARGY EESEGHNTPK LKNQRELEEL KRTTEKLERV LAERNLFQQK 550 560 570 580 590 600 VEELEQERNH WQSEFKKVQH ELVIYSTQEA EGLYWSKKHM GYRQAEFQIL KAELERTKEE 610 620 630 640 KQELKEKLKE TETHLEMLQK AQGFGKAYAA TYPRQLSPYF CPPSLGAS
	Isoform 3 [UniParc]. Checksum: ACBD1DEB6E46671C	FASTA	900	101,877
	10 20 30 40 50 60 MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN 70 80 90 100 110 120 AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV 130 140 150 160 170 180 FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLECVQ AQAVIVPIVP FNQQNKKMII 190 200 210 220 230 240 TEDSLPSLEA ILNYSIFNRE NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY 250 260 270 280 290 300 DILVSDFDTE EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA 310 320 330 340 350 360 NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ VKPTRGEGVG 370 380 390 400 410 420 VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW KEKTSQDNFE TSTVARPIPK 430 440 450 460 470 480 VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS 490 500 510 520 530 540 KAKKQEQTVE EKKKMPMENE NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG 550 560 570 580 590 600 EESRSPSLQL KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE 610 620 630 640 650 660 APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK DQRQGSLLPE 670 680 690 700 710 720 ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG VRDSGAPIQL IPFNREELAE 730 740 750 760 770 780 RRKAVESWNP VPYSVASAAI PAAAIGEKAR GYEESEGHNT PKLKNQRELE ELKRTTEKLE 790 800 810 820 830 840 RVLAERNLFQ QKVEELEQER NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ 850 860 870 880 890 900 ILKAELERTK EEKQELKEKL KETETHLEML QKAQGFGKAY AATYPRQLSP YFCPPSLGAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas." Liggins A.P., Cooper C.D., Lawrie C.H., Brown P.J., Collins G.P., Hatton C.S., Pulford K., Banham A.H. Br. J. Haematol. 138:479-486(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING. Tissue: Testis.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-937 (ISOFORM 1), VARIANT ILE-473. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF125209 mRNA. Translation: ABL84747.1. EF125210 mRNA. Translation: ABL84748.1. AL158821 Genomic DNA. Translation: CAI43049.1. AK021627 mRNA. Translation: BAB13859.1. Different initiation. AK056235 mRNA. Translation: BAB71125.1. Different initiation.
IPI	IPI00163550. IPI00478161. IPI01011202.
RefSeq	NP_001078823.1. NM_001085354.2. NP_078933.3. NM_024657.4.
UniGene	Hs.496544.
3D structure databases
ProteinModelPortal	Q8TE76.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TE76. 3 interactions.
MINT	MINT-1181290.
STRING	9606.ENSP00000347821.
PTM databases
PhosphoSite	Q8TE76.
Polymorphism databases
DMDM	73920232.
Proteomic databases
PaxDb	Q8TE76.
PRIDE	Q8TE76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255495; ENSP00000255495; ENSG00000133131. ENST00000355610; ENSP00000347821; ENSG00000133131. ENST00000535534; ENSP00000440359; ENSG00000133131.
GeneID	79710.
KEGG	hsa:79710.
UCSC	uc004emu.4. human.
Organism-specific databases
CTD	79710.
GeneCards	GC0XM106183.
HGNC	HGNC:23485. MORC4.
HPA	HPA000395.
neXtProt	NX_Q8TE76.
PharmGKB	PA128394718.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302069.
HOGENOM	HOG000246950.
HOVERGEN	HBG103357.
InParanoid	Q8TE76.
OMA	VAEESNR.
OrthoDB	EOG4H19V4.
Gene expression databases
ArrayExpress	Q8TE76.
Bgee	Q8TE76.
CleanEx	HS_MORC4.
Genevestigator	Q8TE76.
GermOnline	ENSG00000133131. Homo sapiens.
Family and domain databases
Gene3D	3.30.565.10. 2 hits.
InterPro	IPR003594. HATPase_ATP-bd. IPR011124. Znf_CW. [Graphical view]
Pfam	PF07496. zf-CW. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit.
PROSITE	PS51050. ZF_CW. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79710.
NextBio	35460570.

Entry information

Entry name

MORC4_HUMAN

Accession

Primary (citable) accession number: Q8TE76
Secondary accession number(s): A1YR23 , A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.