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Q8TE76 (MORC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MORC family CW-type zinc finger protein 4
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 2
Gene names
Name:MORC4
Synonyms:ZCWCC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus Probable Ref.1.

Tissue specificity

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas. Ref.1

Sequence similarities

Contains 1 CW-type zinc finger.

Sequence caution

The sequence BAB13859.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB71125.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 21988832. Source: IntAct

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

STAT3P407632EBI-3940432,EBI-518675

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TE76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TE76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS
Isoform 3 (identifier: Q8TE76-3)

The sequence of this isoform differs from the canonical sequence as follows:
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 937937MORC family CW-type zinc finger protein 4
PRO_0000096539

Regions

Zinc finger420 – 47253CW-type
Coiled coil762 – 876115 Potential

Natural variations

Alternative sequence1 – 252252Missing in isoform 2.
VSP_045025
Alternative sequence875 – 93763VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3.
VSP_045026
Natural variant4731T → I. Ref.3
Corresponds to variant rs6622126 [ dbSNP | Ensembl ].
VAR_051197
Natural variant6531R → C.
Corresponds to variant rs3827464 [ dbSNP | Ensembl ].
VAR_051198

Experimental info

Sequence conflict3071Y → H in BAB71125. Ref.3
Sequence conflict4801S → G in BAB13859. Ref.3
Sequence conflict5191G → E in ABL84747. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 7AABDA01596475D2

FASTA937106,348
        10         20         30         40         50         60 
MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN 

        70         80         90        100        110        120 
AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV 

       130        140        150        160        170        180 
FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLECVQ AQAVIVPIVP FNQQNKKMII 

       190        200        210        220        230        240 
TEDSLPSLEA ILNYSIFNRE NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY 

       250        260        270        280        290        300 
DILVSDFDTE EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA 

       310        320        330        340        350        360 
NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ VKPTRGEGVG 

       370        380        390        400        410        420 
VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW KEKTSQDNFE TSTVARPIPK 

       430        440        450        460        470        480 
VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS 

       490        500        510        520        530        540 
KAKKQEQTVE EKKKMPMENE NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG 

       550        560        570        580        590        600 
EESRSPSLQL KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE 

       610        620        630        640        650        660 
APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK DQRQGSLLPE 

       670        680        690        700        710        720 
ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG VRDSGAPIQL IPFNREELAE 

       730        740        750        760        770        780 
RRKAVESWNP VPYSVASAAI PAAAIGEKAR GYEESEGHNT PKLKNQRELE ELKRTTEKLE 

       790        800        810        820        830        840 
RVLAERNLFQ QKVEELEQER NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ 

       850        860        870        880        890        900 
ILKAELERTK EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS 

       910        920        930 
YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD 

« Hide

Isoform 2 [UniParc].

Checksum: 828D6D1DAC45BA7F
Show »

FASTA64874,353
Isoform 3 [UniParc].

Checksum: ACBD1DEB6E46671C
Show »

FASTA900101,877

References

« Hide 'large scale' references
[1]"MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas."
Liggins A.P., Cooper C.D., Lawrie C.H., Brown P.J., Collins G.P., Hatton C.S., Pulford K., Banham A.H.
Br. J. Haematol. 138:479-486(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
Tissue: Testis.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-937 (ISOFORM 1), VARIANT ILE-473.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF125209 mRNA. Translation: ABL84747.1.
EF125210 mRNA. Translation: ABL84748.1.
AL158821 Genomic DNA. Translation: CAI43049.1.
AK021627 mRNA. Translation: BAB13859.1. Different initiation.
AK056235 mRNA. Translation: BAB71125.1. Different initiation.
CCDSCCDS14525.2. [Q8TE76-1]
CCDS48146.1. [Q8TE76-3]
RefSeqNP_001078823.1. NM_001085354.2. [Q8TE76-3]
NP_078933.3. NM_024657.4. [Q8TE76-1]
UniGeneHs.496544.

3D structure databases

ProteinModelPortalQ8TE76.
SMRQ8TE76. Positions 426-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122827. 6 interactions.
IntActQ8TE76. 5 interactions.
MINTMINT-1181290.
STRING9606.ENSP00000347821.

PTM databases

PhosphoSiteQ8TE76.

Polymorphism databases

DMDM73920232.

Proteomic databases

MaxQBQ8TE76.
PaxDbQ8TE76.
PRIDEQ8TE76.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255495; ENSP00000255495; ENSG00000133131. [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131. [Q8TE76-1]
ENST00000535534; ENSP00000440359; ENSG00000133131. [Q8TE76-2]
GeneID79710.
KEGGhsa:79710.
UCSCuc004emu.4. human. [Q8TE76-1]
uc004emw.4. human.

Organism-specific databases

CTD79710.
GeneCardsGC0XM106070.
HGNCHGNC:23485. MORC4.
HPAHPA015547.
HPA050250.
neXtProtNX_Q8TE76.
PharmGKBPA128394718.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302069.
HOGENOMHOG000246950.
HOVERGENHBG103357.
InParanoidQ8TE76.
OMAKAVESWN.
OrthoDBEOG7X3QQB.
PhylomeDBQ8TE76.
TreeFamTF329118.

Gene expression databases

BgeeQ8TE76.
CleanExHS_MORC4.
GenevestigatorQ8TE76.

Family and domain databases

Gene3D3.30.565.10. 2 hits.
InterProIPR003594. HATPase_ATP-bd.
IPR011124. Znf_CW.
[Graphical view]
PfamPF07496. zf-CW. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. SSF55874. 2 hits.
PROSITEPS51050. ZF_CW. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79710.
NextBio35460570.
PROQ8TE76.

Entry information

Entry nameMORC4_HUMAN
AccessionPrimary (citable) accession number: Q8TE76
Secondary accession number(s): A1YR23 expand/collapse secondary AC list , A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM