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Q8TE76

- MORC4_HUMAN

UniProt

Q8TE76 - MORC4_HUMAN

Protein

MORC family CW-type zinc finger protein 4

Gene

MORC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri420 – 47253CW-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MORC family CW-type zinc finger protein 4
    Alternative name(s):
    Zinc finger CW-type coiled-coil domain protein 2
    Gene namesi
    Name:MORC4
    Synonyms:ZCWCC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:23485. MORC4.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 937937MORC family CW-type zinc finger protein 4PRO_0000096539Add
    BLAST

    Proteomic databases

    MaxQBiQ8TE76.
    PaxDbiQ8TE76.
    PRIDEiQ8TE76.

    PTM databases

    PhosphoSiteiQ8TE76.

    Expressioni

    Tissue specificityi

    Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.1 Publication

    Gene expression databases

    BgeeiQ8TE76.
    CleanExiHS_MORC4.
    GenevestigatoriQ8TE76.

    Organism-specific databases

    HPAiHPA015547.
    HPA050250.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STAT3P407632EBI-3940432,EBI-518675

    Protein-protein interaction databases

    BioGridi122827. 6 interactions.
    IntActiQ8TE76. 5 interactions.
    MINTiMINT-1181290.
    STRINGi9606.ENSP00000347821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE76.
    SMRiQ8TE76. Positions 426-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili762 – 876115Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CW-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri420 – 47253CW-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG302069.
    HOGENOMiHOG000246950.
    HOVERGENiHBG103357.
    InParanoidiQ8TE76.
    OMAiKAVESWN.
    OrthoDBiEOG7X3QQB.
    PhylomeDBiQ8TE76.
    TreeFamiTF329118.

    Family and domain databases

    Gene3Di3.30.565.10. 2 hits.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR011124. Znf_CW.
    [Graphical view]
    PfamiPF07496. zf-CW. 1 hit.
    [Graphical view]
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF55874. SSF55874. 2 hits.
    PROSITEiPS51050. ZF_CW. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE76-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP    50
    FSAIAELLDN AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR 100
    MLSFGFTDKV IKKSQCPIGV FGNGFKSGSM RLGKDALVFT KNGGTLTVGL 150
    LSQTYLECVQ AQAVIVPIVP FNQQNKKMII TEDSLPSLEA ILNYSIFNRE 200
    NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY DILVSDFDTE 250
    EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA 300
    NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ 350
    VKPTRGEGVG VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW 400
    KEKTSQDNFE TSTVARPIPK VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR 450
    WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS KAKKQEQTVE EKKKMPMENE 500
    NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG EESRSPSLQL 550
    KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE 600
    APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK 650
    DQRQGSLLPE ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG 700
    VRDSGAPIQL IPFNREELAE RRKAVESWNP VPYSVASAAI PAAAIGEKAR 750
    GYEESEGHNT PKLKNQRELE ELKRTTEKLE RVLAERNLFQ QKVEELEQER 800
    NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ ILKAELERTK 850
    EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS 900
    YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD 937
    Length:937
    Mass (Da):106,348
    Last modified:August 30, 2005 - v2
    Checksum:i7AABDA01596475D2
    GO
    Isoform 2 (identifier: Q8TE76-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-252: Missing.
         875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

    Show »
    Length:648
    Mass (Da):74,353
    Checksum:i828D6D1DAC45BA7F
    GO
    Isoform 3 (identifier: Q8TE76-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

    Show »
    Length:900
    Mass (Da):101,877
    Checksum:iACBD1DEB6E46671C
    GO

    Sequence cautioni

    The sequence BAB13859.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB71125.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti307 – 3071Y → H in BAB71125. (PubMed:14702039)Curated
    Sequence conflicti480 – 4801S → G in BAB13859. (PubMed:14702039)Curated
    Sequence conflicti519 – 5191G → E in ABL84747. (PubMed:17608765)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti473 – 4731T → I.1 Publication
    Corresponds to variant rs6622126 [ dbSNP | Ensembl ].
    VAR_051197
    Natural varianti653 – 6531R → C.
    Corresponds to variant rs3827464 [ dbSNP | Ensembl ].
    VAR_051198

