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Q8TE69

- CX04A_HUMAN

UniProt

Q8TE69 - CX04A_HUMAN

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Protein

Protein CXorf40A

Gene

CXorf40A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May have an important role of cell protection in inflammation reaction.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CXorf40A
Alternative name(s):
Endothelial-overexpressed lipopolysaccharide-associated factor 1
Gene namesi
Name:CXorf40A
Synonyms:CXorf40, EOLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:28089. CXorf40A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Protein CXorf40APRO_0000079740Add
BLAST

Proteomic databases

PRIDEiQ8TE69.

Expressioni

Tissue specificityi

Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

CleanExiHS_CXorf40A.
ExpressionAtlasiQ8TE69. baseline.
GenevestigatoriQ8TE69.

Organism-specific databases

HPAiHPA060897.

Interactioni

Subunit structurei

Interacts with MT2A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MT2AP027952EBI-996609,EBI-996616

Protein-protein interaction databases

IntActiQ8TE69. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TE69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45203.
GeneTreeiENSGT00390000012182.
HOGENOMiHOG000231371.
HOVERGENiHBG054454.
InParanoidiQ8TE69.
OMAiRISDMNS.
PhylomeDBiQ8TE69.
TreeFamiTF332845.

Family and domain databases

InterProiIPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
[Graphical view]
SMARTiSM01022. ASCH. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TE69-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG
60 70 80 90 100
DAWRELLVER LGMTPAQIQT LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT
110 120 130 140 150
PDEVVELENQ AVLTNLKQKY LTVISNPRWL LEPIPRKGGK DVFQVDIPEH

LIPLGHEV
Length:158
Mass (Da):17,921
Last modified:June 26, 2013 - v2
Checksum:i1843561F5C47B4B1
GO
Isoform 2 (identifier: Q8TE69-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-158: VDIPEHLIPLGHEV → NP

Show »
Length:146
Mass (Da):16,582
Checksum:iA1F29BC3C13F1598
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → E in BAH13262. (PubMed:14702039)Curated
Sequence conflicti7 – 71S → P in BAH13262. (PubMed:14702039)Curated
Sequence conflicti70 – 701T → A in AAL71889. (PubMed:15541360)Curated
Sequence conflicti70 – 701T → A in BAF84588. (PubMed:14702039)Curated
Sequence conflicti70 – 701T → A in BAH13262. (PubMed:14702039)Curated
Sequence conflicti70 – 701T → A in AAH65539. (PubMed:15489334)Curated
Sequence conflicti70 – 701T → A in AAI04931. (PubMed:15489334)Curated
Sequence conflicti70 – 701T → A in AAI04933. (PubMed:15489334)Curated
Sequence conflicti70 – 701T → A in AAI43661. (PubMed:15489334)Curated
Sequence conflicti70 – 701T → A in AAI43662. (PubMed:15489334)Curated
Sequence conflicti70 – 701T → A in AAI43663. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 15814VDIPE…LGHEV → NP in isoform 2. 1 PublicationVSP_047240Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43580 mRNA. No translation available.
AY074889 mRNA. Translation: AAL71889.1.
AC233288 Genomic DNA. No translation available.
AK291899 mRNA. Translation: BAF84588.1.
AK300334 mRNA. Translation: BAH13262.1.
BC065539 mRNA. Translation: AAH65539.1.
BC104930 mRNA. Translation: AAI04931.1.
BC104932 mRNA. Translation: AAI04933.1.
BC143660 mRNA. Translation: AAI43661.1.
BC143661 mRNA. Translation: AAI43662.1.
BC143662 mRNA. Translation: AAI43663.1.
CCDSiCCDS14687.1. [Q8TE69-1]
CCDS55522.1. [Q8TE69-2]
RefSeqiNP_001165378.1. NM_001171907.2.
NP_001165379.1. NM_001171908.2.
NP_001165380.1. NM_001171909.2.
NP_835225.2. NM_178124.5.
XP_005262405.2. XM_005262348.2.
XP_005262406.2. XM_005262349.2.
XP_005278269.1. XM_005278212.1.
UniGeneiHs.534641.
Hs.719441.
Hs.737793.

