Q8TE68 (ES8L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 1
Short name=EPS8-like protein 1

Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 1
Short name=EPS8-related protein 1

Gene names

Name:	EPS8L1
Synonyms:	DRC3, EPS8R1
ORF Names:	PP10566

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Ref.7
Subunit structure	Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin. Ref.7
Subcellular location	Cytoplasm Ref.7.
Tissue specificity	Detected in placenta. Ref.7
Sequence similarities	Belongs to the EPS8 family. Contains 1 SH3 domain.
Sequence caution	The sequence AAG03038.1 differs from that shown. Reason: Frameshift at position 596. The sequence AAG03039.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil SH3 domain
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TE68-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TE68-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     128-143: ERAQPDVHFFQGLRLG → MNRTWPRRIWGSSQDE

Isoform 3 (identifier: Q8TE68-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVN → MGRKAIVLAIANTSLAFPLCQ
     451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL
     509-696: DDSRKWWKVR...VTVQRSLLED → ED

Isoform 4 (identifier: Q8TE68-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-187: QRDRSPAAET → MSPLSPGSPL
     191-300: QRRPSVRAVI...GRRSRRRAAG → ARADLTAILTGCPPLSACLVLAPRPHRRARLLPS
     451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 723

723

Epidermal growth factor receptor kinase substrate 8-like protein 1

PRO_0000239082

Regions

Domain

478 – 537

60

SH3

Coiled coil

689 – 719

31

Potential

Compositional bias

119 – 122

4

Poly-Leu

Compositional bias

448 – 451

4

Poly-Arg

Compositional bias

534 – 576

43

Pro-rich

Natural variations

Alternative sequence

1 – 177

177

Missing in isoform 4.

VSP_019082

Alternative sequence

1 – 127

127

Missing in isoform 2.

VSP_019083

Alternative sequence

1 – 39

39

MSTAT…QYPVN → MGRKAIVLAIANTSLAFPLC Q in isoform 3.

VSP_019084

Alternative sequence

128 – 143

16

ERAQP…GLRLG → MNRTWPRRIWGSSQDE in isoform 2.

VSP_019085

Alternative sequence

178 – 187

10

QRDRSPAAET → MSPLSPGSPL in isoform 4.

VSP_019086

Alternative sequence

191 – 300

110

QRRPS…RRAAG → ARADLTAILTGCPPLSACLV LAPRPHRRARLLPS in isoform 4.

VSP_019087

Alternative sequence

451

1

R → RQVTQATQQGRGWEVRGRGR SAWPRLTRLSYFL in isoform 3 and isoform 4.

VSP_019088

Alternative sequence

509 – 696

188

DDSRK…SLLED → ED in isoform 3.

VSP_019089

Natural variant

4

1

A → T. Ref.2 Ref.3
Corresponds to variant rs12609976 [ dbSNP | Ensembl ].

VAR_060375

Natural variant

288

1

R → G.
Corresponds to variant rs1620074 [ dbSNP | Ensembl ].

VAR_060376

Natural variant

457

1

Q → E. Ref.2 Ref.3
Corresponds to variant rs1628576 [ dbSNP | Ensembl ].

VAR_056870

Natural variant

669

1

K → R. Ref.2 Ref.3 Ref.4
Corresponds to variant rs1054940 [ dbSNP | Ensembl ].

VAR_060377

Natural variant

703

1

L → P.
Corresponds to variant rs60073068 [ dbSNP | Ensembl ].

VAR_061647

Experimental info

Sequence conflict

30

1

M → T in BAC11399. Ref.4

Sequence conflict

555

1

P → S in AAL76117. Ref.2

Sequence conflict

688

1

T → I in BAA91041. Ref.4

Sequence conflict

695

1

E → G in BAC11399. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

723

Helix Strand Turn

Details...