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 252252Missing in isoform 2. 1 PublicationVSP_045025Add
    BLAST
    Alternative sequencei875 – 93763VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3. 1 PublicationVSP_045026Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF125209 mRNA. Translation: ABL84747.1.
    EF125210 mRNA. Translation: ABL84748.1.
    AL158821 Genomic DNA. Translation: CAI43049.1.
    AK021627 mRNA. Translation: BAB13859.1. Different initiation.
    AK056235 mRNA. Translation: BAB71125.1. Different initiation.
    CCDSiCCDS14525.2. [Q8TE76-1]
    CCDS48146.1. [Q8TE76-3]
    RefSeqiNP_001078823.1. NM_001085354.2. [Q8TE76-3]
    NP_078933.3. NM_024657.4. [Q8TE76-1]
    UniGeneiHs.496544.

    Genome annotation databases

    EnsembliENST00000255495; ENSP00000255495; ENSG00000133131. [Q8TE76-3]
    ENST00000355610; ENSP00000347821; ENSG00000133131. [Q8TE76-1]
    GeneIDi79710.
    KEGGihsa:79710.
    UCSCiuc004emu.4. human. [Q8TE76-1]
    uc004emw.4. human.

    Polymorphism databases

    DMDMi73920232.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF125209 mRNA. Translation: ABL84747.1 .
    EF125210 mRNA. Translation: ABL84748.1 .
    AL158821 Genomic DNA. Translation: CAI43049.1 .
    AK021627 mRNA. Translation: BAB13859.1 . Different initiation.
    AK056235 mRNA. Translation: BAB71125.1 . Different initiation.
    CCDSi CCDS14525.2. [Q8TE76-1 ]
    CCDS48146.1. [Q8TE76-3 ]
    RefSeqi NP_001078823.1. NM_001085354.2. [Q8TE76-3 ]
    NP_078933.3. NM_024657.4. [Q8TE76-1 ]
    UniGenei Hs.496544.

    3D structure databases

    ProteinModelPortali Q8TE76.
    SMRi Q8TE76. Positions 426-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122827. 6 interactions.
    IntActi Q8TE76. 5 interactions.
    MINTi MINT-1181290.
    STRINGi 9606.ENSP00000347821.

    PTM databases

    PhosphoSitei Q8TE76.

    Polymorphism databases

    DMDMi 73920232.

    Proteomic databases

    MaxQBi Q8TE76.
    PaxDbi Q8TE76.
    PRIDEi Q8TE76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255495 ; ENSP00000255495 ; ENSG00000133131 . [Q8TE76-3 ]
    ENST00000355610 ; ENSP00000347821 ; ENSG00000133131 . [Q8TE76-1 ]
    GeneIDi 79710.
    KEGGi hsa:79710.
    UCSCi uc004emu.4. human. [Q8TE76-1 ]
    uc004emw.4. human.

    Organism-specific databases

    CTDi 79710.
    GeneCardsi GC0XM106070.
    HGNCi HGNC:23485. MORC4.
    HPAi HPA015547.
    HPA050250.
    neXtProti NX_Q8TE76.
    PharmGKBi PA128394718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302069.
    HOGENOMi HOG000246950.
    HOVERGENi HBG103357.
    InParanoidi Q8TE76.
    OMAi KAVESWN.
    OrthoDBi EOG7X3QQB.
    PhylomeDBi Q8TE76.
    TreeFami TF329118.

    Miscellaneous databases

    GenomeRNAii 79710.
    NextBioi 35460570.
    PROi Q8TE76.

    Gene expression databases

    Bgeei Q8TE76.
    CleanExi HS_MORC4.
    Genevestigatori Q8TE76.

    Family and domain databases

    Gene3Di 3.30.565.10. 2 hits.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR011124. Znf_CW.
    [Graphical view ]
    Pfami PF07496. zf-CW. 1 hit.
    [Graphical view ]
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55874. SSF55874. 2 hits.
    PROSITEi PS51050. ZF_CW. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas."
      Liggins A.P., Cooper C.D., Lawrie C.H., Brown P.J., Collins G.P., Hatton C.S., Pulford K., Banham A.H.
      Br. J. Haematol. 138:479-486(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
      Tissue: Testis.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-937 (ISOFORM 1), VARIANT ILE-473.
      Tissue: Embryo.

    Entry informationi

    Entry nameiMORC4_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE76
    Secondary accession number(s): A1YR23
    , A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3