ID   ES8L3_HUMAN             Reviewed;         593 AA.
AC   Q8TE67; A8K833; Q5T8Q6; Q5T8Q7; Q5T8Q8; Q96E47; Q9H719;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=Epidermal growth factor receptor kinase substrate 8-like protein 3;
DE            Short=EPS8-like protein 3;
DE   AltName: Full=Epidermal growth factor receptor pathway substrate 8-related protein 3;
DE            Short=EPS8-related protein 3;
GN   Name=EPS8L3; Synonyms=EPS8R3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-163.
RX   PubMed=12620401; DOI=10.1016/s0888-7543(03)00002-8;
RA   Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.;
RT   "In silico analysis of the EPS8 gene family: genomic organization,
RT   expression profile, and protein structure.";
RL   Genomics 81:234-244(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   TYR-293.
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT TYR-293.
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1, INTERACTION WITH ABI1,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=14565974; DOI=10.1091/mbc.e03-06-0427;
RA   Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I.,
RA   Iannolo G., Di Fiore P.P., Scita G.;
RT   "The eps8 family of proteins links growth factor stimulation to actin
RT   reorganization generating functional redundancy in the Ras/Rac pathway.";
RL   Mol. Biol. Cell 15:91-98(2004).
RN   [6]
RP   INTERACTION WITH FASLG.
RX   PubMed=19807924; DOI=10.1186/1471-2172-10-53;
RA   Voss M., Lettau M., Janssen O.;
RT   "Identification of SH3 domain interaction partners of human FasL (CD178) by
RT   phage display screening.";
RL   BMC Immunol. 10:53-53(2009).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [8]
RP   STRUCTURE BY NMR OF 453-507.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the SH3 domain of human hypothetical protein
RT   FLJ21522.";
RL   Submitted (JAN-2006) to the PDB data bank.
RN   [9]
RP   VARIANT HYPT5 THR-8, AND INVOLVEMENT IN HYPT5.
RX   PubMed=23099647; DOI=10.1136/jmedgenet-2012-101134;
RA   Zhang X., Guo B.R., Cai L.Q., Jiang T., Sun L.D., Cui Y., Hu J.C., Zhu J.,
RA   Chen G., Tang X.F., Sun G.Q., Tang H.Y., Liu Y., Li M., Li Q.B., Cheng H.,
RA   Gao M., Li P., Yang X., Zuo X.B., Zheng X.D., Wang P.G., Wang J., Wang J.,
RA   Liu J.J., Yang S., Li Y.R., Zhang X.J.;
RT   "Exome sequencing identified a missense mutation of EPS8L3 in Marie Unna
RT   hereditary hypotrichosis.";
RL   J. Med. Genet. 49:727-730(2012).
CC   -!- SUBUNIT: Interacts with ABI1. Part of a complex that contains SOS1,
CC       ABI1 and EPS8L2. Interacts with FASLG. {ECO:0000269|PubMed:14565974,
CC       ECO:0000269|PubMed:19807924}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14565974}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8TE67-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TE67-2; Sequence=VSP_019096;
CC       Name=3; Synonyms=A;
CC         IsoId=Q8TE67-3; Sequence=VSP_019095;
CC   -!- DISEASE: Hypotrichosis 5 (HYPT5) [MIM:612841]: A form of hypotrichosis,
CC       a condition characterized by the presence of less than the normal
CC       amount of hair and abnormal hair follicles and shafts, which are thin
CC       and atrophic. The extent of scalp and body hair involvement can be very
CC       variable, within as well as between families. HYPT5 is an autosomal
CC       dominant form characterized by little or no scalp hair at birth, wiry
CC       and irregular scalp hair in childhood, and sparse or no forehead and
CC       parietal hair at puberty. Eyebrows and eyelashes are thin, and pubic
CC       and axillary hair fails to develop. Scarring alopecia is modest, and
CC       vertex hair is normal. {ECO:0000269|PubMed:23099647}. Note=The disease
CC       may be caused by variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the EPS8 family. {ECO:0000305}.
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DR   EMBL; AY074930; AAL76119.1; -; mRNA.
DR   EMBL; AK025175; BAB15081.1; -; mRNA.
DR   EMBL; AK292198; BAF84887.1; -; mRNA.
DR   EMBL; AL158847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC012926; AAH12926.1; -; mRNA.