Beta strand

482 – 487

6

Beta strand

493 – 496

4

Beta strand

504 – 509

6

Beta strand

511 – 518

8

Beta strand

525 – 528

4

Helix

529 – 531

3

Beta strand

532 – 534

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified May 18, 2010. Version 3. Checksum: E55F71B6E128151E	FASTA	723	80,251
	10 20 30 40 50 60 MSTATGPEAA PKPSAKSIYE QRKRYSTVVM ADVSQYPVNH LVTFCLGEDD GVHTVEDASR 70 80 90 100 110 120 KLAVMDSQGR VWAQEMLLRV SPDHVTLLDP ASKEELESYP LGAIVRCDAV MPPGRSRSLL 130 140 150 160 170 180 LLVCQEPERA QPDVHFFQGL RLGAELIRED IQGALHNYRS GRGERRAAAL RATQEELQRD 190 200 210 220 230 240 RSPAAETPPL QRRPSVRAVI STVERGAGRG RPQAKPIPEA EEAQRPEPVG TSSNADSASP 250 260 270 280 290 300 DLGPRGPDLA VLQAEREVDI LNHVFDDVES FVSRLQKSAE AARVLEHRER GRRSRRRAAG 310 320 330 340 350 360 EGLLTLRAKP PSEAEYTDVL QKIKYAFSLL ARLRGNIADP SSPELLHFLF GPLQMIVNTS 370 380 390 400 410 420 GGPEFASSVR RPHLTSDAVA LLRDNVTPRE NELWTSLGDS WTRPGLELSP EEGPPYRPEF 430 440 450 460 470 480 FSGWEPPVTD PQSRAWEDPV EKQLQHERRR RQQSAPQVAV NGHRDLEPES EPQLESETAG 490 500 510 520 530 540 KWVLCNYDFQ ARNSSELSVK QRDVLEVLDD SRKWWKVRDP AGQEGYVPYN ILTPYPGPRL 550 560 570 580 590 600 HHSQSPARSL NSTPPPPPAP APAPPPALAR PRWDRPRWDS CDSLNGLDPS EKEKFSQMLI 610 620 630 640 650 660 VNEELQARLA QGRSGPSRAV PGPRAPEPQL SPGSDASEVR AWLQAKGFSS GTVDALGVLT 670 680 690 700 710 720 GAQLFSLQKE ELRAVSPEEG ARVYSQVTVQ RSLLEDKEKV SELEAVMEKQ KKKVEGEVEM EVI
	Isoform 2 (B) [UniParc]. Checksum: CA417997A8419B8F	FASTA	596	66,477
	10 20 30 40 50 60 MNRTWPRRIW GSSQDEAELI REDIQGALHN YRSGRGERRA AALRATQEEL QRDRSPAAET 70 80 90 100 110 120 PPLQRRPSVR AVISTVERGA GRGRPQAKPI PEAEEAQRPE PVGTSSNADS ASPDLGPRGP 130 140 150 160 170 180 DLAVLQAERE VDILNHVFDD VESFVSRLQK SAEAARVLEH RERGRRSRRR AAGEGLLTLR 190 200 210 220 230 240 AKPPSEAEYT DVLQKIKYAF SLLARLRGNI ADPSSPELLH FLFGPLQMIV NTSGGPEFAS 250 260 270 280 290 300 SVRRPHLTSD AVALLRDNVT PRENELWTSL GDSWTRPGLE LSPEEGPPYR PEFFSGWEPP 310 320 330 340 350 360 VTDPQSRAWE DPVEKQLQHE RRRRQQSAPQ VAVNGHRDLE PESEPQLESE TAGKWVLCNY 370 380 390 400 410 420 DFQARNSSEL SVKQRDVLEV LDDSRKWWKV RDPAGQEGYV PYNILTPYPG PRLHHSQSPA 430 440 450 460 470 480 RSLNSTPPPP PAPAPAPPPA LARPRWDRPR WDSCDSLNGL DPSEKEKFSQ MLIVNEELQA 490 500 510 520 530 540 RLAQGRSGPS RAVPGPRAPE PQLSPGSDAS EVRAWLQAKG FSSGTVDALG VLTGAQLFSL 550 560 570 580 590 QKEELRAVSP EEGARVYSQV TVQRSLLEDK EKVSELEAVM EKQKKKVEGE VEMEVI
	Isoform 3 (C) [UniParc]. Checksum: 39325B1AB8281946	FASTA	551	61,682
