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Q8TE60

- ATS18_HUMAN

UniProt

Q8TE60 - ATS18_HUMAN

Protein

A disintegrin and metalloproteinase with thrombospondin motifs 18

Gene

ADAMTS18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi254 – 2541Zinc; in inhibited formBy similarity
    Metal bindingi436 – 4361Zinc; catalyticPROSITE-ProRule annotation
    Active sitei437 – 4371PROSITE-ProRule annotation
    Metal bindingi440 – 4401Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi446 – 4461Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. eye development Source: UniProtKB
    2. negative regulation of platelet aggregation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.
    REACT_201925. Degradation of the extracellular matrix.

    Protein family/group databases

    MEROPSiM12.028.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 18 (EC:3.4.24.-)
    Short name:
    ADAM-TS 18
    Short name:
    ADAM-TS18
    Short name:
    ADAMTS-18
    Gene namesi
    Name:ADAMTS18
    Synonyms:ADAMTS21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:17110. ADAMTS18.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) [MIM:615458]: A ocular syndrome characterized by microcornea and myopic chorioretinal atrophy. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. In addition to ocular findings, some patients have telecanthus and posteriorly rotated ears.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti202 – 2021L → P in MMCAT. 1 Publication
    VAR_070849
    Natural varianti577 – 5771C → W in MMCAT. 1 Publication
    VAR_070850

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615458. phenotype.
    Orphaneti369970. Microcornea-myopic chorioretinal atrophy-telecanthus syndrome.
    PharmGKBiPA24544.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4747Sequence AnalysisAdd
    BLAST
    Propeptidei48 – 284237By similarityPRO_0000029200Add
    BLAST
    Chaini285 – 1221937A disintegrin and metalloproteinase with thrombospondin motifs 18PRO_0000042163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi369 ↔ 420By similarity
    Disulfide bondi395 ↔ 402By similarity
    Disulfide bondi414 ↔ 493By similarity
    Disulfide bondi453 ↔ 477By similarity
    Disulfide bondi521 ↔ 546By similarity
    Disulfide bondi532 ↔ 553By similarity
    Disulfide bondi541 ↔ 572By similarity
    Disulfide bondi566 ↔ 577By similarity
    Disulfide bondi601 ↔ 638By similarity
    Disulfide bondi605 ↔ 643By similarity
    Disulfide bondi616 ↔ 628By similarity
    Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi838 – 8381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity
    Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ8TE60.
    PRIDEiQ8TE60.

    PTM databases

    PhosphoSiteiQ8TE60.

    Expressioni

    Tissue specificityi

    Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.

    Gene expression databases

    ArrayExpressiQ8TE60.
    BgeeiQ8TE60.
    CleanExiHS_ADAMTS18.
    GenevestigatoriQ8TE60.

    Organism-specific databases

    HPAiHPA044326.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000282849.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE60.
    SMRiQ8TE60. Positions 295-813.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini293 – 498206Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 57780DisintegrinAdd
    BLAST
    Domaini589 – 64456TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini931 – 99060TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini991 – 104959TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1052 – 111665TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1123 – 117856TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1184 – 122138PLACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni750 – 876127SpacerAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi252 – 2598Cysteine switchBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi644 – 749106Cys-richAdd
    BLAST

