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Q8TE76

- MORC4_HUMAN

UniProt

Q8TE76 - MORC4_HUMAN

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Protein

MORC family CW-type zinc finger protein 4

Gene

MORC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri420 – 47253CW-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 4
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 2
Gene namesi
Name:MORC4
Synonyms:ZCWCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:23485. MORC4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937MORC family CW-type zinc finger protein 4PRO_0000096539Add
BLAST

Proteomic databases

MaxQBiQ8TE76.
PaxDbiQ8TE76.
PRIDEiQ8TE76.

PTM databases

PhosphoSiteiQ8TE76.

Expressioni

Tissue specificityi

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.1 Publication

Gene expression databases

BgeeiQ8TE76.
CleanExiHS_MORC4.
GenevestigatoriQ8TE76.

Organism-specific databases

HPAiHPA015547.
HPA050250.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940432,EBI-518675

Protein-protein interaction databases

BioGridi122827. 7 interactions.
IntActiQ8TE76. 5 interactions.
MINTiMINT-1181290.
STRINGi9606.ENSP00000347821.

Structurei

3D structure databases

ProteinModelPortaliQ8TE76.
SMRiQ8TE76. Positions 53-144, 422-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili762 – 876115Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 CW-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri420 – 47253CW-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG302069.
GeneTreeiENSGT00530000062983.
HOGENOMiHOG000246950.
HOVERGENiHBG103357.
InParanoidiQ8TE76.
OMAiKAVESWN.
OrthoDBiEOG7X3QQB.
PhylomeDBiQ8TE76.
TreeFamiTF329118.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF07496. zf-CW. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 2 hits.
PROSITEiPS51050. ZF_CW. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TE76-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP
60 70 80 90 100
FSAIAELLDN AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR
110 120 130 140 150
MLSFGFTDKV IKKSQCPIGV FGNGFKSGSM RLGKDALVFT KNGGTLTVGL
160 170 180 190 200
LSQTYLECVQ AQAVIVPIVP FNQQNKKMII TEDSLPSLEA ILNYSIFNRE
210 220 230 240 250
NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY DILVSDFDTE
260 270 280 290 300
EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA
310 320 330 340 350
NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ
360 370 380 390 400
VKPTRGEGVG VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW
410 420 430 440 450
KEKTSQDNFE TSTVARPIPK VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR
460 470 480 490 500
WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS KAKKQEQTVE EKKKMPMENE
510 520 530 540 550
NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG EESRSPSLQL
560 570 580 590 600
KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE
610 620 630 640 650
APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK
660 670 680 690 700
DQRQGSLLPE ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG
710 720 730 740 750
VRDSGAPIQL IPFNREELAE RRKAVESWNP VPYSVASAAI PAAAIGEKAR
760 770 780 790 800
GYEESEGHNT PKLKNQRELE ELKRTTEKLE RVLAERNLFQ QKVEELEQER
810 820 830 840 850
NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ ILKAELERTK
860 870 880 890 900
EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS
910 920 930
YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD
Length:937
Mass (Da):106,348
Last modified:August 30, 2005 - v2
Checksum:i7AABDA01596475D2
GO
Isoform 2 (identifier: Q8TE76-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:648
Mass (Da):74,353
Checksum:i828D6D1DAC45BA7F
GO
Isoform 3 (identifier: Q8TE76-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:900
Mass (Da):101,877
Checksum:iACBD1DEB6E46671C
GO

Sequence cautioni

The sequence BAB13859.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71125.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti307 – 3071Y → H in BAB71125. (PubMed:14702039)Curated
Sequence conflicti480 – 4801S → G in BAB13859. (PubMed:14702039)Curated
Sequence conflicti519 – 5191G → E in ABL84747. (PubMed:17608765)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti473 – 4731T → I.1 Publication
Corresponds to variant rs6622126 [ dbSNP | Ensembl ].
VAR_051197
Natural varianti653 – 6531R → C.
Corresponds to variant rs3827464 [ dbSNP | Ensembl ].
VAR_051198