	10 20 30 40 50 60 MGRKAIVLAI ANTSLAFPLC QHLVTFCLGE DDGVHTVEDA SRKLAVMDSQ GRVWAQEMLL 70 80 90 100 110 120 RVSPDHVTLL DPASKEELES YPLGAIVRCD AVMPPGRSRS LLLLVCQEPE RAQPDVHFFQ 130 140 150 160 170 180 GLRLGAELIR EDIQGALHNY RSGRGERRAA ALRATQEELQ RDRSPAAETP PLQRRPSVRA 190 200 210 220 230 240 VISTVERGAG RGRPQAKPIP EAEEAQRPEP VGTSSNADSA SPDLGPRGPD LAVLQAEREV 250 260 270 280 290 300 DILNHVFDDV ESFVSRLQKS AEAARVLEHR ERGRRSRRRA AGEGLLTLRA KPPSEAEYTD 310 320 330 340 350 360 VLQKIKYAFS LLARLRGNIA DPSSPELLHF LFGPLQMIVN TSGGPEFASS VRRPHLTSDA 370 380 390 400 410 420 VALLRDNVTP RENELWTSLG DSWTRPGLEL SPEEGPPYRP EFFSGWEPPV TDPQSRAWED 430 440 450 460 470 480 PVEKQLQHER RRRQVTQATQ QGRGWEVRGR GRSAWPRLTR LSYFLQQSAP QVAVNGHRDL 490 500 510 520 530 540 EPESEPQLES ETAGKWVLCN YDFQARNSSE LSVKQRDVLE VLEDKEKVSE LEAVMEKQKK 550 KVEGEVEMEV I
	Isoform 4 [UniParc]. Checksum: 03BA1843CECD229A	FASTA	502	55,807
	10 20 30 40 50 60 MSPLSPGSPL PPLARADLTA ILTGCPPLSA CLVLAPRPHR RARLLPSEGL LTLRAKPPSE 70 80 90 100 110 120 AEYTDVLQKI KYAFSLLARL RGNIADPSSP ELLHFLFGPL QMIVNTSGGP EFASSVRRPH 130 140 150 160 170 180 LTSDAVALLR DNVTPRENEL WTSLGDSWTR PGLELSPEEG PPYRPEFFSG WEPPVTDPQS 190 200 210 220 230 240 RAWEDPVEKQ LQHERRRRQV TQATQQGRGW EVRGRGRSAW PRLTRLSYFL QQSAPQVAVN 250 260 270 280 290 300 GHRDLEPESE PQLESETAGK WVLCNYDFQA RNSSELSVKQ RDVLEVLDDS RKWWKVRDPA 310 320 330 340 350 360 GQEGYVPYNI LTPYPGPRLH HSQSPARSLN STPPPPPAPA PAPPPALARP RWDRPRWDSC 370 380 390 400 410 420 DSLNGLDPSE KEKFSQMLIV NEELQARLAQ GRSGPSRAVP GPRAPEPQLS PGSDASEVRA 430 440 450 460 470 480 WLQAKGFSSG TVDALGVLTG AQLFSLQKEE LRAVSPEEGA RVYSQVTVQR SLLEDKEKVS 490 500 ELEAVMEKQK KKVEGEVEME VI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer." Wu K., Xu Z., Wang M., Xu X., Han Y., Cao Y., Wang R., Sun Y., Wu M. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 16:325-327(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4).
[2]	"In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure." Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C. Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-4; GLU-457 AND ARG-669.
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-4; GLU-457 AND ARG-669.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-669. Tissue: Placenta.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Muscle and Skin.
[7]	"The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway." Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G. Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1, INTERACTION WITH ABI1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF282168 Genomic DNA. Translation: AAG03039.1. Sequence problems.
AF282167 mRNA. Translation: AAG03038.1. Frameshift.
AY074928 mRNA. Translation: AAL76117.1.
AF370395 mRNA. Translation: AAQ15231.1.
AK000265 mRNA. Translation: BAA91041.1.
AK075098 mRNA. Translation: BAC11399.1.
AC005782 Genomic DNA. No translation available.
AC011476 Genomic DNA. No translation available.
BC004907 mRNA. Translation: AAH04907.2.
BC015763 mRNA. Translation: AAH15763.1.

