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Q8TE69

- CX04A_HUMAN

UniProt

Q8TE69 - CX04A_HUMAN

Protein

Protein CXorf40A

Gene

CXorf40A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have an important role of cell protection in inflammation reaction.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CXorf40A
    Alternative name(s):
    Endothelial-overexpressed lipopolysaccharide-associated factor 1
    Gene namesi
    Name:CXorf40A
    Synonyms:CXorf40, EOLA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:28089. CXorf40A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134915038.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158Protein CXorf40APRO_0000079740Add
    BLAST

    Proteomic databases

    PRIDEiQ8TE69.

    Expressioni

    Tissue specificityi

    Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.1 Publication

    Gene expression databases

    CleanExiHS_CXorf40A.
    GenevestigatoriQ8TE69.

    Organism-specific databases

    HPAiHPA060897.

    Interactioni

    Subunit structurei

    Interacts with MT2A.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MT2AP027952EBI-996609,EBI-996616

    Protein-protein interaction databases

    IntActiQ8TE69. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45203.
    HOGENOMiHOG000231371.
    HOVERGENiHBG054454.
    InParanoidiQ8TE69.
    OMAiRISDMNS.
    PhylomeDBiQ8TE69.
    TreeFamiTF332845.

    Family and domain databases

    InterProiIPR007374. ASCH_domain.
    IPR015947. PUA-like_domain.
    [Graphical view]
    SMARTiSM01022. ASCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE69-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG    50
    DAWRELLVER LGMTPAQIQT LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT 100
    PDEVVELENQ AVLTNLKQKY LTVISNPRWL LEPIPRKGGK DVFQVDIPEH 150
    LIPLGHEV 158
    Length:158
    Mass (Da):17,921
    Last modified:June 26, 2013 - v2
    Checksum:i1843561F5C47B4B1
    GO
    Isoform 2 (identifier: Q8TE69-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-158: VDIPEHLIPLGHEV → NP

    Show »
    Length:146
    Mass (Da):16,582
    Checksum:iA1F29BC3C13F1598
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21K → E in BAH13262. (PubMed:14702039)Curated
    Sequence conflicti7 – 71S → P in BAH13262. (PubMed:14702039)Curated
    Sequence conflicti70 – 701T → A in AAL71889. (PubMed:15541360)Curated
    Sequence conflicti70 – 701T → A in BAF84588. (PubMed:14702039)Curated
    Sequence conflicti70 – 701T → A in BAH13262. (PubMed:14702039)Curated
    Sequence conflicti70 – 701T → A in AAH65539. (PubMed:15489334)Curated
    Sequence conflicti70 – 701T → A in AAI04931. (PubMed:15489334)Curated
    Sequence conflicti70 – 701T → A in AAI04933. (PubMed:15489334)Curated
    Sequence conflicti70 – 701T → A in AAI43661. (PubMed:15489334)Curated
    Sequence conflicti70 – 701T → A in AAI43662. (PubMed:15489334)Curated
    Sequence conflicti70 – 701T → A in AAI43663. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei145 – 15814VDIPE…LGHEV → NP in isoform 2. 1 PublicationVSP_047240Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43580 mRNA. No translation available.
    AY074889 mRNA. Translation: AAL71889.1.
    AC233288 Genomic DNA. No translation available.
    AK291899 mRNA. Translation: BAF84588.1.
    AK300334 mRNA. Translation: BAH13262.1.
    BC065539 mRNA. Translation: AAH65539.1.
    BC104930 mRNA. Translation: AAI04931.1.
    BC104932 mRNA. Translation: AAI04933.1.
    BC143660 mRNA. Translation: AAI43661.1.
    BC143661 mRNA. Translation: AAI43662.1.
    BC143662 mRNA. Translation: AAI43663.1.
    CCDSiCCDS14687.1. [Q8TE69-1]
    CCDS55522.1. [Q8TE69-2]
    RefSeqiNP_001165378.1. NM_001171907.2.
    NP_001165379.1. NM_001171908.2.
    NP_001165380.1. NM_001171909.2.
    NP_835225.2. NM_178124.5.
    XP_005262405.2. XM_005262348.2.
    XP_005262406.2. XM_005262349.2.
    XP_005278269.1. XM_005278212.1.
    UniGeneiHs.534641.
    Hs.719441.
    Hs.737793.

