Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TE67

- ES8L3_HUMAN

UniProt

Q8TE67 - ES8L3_HUMAN

Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

EPS8L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor kinase substrate 8-like protein 3
    Short name:
    EPS8-like protein 3
    Alternative name(s):
    Epidermal growth factor receptor pathway substrate 8-related protein 3
    Short name:
    EPS8-related protein 3
    Gene namesi
    Name:EPS8L3
    Synonyms:EPS8R3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21297. EPS8L3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti444. Marie Unna hereditary hypotrichosis.
    PharmGKBiPA134940846.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Epidermal growth factor receptor kinase substrate 8-like protein 3PRO_0000239087Add
    BLAST

    Proteomic databases

    MaxQBiQ8TE67.
    PaxDbiQ8TE67.
    PRIDEiQ8TE67.

    PTM databases

    PhosphoSiteiQ8TE67.

    Expressioni

    Gene expression databases

    BgeeiQ8TE67.
    CleanExiHS_EPS8L3.
    GenevestigatoriQ8TE67.

    Organism-specific databases

    HPAiHPA030998.

    Interactioni

    Subunit structurei

    Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG.2 Publications

    Protein-protein interaction databases

    BioGridi122721. 5 interactions.
    IntActiQ8TE67. 3 interactions.
    MINTiMINT-7213997.
    STRINGi9606.ENSP00000358820.

    Structurei

    Secondary structure

    1
    593
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi453 – 4597
    Beta strandi465 – 4684
    Beta strandi476 – 4816
    Beta strandi483 – 4908
    Beta strandi496 – 5005
    Helixi501 – 5033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WXTNMR-A453-507[»]
    ProteinModelPortaliQ8TE67.
    SMRiQ8TE67. Positions 28-148, 452-513, 522-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TE67.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini450 – 50960SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi170 – 23566Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPS8 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG277915.
    HOVERGENiHBG099838.
    KOiK17277.
    OMAiWLQAENF.
    OrthoDBiEOG7TMZR9.
    PhylomeDBiQ8TE67.
    TreeFamiTF313069.

    Family and domain databases

    InterProiIPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE67-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRPSSRAIY LHRKEYSQNL TSEPTLLQHR VEHLMTCKQG SQRVQGPEDA    50
    LQKLFEMDAQ GRVWSQDLIL QVRDGWLQLL DIETKEELDS YRLDSIQAMN 100
    VALNTCSYNS ILSITVQEPG LPGTSTLLFQ CQEVGAERLK TSLQKALEEE 150
    LEQRPRLGGL QPGQDRWRGP AMERPLPMEQ ARYLEPGIPP EQPHQRTLEH 200
    SLPPSPRPLP RHTSAREPSA FTLPPPRRSS SPEDPERDEE VLNHVLRDIE 250
    LFMGKLEKAQ AKTSRKKKFG KKNKDQGGLT QAQYIDCFQK IKHSFNLLGR 300
    LATWLKETSA PELVHILFKS LNFILARCPE AGLAAQVISP LLTPKAINLL 350
    QSCLSPPESN LWMGLGPAWT TSRADWTGDE PLPYQPTFSD DWQLPEPSSQ 400
    APLGYQDPVS LRRGSHRLGS TSHFPQEKTH NHDPQPGDPN SRPSSPKPAQ 450
    PALKMQVLYE FEARNPRELT VVQGEKLEVL DHSKRWWLVK NEAGRSGYIP 500
    SNILEPLQPG TPGTQGQSPS RVPMLRLSSR PEEVTDWLQA ENFSTATVRT 550
    LGSLTGSQLL RIRPGELQML CPQEAPRILS RLEAVRRMLG ISP 593
    Length:593
    Mass (Da):66,861
    Last modified:May 30, 2006 - v2
    Checksum:i2BB9B52ADD338F88
    GO
    Isoform 2 (identifier: Q8TE67-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         412-441: Missing.

    Show »
    Length:563
    Mass (Da):63,502
    Checksum:iA3D9199068057B9F
    GO
    Isoform 3 (identifier: Q8TE67-3) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         153-153: Q → QS

    Show »
    Length:594
    Mass (Da):66,948
    Checksum:iE114E2211130CAAA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351M → I.
    Corresponds to variant rs17598321 [ dbSNP | Ensembl ].
    VAR_050976
    Natural varianti163 – 1631G → S.1 Publication
    Corresponds to variant rs6693815 [ dbSNP | Ensembl ].
    VAR_026580
    Natural varianti293 – 2931H → Y.2 Publications
    Corresponds to variant rs3818562 [ dbSNP | Ensembl ].
    VAR_026581
    Natural varianti356 – 3561P → S.
    Corresponds to variant rs11102001 [ dbSNP | Ensembl ].
    VAR_026582
    Natural varianti581 – 5811R → Q.
    Corresponds to variant rs35072794 [ dbSNP | Ensembl ].
    VAR_050977