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 252252Missing in isoform 2. 1 PublicationVSP_045025Add
BLAST
Alternative sequencei875 – 93763VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3. 1 PublicationVSP_045026Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125209 mRNA. Translation: ABL84747.1.
EF125210 mRNA. Translation: ABL84748.1.
AL158821 Genomic DNA. Translation: CAI43049.1.
AK021627 mRNA. Translation: BAB13859.1. Different initiation.
AK056235 mRNA. Translation: BAB71125.1. Different initiation.
CCDSiCCDS14525.2. [Q8TE76-1]
CCDS48146.1. [Q8TE76-3]
RefSeqiNP_001078823.1. NM_001085354.2. [Q8TE76-3]
NP_078933.3. NM_024657.4. [Q8TE76-1]
UniGeneiHs.496544.

Genome annotation databases

EnsembliENST00000255495; ENSP00000255495; ENSG00000133131. [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131. [Q8TE76-1]
GeneIDi79710.
KEGGihsa:79710.
UCSCiuc004emu.4. human. [Q8TE76-1]
uc004emw.4. human.

Polymorphism databases

DMDMi73920232.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125209 mRNA. Translation: ABL84747.1 .
EF125210 mRNA. Translation: ABL84748.1 .
AL158821 Genomic DNA. Translation: CAI43049.1 .
AK021627 mRNA. Translation: BAB13859.1 . Different initiation.
AK056235 mRNA. Translation: BAB71125.1 . Different initiation.
CCDSi CCDS14525.2. [Q8TE76-1 ]
CCDS48146.1. [Q8TE76-3 ]
RefSeqi NP_001078823.1. NM_001085354.2. [Q8TE76-3 ]
NP_078933.3. NM_024657.4. [Q8TE76-1 ]
UniGenei Hs.496544.

3D structure databases

ProteinModelPortali Q8TE76.
SMRi Q8TE76. Positions 53-144, 422-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122827. 7 interactions.
IntActi Q8TE76. 5 interactions.
MINTi MINT-1181290.
STRINGi 9606.ENSP00000347821.

PTM databases

PhosphoSitei Q8TE76.

Polymorphism databases

DMDMi 73920232.

Proteomic databases

MaxQBi Q8TE76.
PaxDbi Q8TE76.
PRIDEi Q8TE76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255495 ; ENSP00000255495 ; ENSG00000133131 . [Q8TE76-3 ]
ENST00000355610 ; ENSP00000347821 ; ENSG00000133131 . [Q8TE76-1 ]
GeneIDi 79710.
KEGGi hsa:79710.
UCSCi uc004emu.4. human. [Q8TE76-1 ]
uc004emw.4. human.

Organism-specific databases

CTDi 79710.
GeneCardsi GC0XM106070.
HGNCi HGNC:23485. MORC4.
HPAi HPA015547.
HPA050250.
neXtProti NX_Q8TE76.
PharmGKBi PA128394718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302069.
GeneTreei ENSGT00530000062983.
HOGENOMi HOG000246950.
HOVERGENi HBG103357.
InParanoidi Q8TE76.
OMAi KAVESWN.
OrthoDBi EOG7X3QQB.
PhylomeDBi Q8TE76.
TreeFami TF329118.

Miscellaneous databases

ChiTaRSi MORC4. human.
GenomeRNAii 79710.
NextBioi 35460570.
PROi Q8TE76.

Gene expression databases

Bgeei Q8TE76.
CleanExi HS_MORC4.
Genevestigatori Q8TE76.

Family and domain databases

Gene3Di 3.30.565.10. 2 hits.
InterProi IPR003594. HATPase_C.
IPR011124. Znf_CW.
[Graphical view ]
Pfami PF07496. zf-CW. 1 hit.
[Graphical view ]
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF55874. SSF55874. 2 hits.
PROSITEi PS51050. ZF_CW. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas."
    Liggins A.P., Cooper C.D., Lawrie C.H., Brown P.J., Collins G.P., Hatton C.S., Pulford K., Banham A.H.
    Br. J. Haematol. 138:479-486(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Tissue: Testis.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-937 (ISOFORM 1), VARIANT ILE-473.
    Tissue: Embryo.

Entry informationi

Entry nameiMORC4_HUMAN
AccessioniPrimary (citable) accession number: Q8TE76
Secondary accession number(s): A1YR23
, A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3