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Contains 1 disintegrin domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
    Contains 1 PLAC domain.PROSITE-ProRule annotation
    Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG237764.
    HOGENOMiHOG000004800.
    HOVERGENiHBG004315.
    InParanoidiQ8TE60.
    KOiK08632.
    OMAiCPAHPVY.
    OrthoDBiEOG73FQKT.
    PhylomeDBiQ8TE60.
    TreeFamiTF313537.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 6 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 5 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE60-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MECALLLACA FPAAGSGPPR GLAGLGRVAK ALQLCCLCCA SVAAALASDS     50
    SSGASGLNDD YVFVTPVEVD SAGSYISHDI LHNGRKKRSA QNARSSLHYR 100
    FSAFGQELHL ELKPSAILSS HFIVQVLGKD GASETQKPEV QQCFYQGFIR 150
    NDSSSSVAVS TCAGLSGLIR TRKNEFLISP LPQLLAQEHN YSSPAGHHPH 200
    VLYKRTAEEK IQRYRGYPGS GRNYPGYSPS HIPHASQSRE TEYHHRRLQK 250
    QHFCGRRKKY APKPPTEDTY LRFDEYGSSG RPRRSAGKSQ KGLNVETLVV 300
    ADKKMVEKHG KGNVTTYILT VMNMVSGLFK DGTIGSDINV VVVSLILLEQ 350
    EPGGLLINHH ADQSLNSFCQ WQSALIGKNG KRHDHAILLT GFDICSWKNE 400
    PCDTLGFAPI SGMCSKYRSC TINEDTGLGL AFTIAHESGH NFGMIHDGEG 450
    NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ YLKKFLSTPQ AGCLVDEPKQ 500
    AGQYKYPDKL PGQIYDADTQ CKWQFGAKAK LCSLGFVKDI CKSLWCHRVG 550
    HRCETKFMPA AEGTVCGLSM WCRQGQCVKF GELGPRPIHG QWSAWSKWSE 600
    CSRTCGGGVK FQERHCNNPK PQYGGLFCPG SSRIYQLCNI NPCNENSLDF 650
    RAQQCAEYNS KPFRGWFYQW KPYTKVEEED RCKLYCKAEN FEFFFAMSGK 700
    VKDGTPCSPN KNDVCIDGVC ELVGCDHELG SKAVSDACGV CKGDNSTCKF 750
    YKGLYLNQHK ANEYYPVVLI PAGARSIEIQ ELQVSSSYLA VRSLSQKYYL 800
    TGGWSIDWPG EFPFAGTTFE YQRSFNRPER LYAPGPTNET LVFEILMQGK 850
    NPGIAWKYAL PKVMNGTPPA TKRPAYTWSI VQSECSVSCG GGYINVKAIC 900
    LRDQNTQVNS SFCSAKTKPV TEPKICNAFS CPAYWMPGEW STCSKACAGG 950
    QQSRKIQCVQ KKPFQKEEAV LHSLCPVSTP TQVQACNSHA CPPQWSLGPW 1000
    SQCSKTCGRG VRKRELLCKG SAAETLPESQ CTSLPRPELQ EGCVLGRCPK 1050
    NSRLQWVASS WSECSATCGL GVRKREMKCS EKGFQGKLIT FPERRCRNIK 1100
    KPNLDLEETC NRRACPAHPV YNMVAGWYSL PWQQCTVTCG GGVQTRSVHC 1150
    VQQGRPSSSC LLHQKPPVLR ACNTNFCPAP EKREDPSCVD FFNWCHLVPQ 1200
    HGVCNHKFYG KQCCKSCTRK I 1221
    Length:1,221
    Mass (Da):135,167
    Last modified:May 18, 2010 - v3
    Checksum:i4F662B2D2ABF5CA3
    GO
    Isoform 2 (identifier: Q8TE60-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1064-1082: CSATCGLGVRKREMKCSEK → VWIRSHCWVRRLRPSWLTQ
         1083-1221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,082
    Mass (Da):119,768
    Checksum:i5620CE80BDFEEA8E
    GO

    Sequence cautioni

    The sequence CAC83612.1 differs from that shown. Reason: Probable intron retention.
    The sequence CAC83612.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAC85503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti410 – 4101I → T in CAC83612. (PubMed:11867212)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791S → L.2 Publications
    Corresponds to variant rs387906972 [ dbSNP | Ensembl ].
    VAR_066554
    Natural varianti191 – 1911Y → H.1 Publication
    Corresponds to variant rs11643211 [ dbSNP | Ensembl ].
    VAR_060231
    Natural varianti202 – 2021L → P in MMCAT. 1 Publication
    VAR_070849
    Natural varianti382 – 3821R → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036152
    Natural varianti455 – 4551K → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036153
    Natural varianti577 – 5771C → W in MMCAT. 1 Publication
    VAR_070850
    Natural varianti626 – 6261L → I.2 Publications
    Corresponds to variant rs11640912 [ dbSNP | Ensembl ].
    VAR_060232
    Natural varianti769 – 7691L → I.1 Publication
    Corresponds to variant rs9930984 [ dbSNP | Ensembl ].
    VAR_057083
    Natural varianti946 – 9461A → S.1 Publication
    Corresponds to variant rs12935394 [ dbSNP | Ensembl ].
    VAR_057084
    Natural varianti1080 – 10801S → R.1 Publication
    Corresponds to variant rs35478105 [ dbSNP | Ensembl ].
    VAR_057085
    Natural varianti1159 – 11591S → T.
    Corresponds to variant rs3743749 [ dbSNP | Ensembl ].
    VAR_057086

