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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

EPS8L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 3
Short name:
EPS8-like protein 3
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 3
Short name:
EPS8-related protein 3
Gene namesi
Name:EPS8L3
Synonyms:EPS8R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21297. EPS8L3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi79574.
MalaCardsiEPS8L3.
OpenTargetsiENSG00000198758.
Orphaneti444. Marie Unna hereditary hypotrichosis.
PharmGKBiPA134940846.

Polymorphism and mutation databases

BioMutaiEPS8L3.
DMDMi108864727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390871 – 593Epidermal growth factor receptor kinase substrate 8-like protein 3Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TE67.
PaxDbiQ8TE67.
PeptideAtlasiQ8TE67.
PRIDEiQ8TE67.

PTM databases

iPTMnetiQ8TE67.
PhosphoSitePlusiQ8TE67.

Expressioni

Gene expression databases

BgeeiENSG00000198758.
CleanExiHS_EPS8L3.
ExpressionAtlasiQ8TE67. baseline and differential.
GenevisibleiQ8TE67. HS.

Organism-specific databases

HPAiHPA030998.

Interactioni

Subunit structurei

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG.2 Publications

Protein-protein interaction databases

BioGridi122721. 4 interactors.
IntActiQ8TE67. 3 interactors.
MINTiMINT-7213997.
STRINGi9606.ENSP00000358820.

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi453 – 459Combined sources7
Beta strandi465 – 468Combined sources4
Beta strandi476 – 481Combined sources6
Beta strandi483 – 490Combined sources8
Beta strandi496 – 500Combined sources5
Helixi501 – 503Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WXTNMR-A453-507[»]
ProteinModelPortaliQ8TE67.
SMRiQ8TE67.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TE67.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini450 – 509SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 235Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the EPS8 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IP0I. Eukaryota.
ENOG4111SRJ. LUCA.
GeneTreeiENSGT00390000003646.
HOVERGENiHBG099838.
InParanoidiQ8TE67.
KOiK17277.
OMAiWLQAENF.
OrthoDBiEOG091G023T.
PhylomeDBiQ8TE67.
TreeFamiTF313069.

Family and domain databases

CDDicd01210. PTB_EPS8. 1 hit.
InterProiIPR033928. EPS8_PTB.
IPR011993. PH_dom-like.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPSSRAIY LHRKEYSQNL TSEPTLLQHR VEHLMTCKQG SQRVQGPEDA
60 70 80 90 100
LQKLFEMDAQ GRVWSQDLIL QVRDGWLQLL DIETKEELDS YRLDSIQAMN
110 120 130 140 150
VALNTCSYNS ILSITVQEPG LPGTSTLLFQ CQEVGAERLK TSLQKALEEE
160 170 180 190 200
LEQRPRLGGL QPGQDRWRGP AMERPLPMEQ ARYLEPGIPP EQPHQRTLEH
210 220 230 240 250
SLPPSPRPLP RHTSAREPSA FTLPPPRRSS SPEDPERDEE VLNHVLRDIE
260 270 280 290 300
LFMGKLEKAQ AKTSRKKKFG KKNKDQGGLT QAQYIDCFQK IKHSFNLLGR
310 320 330 340 350
LATWLKETSA PELVHILFKS LNFILARCPE AGLAAQVISP LLTPKAINLL
360 370 380 390 400
QSCLSPPESN LWMGLGPAWT TSRADWTGDE PLPYQPTFSD DWQLPEPSSQ
410 420 430 440 450
APLGYQDPVS LRRGSHRLGS TSHFPQEKTH NHDPQPGDPN SRPSSPKPAQ
460 470 480 490 500
PALKMQVLYE FEARNPRELT VVQGEKLEVL DHSKRWWLVK NEAGRSGYIP
510 520 530 540 550
SNILEPLQPG TPGTQGQSPS RVPMLRLSSR PEEVTDWLQA ENFSTATVRT
560 570 580 590
LGSLTGSQLL RIRPGELQML CPQEAPRILS RLEAVRRMLG ISP
Length:593
Mass (Da):66,861
Last modified:May 30, 2006 - v2
Checksum:i2BB9B52ADD338F88
GO
Isoform 2 (identifier: Q8TE67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-441: Missing.