DR   CCDS; CCDS813.1; -. [Q8TE67-2]
DR   CCDS; CCDS814.1; -. [Q8TE67-1]
DR   CCDS; CCDS815.1; -. [Q8TE67-3]
DR   RefSeq; NP_001306881.1; NM_001319952.1.
DR   RefSeq; NP_078802.2; NM_024526.3. [Q8TE67-2]
DR   RefSeq; NP_573444.2; NM_133181.3. [Q8TE67-1]
DR   RefSeq; NP_620641.1; NM_139053.2. [Q8TE67-3]
DR   PDB; 1WXT; NMR; -; A=453-507.
DR   PDBsum; 1WXT; -.
DR   AlphaFoldDB; Q8TE67; -.
DR   SMR; Q8TE67; -.
DR   BioGRID; 122721; 6.
DR   CORUM; Q8TE67; -.
DR   IntAct; Q8TE67; 4.
DR   MINT; Q8TE67; -.
DR   STRING; 9606.ENSP00000358820; -.
DR   GlyGen; Q8TE67; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8TE67; -.
DR   PhosphoSitePlus; Q8TE67; -.
DR   BioMuta; EPS8L3; -.
DR   DMDM; 108864727; -.
DR   jPOST; Q8TE67; -.
DR   MassIVE; Q8TE67; -.
DR   MaxQB; Q8TE67; -.
DR   PaxDb; 9606-ENSP00000358820; -.
DR   PeptideAtlas; Q8TE67; -.
DR   ProteomicsDB; 74404; -. [Q8TE67-1]
DR   ProteomicsDB; 74405; -. [Q8TE67-2]
DR   ProteomicsDB; 74406; -. [Q8TE67-3]
DR   ABCD; Q8TE67; 5 sequenced antibodies.
DR   Antibodypedia; 53746; 199 antibodies from 26 providers.
DR   DNASU; 79574; -.
DR   Ensembl; ENST00000361852.8; ENSP00000354551.4; ENSG00000198758.11. [Q8TE67-2]
DR   Ensembl; ENST00000361965.9; ENSP00000355255.4; ENSG00000198758.11. [Q8TE67-1]
DR   Ensembl; ENST00000369805.7; ENSP00000358820.3; ENSG00000198758.11. [Q8TE67-3]
DR   GeneID; 79574; -.
DR   KEGG; hsa:79574; -.
DR   MANE-Select; ENST00000361965.9; ENSP00000355255.4; NM_133181.4; NP_573444.2.
DR   UCSC; uc001dyq.3; human. [Q8TE67-1]
DR   AGR; HGNC:21297; -.
DR   CTD; 79574; -.
DR   DisGeNET; 79574; -.
DR   GeneCards; EPS8L3; -.
DR   HGNC; HGNC:21297; EPS8L3.
DR   HPA; ENSG00000198758; Group enriched (gallbladder, intestine, stomach).
DR   MalaCards; EPS8L3; -.
DR   MIM; 612841; phenotype.
DR   MIM; 614989; gene.
DR   neXtProt; NX_Q8TE67; -.
DR   OpenTargets; ENSG00000198758; -.
DR   Orphanet; 444; Marie Unna hereditary hypotrichosis.
DR   PharmGKB; PA134940846; -.
DR   VEuPathDB; HostDB:ENSG00000198758; -.
DR   eggNOG; KOG3557; Eukaryota.
DR   GeneTree; ENSGT00940000158169; -.
DR   HOGENOM; CLU_014510_0_1_1; -.
DR   InParanoid; Q8TE67; -.
DR   OMA; LLTCKLG; -.
DR   OrthoDB; 2997036at2759; -.
DR   PhylomeDB; Q8TE67; -.
DR   TreeFam; TF313069; -.
DR   PathwayCommons; Q8TE67; -.
DR   SignaLink; Q8TE67; -.
DR   BioGRID-ORCS; 79574; 43 hits in 1141 CRISPR screens.
DR   EvolutionaryTrace; Q8TE67; -.
DR   GeneWiki; EPS8L3; -.
DR   GenomeRNAi; 79574; -.
DR   Pharos; Q8TE67; Tbio.
DR   PRO; PR:Q8TE67; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8TE67; Protein.