IPI

IPI00157535.
IPI00253281.
IPI00301250.
IPI00795545.

RefSeq

NP_060199.3. NM_017729.3.
NP_573441.2. NM_133180.2.

UniGene

Hs.438862.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K2M	NMR	-	A	481-536	[»]
2ROL	NMR	-	A	478-537	[»]

ProteinModelPortal

Q8TE68.

SMR

Q8TE68. Positions 30-159, 478-537, 612-694.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-4829629.

STRING

9606.ENSP00000201647.

PTM databases

PhosphoSite

Q8TE68.

Polymorphism databases

DMDM

296439363.

Proteomic databases

PaxDb

Q8TE68.

PRIDE

Q8TE68.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000201647; ENSP00000201647; ENSG00000131037.
ENST00000245618; ENSP00000245618; ENSG00000131037.
ENST00000570966; ENSP00000460865; ENSG00000262092.
ENST00000571441; ENSP00000459036; ENSG00000262225.
ENST00000571474; ENSP00000459625; ENSG00000262287.
ENST00000572133; ENSP00000459405; ENSG00000263295.
ENST00000572335; ENSP00000461108; ENSG00000262430.
ENST00000572411; ENSP00000458499; ENSG00000262430.
ENST00000572780; ENSP00000461691; ENSG00000263295.
ENST00000573442; ENSP00000459703; ENSG00000262092.
ENST00000573454; ENSP00000459674; ENSG00000262467.
ENST00000574541; ENSP00000458597; ENSG00000262225.
ENST00000574553; ENSP00000460946; ENSG00000262878.
ENST00000574658; ENSP00000461137; ENSG00000262878.
ENST00000575092; ENSP00000460617; ENSG00000262467.
ENST00000576005; ENSP00000459396; ENSG00000262835.
ENST00000576261; ENSP00000459340; ENSG00000262287.
ENST00000577025; ENSP00000459502; ENSG00000262835.

GeneID

54869.

KEGG

hsa:54869.

UCSC

uc002qis.4. human.
uc002qiu.3. human.
uc002qiv.3. human.
uc010ess.1. human.

Organism-specific databases

CTD

54869.

GeneCards

GC19P055583.

HGNC

HGNC:21295. EPS8L1.

MIM

614987. gene.

neXtProt

NX_Q8TE68.

PharmGKB

PA134990326.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG263108.

HOVERGEN

HBG003090.

InParanoid

Q8TE68.

OMA

SQYPVNH.

PhylomeDB

Q8TE68.

Gene expression databases

ArrayExpress

Q8TE68.

Bgee

Q8TE68.

CleanEx

HS_EPS8L1.

Genevestigator

Q8TE68.

GermOnline

ENSG00000131037. Homo sapiens.

Family and domain databases

InterPro

IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

SMART

SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

EPS8L1. human.

EvolutionaryTrace

Q8TE68.

GenomeRNAi

54869.

NextBio

57779.

SOURCE

Search...

Entry information

Entry name

ES8L1_HUMAN

Accession

Primary (citable) accession number: Q8TE68
Secondary accession number(s): Q71RE2 , Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.