Show »
Length:563
Mass (Da):63,502
Checksum:iA3D9199068057B9F
GO
Isoform 3 (identifier: Q8TE67-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: Q → QS

Show »
Length:594
Mass (Da):66,948
Checksum:iE114E2211130CAAA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05097635M → I.Corresponds to variant rs17598321dbSNPEnsembl.1
Natural variantiVAR_026580163G → S.1 PublicationCorresponds to variant rs6693815dbSNPEnsembl.1
Natural variantiVAR_026581293H → Y.2 PublicationsCorresponds to variant rs3818562dbSNPEnsembl.1
Natural variantiVAR_026582356P → S.Corresponds to variant rs11102001dbSNPEnsembl.1
Natural variantiVAR_050977581R → Q.Corresponds to variant rs35072794dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019095153Q → QS in isoform 3. 1 Publication1
Alternative sequenceiVSP_019096412 – 441Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074930 mRNA. Translation: AAL76119.1.
AK025175 mRNA. Translation: BAB15081.1.
AK292198 mRNA. Translation: BAF84887.1.
AL158847 Genomic DNA. Translation: CAI22582.1.
AL158847 Genomic DNA. Translation: CAI22583.1.
AL158847 Genomic DNA. Translation: CAI22584.1.
BC012926 mRNA. Translation: AAH12926.1.
CCDSiCCDS813.1. [Q8TE67-2]
CCDS814.1. [Q8TE67-1]
CCDS815.1. [Q8TE67-3]
RefSeqiNP_001306881.1. NM_001319952.1.
NP_078802.2. NM_024526.3. [Q8TE67-2]
NP_573444.2. NM_133181.3. [Q8TE67-1]
NP_620641.1. NM_139053.2. [Q8TE67-3]
UniGeneiHs.485352.

Genome annotation databases

EnsembliENST00000361852; ENSP00000354551; ENSG00000198758. [Q8TE67-2]
ENST00000361965; ENSP00000355255; ENSG00000198758. [Q8TE67-1]
ENST00000369805; ENSP00000358820; ENSG00000198758. [Q8TE67-3]
GeneIDi79574.
KEGGihsa:79574.
UCSCiuc001dyq.3. human. [Q8TE67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074930 mRNA. Translation: AAL76119.1.
AK025175 mRNA. Translation: BAB15081.1.
AK292198 mRNA. Translation: BAF84887.1.
AL158847 Genomic DNA. Translation: CAI22582.1.
AL158847 Genomic DNA. Translation: CAI22583.1.
AL158847 Genomic DNA. Translation: CAI22584.1.
BC012926 mRNA. Translation: AAH12926.1.
CCDSiCCDS813.1. [Q8TE67-2]
CCDS814.1. [Q8TE67-1]
CCDS815.1. [Q8TE67-3]
RefSeqiNP_001306881.1. NM_001319952.1.
NP_078802.2. NM_024526.3. [Q8TE67-2]
NP_573444.2. NM_133181.3. [Q8TE67-1]
NP_620641.1. NM_139053.2. [Q8TE67-3]
UniGeneiHs.485352.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WXTNMR-A453-507[»]
ProteinModelPortaliQ8TE67.
SMRiQ8TE67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122721. 4 interactors.
IntActiQ8TE67. 3 interactors.
MINTiMINT-7213997.
STRINGi9606.ENSP00000358820.

PTM databases

iPTMnetiQ8TE67.
PhosphoSitePlusiQ8TE67.

Polymorphism and mutation databases

BioMutaiEPS8L3.
DMDMi108864727.

Proteomic databases

MaxQBiQ8TE67.
PaxDbiQ8TE67.
PeptideAtlasiQ8TE67.
PRIDEiQ8TE67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361852; ENSP00000354551; ENSG00000198758. [Q8TE67-2]
ENST00000361965; ENSP00000355255; ENSG00000198758. [Q8TE67-1]
ENST00000369805; ENSP00000358820; ENSG00000198758. [Q8TE67-3]
GeneIDi79574.
KEGGihsa:79574.
UCSCiuc001dyq.3. human. [Q8TE67-1]

Organism-specific databases

CTDi79574.
DisGeNETi79574.
GeneCardsiEPS8L3.
HGNCiHGNC:21297. EPS8L3.
HPAiHPA030998.
MalaCardsiEPS8L3.
MIMi614989. gene.
neXtProtiNX_Q8TE67.
OpenTargetsiENSG00000198758.
Orphaneti444. Marie Unna hereditary hypotrichosis.
PharmGKBiPA134940846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP0I. Eukaryota.
ENOG4111SRJ. LUCA.
GeneTreeiENSGT00390000003646.
HOVERGENiHBG099838.
InParanoidiQ8TE67.
KOiK17277.
OMAiWLQAENF.
OrthoDBiEOG091G023T.
PhylomeDBiQ8TE67.
TreeFamiTF313069.

Enzyme and pathway databases

BioCyciZFISH:G66-31884-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8TE67.
GeneWikiiEPS8L3.
GenomeRNAii79574.
PROiQ8TE67.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198758.
CleanExiHS_EPS8L3.
ExpressionAtlasiQ8TE67. baseline and differential.
GenevisibleiQ8TE67. HS.

Family and domain databases

CDDicd01210. PTB_EPS8. 1 hit.
InterProiIPR033928. EPS8_PTB.
IPR011993. PH_dom-like.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiES8L3_HUMAN
AccessioniPrimary (citable) accession number: Q8TE67
Secondary accession number(s): A8K833
, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.