    Genome annotation databases

    EnsembliENST00000359293; ENSP00000420882; ENSG00000197620. [Q8TE69-1]
    ENST00000393985; ENSP00000421745; ENSG00000197620. [Q8TE69-1]
    ENST00000422892; ENSP00000422312; ENSG00000197620. [Q8TE69-2]
    ENST00000423421; ENSP00000422512; ENSG00000197620. [Q8TE69-1]
    ENST00000423540; ENSP00000425520; ENSG00000197620. [Q8TE69-1]
    ENST00000434353; ENSP00000423160; ENSG00000197620. [Q8TE69-2]
    ENST00000441248; ENSP00000423099; ENSG00000197620. [Q8TE69-1]
    ENST00000450602; ENSP00000427540; ENSG00000197620. [Q8TE69-1]
    ENST00000514208; ENSP00000423708; ENSG00000197620. [Q8TE69-2]
    GeneIDi91966.
    KEGGihsa:91966.
    UCSCiuc004fdf.3. human. [Q8TE69-1]

    Polymorphism databases

    DMDMi519668664.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43580 mRNA. No translation available.
    AY074889 mRNA. Translation: AAL71889.1 .
    AC233288 Genomic DNA. No translation available.
    AK291899 mRNA. Translation: BAF84588.1 .
    AK300334 mRNA. Translation: BAH13262.1 .
    BC065539 mRNA. Translation: AAH65539.1 .
    BC104930 mRNA. Translation: AAI04931.1 .
    BC104932 mRNA. Translation: AAI04933.1 .
    BC143660 mRNA. Translation: AAI43661.1 .
    BC143661 mRNA. Translation: AAI43662.1 .
    BC143662 mRNA. Translation: AAI43663.1 .
    CCDSi CCDS14687.1. [Q8TE69-1 ]
    CCDS55522.1. [Q8TE69-2 ]
    RefSeqi NP_001165378.1. NM_001171907.2.
    NP_001165379.1. NM_001171908.2.
    NP_001165380.1. NM_001171909.2.
    NP_835225.2. NM_178124.5.
    XP_005262405.2. XM_005262348.2.
    XP_005262406.2. XM_005262349.2.
    XP_005278269.1. XM_005278212.1.
    UniGenei Hs.534641.
    Hs.719441.
    Hs.737793.

    3D structure databases

    ProteinModelPortali Q8TE69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8TE69. 1 interaction.

    Polymorphism databases

    DMDMi 519668664.

    Proteomic databases

    PRIDEi Q8TE69.

    Protocols and materials databases

    DNASUi 91966.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359293 ; ENSP00000420882 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000393985 ; ENSP00000421745 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000422892 ; ENSP00000422312 ; ENSG00000197620 . [Q8TE69-2 ]
    ENST00000423421 ; ENSP00000422512 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000423540 ; ENSP00000425520 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000434353 ; ENSP00000423160 ; ENSG00000197620 . [Q8TE69-2 ]
    ENST00000441248 ; ENSP00000423099 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000450602 ; ENSP00000427540 ; ENSG00000197620 . [Q8TE69-1 ]
    ENST00000514208 ; ENSP00000423708 ; ENSG00000197620 . [Q8TE69-2 ]
    GeneIDi 91966.
    KEGGi hsa:91966.
    UCSCi uc004fdf.3. human. [Q8TE69-1 ]

    Organism-specific databases

    CTDi 91966.
    GeneCardsi GC0XP148623.
    HGNCi HGNC:28089. CXorf40A.
    HPAi HPA060897.
    neXtProti NX_Q8TE69.
    PharmGKBi PA134915038.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45203.
    HOGENOMi HOG000231371.
    HOVERGENi HBG054454.
    InParanoidi Q8TE69.
    OMAi RISDMNS.
    PhylomeDBi Q8TE69.
    TreeFami TF332845.

    Miscellaneous databases

    GeneWikii CXorf40A.
    GenomeRNAii 91966.
    NextBioi 35493172.

    Gene expression databases

    CleanExi HS_CXorf40A.
    Genevestigatori Q8TE69.

    Family and domain databases

    InterProi IPR007374. ASCH_domain.
    IPR015947. PUA-like_domain.
    [Graphical view ]
    SMARTi SM01022. ASCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus."
      Timms K.M., Lu F., Shen Y., Pierson C.A., Muzny D.M., Gu Y., Nelson D.L., Gibbs R.A.
      Genome Res. 5:71-78(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation."
      Liang Z., Yang Z.
      Biochem. Biophys. Res. Commun. 325:798-802(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH MT2A.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Skeletal muscle.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiCX04A_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE69
    Secondary accession number(s): A8K784
    , B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM

    External Data

    Dasty 3