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1064 – 108219CSATC…KCSEK → VWIRSHCWVRRLRPSWLTQ in isoform 2. 1 PublicationVSP_015776Add
    BLAST
    Alternative sequencei1083 – 1221139Missing in isoform 2. 1 PublicationVSP_015777Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311903 mRNA. Translation: CAC83612.1. Sequence problems.
    AC009139 Genomic DNA. No translation available.
    AC010548 Genomic DNA. No translation available.
    AC025284 Genomic DNA. No translation available.
    BC063283 mRNA. Translation: AAH63283.1.
    AK122677 mRNA. Translation: BAC85503.1. Different initiation.
    CCDSiCCDS10926.1. [Q8TE60-1]
    RefSeqiNP_955387.1. NM_199355.2. [Q8TE60-1]
    UniGeneiHs.188746.

    Genome annotation databases

    EnsembliENST00000282849; ENSP00000282849; ENSG00000140873. [Q8TE60-1]
    GeneIDi170692.
    KEGGihsa:170692.
    UCSCiuc002ffc.4. human. [Q8TE60-1]
    uc010chc.1. human. [Q8TE60-2]

    Polymorphism databases

    DMDMi296439427.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311903 mRNA. Translation: CAC83612.1 . Sequence problems.
    AC009139 Genomic DNA. No translation available.
    AC010548 Genomic DNA. No translation available.
    AC025284 Genomic DNA. No translation available.
    BC063283 mRNA. Translation: AAH63283.1 .
    AK122677 mRNA. Translation: BAC85503.1 . Different initiation.
    CCDSi CCDS10926.1. [Q8TE60-1 ]
    RefSeqi NP_955387.1. NM_199355.2. [Q8TE60-1 ]
    UniGenei Hs.188746.

    3D structure databases

    ProteinModelPortali Q8TE60.
    SMRi Q8TE60. Positions 295-813.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000282849.

    Protein family/group databases

    MEROPSi M12.028.

    PTM databases

    PhosphoSitei Q8TE60.

    Polymorphism databases

    DMDMi 296439427.

    Proteomic databases

    PaxDbi Q8TE60.
    PRIDEi Q8TE60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282849 ; ENSP00000282849 ; ENSG00000140873 . [Q8TE60-1 ]
    GeneIDi 170692.
    KEGGi hsa:170692.
    UCSCi uc002ffc.4. human. [Q8TE60-1 ]
    uc010chc.1. human. [Q8TE60-2 ]

    Organism-specific databases

    CTDi 170692.
    GeneCardsi GC16M077316.
    H-InvDB HIX0026938.
    HGNCi HGNC:17110. ADAMTS18.
    HPAi HPA044326.
    MIMi 607512. gene.
    615458. phenotype.
    neXtProti NX_Q8TE60.
    Orphaneti 369970. Microcornea-myopic chorioretinal atrophy-telecanthus syndrome.
    PharmGKBi PA24544.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237764.
    HOGENOMi HOG000004800.
    HOVERGENi HBG004315.
    InParanoidi Q8TE60.
    KOi K08632.
    OMAi CPAHPVY.
    OrthoDBi EOG73FQKT.
    PhylomeDBi Q8TE60.
    TreeFami TF313537.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.
    REACT_201925. Degradation of the extracellular matrix.

    Miscellaneous databases

    GenomeRNAii 170692.
    NextBioi 89110.
    PROi Q8TE60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TE60.
    Bgeei Q8TE60.
    CleanExi HS_ADAMTS18.
    Genevestigatori Q8TE60.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 6 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 5 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
      Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
      Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-626 AND SER-946.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-191; ILE-626 AND ILE-769.
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-1221 (ISOFORM 1), VARIANT ARG-1080.
      Tissue: Cerebellum.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-382 AND THR-455.
    7. Cited for: VARIANT LEU-179.
    8. "The syndrome of microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) is caused by mutations in ADAMTS18."
      Aldahmesh M.A., Alshammari M.J., Khan A.O., Mohamed J.Y., Alhabib F.A., Alkuraya F.S.
      Hum. Mutat. 34:1195-1199(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MMCAT PRO-202 AND TRP-577.
    9. Cited for: VARIANT LEU-179, LACK OF INVOLVEMENT IN KNOBLOCH SYNDROME.

    Entry informationi

    Entry nameiATS18_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE60
    Secondary accession number(s): Q6P4R5, Q6ZWJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3