DR   Bgee; ENSG00000198758; Expressed in mucosa of transverse colon and 141 other cell types or tissues.
DR   ExpressionAtlas; Q8TE67; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032587; C:ruffle membrane; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; IBA:GO_Central.
DR   GO; GO:0042634; P:regulation of hair cycle; IMP:UniProtKB.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   CDD; cd01210; PTB_EPS8; 1.
DR   CDD; cd11764; SH3_Eps8; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR039801; EPS8-like.
DR   InterPro; IPR033928; EPS8_PTB.
DR   InterPro; IPR035462; Eps8_SH3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12287:SF22; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   Genevisible; Q8TE67; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cytoplasm; Disease variant;
KW   Hypotrichosis; Phosphoprotein; Reference proteome; SH3 domain.
FT   CHAIN           1..593
FT                   /note="Epidermal growth factor receptor kinase substrate 8-
FT                   like protein 3"
FT                   /id="PRO_0000239087"
FT   DOMAIN          28..155
FT                   /note="PTB"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          450..509
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          149..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         231
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         153
FT                   /note="Q -> QS (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_019095"
FT   VAR_SEQ         412..441
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_019096"
FT   VARIANT         8
FT                   /note="A -> T (in HYPT5; uncertain significance;
FT                   dbSNP:rs1650987435)"
FT                   /evidence="ECO:0000269|PubMed:23099647"
FT                   /id="VAR_083829"
FT   VARIANT         35
FT                   /note="M -> I (in dbSNP:rs17598321)"
FT                   /id="VAR_050976"
FT   VARIANT         163
FT                   /note="G -> S (in dbSNP:rs6693815)"
FT                   /evidence="ECO:0000269|PubMed:12620401"
FT                   /id="VAR_026580"
FT   VARIANT         293
FT                   /note="H -> Y (in dbSNP:rs3818562)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_026581"
FT   VARIANT         356
FT                   /note="P -> S (in dbSNP:rs11102001)"
FT                   /id="VAR_026582"
FT   VARIANT         581
FT                   /note="R -> Q (in dbSNP:rs35072794)"
FT                   /id="VAR_050977"
FT   STRAND          453..459
FT                   /evidence="ECO:0007829|PDB:1WXT"
FT   STRAND          465..468
FT                   /evidence="ECO:0007829|PDB:1WXT"
FT   STRAND          476..481
FT                   /evidence="ECO:0007829|PDB:1WXT"
FT   STRAND          483..490
FT                   /evidence="ECO:0007829|PDB:1WXT"
FT   STRAND          496..500
FT                   /evidence="ECO:0007829|PDB:1WXT"
FT   HELIX           501..503
FT                   /evidence="ECO:0007829|PDB:1WXT"
SQ   SEQUENCE   593 AA;  66861 MW;  2BB9B52ADD338F88 CRC64;
     MSRPSSRAIY LHRKEYSQNL TSEPTLLQHR VEHLMTCKQG SQRVQGPEDA LQKLFEMDAQ
     GRVWSQDLIL QVRDGWLQLL DIETKEELDS YRLDSIQAMN VALNTCSYNS ILSITVQEPG
     LPGTSTLLFQ CQEVGAERLK TSLQKALEEE LEQRPRLGGL QPGQDRWRGP AMERPLPMEQ
     ARYLEPGIPP EQPHQRTLEH SLPPSPRPLP RHTSAREPSA FTLPPPRRSS SPEDPERDEE
     VLNHVLRDIE LFMGKLEKAQ AKTSRKKKFG KKNKDQGGLT QAQYIDCFQK IKHSFNLLGR
     LATWLKETSA PELVHILFKS LNFILARCPE AGLAAQVISP LLTPKAINLL QSCLSPPESN
     LWMGLGPAWT TSRADWTGDE PLPYQPTFSD DWQLPEPSSQ APLGYQDPVS LRRGSHRLGS
     TSHFPQEKTH NHDPQPGDPN SRPSSPKPAQ PALKMQVLYE FEARNPRELT VVQGEKLEVL
     DHSKRWWLVK NEAGRSGYIP SNILEPLQPG TPGTQGQSPS RVPMLRLSSR PEEVTDWLQA
     ENFSTATVRT LGSLTGSQLL RIRPGELQML CPQEAPRILS RLEAVRRMLG ISP
//