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Protein

Protein CXorf40A

Gene

CXorf40A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role of cell protection in inflammation reaction.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CXorf40A
Alternative name(s):
Endothelial-overexpressed lipopolysaccharide-associated factor 1
Gene namesi
Name:CXorf40A
Synonyms:CXorf40, EOLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28089. CXorf40A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915038.

Polymorphism and mutation databases

BioMutaiCXorf40A.
DMDMi519668664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Protein CXorf40APRO_0000079740Add
BLAST

Proteomic databases

PRIDEiQ8TE69.

Expressioni

Tissue specificityi

Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

CleanExiHS_CXorf40A.
ExpressionAtlasiQ8TE69. baseline.
GenevestigatoriQ8TE69.

Organism-specific databases

HPAiHPA060897.

Interactioni

Subunit structurei

Interacts with MT2A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MT2AP027952EBI-996609,EBI-996616

Protein-protein interaction databases

IntActiQ8TE69. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TE69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45203.
HOGENOMiHOG000231371.
HOVERGENiHBG054454.
InParanoidiQ8TE69.
PhylomeDBiQ8TE69.
TreeFamiTF332845.

Family and domain databases

InterProiIPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
[Graphical view]
SMARTiSM01022. ASCH. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG
60 70 80 90 100
DAWRELLVER LGMTPAQIQT LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT
110 120 130 140 150
PDEVVELENQ AVLTNLKQKY LTVISNPRWL LEPIPRKGGK DVFQVDIPEH

LIPLGHEV
Length:158
Mass (Da):17,921
Last modified:June 26, 2013 - v2
Checksum:i1843561F5C47B4B1
GO
Isoform 2 (identifier: Q8TE69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-158: VDIPEHLIPLGHEV → NP

Show »
Length:146
Mass (Da):16,582
Checksum:iA1F29BC3C13F1598
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → E in BAH13262 (PubMed:14702039).Curated
Sequence conflicti7 – 71S → P in BAH13262 (PubMed:14702039).Curated
Sequence conflicti70 – 701T → A in AAL71889 (PubMed:15541360).Curated
Sequence conflicti70 – 701T → A in BAF84588 (PubMed:14702039).Curated
Sequence conflicti70 – 701T → A in BAH13262 (PubMed:14702039).Curated
Sequence conflicti70 – 701T → A in AAH65539 (PubMed:15489334).Curated
Sequence conflicti70 – 701T → A in AAI04931 (PubMed:15489334).Curated
Sequence conflicti70 – 701T → A in AAI04933 (PubMed:15489334).Curated
Sequence conflicti70 – 701T → A in AAI43661 (PubMed:15489334).Curated
Sequence conflicti70 – 701T → A in AAI43662 (PubMed:15489334).Curated
Sequence conflicti70 – 701T → A in AAI43663 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 15814VDIPE…LGHEV → NP in isoform 2. 1 PublicationVSP_047240Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43580 mRNA. No translation available.
AY074889 mRNA. Translation: AAL71889.1.
AC233288 Genomic DNA. No translation available.
AK291899 mRNA. Translation: BAF84588.1.
AK300334 mRNA. Translation: BAH13262.1.
BC065539 mRNA. Translation: AAH65539.1.
BC104930 mRNA. Translation: AAI04931.1.
BC104932 mRNA. Translation: AAI04933.1.
BC143660 mRNA. Translation: AAI43661.1.
BC143661 mRNA. Translation: AAI43662.1.
BC143662 mRNA. Translation: AAI43663.1.
CCDSiCCDS14687.1. [Q8TE69-1]
CCDS55522.1. [Q8TE69-2]
RefSeqiNP_001165378.1. NM_001171907.2.
NP_001165379.1. NM_001171908.2.
NP_001165380.1. NM_001171909.2.
NP_835225.2. NM_178124.5.
XP_005262405.2. XM_005262348.3.
XP_005262406.2. XM_005262349.3.
XP_005278269.1. XM_005278212.1.
UniGeneiHs.534641.
Hs.719441.
Hs.737793.