Genome annotation databases

EnsembliENST00000359293; ENSP00000420882; ENSG00000197620.
ENST00000393985; ENSP00000421745; ENSG00000197620.
ENST00000423421; ENSP00000422512; ENSG00000197620.
ENST00000423540; ENSP00000425520; ENSG00000197620.
ENST00000441248; ENSP00000423099; ENSG00000197620.
ENST00000450602; ENSP00000427540; ENSG00000197620.
GeneIDi91966.
KEGGihsa:91966.
UCSCiuc004fdf.3. human. [Q8TE69-1]

Polymorphism databases

DMDMi519668664.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43580 mRNA. No translation available.
AY074889 mRNA. Translation: AAL71889.1 .
AC233288 Genomic DNA. No translation available.
AK291899 mRNA. Translation: BAF84588.1 .
AK300334 mRNA. Translation: BAH13262.1 .
BC065539 mRNA. Translation: AAH65539.1 .
BC104930 mRNA. Translation: AAI04931.1 .
BC104932 mRNA. Translation: AAI04933.1 .
BC143660 mRNA. Translation: AAI43661.1 .
BC143661 mRNA. Translation: AAI43662.1 .
BC143662 mRNA. Translation: AAI43663.1 .
CCDSi CCDS14687.1. [Q8TE69-1 ]
CCDS55522.1. [Q8TE69-2 ]
RefSeqi NP_001165378.1. NM_001171907.2.
NP_001165379.1. NM_001171908.2.
NP_001165380.1. NM_001171909.2.
NP_835225.2. NM_178124.5.
XP_005262405.2. XM_005262348.2.
XP_005262406.2. XM_005262349.2.
XP_005278269.1. XM_005278212.1.
UniGenei Hs.534641.
Hs.719441.
Hs.737793.

3D structure databases

ProteinModelPortali Q8TE69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8TE69. 1 interaction.

Polymorphism databases

DMDMi 519668664.

Proteomic databases

PRIDEi Q8TE69.

Protocols and materials databases

DNASUi 91966.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359293 ; ENSP00000420882 ; ENSG00000197620 .
ENST00000393985 ; ENSP00000421745 ; ENSG00000197620 .
ENST00000423421 ; ENSP00000422512 ; ENSG00000197620 .
ENST00000423540 ; ENSP00000425520 ; ENSG00000197620 .
ENST00000441248 ; ENSP00000423099 ; ENSG00000197620 .
ENST00000450602 ; ENSP00000427540 ; ENSG00000197620 .
GeneIDi 91966.
KEGGi hsa:91966.
UCSCi uc004fdf.3. human. [Q8TE69-1 ]

Organism-specific databases

CTDi 91966.
GeneCardsi GC0XP148623.
HGNCi HGNC:28089. CXorf40A.
HPAi HPA060897.
neXtProti NX_Q8TE69.
PharmGKBi PA134915038.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45203.
GeneTreei ENSGT00390000012182.
HOGENOMi HOG000231371.
HOVERGENi HBG054454.
InParanoidi Q8TE69.
OMAi RISDMNS.
PhylomeDBi Q8TE69.
TreeFami TF332845.

Miscellaneous databases

GeneWikii CXorf40A.
GenomeRNAii 91966.
NextBioi 35493172.

Gene expression databases

CleanExi HS_CXorf40A.
ExpressionAtlasi Q8TE69. baseline.
Genevestigatori Q8TE69.

Family and domain databases

InterProi IPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
[Graphical view ]
SMARTi SM01022. ASCH. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus."
    Timms K.M., Lu F., Shen Y., Pierson C.A., Muzny D.M., Gu Y., Nelson D.L., Gibbs R.A.
    Genome Res. 5:71-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation."
    Liang Z., Yang Z.
    Biochem. Biophys. Res. Commun. 325:798-802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH MT2A.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Skeletal muscle.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Eye.

Entry informationi

Entry nameiCX04A_HUMAN
AccessioniPrimary (citable) accession number: Q8TE69
Secondary accession number(s): A8K784
, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 26, 2013
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

External Data

Dasty 3