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei153 – 1531Q → QS in isoform 3. 1 PublicationVSP_019095
    Alternative sequencei412 – 44130Missing in isoform 2. 1 PublicationVSP_019096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074930 mRNA. Translation: AAL76119.1.
    AK025175 mRNA. Translation: BAB15081.1.
    AK292198 mRNA. Translation: BAF84887.1.
    AL158847 Genomic DNA. Translation: CAI22582.1.
    AL158847 Genomic DNA. Translation: CAI22583.1.
    AL158847 Genomic DNA. Translation: CAI22584.1.
    BC012926 mRNA. Translation: AAH12926.1.
    CCDSiCCDS813.1. [Q8TE67-2]
    CCDS814.1. [Q8TE67-1]
    CCDS815.1. [Q8TE67-3]
    RefSeqiNP_078802.2. NM_024526.3. [Q8TE67-2]
    NP_573444.2. NM_133181.3. [Q8TE67-1]
    NP_620641.1. NM_139053.2. [Q8TE67-3]
    UniGeneiHs.485352.

    Genome annotation databases

    EnsembliENST00000361852; ENSP00000354551; ENSG00000198758. [Q8TE67-2]
    ENST00000361965; ENSP00000355255; ENSG00000198758. [Q8TE67-1]
    ENST00000369805; ENSP00000358820; ENSG00000198758. [Q8TE67-3]
    GeneIDi79574.
    KEGGihsa:79574.
    UCSCiuc001dyq.2. human. [Q8TE67-3]
    uc001dyr.2. human. [Q8TE67-1]
    uc001dys.2. human. [Q8TE67-2]

    Polymorphism databases

    DMDMi108864727.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074930 mRNA. Translation: AAL76119.1 .
    AK025175 mRNA. Translation: BAB15081.1 .
    AK292198 mRNA. Translation: BAF84887.1 .
    AL158847 Genomic DNA. Translation: CAI22582.1 .
    AL158847 Genomic DNA. Translation: CAI22583.1 .
    AL158847 Genomic DNA. Translation: CAI22584.1 .
    BC012926 mRNA. Translation: AAH12926.1 .
    CCDSi CCDS813.1. [Q8TE67-2 ]
    CCDS814.1. [Q8TE67-1 ]
    CCDS815.1. [Q8TE67-3 ]
    RefSeqi NP_078802.2. NM_024526.3. [Q8TE67-2 ]
    NP_573444.2. NM_133181.3. [Q8TE67-1 ]
    NP_620641.1. NM_139053.2. [Q8TE67-3 ]
    UniGenei Hs.485352.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WXT NMR - A 453-507 [» ]
    ProteinModelPortali Q8TE67.
    SMRi Q8TE67. Positions 28-148, 452-513, 522-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122721. 5 interactions.
    IntActi Q8TE67. 3 interactions.
    MINTi MINT-7213997.
    STRINGi 9606.ENSP00000358820.

    PTM databases

    PhosphoSitei Q8TE67.

    Polymorphism databases

    DMDMi 108864727.

    Proteomic databases

    MaxQBi Q8TE67.
    PaxDbi Q8TE67.
    PRIDEi Q8TE67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361852 ; ENSP00000354551 ; ENSG00000198758 . [Q8TE67-2 ]
    ENST00000361965 ; ENSP00000355255 ; ENSG00000198758 . [Q8TE67-1 ]
    ENST00000369805 ; ENSP00000358820 ; ENSG00000198758 . [Q8TE67-3 ]
    GeneIDi 79574.
    KEGGi hsa:79574.
    UCSCi uc001dyq.2. human. [Q8TE67-3 ]
    uc001dyr.2. human. [Q8TE67-1 ]
    uc001dys.2. human. [Q8TE67-2 ]

    Organism-specific databases

    CTDi 79574.
    GeneCardsi GC01M110292.
    HGNCi HGNC:21297. EPS8L3.
    HPAi HPA030998.
    MIMi 614989. gene.
    neXtProti NX_Q8TE67.
    Orphaneti 444. Marie Unna hereditary hypotrichosis.
    PharmGKBi PA134940846.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277915.
    HOVERGENi HBG099838.
    KOi K17277.
    OMAi WLQAENF.
    OrthoDBi EOG7TMZR9.
    PhylomeDBi Q8TE67.
    TreeFami TF313069.

    Miscellaneous databases

    EvolutionaryTracei Q8TE67.
    GeneWikii EPS8L3.
    GenomeRNAii 79574.
    NextBioi 68546.
    PROi Q8TE67.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TE67.
    CleanExi HS_EPS8L3.
    Genevestigatori Q8TE67.

    Family and domain databases

    InterProi IPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
      Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
      Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-163.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-293.
      Tissue: Colon.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT TYR-293.
      Tissue: Colon.
    5. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
      Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
      Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1, INTERACTION WITH ABI1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    7. "Solution structure of the SH3 domain of human hypothetical protein FLJ21522."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JAN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 453-507.

    Entry informationi

    Entry nameiES8L3_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE67
    Secondary accession number(s): A8K833
    , Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3