Genome annotation databases

EnsembliENST00000359293; ENSP00000420882; ENSG00000197620.
ENST00000393985; ENSP00000421745; ENSG00000197620.
ENST00000423421; ENSP00000422512; ENSG00000197620.
ENST00000423540; ENSP00000425520; ENSG00000197620.
ENST00000441248; ENSP00000423099; ENSG00000197620.
ENST00000450602; ENSP00000427540; ENSG00000197620.
GeneIDi91966.
KEGGihsa:91966.
UCSCiuc004fdf.3. human. [Q8TE69-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43580 mRNA. No translation available.
AY074889 mRNA. Translation: AAL71889.1.
AC233288 Genomic DNA. No translation available.
AK291899 mRNA. Translation: BAF84588.1.
AK300334 mRNA. Translation: BAH13262.1.
BC065539 mRNA. Translation: AAH65539.1.
BC104930 mRNA. Translation: AAI04931.1.
BC104932 mRNA. Translation: AAI04933.1.
BC143660 mRNA. Translation: AAI43661.1.
BC143661 mRNA. Translation: AAI43662.1.
BC143662 mRNA. Translation: AAI43663.1.
CCDSiCCDS14687.1. [Q8TE69-1]
CCDS55522.1. [Q8TE69-2]
RefSeqiNP_001165378.1. NM_001171907.2.
NP_001165379.1. NM_001171908.2.
NP_001165380.1. NM_001171909.2.
NP_835225.2. NM_178124.5.
XP_005262405.2. XM_005262348.3.
XP_005262406.2. XM_005262349.3.
XP_005278269.1. XM_005278212.1.
UniGeneiHs.534641.
Hs.719441.
Hs.737793.

3D structure databases

ProteinModelPortaliQ8TE69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TE69. 1 interaction.

Polymorphism and mutation databases

BioMutaiCXorf40A.
DMDMi519668664.

Proteomic databases

PRIDEiQ8TE69.

Protocols and materials databases

DNASUi91966.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359293; ENSP00000420882; ENSG00000197620.
ENST00000393985; ENSP00000421745; ENSG00000197620.
ENST00000423421; ENSP00000422512; ENSG00000197620.
ENST00000423540; ENSP00000425520; ENSG00000197620.
ENST00000441248; ENSP00000423099; ENSG00000197620.
ENST00000450602; ENSP00000427540; ENSG00000197620.
GeneIDi91966.
KEGGihsa:91966.
UCSCiuc004fdf.3. human. [Q8TE69-1]

Organism-specific databases

CTDi91966.
GeneCardsiGC0XP148623.
HGNCiHGNC:28089. CXorf40A.
HPAiHPA060897.
neXtProtiNX_Q8TE69.
PharmGKBiPA134915038.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45203.
HOGENOMiHOG000231371.
HOVERGENiHBG054454.
InParanoidiQ8TE69.
PhylomeDBiQ8TE69.
TreeFamiTF332845.

Miscellaneous databases

GeneWikiiCXorf40A.
GenomeRNAii91966.
NextBioi35493172.
PROiQ8TE69.

Gene expression databases

CleanExiHS_CXorf40A.
ExpressionAtlasiQ8TE69. baseline.
GenevestigatoriQ8TE69.

Family and domain databases

InterProiIPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
[Graphical view]
SMARTiSM01022. ASCH. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus."
    Timms K.M., Lu F., Shen Y., Pierson C.A., Muzny D.M., Gu Y., Nelson D.L., Gibbs R.A.
    Genome Res. 5:71-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation."
    Liang Z., Yang Z.
    Biochem. Biophys. Res. Commun. 325:798-802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH MT2A.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Skeletal muscle.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Eye.

Entry informationi

Entry nameiCX04A_HUMAN
AccessioniPrimary (citable) accession number: Q8TE69
Secondary accession number(s): A8K784
, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 26, 2013
Last modified: April 29, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.