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Q8TE69 (CX04A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CXorf40A
Alternative name(s):
Endothelial-overexpressed lipopolysaccharide-associated factor 1
Gene names
Name:CXorf40A
Synonyms:CXorf40, EOLA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have an important role of cell protection in inflammation reaction.

Subunit structure

Interacts with MT2A. Ref.2

Tissue specificity

Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes. Ref.2

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MT2AP027952EBI-996609,EBI-996616

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TE69-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TE69-2)

The sequence of this isoform differs from the canonical sequence as follows:
     145-158: VDIPEHLIPLGHEV → NP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 158158Protein CXorf40A
PRO_0000079740

Natural variations

Alternative sequence145 – 15814VDIPE…LGHEV → NP in isoform 2.
VSP_047240

Experimental info

Sequence conflict21K → E in BAH13262. Ref.3
Sequence conflict71S → P in BAH13262. Ref.3
Sequence conflict701T → A in AAL71889. Ref.2
Sequence conflict701T → A in BAF84588. Ref.3
Sequence conflict701T → A in BAH13262. Ref.3
Sequence conflict701T → A in AAH65539. Ref.5
Sequence conflict701T → A in AAI04931. Ref.5
Sequence conflict701T → A in AAI04933. Ref.5
Sequence conflict701T → A in AAI43661. Ref.5
Sequence conflict701T → A in AAI43662. Ref.5
Sequence conflict701T → A in AAI43663. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: 1843561F5C47B4B1

FASTA15817,921
        10         20         30         40         50         60 
MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG DAWRELLVER 

        70         80         90        100        110        120 
LGMTPAQIQT LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT PDEVVELENQ AVLTNLKQKY 

       130        140        150 
LTVISNPRWL LEPIPRKGGK DVFQVDIPEH LIPLGHEV 

« Hide

Isoform 2 [UniParc].

Checksum: A1F29BC3C13F1598
Show »

FASTA14616,582

References

« Hide 'large scale' references
[1]"130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus."
Timms K.M., Lu F., Shen Y., Pierson C.A., Muzny D.M., Gu Y., Nelson D.L., Gibbs R.A.
Genome Res. 5:71-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation."
Liang Z., Yang Z.
Biochem. Biophys. Res. Commun. 325:798-802(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH MT2A.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta and Skeletal muscle.
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43580 mRNA. No translation available.
AY074889 mRNA. Translation: AAL71889.1.
AC233288 Genomic DNA. No translation available.
AK291899 mRNA. Translation: BAF84588.1.
AK300334 mRNA. Translation: BAH13262.1.
BC065539 mRNA. Translation: AAH65539.1.
BC104930 mRNA. Translation: AAI04931.1.
BC104932 mRNA. Translation: AAI04933.1.
BC143660 mRNA. Translation: AAI43661.1.
BC143661 mRNA. Translation: AAI43662.1.
BC143662 mRNA. Translation: AAI43663.1.
CCDSCCDS14687.1. [Q8TE69-1]
CCDS55522.1. [Q8TE69-2]
RefSeqNP_001165378.1. NM_001171907.2.
NP_001165379.1. NM_001171908.2.
NP_001165380.1. NM_001171909.2.
NP_835225.2. NM_178124.5.
XP_005262405.2. XM_005262348.2.
XP_005262406.2. XM_005262349.2.
XP_005278269.1. XM_005278212.1.
UniGeneHs.534641.
Hs.719441.
Hs.737793.

3D structure databases

ProteinModelPortalQ8TE69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8TE69. 1 interaction.

Polymorphism databases

DMDM519668664.

Proteomic databases

PRIDEQ8TE69.

Protocols and materials databases

DNASU91966.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359293; ENSP00000420882; ENSG00000197620. [Q8TE69-1]
ENST00000393985; ENSP00000421745; ENSG00000197620. [Q8TE69-1]
ENST00000422892; ENSP00000422312; ENSG00000197620. [Q8TE69-2]
ENST00000423421; ENSP00000422512; ENSG00000197620. [Q8TE69-1]
ENST00000423540; ENSP00000425520; ENSG00000197620. [Q8TE69-1]
ENST00000434353; ENSP00000423160; ENSG00000197620. [Q8TE69-2]
ENST00000441248; ENSP00000423099; ENSG00000197620. [Q8TE69-1]
ENST00000450602; ENSP00000427540; ENSG00000197620. [Q8TE69-1]
ENST00000514208; ENSP00000423708; ENSG00000197620. [Q8TE69-2]
ENST00000593915; ENSP00000469237; ENSG00000268314.
ENST00000595814; ENSP00000473015; ENSG00000268314.
ENST00000596374; ENSP00000469025; ENSG00000268314.
ENST00000597294; ENSP00000471848; ENSG00000268314.
ENST00000598640; ENSP00000469172; ENSG00000268314.
ENST00000601066; ENSP00000470317; ENSG00000268314.
GeneID91966.
KEGGhsa:91966.
UCSCuc004fdf.3. human. [Q8TE69-1]

Organism-specific databases

CTD91966.
GeneCardsGC0XP148623.
HGNCHGNC:28089. CXorf40A.
HPAHPA060897.
neXtProtNX_Q8TE69.
PharmGKBPA134915038.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45203.
HOGENOMHOG000231371.
HOVERGENHBG054454.
InParanoidQ8TE69.
OMARISDMNS.
PhylomeDBQ8TE69.
TreeFamTF332845.

Gene expression databases

CleanExHS_CXorf40A.
GenevestigatorQ8TE69.

Family and domain databases

InterProIPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
[Graphical view]
SMARTSM01022. ASCH. 1 hit.
[Graphical view]
SUPFAMSSF88697. SSF88697. 2 hits.
ProtoNetSearch...

Other

GeneWikiCXorf40A.
GenomeRNAi91966.
NextBio35493172.

Entry information

Entry nameCX04A_HUMAN
AccessionPrimary (citable) accession number: Q8TE69
Secondary accession number(s): A8K784 expand/collapse secondary AC list , B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 26, 2013
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

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Human chromosome X: entries, gene names and cross-references to MIM